Prescription ID | TCMF3935 |
Pinyin Name | Gui Pi He Ji |
Chinese Name | 归脾合剂 |
English Name | Gui Pi Recipe |
Function Description | 不寐, 心悸, 不寐, 眩晕, 崩漏, 便血 |
Indications | Metrorrhagia disorder, Vertigo disorder, Insomnia disorder, Abnormal uterine and vaginal bleeding, Melena, Insomnia, Insomnia, Palpitations, Dizziness |
Disease ICD-11 Category |
SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; GA2Z [Abnormal uterine or vaginal bleeding, unspecified, 异常子宫或阴道出血,未特指的 ]; ME24.A4 [Melaena, 黑便 ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
TCMH1329 | Arillus longan | 龙眼肉 | TCMH1329 | |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
TCMH388 | Ziziphus jujuba | 大枣 | TCMH388 | ITSAM869-14 |
TCMH1903 | Zingiber officinale | 生姜 | TCMH1903 | ITSAO3969-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT208 | MAOA | Monoamine oxidase A | Oxidoreductase | P21397 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT27 | DRD1 | Dopamine D1 receptor | GPCR | P21728 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT289 | TBXAS1 | Thromboxane-A synthase | Isomerase | P24557 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT301 | PTGES | Prostaglandin E synthase | Isomerase | O14684 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT316 | MTNR1A | Melatonin receptor 1A | GPCR | P48039 |
TCMT317 | MTNR1B | Melatonin receptor 1B | GPCR | P49286 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT38 | DRD2 | Dopamine D2 receptor | GPCR | P14416 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT565 | EP300 | Histone acetyltransferase p300 | Transferase | Q09472 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT632 | PNP | Purine nucleoside phosphorylase | Transferase | P00491 |
TCMT649 | DRD5 | Dopamine D5 receptor | GPCR | P21918 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT651 | DRD3 | Dopamine D3 receptor | GPCR | P35462 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT807 | SLC22A12 | Solute carrier family 22 member 12 | Transporter | Q96S37 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1188 | Leishmania braziliensis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1207 | Legionella pneumophila |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1219 | Enterococcus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1282 | Colletotrichum orbiculare |
TCMT1283 | Human enterovirus 71 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1293 | Vaccinia virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1321 | Staphylococcus hominis |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, RORC, SRC, TEK, TRPV1, TYR | 13.2457 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 12.9451 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 11.8822 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 | 11.3413 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.0768 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, RORC, SRC, TEK, TRPV1, TYR | 10.9991 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR | 10.463 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.2419 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 9.9549 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MTNR1B, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH | 9.9549 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 9.66639 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 9.63701 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH | 9.35901 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH | 9.15714 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 9.09176 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 9.06091 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 8.91703 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 | 8.56517 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2, TRPV1 | 7.7833 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 7.72711 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH | 7.72711 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 7.72711 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, RORC, SRC, TYR | 7.71162 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SRC, TEK, TRPV1 | 7.47829 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 7.47659 |
[BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 7.29436 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 7.15733 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 6.82121 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC, TOP2A | 6.80937 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HMGCR, HSD11B2, KDR, SRC, TRPV1 | 6.79259 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 | 6.77675 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 6.7397 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 6.72484 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 6.72201 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B | 6.60264 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 6.51586 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, PTGES, TBXAS1 | 6.51001 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 6.50914 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK | 6.36697 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 6.32376 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, SRC | 6.28237 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 6.26432 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 6.26432 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 6.13902 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, HMGCR, KDR, SRC | 6.13902 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 6.13681 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 6.10516 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR | 6.10014 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, MTNR1B, SMAD3, SRC, TRPV1 | 6.10014 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC, TRPV1 | 6.06269 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 6.02887 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK | 5.92912 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 5.89739 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 5.89703 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK | 5.81382 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 5.81382 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR | 5.80436 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR | 5.73884 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR | 5.70447 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 5.66744 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.66433 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 5.65283 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA | 5.65123 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC, TRPV1 | 5.64819 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 5.63466 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HMGCR, HSD11B2, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR | 5.62784 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 5.55242 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 5.55242 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 5.51076 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 | 5.50543 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 5.48544 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 5.48544 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.48544 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 5.42206 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 5.33534 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, MTNR1B, SMAD3, TRPV1 | 5.33534 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS | 5.30475 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH | 5.29671 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH | 5.27672 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC, TRPV1 | 5.26959 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 5.26827 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK | 5.26591 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.2532 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH | 5.23067 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HMGCR, MAOA, TYR | 5.22735 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH | 5.14998 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH | 5.10946 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, RORC, SRC, TRPV1 | 5.09207 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH | 5.05742 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH | 5.05742 |
[BP] GO:0018958 | None | AKR1B1, BCL2, DRD1, DRD2, DRD3, MAOA, TYR | 5.02997 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 5.02423 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, TNKS, TNKS2 | 4.98666 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH | 4.95337 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 4.90471 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 | 4.90471 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 | 4.80094 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 | 4.76595 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH | 4.7602 |
[BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS | 4.75256 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.67978 |
[BP] GO:0009891 | positive regulation of biosynthetic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 4.63494 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.62693 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SRC, TRPV1 | 4.59352 |
[BP] GO:0032787 | None | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PPARA, PTGES, TBXAS1 | 4.5825 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A | 4.58075 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, MAOA, SMAD3, TRPV1 | 4.5634 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.50382 |
[BP] GO:0032845 | None | ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2, TRPV1 | 4.45355 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A | 4.44859 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 4.44806 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH | 4.40455 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.40455 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SMAD3, TEK | 4.40455 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.39737 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 4.39578 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.36321 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 4.33661 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.33661 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH | 4.26577 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 | 4.2354 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 4.23185 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 4.23185 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, SRC, TRPV1 | 4.22607 |
[BP] GO:0001963 | None | DRD1, DRD2, DRD3, DRD5 | 4.21739 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.1998 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 4.1998 |
[BP] GO:0030335 | positive regulation of cell migration | BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.1747 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK | 4.15229 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.11693 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, RORC | 4.0503 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 4.02437 |
[BP] GO:2000147 | positive regulation of cell motility | BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.02437 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HMGCR, HSPA1A, INSR, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TRPV1 | 3.93104 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 3.9262 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.91934 |
[BP] GO:0051272 | positive regulation of cellular component movement | BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 3.91152 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC | 3.90542 |
[BP] GO:0045776 | None | ADORA1, DRD2, DRD3, DRD5, PPARA | 3.87976 |
[BP] GO:0006584 | None | AKR1B1, DRD1, DRD2, DRD3, MAOA | 3.83471 |
[BP] GO:0009712 | None | AKR1B1, DRD1, DRD2, DRD3, MAOA | 3.83471 |
[BP] GO:0050801 | ion homeostasis | BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 | 3.83461 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, HMGCR | 3.81636 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, MTNR1A, SRC, TOP2A | 3.81376 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.79838 |
[BP] GO:0097164 | None | ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, MAOA | 3.79838 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 3.77887 |
[BP] GO:0040017 | positive regulation of locomotion | BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 3.77887 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 3.77096 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.72019 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK | 3.68951 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.66799 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 | 3.61625 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.61625 |
[BP] GO:0016310 | phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS | 3.61625 |
[BP] GO:0007623 | circadian rhythm | DRD2, DRD3, EGFR, MTNR1A, MTNR1B, PPARA, RORC | 3.60658 |
[BP] GO:0051726 | regulation of cell cycle | APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS, TOP2A | 3.54882 |
[BP] GO:0010638 | positive regulation of organelle organization | AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.52775 |
[BP] GO:0051130 | positive regulation of cellular component organization | AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.52695 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 | 3.49126 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH | 3.44856 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.444 |
[BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, SMAD3, TEK | 3.40699 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 3.40544 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC, TRPV1 | 3.37559 |
[BP] GO:0008217 | None | ADORA1, DRD2, DRD3, DRD5, HSD11B2, PPARA, SMAD3 | 3.36803 |
[BP] GO:0098771 | inorganic ion homeostasis | BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 | 3.34528 |
[BP] GO:0051940 | None | DRD1, DRD2, DRD3 | 3.34214 |
[BP] GO:0051584 | None | DRD1, DRD2, DRD3 | 3.34214 |
[BP] GO:0042752 | None | ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A | 3.33539 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR | 3.33157 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F3, INSR, MET, SRC, TEK | 3.3228 |
[BP] GO:0001975 | None | DRD1, DRD2, DRD3, DRD5 | 3.32082 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC | 3.28675 |
[BP] GO:0003018 | None | ADORA1, DRD1, DRD5, EGFR, HMGCR, SRC, TEK | 3.27267 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR | 3.24825 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A | 3.23079 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.22755 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.22748 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH | 3.21732 |
[BP] GO:0042417 | None | DRD1, DRD2, DRD3, MAOA | 3.20448 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 3.19971 |
[BP] GO:0051047 | None | ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, SRC, TRPV1 | 3.19631 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR | 3.18692 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR | 3.18692 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK | 3.1581 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR | 3.15246 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC | 3.13818 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK | 3.13343 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC, TRPV1 | 3.11271 |
[BP] GO:1900542 | None | DRD1, DRD2, DRD3, DRD5, ESRRB, INSR, MTNR1A, PPARA | 3.10466 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.10444 |
[BP] GO:0050805 | negative regulation of synaptic transmission | ACHE, ADORA1, DRD1, DRD2, DRD5 | 3.09818 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 3.09818 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH | 3.08058 |
[BP] GO:0007191 | None | DRD1, DRD3, DRD5 | 3.08058 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.08058 |
[BP] GO:0001659 | None | ADORA1, DRD1, DRD2, TRPV1 | 3.06557 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK | 3.05455 |
[BP] GO:0006140 | None | DRD1, DRD2, DRD3, DRD5, ESRRB, INSR, MTNR1A, PPARA | 3.03218 |
[BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.03083 |
[BP] GO:0010038 | response to metal ion | BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES | 3.02863 |
[BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7, DRD2 | 3.02062 |
[BP] GO:0010907 | None | ESRRB, INSR, PPARA, SRC | 2.96762 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR | 2.96152 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 | 2.95632 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, DRD1, DRD2, MET, TRPV1 | 2.95499 |
[BP] GO:0009968 | negative regulation of signal transduction | BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH | 2.95096 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSD11B2, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 | 2.92766 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH | 2.92766 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, DRD2, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH | 2.92284 |
[BP] GO:0072507 | divalent inorganic cation homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 | 2.92033 |
[BP] GO:0010564 | regulation of cell cycle process | APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS | 2.91968 |
[BP] GO:0008306 | None | DRD1, DRD2, DRD3, DRD5, HMGCR | 2.91523 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR | 2.9116 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, CA2, CA7, DRD1, DRD2, EGFR | 2.90723 |
[BP] GO:0007187 | None | ADORA1, DRD1, DRD2, DRD3, DRD5, MTNR1A, MTNR1B | 2.89261 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 2.89261 |
[BP] GO:0021885 | forebrain cell migration | AXL, DRD1, DRD2, EGFR | 2.88921 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 2.88469 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TOP2A | 2.86325 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 2.85242 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC | 2.84714 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR | 2.84255 |
[BP] GO:0046960 | None | DRD1, DRD5 | 2.84255 |
[BP] GO:0009115 | None | AOX1, XDH | 2.84255 |
[BP] GO:0055080 | cation homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 | 2.84254 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 2.84179 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR | 2.83353 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 2.83353 |
[BP] GO:0051098 | regulation of binding | AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS | 2.83353 |
[BP] GO:0007212 | None | DRD1, DRD2, DRD3, DRD5 | 2.82146 |
[BP] GO:0032467 | None | AURKB, CDC25B, DRD2, DRD3 | 2.82146 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9 | 2.81184 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.78587 |
[BP] GO:0060134 | None | DRD1, DRD2, DRD3 | 2.78587 |
[BP] GO:0060158 | None | DRD1, DRD2, DRD5 | 2.78587 |
[BP] GO:0014075 | None | DRD1, DRD2, DRD3, DRD5 | 2.78326 |
[BP] GO:0007610 | None | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR, MTNR1A, PPARA, TRPV1 | 2.76235 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 | 2.75068 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.74815 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.73303 |
[BP] GO:0050890 | None | ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR | 2.73303 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A | 2.71967 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK | 2.71491 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR | 2.70273 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.70076 |
[BP] GO:0051580 | None | DRD1, DRD2, DRD3 | 2.70076 |
[BP] GO:0002791 | None | ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, MTNR1B, SRC | 2.69937 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES | 2.68585 |
[BP] GO:0007612 | None | DRD1, DRD2, DRD3, DRD5, HMGCR, INSR | 2.68543 |
[BP] GO:0043434 | None | APEX1, FABP3, HSD11B2, INSR, PPARA, SRC, TEK, TRPV1 | 2.67967 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, SMAD3, TRPV1 | 2.67527 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.67527 |
[BP] GO:0003013 | None | ADORA1, DRD1, DRD5, EGFR, HMGCR, SRC, TEK | 2.6456 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK, TNKS | 2.6423 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.6423 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 2.62027 |
[BP] GO:0009416 | response to light stimulus | AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, HMGCR, TYR | 2.61236 |
[BP] GO:0043271 | negative regulation of ion transport | ADORA1, BCL2, DRD2, DRD3, GPR35, MMP9 | 2.60928 |
[BP] GO:0030003 | cellular cation homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.60297 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.60297 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 2.59044 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR | 2.56456 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 | 2.55432 |
[BP] GO:0050793 | regulation of developmental process | AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH | 2.54722 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 | 2.54722 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.54567 |
[BP] GO:0032225 | None | DRD1, DRD2, DRD3 | 2.54567 |
[BP] GO:0006874 | cellular calcium ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.5383 |
[BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.5383 |
[BP] GO:0097366 | None | DRD1, DRD2, DRD3, DRD5 | 2.5383 |
[BP] GO:0006873 | cellular ion homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.52263 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, SMAD3, TRPV1, XDH | 2.51602 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC | 2.49069 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.47202 |
[BP] GO:0090087 | None | ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, MTNR1B, PTPN1, SMAD3, SRC | 2.47202 |
[BP] GO:0051172 | None | APEX1, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 2.45918 |
[BP] GO:0046110 | None | AOX1, XDH | 2.44972 |
[BP] GO:0060160 | None | DRD2, DRD3 | 2.44972 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.44972 |
[BP] GO:0055074 | calcium ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.44972 |
[BP] GO:0008542 | None | DRD1, DRD2, DRD3, HMGCR | 2.44175 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTPN1, SRC | 2.41717 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC | 2.41437 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC | 2.41437 |
[BP] GO:0072503 | cellular divalent inorganic cation homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.41384 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.41384 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.41111 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.40923 |
[BP] GO:0010906 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.40514 |
[BP] GO:0003014 | None | ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 | 2.40514 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 2.39448 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH | 2.3734 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR | 2.36644 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.35189 |
[BP] GO:0045187 | None | ADORA1, DRD2, DRD3 | 2.35096 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.35096 |
[BP] GO:0007617 | None | DRD1, DRD5, MTNR1A | 2.35096 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH | 2.34282 |
[BP] GO:0007611 | None | DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR | 2.33193 |
[BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH | 2.33039 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.33039 |
[BP] GO:0010676 | None | ESRRB, INSR, PPARA, SRC | 2.33039 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.31998 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.31998 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.31998 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.31998 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK | 2.31689 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC | 2.30806 |
[BP] GO:0051046 | None | ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, MTNR1B, SRC, TRPV1 | 2.30806 |
[BP] GO:0007632 | None | DRD1, DRD2, DRD3, HMGCR | 2.30806 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.30806 |
[BP] GO:0048148 | None | DRD1, DRD2, DRD3 | 2.30015 |
[BP] GO:0035813 | None | ADORA1, DRD2, DRD3 | 2.30015 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.28059 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.28059 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.27169 |
[BP] GO:0032922 | None | DRD2, DRD3, PPARA, RORC | 2.25149 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.24575 |
[BP] GO:0050678 | None | CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH | 2.24575 |
[BP] GO:0050708 | None | ACHE, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, MTNR1B, SRC | 2.24575 |
[BP] GO:0042749 | None | ADORA1, DRD2, DRD3 | 2.24349 |
[BP] GO:0044236 | multicellular organism metabolic process | MMP1, MMP12, MMP2, MMP9, TRPV1 | 2.23839 |
[BP] GO:0009605 | response to external stimulus | ADORA1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, DRD3, EGFR, HMGCR, HSD11B2, MMP12, PTGES, SMAD3, SRC, TRPV1, TYR | 2.2112 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.20872 |
[BP] GO:0006145 | None | AOX1, XDH | 2.20872 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.20872 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.20592 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.20592 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.19423 |
[BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, XDH | 2.18081 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.15658 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, DRD1, DRD2, EGFR | 2.15658 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP2D6 | 2.15658 |
[BP] GO:0002793 | None | ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC | 2.15658 |
[BP] GO:0040008 | regulation of growth | BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3, TNKS2 | 2.14942 |
[BP] GO:0055082 | cellular chemical homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.14942 |
[BP] GO:0044062 | None | ADORA1, DRD2, DRD3 | 2.14652 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.14652 |
[BP] GO:0055065 | metal ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 | 2.14323 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.13462 |
[BP] GO:0045934 | None | APEX1, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 | 2.12432 |
[BP] GO:0042737 | drug catabolic process | ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA | 2.11707 |
[BP] GO:0051128 | regulation of cellular component organization | AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.11481 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH | 2.11177 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.11177 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.10667 |
[BP] GO:1900544 | None | DRD1, DRD5, ESRRB, INSR, MTNR1A | 2.10642 |
[BP] GO:0045981 | None | DRD1, DRD5, ESRRB, INSR, MTNR1A | 2.10642 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, SMAD3, TEK | 2.10642 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.10325 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.10325 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 | 2.09335 |
[BP] GO:0046883 | regulation of hormone secretion | ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, MTNR1B | 2.09335 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, PPARA, TRPV1 | 2.09116 |
[BP] GO:0009889 | regulation of biosynthetic process | ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PIM1, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 2.08633 |
[BP] GO:0019725 | cellular homeostasis | APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 | 2.07864 |
[BP] GO:0030336 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 | 2.07711 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.07452 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC | 2.0683 |
[BP] GO:0050927 | None | F3, KDR, SMAD3 | 2.06302 |
[BP] GO:0050886 | None | DRD3, DRD5, HSD11B2 | 2.06302 |
[BP] GO:0001990 | None | DRD3, DRD5, HSD11B2 | 2.06302 |
[BP] GO:0030802 | None | DRD1, DRD2, DRD3, DRD5, MTNR1A | 2.05375 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 2.05359 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.05359 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.04571 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC | 2.04571 |
[BP] GO:0021853 | None | DRD1, DRD2 | 2.04571 |
[BP] GO:0043696 | None | CDK6, ESRRB | 2.04571 |
[BP] GO:0043697 | None | CDK6, ESRRB | 2.04571 |
[BP] GO:0010641 | None | F3, SRC | 2.04571 |
[BP] GO:0090325 | None | DRD2, DRD3 | 2.04571 |
[BP] GO:1904936 | None | DRD1, DRD2 | 2.04571 |
[BP] GO:0042321 | None | ADORA1, DRD2 | 2.04571 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.0399 |
[BP] GO:0010675 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.03527 |
[BP] GO:1903530 | regulation of secretion by cell | ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, MTNR1B, SRC | 2.03309 |
[BP] GO:0050926 | None | F3, KDR, SMAD3 | 2.03309 |
[BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.03309 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.03309 |
[BP] GO:0003044 | None | DRD3, DRD5, HSD11B2 | 2.03309 |
[BP] GO:0010605 | negative regulation of macromolecule metabolic process | APEX1, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 2.0282 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK, TNKS | 2.02211 |
[BP] GO:0090068 | positive regulation of cell cycle process | APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR | 2.02082 |
[BP] GO:0007584 | response to nutrient | ALPL, CYP1A1, EGFR, HMGCR, TRPV1, TYR | 2.01549 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, SRC, TEK | 2.01321 |
[BP] GO:0040014 | regulation of multicellular organism growth | BCL2, DRD2, DRD3, TNKS2 | 2.00285 |
[BP] GO:0015908 | None | DRD2, DRD3, FABP3, PPARA | 2.00285 |
[BP] GO:0097746 | None | ADORA1, DRD1, DRD5, EGFR, HMGCR | 2.00049 |
[BP] GO:0035296 | None | ADORA1, DRD1, DRD5, EGFR, HMGCR | 2.00049 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 | 4.2308 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR | 3.63937 |
[CC] GO:0044432 | endoplasmic reticulum part | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 | 3.54938 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MMP2, MMP9, NQO2, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 3.08956 |
[CC] GO:0031253 | None | ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 | 3.06557 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SRC, TBXAS1, TEK, TRPV1, TYR | 2.89261 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 | 2.88664 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 | 2.3734 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 | 2.20107 |
[CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOA, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 2.18206 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, EGFR, TEK | 2.07096 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH | 19.2982 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 16.2962 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 15.34 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 13.6596 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.3627 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.2142 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS | 10.1095 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 9.7401 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH | 9.31022 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 | 7.92548 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A, TRPV1 | 7.87072 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 | 7.72711 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 | 7.25425 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH | 7.21436 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 7.11748 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.84856 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH | 6.83697 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR | 6.79479 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CDK6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 | 6.66959 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 | 6.63327 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 | 6.30772 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.16683 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SMAD3, TEK, TRPV1 | 6.13902 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 | 5.85555 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 5.66433 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 | 5.63466 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR | 5.26827 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 | 5.09207 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.89935 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.89935 |
[MF] GO:0042562 | hormone binding | ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 | 4.80094 |
[MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC | 4.76899 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.7678 |
[MF] GO:0004952 | None | DRD1, DRD2, DRD3, DRD5 | 4.58075 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.46141 |
[MF] GO:0035240 | None | DRD1, DRD2, DRD3, DRD5 | 4.44513 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 4.28912 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 | 4.28912 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 | 4.28912 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.93403 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.93403 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.84419 |
[MF] GO:1901338 | None | DRD1, DRD2, DRD3, DRD5 | 3.74259 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC | 3.70489 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, XDH | 3.48434 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.25849 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.19647 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.1545 |
[MF] GO:0008289 | lipid binding | AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 | 3.1498 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.14529 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 | 3.14529 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH | 3.13818 |
[MF] GO:0036094 | small molecule binding | ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH | 3.06557 |
[MF] GO:0070405 | ammonium ion binding | ACHE, DRD1, DRD2, DRD3, DRD5 | 2.87029 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.84255 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.84255 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.84255 |
[MF] GO:0042802 | identical protein binding | ACHE, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, SMAD3, TOP2A, TRPV1, TYR, XDH | 2.83024 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 2.80932 |
[MF] GO:0000166 | nucleotide binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH | 2.73303 |
[MF] GO:1901265 | nucleoside phosphate binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH | 2.73112 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.56566 |
[MF] GO:0008502 | None | MTNR1A, MTNR1B | 2.44972 |
[MF] GO:0043168 | anion binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SRC, TEK, TOP2A, TRPV1, XDH | 2.2242 |
[MF] GO:0001588 | None | DRD1, DRD5 | 2.20872 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.20872 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 2.16603 |
[MF] GO:0005518 | collagen binding | ACHE, MMP12, MMP9, SMAD3 | 2.07133 |
[MF] GO:0019903 | protein phosphatase binding | BCL2, EGFR, HMGCR, MET, PTPN1 | 2.06698 |
[MF] GO:0019899 | enzyme binding | AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A | 2.05354 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.04571 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.04571 |
[MF] GO:0003674 | molecular_function | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 2.03309 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 | 2.02025 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 17.4743 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.5521 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 8.1874 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.4406 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 6.0945 |
Metabolic pathways_Homo sapiens_hsa01100 | MAOA, AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES | 5.3352 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A | 5.3184 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | MTNR1A, GPR35, MTNR1B, ADORA3, ADORA1, TRPV1, DRD1, DRD2, DRD3, DRD5 | 5.2592 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R | 4.529 |
Tryptophan metabolism_Homo sapiens_hsa00380 | MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 | 4.9314 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R | 4.4364 |
Pathways in cancer_Homo sapiens_hsa05200 | CDK6, SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R | 4.1262 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 4.9274 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.753 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B | 3.4439 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 | 3.9547 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.2038 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R | 3.0946 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.0502 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, BCL2, TEK, EGFR, IGF1R | 3.1868 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, ADORA1, DRD1, DRD2, PPARA, DRD5 | 2.863 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, MET, EGFR, IGF1R | 2.863 |
Dopaminergic synapse_Homo sapiens_hsa04728 | MAOA, DRD1, DRD2, DRD3, DRD5 | 2.863 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, TEK, MET, EGFR, IGF1R | 2.6432 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, SMAD3, SRC, BCL2, MMP9 | 2.6469 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, AOX1 | 2.9136 |
Melanoma_Homo sapiens_hsa05218 | CDK6, MET, EGFR, IGF1R | 2.8539 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 2.863 |
Gap junction_Homo sapiens_hsa04540 | SRC, DRD1, DRD2, EGFR | 2.5575 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, EGFR, IGF1R | 1.9465 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR, ADORA1 | 2.0752 |
Glioma_Homo sapiens_hsa05214 | CDK6, EGFR, IGF1R | 1.9393 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 1.9465 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6, SMAD3, EGFR | 1.9318 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, TBXAS1, PTGES | 1.961 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2, EGFR, IGF1R | 1.6212 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 1.8579 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.6047 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.5984 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 1.9248 |
Cocaine addiction_Homo sapiens_hsa05030 | MAOA, DRD1, DRD2 | 2.2299 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 1.9176 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PPARA | 1.4375 |
Serotonergic synapse_Homo sapiens_hsa04726 | MAOA, CYP2D6, ALOX5 | 1.4231 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2, HSPA1A | 1.3708 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.202 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, BCL2, ADORA1 | 1.3596 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, HMGCR, IGF1R | 1.3379 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1, HSPA1A | 1.2478 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, ESRRB, IGF1R | 1.2065 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, SMAD3, CDC25B | 1.3379 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.1822 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1, AOX1 | 1.15 |
Tyrosine metabolism_Homo sapiens_hsa00350 | MAOA, AOX1, TYR | 2.6328 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, INSR, ADORA1 | 1.108 |
Calcium signaling pathway_Homo sapiens_hsa04020 | DRD1, EGFR, DRD5 | 1.0508 |
Alcoholism_Homo sapiens_hsa05034 | MAOA, DRD1, DRD2 | 1.0509 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2, HSPA1A | 0.9512 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3 | 0.1745 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, EGFR | 0.9614 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 0.8395 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2566 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 0.9183 |
Platelet activation_Homo sapiens_hsa04611 | SRC, TBXAS1 | 0.7889 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2683 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC, TRPV1 | 0.9183 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, DRD1 | 0.9442 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6, SMAD3 | 1.0692 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.2563 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, IGF1R | 0.9344 |
Influenza A_Homo sapiens_hsa05164 | HSPA1A | 0.2683 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 0.9465 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 0.9646 |
Circadian entrainment_Homo sapiens_hsa04713 | MTNR1A, MTNR1B | 0.9318 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 0.8088 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.8088 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3048 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.7491 |
Parkinson's disease_Homo sapiens_hsa05012 | DRD1, DRD2 | 0.7324 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.7349 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3123 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 0.9374 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.7349 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.327 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6, EGFR | 1.202 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3381 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.1677 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.7324 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.1948 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.6472 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.0348 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.7053 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | INSR, EGFR | 0.7307 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.616 |
Amphetamine addiction_Homo sapiens_hsa05031 | MAOA, DRD1 | 1.1186 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, EGFR | 0.6817 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC, EGFR | 0.5393 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3527 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, SRC | 0.5597 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3603 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.3656 |
Bile secretion_Homo sapiens_hsa04976 | CA2, HMGCR | 1.085 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, BCL2 | 1.1613 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.392 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.4084 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.1822 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.1364 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4156 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | EGFR | 0.4156 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4156 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4248 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4242 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4459 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4459 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4563 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4449 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4575 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.4231 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F3 | 0.4722 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.4785 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.4899 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5072 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.5093 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5227 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.3328 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5275 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5251 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5453 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.5984 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.5717 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.5899 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.4695 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.594 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6024 |
Arginine and proline metabolism_Homo sapiens_hsa00330 | MAOA | 0.5981 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.5596 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6077 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR | 0.6068 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.6068 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.6077 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.7924 |
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | MAOA | 0.6564 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 4.9314 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.6983 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.6564 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.7491 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7312 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.7349 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.714 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.7349 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.7557 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.7324 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7491 |
Histidine metabolism_Homo sapiens_hsa00340 | MAOA | 0.7841 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | HMGCR | 0.8088 |
Phenylalanine metabolism_Homo sapiens_hsa00360 | MAOA | 0.8938 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.8748 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 0.9442 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.189 |