TCM Prescription: Zheng Tian Pills



Prescription Description
Prescription IDTCMF392
Pinyin NameZheng Tian Wan 
Chinese Name正天丸
English NameZheng Tian Pills
Function Description头痛
IndicationsHeadache
Disease ICD-11 Category MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.7264
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7933
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, XDH 12.0431
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, XDH 12.0431
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, MIF, PIM1, PPARA, TYR, XDH 11.6474
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TYR 10.8196
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 10.8196
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 9.58607
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 9.32442
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TYR 9.13055
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, SMAD3, SRC, TEK, XDH 8.66861
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, SRC, TEK, XDH 8.56118
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, SMAD3, SRC, TEK, XDH 8.56118
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 8.46204
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 8.31992
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, EGFR, ERBB2, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, SRC, TEK, XDH 8.18476
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.17359
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.0956
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 8.0956
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 8.0956
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 8.04917
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 8.03759
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK 7.89629
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.7337
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 7.52367
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA 7.50988
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.37705
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.29636
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 7.29636
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F10, INSR, MET, SRC, TEK, XDH 7.07899
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, XDH 7.0336
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 6.98409
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 6.93298
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, RORC, SRC, TEK, TYR 6.84735
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.70828
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 6.63824
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 6.60471
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.53614
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.45941
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, RORC, SMAD3, SRC, TEK, TYR 6.45801
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.40811
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 6.27071
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.23158
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.17692
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 6.02038
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD1, DRD2, DRD3, EGFR, HSPA1A 5.99439
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 5.97584
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.96449
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 5.9607
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 5.74487
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 5.73813
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, GPR35, HCAR2, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, SMAD3, SRC 5.73813
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, MIF, SRC 5.61268
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.58252
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, ERBB2, PPARA, SMAD3 5.46802
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.4266
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.4197
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ERBB2, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.35411
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 5.3343
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 5.3343
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 5.31575
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.31476
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH 5.31476
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, EGFR, ERBB2, FLT3, INSR, KDR, MIF, SRC, TEK, XDH 5.31379
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 5.31379
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, HCAR2, INSR, MIF, MMP12, SMAD3, SRC 5.26261
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 5.21153
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 5.21153
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 5.20665
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, SMAD3, SRC, TEK 5.09317
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, ERBB2, KDR, MIF, SRC, TEK 5.08816
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.08816
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 5.04128
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 5.03281
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, KDR, SRC 5.02925
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 5.02088
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 4.95568
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.95568
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, INSR, MET, SRC, TEK 4.93119
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.93119
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, RORC, SMAD3, SRC 4.88087
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.84034
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.75803
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, XDH 4.75803
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.71851
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.68967
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 4.67618
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.67306
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, SMAD3, SRC, TEK, XDH 4.61764
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 4.61037
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 4.60865
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 4.56391
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HCAR2, HSD17B1, HSD17B2 4.52332
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, SMAD3, SRC, TEK 4.47267
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 4.4239
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, XDH 4.34848
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, XDH 4.33213
[BP] GO:0045776 None ADORA1, ADRB1, DRD2, DRD3, PPARA 4.2234
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.2227
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.2189
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 4.20281
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 4.165
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, KDR, MIF, SRC, TEK 4.165
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 4.10589
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 4.10536
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SMAD3, TEK 4.08713
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PPARA, SRC, TEK, XDH 4.07166
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, SMAD3, SRC, TEK, XDH 4.07051
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.05491
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.04187
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.0271
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 4.01673
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AURKB, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 3.97853
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK 3.97306
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, HCAR2, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 3.97205
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.97205
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 3.96659
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 3.95421
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR 3.87203
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR 3.87203
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.7984
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 3.79691
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.76585
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, KDR, SRC 3.76585
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.7383
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, CA2, CACNA1C, CYP1B1, DRD2, DRD3, EGFR, ERBB2, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, XDH 3.735
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.735
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.735
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, SRC, TEK, XDH 3.735
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.70248
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.70248
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.69976
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, PPARA 3.69976
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.6419
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 3.62305
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.62284
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.597
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.597
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.58118
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, RORC, SMAD3, SRC, TEK, XDH 3.56766
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.56638
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.56638
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.55595
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, MIF, SRC 3.51215
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.48666
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 3.48666
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 3.48666
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.48666
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GPR35, SMAD3 3.4712
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 3.45353
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, INSR, KDR, MET, MIF, NUAK1, SRC, TEK 3.45353
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.44641
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.43727
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, RORC, SRC 3.42273
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 3.41798
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, MET 3.41798
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 3.4083
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.40163
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD2, EGFR, ERBB2, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.38428
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.37032
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2 3.37032
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.31862
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, RORC, SMAD3, SRC, TEK, XDH 3.31862
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29493
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.28521
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.27156
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 3.21186
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.2026
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, PPARA, RORC, SRC 3.20178
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, DRD2, EGFR, ERBB2, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 3.19667
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.18539
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 3.15946
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 3.14772
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, MIF, MMP9 3.13729
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.13661
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, TYR 3.12613
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 3.12092
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, ERBB2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, SMAD3, SRC, TEK 3.11674
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.10626
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, MIF, MMP12, MMP9, PPARA, SRC, XDH 3.10564
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.09611
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.0583
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, RORC, SMAD3, SRC, TEK, XDH 3.0583
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.0377
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, ERBB2, FABP3, FABP4, MET 3.01469
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, DRD2, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 3.00426
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DRD2, DUSP3, ERBB2, MIF, MMP12 3.0013
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, SRC, XDH 2.99337
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.99038
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.99038
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, DRD2, DRD3, EGFR, GPR35, HCAR2, SMAD3 2.98618
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, SMAD3 2.96318
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.95197
[BP] GO:0008217 None ADORA1, ADRB1, DRD2, DRD3, PPARA, SMAD3 2.93708
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TYR, XDH 2.91567
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.91005
[BP] GO:0040008 regulation of growth ADRB1, APP, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, HSPA1A, INSR, PIM1, SMAD3 2.9066
[BP] GO:0051223 None ACHE, APP, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 2.9066
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.9066
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, F10, FABP3, HSPA1A, MIF, MMP12, MMP9, PPARA, SRC, XDH 2.9066
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, CBR1, CYP1A1, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, FUT7, KDR, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK 2.89684
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.89684
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.89684
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.89684
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.89058
[BP] GO:0050708 None ACHE, CACNA1C, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 2.89058
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, MIF, SRC 2.88183
[BP] GO:0003018 None ADORA1, ADRB1, DRD1, EGFR, SRC, TEK 2.8651
[BP] GO:0019932 second-messenger-mediated signaling ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, KDR 2.8516
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 2.8516
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.83444
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.7886
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 2.75931
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, EGFR, ERBB2, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.75509
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.75193
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.74733
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, MIF, MMP12, MMP9, PPARA, SRC, XDH 2.74733
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.73481
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.7346
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.72355
[BP] GO:0070201 None ACHE, APP, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 2.72355
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.71985
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK 2.71902
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, RORC, SMAD3, SRC, TEK, XDH 2.6918
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.68725
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.68725
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.68725
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.68725
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.67905
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CSNK2A1, DRD2, EGFR, ERBB2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 2.66899
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.65025
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.62582
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.62531
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, MIF, MMP12, SRC 2.62531
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.59676
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.58917
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.58015
[BP] GO:0060160 None DRD2, DRD3 2.57802
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57802
[BP] GO:0002520 None CACNA1C, SMAD3 2.57802
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, INSR, MIF, SRC 2.57802
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.56877
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.56877
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.5649
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC 2.54149
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.54149
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.52626
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 2.52447
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, EGFR, INSR 2.50883
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.50552
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.50552
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48884
[BP] GO:0032880 regulation of protein localization ACHE, APP, CACNA1C, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, SMAD3, SRC 2.48884
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, SMAD3, SRC, XDH 2.48135
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.47716
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.46042
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.45175
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.45093
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.44058
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DRD2, DUSP3, ERBB2, HCAR2, HSPA1A, MIF, MMP12, MMP2, SMAD3, SRC 2.43944
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, DRD2, EGFR, ERBB2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, SMAD3, SRC, TEK, XDH 2.4306
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.42936
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, MIF, SRC 2.40498
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, EGFR, TYR 2.40459
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, DRD2, EGFR, ERBB2, FLT3, INSR, KDR, MIF, MMP9, SRC, TEK, XDH 2.40459
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, SMAD3 2.40459
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.39574
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.39212
[BP] GO:1904062 None APP, CACNA1C, DRD1, DRD2, DRD3, GPR35, MMP9 2.39212
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.36968
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.36378
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.35044
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35044
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.34828
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33448
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33448
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AURKB, DRD2, EGFR, ERBB2, FLT3, HSPA1A, INSR, MET, MIF, MMP9, SMAD3, SRC, TEK, XDH 2.33426
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.33084
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.32411
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.32411
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3104
[BP] GO:0051894 None KDR, SMAD3, TEK 2.3104
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3104
[BP] GO:0003013 None ADORA1, ADRB1, DRD1, EGFR, SRC, TEK 2.30894
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.30894
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, DRD2, DRD3 2.26679
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.26679
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, DRD2, EGFR, ERBB2, FLT3, HSPA1A, INSR, MIF, SMAD3, SRC, TEK, XDH 2.26593
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.26593
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.24748
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.23483
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.22729
[BP] GO:0072507 divalent inorganic cation homeostasis APP, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, SMAD3 2.22725
[BP] GO:1903393 None KDR, SMAD3, TEK 2.22188
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.22188
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.22188
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.20717
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 2.20279
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.18727
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.18727
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.18431
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, INSR 2.18431
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, INSR, MIF, SRC, TEK 2.18206
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.17198
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.17138
[BP] GO:0007189 None ADRB1, DRD1, DRD2, DRD3 2.17138
[BP] GO:0021853 None DRD1, DRD2 2.16403
[BP] GO:0090325 None DRD2, DRD3 2.16403
[BP] GO:1904936 None DRD1, DRD2 2.16403
[BP] GO:0042321 None ADORA1, DRD2 2.16403
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF 2.16397
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, FLT3, INSR, MIF, SRC, TEK 2.16138
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA 2.16128
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.16083
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.15261
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.15055
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, PPARA 2.14716
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, MMP9 2.1349
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.1231
[BP] GO:0034762 None APP, CA2, CACNA1C, DRD1, DRD2, DRD3, GPR35, MMP9 2.12036
[BP] GO:0050808 None ACHE, APP, DRD1, DRD2, ERBB2 2.11068
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3 2.10745
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.10745
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.10745
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, SMAD3 2.1025
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CYP1A1, DRD3, DUSP3, INSR 2.10203
[BP] GO:0050678 None EGFR, ERBB2, KDR, MMP12, SMAD3, TEK, XDH 2.10037
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, DRD2, ERBB2, FABP3, HSPA1A, SMAD3, XDH 2.09197
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CACNA1C, CYP1B1, DRD2, EGFR, INSR, MET, MMP2, SMAD3, SRC, TEK 2.08926
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, MIF, SRC 2.08926
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.08386
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.08386
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, INSR, PPARA 2.06205
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, ERBB2, MET 2.06068
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ERBB2, INSR, KDR, MIF, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 2.06068
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.0563
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, INSR 2.0563
[BP] GO:1901890 None KDR, SMAD3, TEK 2.04933
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.04933
[BP] GO:0045744 None DRD2, DRD3, MET 2.04933
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, SMAD3 2.04148
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.03618
[BP] GO:0021843 None DRD1, DRD2 2.03618
[BP] GO:1990535 None APP, INSR 2.03618
[BP] GO:0021830 None DRD1, DRD2 2.03618
[BP] GO:0021826 None DRD1, DRD2 2.03618
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.03618
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF 2.03618
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.02928
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC 2.0249
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.02334
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.02334
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, INSR, PPARA 2.01779
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.01779
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.01779
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.01779
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.01779
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.01221
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9 2.0005
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9 2.0005
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK 3.735
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK 3.52527
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 3.38838
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.12092
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, PIM1, SMAD3, SRC, TYR, XDH 2.75072
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.3104
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, SRC, TEK, TYR 2.26994
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK, TYR 2.26535
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC 2.18727
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, EGFR, ERBB2, INSR, MET, SRC, TEK 2.14959
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.9653
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, TYR, XDH 14.5358
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7678
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR, XDH 12.0787
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TYR, XDH 12.0431
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5212
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 9.0293
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 8.18476
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.63539
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, TYR, XDH 7.21083
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 6.9594
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.84491
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.55787
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, RORC, SMAD3 6.21021
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 6.00347
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.8566
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.39055
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 5.3343
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, RORC, SMAD3, TYR, XDH 5.20665
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.0457
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.02088
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.60865
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.26793
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.16314
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.10082
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.08713
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 4.01673
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 3.91569
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 3.91192
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.88646
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.88646
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.80787
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.78909
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 3.7383
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 3.3495
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.22034
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 3.20714
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 3.2026
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 3.2026
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.12092
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.10978
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.08452
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.99038
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.98281
[MF] GO:0008389 None CYP2A13, CYP2A6 2.96845
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.8651
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 2.8651
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.56877
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.47887
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.40459
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.34988
[MF] GO:0051425 None APP, INSR 2.33448
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 2.22105
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.16403
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16403
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3 2.16083
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.1349
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.11531
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.0493
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03618
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.02928


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.2993
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.3919
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.1472
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.7235
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.8854
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.156
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3578
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.0743
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.4853
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.156
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 4.4853
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 4.1013
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, ADRB1, CACNA1C, DRD1, DRD2, PPARA 4.2402
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.7075
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, DRD1, DRD2, EGFR 3.9303
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, TEK, EGFR, IGF1R 3.649
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, ADRB1, DRD1, DRD2, DRD3 3.4977
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1 3.9792
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.3371
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1158
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.4977
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.2513
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.8239
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, DRD1, EGFR 2.6964
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.8239
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR 2.5701
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2205
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3013
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, CACNA1C 2.5264
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD1, DRD2, DRD3 2.3104
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3013
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2415
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.3013
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9333
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 2.2257
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.2574
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.7908
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1561
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.9333
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.2415
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 1.9169
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1993
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2336
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, HSPA1A 1.4774
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8239
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4454
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4217
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.3584
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 0.9266
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9344
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.038
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8114
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0599
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0574
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0649
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8228
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8969
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8063
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8969
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8703
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8894
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0599
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8063
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8063
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8063
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8063
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1545
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2817
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.794
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.8038
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6308
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2354
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3197
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6981
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C, DRD1 1.2639
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7347
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6117
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.368
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3609
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2991
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3254
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3358
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3433
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2468
Tuberculosis_Homo sapiens_hsa05152 SRC 0.335
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3358
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2817
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3248
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4217
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3626
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3705
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4001
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4098
Platelet activation_Homo sapiens_hsa04611 SRC 0.4311
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4311
Axon guidance_Homo sapiens_hsa04360 MET 0.4256
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4311
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4369
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4561
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4462
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4339
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.4567
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.481
Melanogenesis_Homo sapiens_hsa04916 TYR 0.481
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4734
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4476
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.481
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.481
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.481
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4817
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4817
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4811
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.156
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4832
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.481
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4962
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5058
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4962
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5047
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4962
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5036
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5251
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5058
Peroxisome_Homo sapiens_hsa04146 XDH 0.5058
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4774
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5251
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.512
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5058
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5107
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5251
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5134
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5281
Bile secretion_Homo sapiens_hsa04976 CA2 0.5264
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5433
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5433
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5251
Shigellosis_Homo sapiens_hsa05131 SRC 0.5433
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.565
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5412
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5561
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5953
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6117
Malaria_Homo sapiens_hsa05144 MET 0.6251
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6212
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8013
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.6293
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.697
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.821
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6959
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6558
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7645
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7314
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.6902
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9813
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8063
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7724
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7724
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8063
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7768
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8063
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8063
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8102
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9161
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9805


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)