TCM Prescription: Jin Mao Gou Ji Pills



Prescription Description
Prescription IDTCMF4032
Pinyin NameJin Mao Gou Ji Wan
Chinese Name金毛狗脊丸
English NameJin Mao Gou Ji Pills
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH289 Cyathula officinalis 川牛膝 TCMH289 ITSAF2788-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH1798 Morus alba 桑枝 TCMH1798 ITSAL1073-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH2522 NA 油松节 TCMH2522
TCMH776 Piper kadsura 海风藤 TCMH776 EF450290
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT466 MAPK9 c-Jun N-terminal kinase 2 Kinase P45984
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 15.8644
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP3, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 15.8644
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, GBA, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP3, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 15.0192
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP3, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 13.1308
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP3, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 12.7537
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, HMGCR, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TRPV1, XDH 12.5048
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 12.3751
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.9437
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.9348
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TRPV1 11.3697
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.3697
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 11.3697
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 11.3278
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.3161
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, FABP3, FLT3, GBA, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TRPV1 11.0268
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP3, MMP9, PRKCD, PTGS2, SRC, TERT 10.9353
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 10.9118
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, PIK3CA, PIM1, PPARA, PTAFR, PTGS1, PTGS2, TYR, XDH 10.8505
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.7952
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 10.5921
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 10.5042
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.4568
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, GBA, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 10.3001
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, PPARA, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TEK, TRPV1 10.1959
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 10.0899
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.0078
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.81798
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, MMP3, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.60203
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP3, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.5729
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 9.56864
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 9.52693
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FLT3, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 9.22266
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.22266
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 9.22266
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP3, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TRPV1 9.17699
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.06421
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, RORC, SMAD3, SRC, TRPV1 8.87273
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.72174
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 8.63257
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.57883
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, GBA, HMGCR, KDR, MMP3, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TRPV1 8.5128
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.5128
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.5128
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.45735
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.42819
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.3013
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.20115
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.16652
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 8.15915
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.14973
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.04874
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HIF1A, HMGCR, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 7.97801
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.97801
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.89833
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, PRKCE, PTAFR, PTGS2, RORC, SRC, TYR 7.87405
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.84996
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.80829
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HMGCR, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 7.80829
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, MMP3, PPARA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 7.77524
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, GAA, GBA, HIF1A, HMGCR, HSD17B2, IGF1R, INSR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.77524
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.69055
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.52105
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 7.52105
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 7.48975
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.46809
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.44218
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.43502
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.34343
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.26774
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTAFR, PTGS2, TEK, TERT 7.25225
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 7.25093
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP3, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.25093
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, MMP3, PRKCD, PTGS2, SMAD3, TRPV1, XDH 7.23469
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 7.19527
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.1924
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 7.15387
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP3, MMP9, PRKCD, PTGS1, PTGS2, SRC 7.08859
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, MMP3, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TRPV1 7.0826
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.02894
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.02334
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.00146
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.99865
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.85092
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.81912
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 6.81632
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.80858
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.79843
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 6.70942
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.70942
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.68265
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.66536
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.64241
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP3, MMP9, PRKCD, SRC 6.61584
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.5484
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP3, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.53598
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.50995
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.50995
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 6.50995
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HIF1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.50583
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.49285
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.46224
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 6.40136
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP3, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 6.39572
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HIF1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.37817
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.32865
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP3, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 6.31106
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP3, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 6.24344
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, HIF1A, HMGCR, PTAFR, TYR 6.18814
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.12951
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 6.12951
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.12209
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, PTGS2, RORC, SRC, TRPV1 6.09362
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 6.09362
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP3, MMP9, PRKCD, SRC 6.07243
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.04503
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP3, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 6.04503
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, MMP3, PRKCD, PTAFR, PTGS2, SRC, TRPV1 6.04503
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HIF1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.02969
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.97098
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TRPV1 5.97032
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, GBA, HIF1A, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 5.96818
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 5.92358
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP3, MMP9, PRKCD, SRC 5.66139
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, CSNK2A1, EGFR, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.64393
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.64185
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.63871
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGS2, TERT 5.61744
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTAFR, PTGS2, SRC, TRPV1 5.55119
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HIF1A, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.53889
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 5.39698
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HIF1A, INSR, MMP12, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TERT, TRPV1 5.30545
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SMAD3, SRC, TEK 5.29952
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.27856
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 5.26023
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.21219
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.17221
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 5.16035
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, EGFR, FLT3, HMGCR, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 5.14754
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, PIK3CB, SRC, XDH 5.12666
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, GAA, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.06519
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 5.01794
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, PTAFR 5.01794
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 4.9877
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC, TERT 4.94599
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.89124
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.83537
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP3, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 4.80762
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.79874
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.76252
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MMP3, MMP9, NUAK1, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 4.7586
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B2 4.75167
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.74621
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PRKCB, PRKCD, PRKCE, PTAFR, RORC, SMAD3, TRPV1 4.74596
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.7376
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.71032
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.70687
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, EGFR, HIF1A, HMGCR, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 4.69715
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 4.68399
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTAFR, PTGS2, SRC 4.67043
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TOP2A 4.64842
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, PRKCD, PRKCE, SRC 4.61737
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 4.61175
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.61164
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.57369
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.55612
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT 4.55217
[BP] GO:0051239 regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GAA, GBA, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.53276
[BP] GO:0051171 regulation of nitrogen compound metabolic process ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.49879
[BP] GO:0080090 regulation of primary metabolic process ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.48838
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, FABP4, GBA, HMGCR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 4.46398
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 4.46398
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.46398
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 4.46364
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.45242
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.45026
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HIF1A, HMGCR, HSD17B2, PRKCA, PRKCE, SLC22A1 4.40848
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, PRKCA, PTPN1, SRC, TEK 4.40807
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.40799
[BP] GO:0006855 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.39671
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.39055
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.38462
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 4.37461
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, PTAFR, PTGS2, SRC 4.35709
[BP] GO:0044236 multicellular organism metabolic process HIF1A, MMP1, MMP12, MMP2, MMP3, MMP9, TRPV1 4.34588
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.32779
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.2963
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTAFR, PTGS2, SRC 4.26448
[BP] GO:0045913 None HIF1A, INSR, PPARA, PRKCE, PTAFR, SRC 4.26204
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HMGCR, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 4.23208
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SRC, TEK 4.22831
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, DAO, GBA, HMGCR, PTAFR, TYR 4.22831
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 4.22621
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TERT, TOP2A 4.17937
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.15175
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.13258
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.0898
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.06675
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, GBA, HMGCR, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.0536
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP3, MMP9, PTGS2 4.04793
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.03411
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.03411
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 4.01917
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.01917
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, HIF1A, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 4.00024
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.99877
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, PRKCE, PTAFR, SRC 3.9482
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD 3.94352
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.94079
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.93657
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TRPV1 3.89863
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, MMP3, PRKCA, PRKCE, SMAD3, SRC, TEK 3.86243
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP3, MMP9 3.85523
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.82428
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, PRKCG, TERT 3.82217
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 3.81123
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTAFR, PTGS2, TEK, TRPV1, TYR 3.81123
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, GAA, GPR35, HIF1A, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.81056
[BP] GO:0001816 cytokine production APP, FABP4, HIF1A, PRKCD, PTAFR, PTGS2 3.80624
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.79578
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.79518
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 3.78118
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.77155
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 3.77103
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.77103
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD 3.75846
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PRKCA, PTGS2, TEK 3.75846
[BP] GO:0051248 None APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH 3.74744
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP3, MMP9 3.73181
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.66723
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, PRKCA, SRC, TEK 3.66237
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.65432
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTAFR, PTGS2 3.64464
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 3.63795
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TRPV1, TYR 3.58508
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.57714
[BP] GO:0010676 None INSR, PPARA, PRKCE, PTAFR, SRC 3.57714
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTAFR, PTGS2, TEK, TRPV1, TYR 3.51532
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.51347
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.5092
[BP] GO:0015893 None ABCB1, CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.48378
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.48378
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 3.47735
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 3.46907
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.46783
[BP] GO:0007610 None APP, BCL2, EGFR, GAA, HIF1A, HMGCR, INSR, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 3.45694
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 3.44331
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.42071
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.40158
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.39348
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.38047
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.38047
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.37328
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.35963
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, MMP2, MMP9, PTAFR, PTGS2, SRC, TOP2A 3.33344
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.32912
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.3256
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.3256
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 3.32505
[BP] GO:0002252 None ALOX5, APP, BCL2, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, PRKCD, PRKCE, PTAFR, RORC, SRC 3.32076
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.31809
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, HMGCR, MMP3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.31809
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PRKCE, PTGS2, SRC, TERT 3.31809
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.31138
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, MMP3, PRKCE, SRC 3.30627
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 3.30069
[BP] GO:0002376 immune system process ALOX5, APP, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HIF1A, HSPA1A, IGF1R, MGAM, MMP1, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTAFR, RORC, SMAD3, SRC, TEK, TRPV1 3.29816
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.29143
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.28722
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.28659
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SRC 3.24436
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.24171
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.24171
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GBA, HIF1A, PRKCA, PTGS2, SRC, TRPV1 3.24171
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 3.24171
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PRKCD, PTGS2, TERT 3.23911
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, HIF1A, PPARA, PTGS1, PTGS2 3.23623
[BP] GO:0051234 None ABCB1, ACHE, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, EGFR, FABP3, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1, XDH 3.22504
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.19774
[BP] GO:0043254 regulation of protein complex assembly ALOX15, ESR1, GBA, HSPA1A, MET, MMP1, MMP3, PRKCD, PRKCE, SRC 3.19594
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19364
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PRKCE, PTGS2, SRC, TERT 3.18742
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP3, MMP9 3.17971
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTAFR, SRC, TEK 3.17971
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DUSP3, ESR1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 3.17971
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CSNK2A1, EGFR, HIF1A, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 3.15991
[BP] GO:0031348 negative regulation of defense response CYP19A1, GBA, MMP12, PPARA, PRKCD, SMAD3, TEK 3.15004
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.12853
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.11259
[BP] GO:0032409 None ABCB1, APP, BCL2, GPR35, MMP9, PRKCD, PRKCE, PTAFR 3.11259
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, GBA, PPARA, PRKCD, SMAD3, TEK 3.11054
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TRPV1, TYR 3.10835
[BP] GO:0006109 regulation of carbohydrate metabolic process HIF1A, INSR, PPARA, PRKCE, PTAFR, RORC, SRC 3.10835
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MMP9, PRKCD, PTAFR, SLC22A2, TRPV1, XDH 3.09184
[BP] GO:0090087 None ACHE, APP, CA2, EGFR, HIF1A, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.08181
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, PTGS2, SRC 3.08061
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 3.08061
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.07064
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 3.06913
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 3.05975
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.04066
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.03192
[BP] GO:0070201 None ACHE, APP, BCL2, EGFR, HIF1A, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.02284
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, ESR1, ESR2, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.01605
[BP] GO:1901342 regulation of vasculature development CYP1B1, HIF1A, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH 3.00946
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.00946
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, EGFR, PRKCE, PTGS2 3.00848
[BP] GO:0010675 None INSR, PPARA, PRKCE, PTAFR, RORC, SRC 3.00848
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.9991
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.99785
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.99785
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HIF1A, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.99192
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.97921
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.97921
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.97663
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP3, MMP9 2.97663
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 2.97027
[BP] GO:0051179 None ABCB1, ACHE, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, EGFR, ESR1, FABP3, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1, XDH 2.96402
[BP] GO:0032269 None APP, CSNK2A1, DNMT1, DUSP3, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.96402
[BP] GO:0035408 None PRKCA, PRKCB 2.95765
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.94874
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TOP2A 2.93493
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, HMGCR, KDR, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.93112
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.92043
[BP] GO:0071453 cellular response to oxygen levels BCL2, HIF1A, PRKCE, PTGS2, SRC, TERT 2.91517
[BP] GO:0031400 None DNMT1, DUSP3, FABP4, GBA, HMGCR, HSPA1A, IGF1R, PRKCD, PRKCE, PRKCG, PTPN1, XDH 2.90816
[BP] GO:0043407 None DUSP3, GBA, HMGCR, PRKCD, PTPN1 2.90808
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.88906
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.88129
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TRPV1, TYR 2.87304
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.86557
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, GBA, HMGCR, PTAFR, PTGS1, PTGS2 2.86557
[BP] GO:0071229 cellular response to acid chemical DNMT1, EGFR, KDR, MMP2, PRKCE, PTAFR, SRC 2.86188
[BP] GO:0065007 biological regulation ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.84487
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.84225
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP3, MMP9 2.83823
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.83737
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.81697
[BP] GO:0070542 None FABP3, PRKCE, PTAFR, PTGS2, SRC 2.81597
[BP] GO:0055065 metal ion homeostasis APP, BCL2, EGFR, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.80675
[BP] GO:0032459 None GBA, MMP1, MMP3, SRC 2.8054
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80179
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, PRKCE, TERT 2.79926
[BP] GO:0044087 regulation of cellular component biogenesis ALOX15, ESR1, GBA, HSPA1A, KDR, MET, MMP1, MMP3, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 2.78207
[BP] GO:0044070 regulation of anion transport ABCB1, CA2, CA7, PRKCD, PTAFR 2.77343
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.77343
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.77343
[BP] GO:0009268 None CA2, GBA, SRC, TRPV1 2.77065
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, PRKCG, TERT 2.76178
[BP] GO:0043524 negative regulation of neuron apoptotic process AXL, BCL2, HIF1A, PIK3CA, PRKCG, TERT 2.74236
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, HIF1A, HMGCR, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT 2.72915
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.72798
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.71872
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.6957
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PRKCD, SRC 2.6957
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, KDR, PRKCE, SRC, TRPV1 2.6957
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HIF1A, HMGCR, PTGS2, TYR 2.6944
[BP] GO:0051223 None ACHE, APP, EGFR, HIF1A, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.67989
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.67899
[BP] GO:0043536 positive regulation of blood vessel endothelial cell migration HIF1A, KDR, PRKCA, PTGS2 2.66104
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.645
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.645
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.645
[BP] GO:0070920 None EGFR, ESR1, TERT 2.645
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.645
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.645
[BP] GO:0006810 None ABCB1, ACHE, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 2.63287
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.62136
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.62136
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.61692
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.61055
[BP] GO:0051047 None ACHE, CYP19A1, EGFR, HIF1A, MMP12, PRKCE, PTAFR, SRC, TRPV1 2.61012
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, HIF1A, HMGCR, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.61012
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.60296
[BP] GO:0045765 regulation of angiogenesis CYP1B1, HIF1A, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 2.59167
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, HIF1A, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.58438
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, PIK3CB, PRKCG, PTPN1, SRC 2.58037
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.57949
[BP] GO:0045785 positive regulation of cell adhesion ALOX15, KDR, PIK3CA, PRKCA, PRKCE, PTAFR, SMAD3, SRC, TEK 2.5761
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.57316
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC 2.57143
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.57143
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, ESR1, GPR35, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.57143
[BP] GO:0000023 None GAA, MGAM 2.57143
[BP] GO:0023021 None GBA, PRKCD 2.57143
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57143
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 2.57143
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 2.57143
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.54234
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK 2.53954
[BP] GO:0031331 positive regulation of cellular catabolic process GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PTPN1 2.52724
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.52431
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.52431
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HIF1A, PIK3CB, PTGS2 2.52269
[BP] GO:0003018 None EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 2.52269
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP3, MMP9 2.51236
[BP] GO:0051591 None APEX1, APP, PTAFR, TEK, TYR 2.51143
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.51101
[BP] GO:0010594 regulation of endothelial cell migration HIF1A, KDR, MET, PRKCA, PTGS2, TEK 2.51075
[BP] GO:0002263 None ALOX5, APP, FUCA1, GAA, HSPA1A, MGAM, MMP9, PRKCD, PRKCE, PTAFR, RORC 2.5076
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP3, MMP9 2.50695
[BP] GO:0022898 None ABCB1, APP, BCL2, GPR35, MMP9, PRKCE, PTAFR 2.50499
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, EGFR, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT 2.49964
[BP] GO:0050878 regulation of body fluid levels AKR1B1, GBA, HIF1A, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.49964
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.48916
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.47665
[BP] GO:0050730 None APP, EGFR, FLT3, PRKCD, PRKCE, PTPN1, SRC 2.47375
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.4701
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.46745
[BP] GO:1903827 regulation of cellular protein localization APP, BCL2, CSNK2A1, EGFR, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.46505
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, PRKCE, TERT 2.46129
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.46129
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, GPR35, MMP9, PRKCD, PRKCE, PTAFR, PTGS2 2.46129
[BP] GO:1904591 positive regulation of protein import APP, EGFR, PRKCD, PTGS2, SMAD3 2.44181
[BP] GO:0007611 None APP, EGFR, HIF1A, HMGCR, INSR, PRKCG, PTGS2 2.43399
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.42554
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.42554
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.42554
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.42554
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.42007
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.41848
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.40861
[BP] GO:0016043 cellular component organization ABCB1, ACHE, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CYP1B1, DNMT1, EGFR, ESR1, GAA, GBA, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SLC22A1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 2.40853
[BP] GO:0043409 None DUSP3, GBA, HMGCR, IGF1R, PRKCD, PTPN1 2.3985
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.38714
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.38714
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.37457
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, TEK, TYR 2.37304
[BP] GO:0071840 cellular component organization or biogenesis ABCB1, ACHE, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CYP1B1, DNMT1, EGFR, ESR1, GAA, GBA, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SLC22A1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 2.36941
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35469
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.35469
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35469
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 2.35448
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.34112
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.34098
[BP] GO:0050678 None EGFR, HIF1A, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.34098
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 2.33691
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.33666
[BP] GO:0003008 None AKR1B1, APP, BCL2, CYP1B1, EGFR, GAA, HIF1A, HMGCR, INSR, PIK3CA, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 2.32911
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.32911
[BP] GO:0098908 None GBA, GPR35 2.32911
[BP] GO:1901374 None SLC22A1, SLC22A2 2.32911
[BP] GO:1901529 None ABCB1, PTAFR 2.32911
[BP] GO:0015874 None SLC22A1, SLC22A2 2.32911
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32911
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.31651
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.31412
[BP] GO:1902905 positive regulation of supramolecular fiber organization ALOX15, APP, HSPA1A, MET, PRKCE, SMAD3 2.31412
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.31412
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.31412
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.31412
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.31412
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MGAM, PIK3CB, SRC, XDH 2.30968
[BP] GO:0050679 None EGFR, HIF1A, KDR, MMP12, PRKCA, TEK 2.2906
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.2906
[BP] GO:0007165 signal transduction AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, FLT3, GPR35, HIF1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 2.27129
[BP] GO:0060341 regulation of cellular localization APP, BCL2, CSNK2A1, EGFR, HIF1A, HMGCR, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.26208
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.26104
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26104
[BP] GO:0043086 negative regulation of catalytic activity APP, CSNK2A1, DUSP3, FABP4, GBA, HMGCR, IGF1R, MMP9, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.2547
[BP] GO:1901575 None ACHE, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, XDH 2.25298
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.25256
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.23801
[BP] GO:0006469 None DUSP3, FABP4, GBA, HMGCR, IGF1R, PRKCD, PTPN1 2.23086
[BP] GO:0048015 phosphatidylinositol-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.21909
[BP] GO:0033674 positive regulation of kinase activity CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.21505
[BP] GO:0051894 None KDR, SMAD3, TEK 2.21362
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.21362
[BP] GO:0061900 None APP, EGFR, TRPV1 2.21362
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21362
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA 2.2115
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.20755
[BP] GO:0009895 negative regulation of catabolic process BCL2, EGFR, MET, PIK3CA, PPARA, PRKCG, SMAD3 2.18792
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, GBA, MET, PIK3CA, TRPV1 2.1643
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HIF1A, MMP12, PRKCE, PTAFR, SRC 2.15738
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, PRKCE, PTAFR, RORC, SRC 2.15738
[BP] GO:0060249 None AKR1B1, APEX1, BCL2, GAA, HIF1A, SRC, TERT 2.15368
[BP] GO:0048017 inositol lipid-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.15231
[BP] GO:0009889 regulation of biosynthetic process APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.14776
[BP] GO:0002274 None ALOX5, FUCA1, GAA, HSPA1A, MGAM, MMP9, PRKCD, PRKCE, PTAFR, TRPV1 2.14776
[BP] GO:0046618 None SLC47A1, SLC47A2 2.14604
[BP] GO:0008150 biological_process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.13585
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.13082
[BP] GO:0046466 None CYP1B1, FUCA1, GBA 2.12689
[BP] GO:0030947 None HIF1A, PRKCB, PTPN1 2.12689
[BP] GO:1903393 None KDR, SMAD3, TEK 2.12689
[BP] GO:0050890 None APP, EGFR, HIF1A, HMGCR, INSR, PRKCG, PTGS2 2.11537
[BP] GO:0042326 None DUSP3, FABP4, GBA, HMGCR, IGF1R, PPARA, PRKCD, PTPN1, XDH 2.11222
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP4, GLO1, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCG, PTAFR, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.1094
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.08908
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, SRC 2.08908
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.08859
[BP] GO:0043523 regulation of neuron apoptotic process AXL, BCL2, HIF1A, PIK3CA, PRKCG, TERT 2.08552
[BP] GO:0010575 positive regulation of vascular endothelial growth factor production CYP1B1, HIF1A, PTGS2 2.08528
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.08528
[BP] GO:0033673 None DUSP3, FABP4, GBA, HMGCR, IGF1R, PRKCD, PTPN1 2.08528
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, GBA, HMGCR, PTAFR 2.08528
[BP] GO:0051495 positive regulation of cytoskeleton organization ALOX15, HSPA1A, MET, PRKCE, SMAD3, TEK 2.07845
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, GBA, HMGCR, PPARA, PRKCD, SMAD3, TEK 2.06023
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 2.06023
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.06023
[BP] GO:0051348 None DUSP3, FABP4, GBA, HMGCR, IGF1R, PRKCD, PTPN1, SRC 2.04548
[BP] GO:0071634 None HIF1A, PTGS2, SMAD3 2.04495
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.02768
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.00371
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.00371
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.00371
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.00371
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.00371
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00371
[BP] GO:1990535 None APP, INSR 2.00371
[BP] GO:1903961 None ABCB1, PTAFR 2.00371
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00371
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GAA, GLO1, GPR35, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1 6.35047
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, FLT3, FUT7, GAA, GBA, GLO1, GPR35, HMGCR, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 4.83905
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 4.40848
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.41997
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 3.40145
[CC] GO:0031982 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, BACE1, CA1, CA2, CA4, CA6, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, KDR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, PTPN1, SLC22A2, SLC47A1, SRC, TYR 3.05189
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HMGCR, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.01329
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, HSPA1A, INSR, KDR, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TOP2A, TRPV1, TYR, XDH 2.98333
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SRC 2.94199
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SRC 2.90043
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SRC 2.89891
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SRC, XDH 2.78772
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.62343
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.60943
[CC] GO:0098590 plasma membrane region ABCB1, CA2, CA4, CA9, EGFR, INSR, MET, MGAM, PRKCG, PTGS2, SLC22A1, SRC, TEK, TRPV1 2.36788
[CC] GO:0044459 plasma membrane part ABCB1, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MGAM, PRKCG, PTAFR, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 2.36148
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.1703
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.16471
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, FUT7, GAA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.08247
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00371
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 15.8644
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 15.8644
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 14.2296
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.9348
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 10.2558
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 9.37278
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.5128
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.06629
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 7.97801
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.83577
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 7.75025
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.48721
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.475
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.12801
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 7.05128
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.97261
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.81912
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.39572
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 6.29576
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 6.29431
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.26174
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.08122
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 6.06776
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DAO, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TEK, TOP2A, TRPV1, XDH 6.06634
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.04503
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.00812
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 5.8784
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.57941
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.69914
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.67043
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.49879
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.4594
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.45242
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.45242
[MF] GO:0097367 carbohydrate derivative binding ABCB1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TEK, TOP2A, TRPV1 4.3851
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.35709
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, HIF1A, HMGCR, HSPA1A, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.32896
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 4.15155
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.84793
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.84124
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.66237
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.62321
[MF] GO:1901363 heterocyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.58803
[MF] GO:0015238 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.52445
[MF] GO:0097159 organic cyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.5086
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.42596
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.37328
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HIF1A, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.32505
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.31809
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.31809
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.31809
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.30627
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.24436
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, HIF1A, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.21772
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HMGCR, NQO2, PTGS1, PTGS2, SRC, XDH 3.20622
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.07792
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.97921
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.95765
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.95765
[MF] GO:0035403 None PRKCA, PRKCB 2.95765
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.8194
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NQO2 2.70521
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.645
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.63102
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.6297
[MF] GO:0035257 None ESR1, FLT3, HIF1A, PRKCB, SMAD3, SRC 2.60296
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.57949
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.57143
[MF] GO:1901375 None SLC22A1, SLC22A2 2.57143
[MF] GO:0015307 None SLC47A1, SLC47A2 2.57143
[MF] GO:0005333 None SLC22A1, SLC22A2 2.57143
[MF] GO:0032450 None GAA, MGAM 2.57143
[MF] GO:0005277 None SLC22A1, SLC22A2 2.57143
[MF] GO:0008513 None SLC22A1, SLC22A2 2.57143
[MF] GO:0004699 None PRKCD, PRKCE 2.57143
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, FLT3, HIF1A, PIM1, PPARA, PRKCB, SMAD3, SRC, TERT 2.55947
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.52598
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.52431
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.52431
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40939
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32911
[MF] GO:0051425 None APP, INSR 2.32911
[MF] GO:0004558 None GAA, MGAM 2.32911
[MF] GO:0051427 hormone receptor binding ESR1, FLT3, HIF1A, PRKCB, SMAD3, SRC 2.32145
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.31651
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 2.31577
[MF] GO:0046983 protein dimerization activity ACHE, AXL, BCL2, DAO, EGFR, FLT3, HIF1A, HMGCR, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH 2.31412
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.26863
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.21362
[MF] GO:0004222 metalloendopeptidase activity MMP1, MMP12, MMP2, MMP3, MMP9 2.21143
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.17291
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.1643
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14604
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14604
[MF] GO:0003674 molecular_function ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP3, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.13585
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, FLT3, HMGCR, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH 2.13082
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.12689
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.11219
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.08528
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.04897
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.04495
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.00371
[MF] GO:0016798 None APEX1, FUCA1, GAA, GBA, MGAM 2.00371
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.00371
[MF] GO:0090599 None GAA, MGAM 2.00371
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00371


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, HIF1A, EGFR, IGF1R, PIK3CA, KDR, MET 10.7775
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.4547
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, PIK3CA, BCL2, MET 9.4065
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, HIF1A, EGFR, IGF1R 10.3851
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 10.002
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 9.4065
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 9.4065
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, HIF1A, EGFR 9.4065
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 8.7196
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.1146
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 8.2522
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.4793
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.8652
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 7.3618
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.8652
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.8722
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.8626
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 6.6784
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, PRKCB, ALOX5, ALOX15, PRKCA, PTGS2, PTGS1 6.6077
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1, HIF1A 6.4509
Metabolic pathways_Homo sapiens_hsa01100 MGAM, DNMT1, GAA, ALOX15, GBA, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, FUT7, DAO, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.8383
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 6.1197
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.5948
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.9743
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 5.9743
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.5261
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 6.8167
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.9743
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 4.983
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, HIF1A 5.8383
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, PRKCE, BCL2, PRKCA, PIK3CB 5.33
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 5.58
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.3599
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.8969
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.9465
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.0123
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.2283
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.209
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7943
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.4047
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.4397
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3712
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.8055
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.9944
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, MMP3, PIK3CB, PTGS2, MMP9 3.4069
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.6189
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.586
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.33
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.6299
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.3118
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.2851
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 3.2475
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.1032
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 3.015
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 2.9935
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4241
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.3703
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PTAFR, PRKCA, EGFR 2.6405
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.6847
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.4396
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP3, MMP9, MET, IGF1R 2.6405
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.3305
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.2621
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2588
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.1032
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2707
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.572
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7196
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3102
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.9796
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 3.2621
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3494
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.6923
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7765
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0233
Axon guidance_Homo sapiens_hsa04360 MET 0.3643
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3723
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.3305
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.7284
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.4396
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4194
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, PTGS2 2.6847
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.2626
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.8671
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.7883
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.288
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8989
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.7476
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1, HMGCR 3.1603
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4366
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.2425
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7124
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.9658
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4554
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2013
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, PTAFR, TRPV1 0.8339
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PRKCB, PIK3CB 3.7943
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6861
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.2226
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.1777
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7135
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4776
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4917
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1058
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4761
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.1532
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8551
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8877
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0918
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4076
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.4377
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, PIK3CB, PPARA 1.1306
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6855
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PRKCE, PIK3CB 2.0135
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4796
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.997
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5207
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0082
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.6198
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5535
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.5688
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.7005
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5561
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.8002
Shigellosis_Homo sapiens_hsa05131 SRC 0.5759
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.9
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1672
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 1.9473
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.9622
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, MMP3, TEK 1.9566
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.4397
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.63
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.0135
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6343
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.1777
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.1777
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6343
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.2642
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.2387
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.2573
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2827
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.2434
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6582
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6582
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6603
Malaria_Homo sapiens_hsa05144 MET 0.6655
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.1945
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1777
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2387
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3494
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3494
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.679
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6847
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6936
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6876
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.5206
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4167
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.4517
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.7228
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7703
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7228
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8105
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7703
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8551
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7883
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7945
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.9492
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8639
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8207
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8551
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.794
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8854
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9566
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9266
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1312
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1058
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.2815
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2622


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)