TCM Prescription: Fu Fang Re Fu Powder



Prescription Description
Prescription IDTCMF3903
Pinyin NameFu Fang Re Fu San
Chinese Name复方热敷散
English NameFu Fang Re Fu Powder
Function Description腹痛, 痛经, 跌打损伤
IndicationsAbdominal pain disorder, Dysmenorrhea disorder, Dysmenorrhea
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
Human Tissues Associated with IndicationIntestine, Stomach, SkeletalMuscle, Uterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH224 Thuja orientalis 侧柏叶 TCMH224 ITSAJ4756-14
TCMH2106 NA 铁粉 TCMH2106
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.9285
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.039
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.7818
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 11.4715
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 10.44
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2 9.98334
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.725
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGS2, SRC, TEK, TYR 9.4692
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 9.35334
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TOP1, TYR 8.59213
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 8.1893
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.15223
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.96267
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.45099
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 7.34075
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 7.31756
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.22445
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.82921
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 6.82921
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 6.53903
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 6.5167
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.45713
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, HSD17B2 6.40201
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.1906
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 6.18632
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.14854
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 6.1114
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.1114
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR 6.0985
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.08398
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, PTGS2, SRC, TEK, TYR 6.02625
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 6.01413
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS1, PTGS2 5.98334
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.95723
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 5.95723
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.95723
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.95723
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTGS2, SRC, TEK, XDH 5.95496
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F2, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TOP1, TYR 5.95496
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CXCL8, CYP1B1, EGFR, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 5.8667
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.81796
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.78264
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 5.78264
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.74346
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.72867
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 5.72106
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.71456
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.59035
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.54414
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.50602
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, SMAD3, SRC 5.45683
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.38829
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK 5.38829
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.33953
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.22214
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.21664
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 5.13039
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.0729
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.05436
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, EGFR, F10, F2, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK 4.94813
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.93458
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, ESR1, F2, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.90446
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.80271
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 4.76297
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 4.75355
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.69549
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PTGS2, SMAD3, SRC 4.69505
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 4.69505
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.66547
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 4.47341
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PTGS2, SRC, TEK 4.33034
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.30685
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, EGFR, ESR1, F2, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 4.29448
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CA3, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, SRC, TEK, TOP1, XDH 4.20651
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 4.14706
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CXCL8, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.14458
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.13336
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.072
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.06858
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 4.04033
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.02507
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.9607
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 3.93103
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 3.92175
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CA3, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, SRC, TEK, TOP1, XDH 3.92044
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.91761
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2, SMAD3, TEK 3.85833
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTGS2, SMAD3, SRC 3.84816
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 3.83589
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.8037
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 3.78816
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.78788
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 3.75496
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 3.73979
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.71868
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 3.71868
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 3.71868
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 3.67749
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67749
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1 3.67558
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.66513
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.66513
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PTGS2, SRC 3.65858
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.63795
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.62045
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 3.59957
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 3.56934
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.56555
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.54695
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 3.53762
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.47378
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CXCL8, CYP1B1, EGFR, ESRRB, F2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 3.42056
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, F2, PPARA, SMAD3 3.42051
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.41291
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, SMAD3, TEK 3.41158
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 3.41115
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.4018
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.4018
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 3.38438
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.3737
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, CXCL8, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.3737
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.32055
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.31686
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.31638
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.31638
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.31638
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.31052
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.29294
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.24285
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.23945
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22946
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.21333
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.21333
[BP] GO:0032103 positive regulation of response to external stimulus CXCL8, EGFR, F2, FABP4, KDR, MET, PTGS2, SMAD3 3.21177
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, PTGS2, SMAD3, SRC 3.16505
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.16505
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.14288
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.11657
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.11657
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.11657
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTGS2, SRC, TOP1 3.10015
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.10014
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA3, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK 3.09524
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2 3.0007
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTGS2, SRC, TEK, XDH 2.98859
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.97559
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90253
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.88695
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.88695
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.88695
[BP] GO:0009115 None AOX1, XDH 2.88695
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.86084
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.85167
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.82888
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.82888
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.82078
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.81751
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 2.78069
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.75216
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.69159
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, F2, INSR, MMP12, PTGS2, SMAD3, SRC 2.69092
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.68559
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.68559
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.68333
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6751
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, F2, PTGS2, SMAD3 2.66581
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, CXCL8, EGFR, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.64691
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.64273
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.63764
[BP] GO:1904591 positive regulation of protein import APP, EGFR, F2, PTGS2, SMAD3 2.63334
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62029
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62029
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.62029
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.62029
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, SRC 2.61917
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, EGFR, ESRRB, F2, FLT3, INSR, KDR, MMP9, PTGS2, SRC, TEK, XDH 2.60183
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.59013
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.56379
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 2.5541
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.55221
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.55221
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.55221
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.51705
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, F2, KDR, PTGS2, SRC 2.51705
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.50353
[BP] GO:0046110 None AOX1, XDH 2.50353
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50353
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.50353
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.50353
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.50353
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, EGFR, F2, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC 2.49554
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, EGFR, F2, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.4793
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.4793
[BP] GO:0009968 negative regulation of signal transduction CXCL8, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 2.46017
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 2.42921
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.42628
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.42628
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.42025
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.42025
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, PTGS1 2.42025
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, F2, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.41117
[BP] GO:0070848 response to growth factor APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.40642
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.39086
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.38793
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.3863
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.3855
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.3855
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.37358
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, SRC, TOP1 2.37271
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTGS2, SRC, TEK, XDH 2.37271
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33847
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.33847
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, SRC, TEK, XDH 2.33024
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.32782
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.32782
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.2993
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29187
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, KDR, SRC 2.287
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.287
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.28367
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.27848
[BP] GO:0006145 None AOX1, XDH 2.27848
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27848
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27848
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 2.27421
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.26694
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.26286
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.25959
[BP] GO:0051894 None KDR, SMAD3, TEK 2.25959
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25959
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.25938
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.25938
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.24728
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.24728
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, F2, KDR, SRC 2.24554
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, EGFR, F2, FLT3, INSR, KDR, MMP9, PTGS2, SRC, TEK, XDH 2.24114
[BP] GO:0050927 None CXCL8, KDR, SMAD3 2.21695
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.20722
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.20713
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CSNK2A1, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 2.20713
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, GPR35, SMAD3 2.20713
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.2042
[BP] GO:0001775 cell activation ALOX5, APP, AXL, CXCL8, EGFR, F2, FLT3, FUT7, HSPA1A, MMP9, SMAD3, SRC 2.19641
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.18223
[BP] GO:0050926 None CXCL8, KDR, SMAD3 2.1791
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1791
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.1471
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, PTGS2, SRC 2.14669
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS1, PTGS2 2.13713
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.12919
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, F2, PTGS2, SMAD3, SRC 2.12919
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.10875
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC 2.10284
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, F2, PTGS2 2.08555
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, INSR, KDR, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 2.0641
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CXCL8, CYP1B1, FABP3, HSPA1A, PTGS2, SMAD3, XDH 2.06082
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.05915
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.05458
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.05458
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.03544
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CXCL8, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.03544
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02368
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.02368
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP1 2.01376
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.00806
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.00454
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.00454
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.00454
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.43631
[CC] GO:0044421 None ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, CXCL8, DUSP3, EGFR, ESRRA, F2, FABP3, FABP4, HSPA1A, INSR, MMP1, MMP12, MMP2, MMP9, PTGS1, SRC, XDH 2.30652
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.3004
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.28819
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, F2, FLT3, HSD17B2, PTGS1, PTGS2 2.15952
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SMAD3, SRC, TOP1, TYR, XDH 2.1471
[CC] GO:0005576 None ACHE, ALOX5, ALPL, APP, CA6, CXCL8, ESR2, F10, F2, HSPA1A, KDR, MET, MMP1, MMP12, MMP2, MMP9, TEK 2.10284
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.0431
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, TYR, XDH 18.2979
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 14.3763
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, F2, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SRC, TEK, TOP1, TYR, XDH 13.2939
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.9909
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5107
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 8.6683
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 8.62186
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 8.23173
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.55291
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.49793
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.76978
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.75522
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.74102
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.5167
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.26321
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.95723
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.8667
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.4727
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.40592
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1 5.08953
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.03861
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.03861
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGS1, PTGS2, SRC, XDH 4.73403
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.14474
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 4.072
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.04511
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.89174
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.89174
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 3.78788
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.7725
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.56629
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.44158
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 3.42056
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35631
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.16523
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.09524
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.90253
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.88695
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.88695
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88695
[MF] GO:0008389 None CYP2A13, CYP2A6 2.88695
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 2.88199
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.84731
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.78482
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, HSD17B1, PPARA 2.74896
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, XDH 2.70076
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.69159
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TOP1 2.63764
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.50353
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, XDH 2.48303
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, MMP1, MMP12, MMP2, MMP9 2.37746
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.3513
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.29453
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.27848
[MF] GO:0051425 None APP, INSR 2.27848
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.21985
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, PTGS2, SMAD3, TYR, XDH 2.18993
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.12862
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.10807
[MF] GO:0043559 insulin binding IGF1R, INSR 2.10807
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05915
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.03527
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.00873


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.4246
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.3609
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 6.7678
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.7678
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.1189
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.5488
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.3145
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1189
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.3145
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, CXCL8, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, EGFR, IGF1R 5.0892
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5698
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2, PTGS1 4.8955
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.197
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6776
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0527
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.142
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.3451
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 3.2355
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.289
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, PIM1 2.6538
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 2.5885
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2329
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.6698
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6398
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3239
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5297
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.5366
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3043
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, MMP9 2.2007
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 2.141
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2774
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2311
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2007
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1537
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1484
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9045
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.1768
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.9069
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.8887
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.5088
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, F2 1.4177
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8, INSR, EGFR 1.4519
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4594
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.4136
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.3856
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3376
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.1178
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9788
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1178
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9817
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9809
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0786
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1154
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 1.012
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.9359
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3177
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8649
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.95
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.95
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.187
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1178
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8435
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.95
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9431
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8539
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9292
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3856
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7953
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2 1.1837
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.657
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.7359
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3151
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6594
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2395
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.6983
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.4594
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.4036
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3034
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3698
Purine metabolism_Homo sapiens_hsa00230 XDH 0.339
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3323
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3491
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3379
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3385
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.3177
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3491
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3757
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4051
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4145
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4352
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4352
Axon guidance_Homo sapiens_hsa04360 MET 0.43
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4959
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4683
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.4816
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4959
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4959
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.4959
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4959
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4959
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4959
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4959
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5036
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4959
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5117
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5089
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5089
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5103
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5103
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5084
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5461
Peroxisome_Homo sapiens_hsa04146 XDH 0.5126
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5461
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5447
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5504
Pertussis_Homo sapiens_hsa05133 CXCL8 0.5435
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5373
Bile secretion_Homo sapiens_hsa04976 CA2 0.549
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.5504
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5651
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5688
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5857
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5771
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5669
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6043
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.6015
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6293
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.813
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7018
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6876
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.657
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.657
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.768
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.657
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7135
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9983
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7481
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8303
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7932
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3145
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8111
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8111
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8359
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8303
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0161
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3177


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)