Prescription Description
| Prescription ID | TCMF407 |
| Pinyin Name | You Gui Wan |
| Chinese Name | 右归丸 |
| English Name | You Gui Pills |
| Function Description | 腰痛, 遗精, 阳痿 |
| Indications | Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; |
| Human Tissues Associated with Indication | Kidney |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
| TCMH1742 | Cinnamomum cassia | 肉桂 | TCMH1742 | GQ255631 |
| TCMH1175 | Cornus officinalis | 酒萸肉 | TCMH1175 | ITSAO2979-14 |
| TCMH1345 | Pulvis cornu cervi | 鹿角胶 | TCMH1345 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH613 | Aconitum carmichaeli | 附片 | TCMH613 | ITSAH2410-14 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 100 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
| TCMT1212 | Verticillium dahliae |
| TCMT1214 | Enterococcus faecium |
Showing 1 to 10 of 62 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.39925 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.27622 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.69699 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH | 2.64787 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH | 3.15167 |
| [BP] GO:0003008 | None | ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD3, GRM1, GRM5, GRM8, HMGCR, SRC, TYR | 2.12252 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC | 2.05733 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA | 9.5491 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 4.59019 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.6841 |
Showing 1 to 10 of 241 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3486 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.2155 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5075 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3619 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1 | 1.7196 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3318 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.25 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | HMGCR, IGF1R | 0.9083 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.4136 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3724 |
Showing 1 to 10 of 139 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples