TCM Prescription: Bu Nao Pills



Prescription Description
Prescription IDTCMF3875
Pinyin NameBu Nao Wan
Chinese Name补脑丸
English NameBu Nao Pills
Function Description健忘, 眩晕, 耳鸣, 不寐, 心悸, 癫病, 痫病
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness, Epilepsy
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MC81.2 [Palpitations, 心悸 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
8A6Z [Epilepsy or seizures, unspecified, 癫痫或癫痫发作，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2488 Alpinia oxyphylla 益智 TCMH2488 ITSAJ4276-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH823 Semen juglandis 核桃仁 TCMH823
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH916 Succinus 琥珀 TCMH916
TCMH2090 Gastrodia elata 天麻 TCMH2090
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3567
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, KDR, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SRC, TRPV1, XDH 10.7085
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7085
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FDPS, GLO1, HMGCR, IDO1, PIM1, PPARA, PTAFR, XDH 9.67985
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FDPS, HMGCR, HSD11B1, HSD17B1, MET, PPARA, TRPV1 8.94094
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IDO1, IGF1R, KDR, MMP2, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 8.90285
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, SRC, TOP2A, TRPV1, XDH 8.59828
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC, TOP2A, TRPV1, XDH 8.55584
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HMGCR, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1 8.53273
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.02493
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC, TOP2A, TRPV1, XDH 8.01021
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.72188
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 7.51592
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.17926
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1 7.09625
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.95871
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 6.8424
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.84128
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 6.81699
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 6.71631
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.37805
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, SRC 6.25014
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1 6.10805
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1 6.08527
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PRKCD, PRKCE, PTAFR, SRC, TRPV1 6.06882
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC 6.06882
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1 6.06882
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PRKCD, PRKCE, PTAFR, SRC, TRPV1 6.06658
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.99527
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD17B1, IDO1, XDH 5.91468
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.89873
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 5.79821
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, PRKCA, PRKCE 5.78695
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.69389
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.676
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, PRKCD, PRKCE, PTAFR, SRC, TRPV1 5.62729
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PRKCD, PRKCE, SRC 5.53882
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, NR3C1, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 5.51848
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.49572
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.49572
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FDPS, HMGCR, MET, PPARA 5.49242
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 5.46807
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC 5.46529
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 5.45874
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.45874
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.43031
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.43031
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, SRC 5.41613
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PPARA 5.24162
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.23261
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.17086
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.13519
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.05732
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PRKCB, PRKCE, SLC1A1, TRPV1 5.03769
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 5.03769
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 4.97816
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, PRKCE, PRKCG, PTAFR, SRC, TRPV1 4.84392
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 4.7549
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PRKCB, PRKCE, SRC, TRPV1 4.7549
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 4.72714
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TOP2A, TRPV1 4.69722
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1 4.57015
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 4.51809
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.47636
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 4.47636
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, FDPS, HMGCR, PTAFR 4.47262
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE 4.45853
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE 4.45853
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.44685
[BP] GO:0030168 platelet activation AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.44685
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, XDH 4.24712
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTAFR, SRC, XDH 4.22074
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.22074
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.21955
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, IDO1, NR3C1, PRKCE, PTAFR, SRC 4.158
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 4.15626
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.10977
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1 4.09014
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 4.06113
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 4.0553
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TRPV1 3.9755
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 3.9755
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PRKCD, PTAFR 3.9755
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, GRM1, GRM5, GRM8, HMGCR, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, PTAFR, SRC, TRPV1 3.96758
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, IDO1, PTAFR 3.9627
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.94719
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 3.93051
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 3.87258
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 3.86495
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1 3.86495
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SRC, XDH 3.86495
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.86495
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1 3.86495
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SRC, XDH 3.81645
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.81463
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, SRC 3.80933
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 3.7553
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PRKCD, PRKCE, PTAFR, SRC, TRPV1 3.71631
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD, PRKCE 3.67197
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.65643
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.65643
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 3.62358
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PRKCB, PRKCE, TRPV1 3.60561
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.60561
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.60561
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TRPV1 3.6027
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 3.59882
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 3.59882
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, GRM1, HCAR2, HMGCR, IDO1, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SRC, TRPV1, XDH 3.57888
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, MET, PRKCA, PRKCD, PRKCE, XDH 3.51269
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, HMGCR, IDO1, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, XDH 3.51007
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 3.50545
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, PRKCD, PRKCE, SRC 3.50305
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM3, CYP1B1, HCAR2, HMGCR, IDO1, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTAFR, SLC1A1, SRC, TRPV1 3.50305
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, PRKCA, PRKCB, PRKCE, SRC, XDH 3.46447
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.44951
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.44824
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.42222
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA 3.41983
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, HMGCR, PTAFR 3.41408
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD, SRC 3.40709
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.40029
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.40029
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, PRKCA, PTAFR, SLC1A1, TRPV1 3.38976
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 3.38526
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.3774
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 3.34472
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A 3.33736
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.33557
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CHRM1, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTAFR 3.3048
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTAFR 3.28956
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, NR3C1, PRKCE, PTAFR, SRC 3.27988
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 3.26366
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, PRKCD, SRC 3.24061
[BP] GO:0018209 peptidyl-serine modification AURKB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.19665
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, IDO1, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG 3.18504
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, PPARA, PRKCD, SRC, TRPV1 3.18504
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HMGCR, IDO1 3.18504
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.18504
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18504
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 3.18489
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, XDH 3.18489
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.18371
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTAFR, SRC, TRPV1 3.17847
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, SRC 3.14772
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.14679
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR 3.1185
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC 3.1185
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, PRKCD, SRC 3.1185
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.08316
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.07802
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH 3.07479
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SRC, TRPV1, XDH 3.07278
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA 3.02254
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 3.01731
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, PRKCE, SRC, TRPV1 2.98909
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.96855
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTAFR, SRC, XDH 2.95409
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTAFR, SRC, XDH 2.95409
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA 2.94959
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, XDH 2.92932
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, PRKCE, SRC, TRPV1 2.9203
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, GRM1, HMGCR, IGF1R, KDR, PRKCA, PRKCD, PRKCE, SRC, XDH 2.90793
[BP] GO:0035408 None PRKCA, PRKCB 2.89262
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.89262
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.89262
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.89262
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.89053
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SRC, TOP2A, TRPV1, XDH 2.87101
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PRKCD, PTAFR, SRC, TRPV1 2.8442
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SRC, TOP2A, TRPV1, XDH 2.83689
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PRKCB, PRKCE, PTAFR, SRC, TRPV1 2.80337
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80156
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SRC, TRPV1, XDH 2.7884
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, GRM1, HMGCR, KDR, PRKCA, PRKCE, SRC, XDH 2.77214
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.76033
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, ESR1, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SRC, TRPV1, XDH 2.74894
[BP] GO:0046165 None AKR1B1, CYP3A4, FDPS, HMGCR, PTAFR 2.74813
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, IDO1, IGF1R, MET, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, SRC, XDH 2.74556
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR, SRC 2.67324
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63782
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.63782
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PRKCD, PTAFR, SRC, TRPV1 2.60166
[BP] GO:0010942 positive regulation of cell death CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SRC, TOP2A, TRPV1, XDH 2.56919
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, IDO1, KDR, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SRC 2.52497
[BP] GO:0030335 positive regulation of cell migration ALOX12, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 2.5011
[BP] GO:0090330 regulation of platelet aggregation ALOX12, PRKCA, PRKCD 2.48845
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.48522
[BP] GO:0099566 None GRM1, GRM5 2.47894
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47894
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.47858
[BP] GO:0010676 None PPARA, PRKCE, PTAFR, SRC 2.47218
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH 2.46519
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GLO1, HMGCR, HSD11B1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, SRC, TOP2A 2.42664
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, SRC 2.42186
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.4136
[BP] GO:2000147 positive regulation of cell motility ALOX12, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 2.4136
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, SRC 2.40857
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.38071
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.37912
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.36175
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, SRC 2.33443
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 2.33219
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.30693
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.3069
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.30028
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH 2.29891
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, CHRM3, HMGCR, PRKCD, PRKCE, PTAFR 2.29771
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, HMGCR, IDO1, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, XDH 2.29574
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR, SRC 2.29574
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.2949
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2763
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.2763
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.2423
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 2.23929
[BP] GO:0040017 positive regulation of locomotion ALOX12, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, SRC 2.23917
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, GRIK5, HCAR2, HMGCR, PRKCA, PRKCE, PTAFR, SRC, TRPV1 2.23917
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.23917
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23917
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23385
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, PRKCE, PTAFR, SRC, TRPV1 2.22303
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, PRKCG, SRC, TOP2A 2.20687
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PTAFR, SLC1A1 2.19873
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.18805
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.18805
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18805
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, SRC 2.18633
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.17102
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.17102
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.16736
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, CSNK2A1, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TRPV1, XDH 2.16709
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, IDO1, MMP1, MMP2, MMP9, SRC, XDH 2.16032
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, SRC 2.15726
[BP] GO:0034110 regulation of homotypic cell-cell adhesion ALOX12, PRKCA, PRKCD 2.1471
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PRKCD, PRKCE, SRC, XDH 2.14137
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, MMP9, PRKCD, PTAFR, SLC1A1, TRPV1, XDH 2.1231
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.1231
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR, SRC 2.1231
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, PRKCD, SRC 2.1231
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1 2.11542
[BP] GO:0042391 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.11542
[BP] GO:0045913 None PPARA, PRKCE, PTAFR, SRC 2.10934
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.1093
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1093
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, SRC 2.10043
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GRM5, IGF1R, PRKCD, SRC 2.09883
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SRC, TRPV1, XDH 2.08942
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.07684
[BP] GO:0046541 None CHRM1, CHRM3 2.07684
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.07684
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.07684
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.07007
[BP] GO:1900543 None GRM3, GRM8, PPARA, PRKCA 2.05886
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, IDO1 2.04884
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH 2.04884
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.04143
[BP] GO:0045980 None GRM3, GRM8, PPARA, PRKCA 2.04131
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.03968
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.03968
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 7.49599
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PRKCG, SLC1A1, SRC, TRPV1 6.84128
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TRPV1 6.70598
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SRC, TRPV1 5.82395
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.69722
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TRPV1 4.41982
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, TRPV1 4.29898
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PRKCG, PTAFR, SLC1A1, SRC, TRPV1 4.06344
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, TRPV1 3.96829
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.92382
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.92382
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.3774
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.14679
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, IDO1, KDR, MMP2, MMP9, NR3C1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TOP2A, TRPV1, XDH 2.66151
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IDO1, PRKCG, SRC, TRPV1 2.43633
[CC] GO:0030054 cell junction ACHE, AKR1B1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, HCAR2, KDR, PRKCD, PRKCG, TRPV1 2.09039
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.08795
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.08795
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, IGF1R, KDR, MET, PRKCG, PTAFR, SLC1A1, SRC, TRPV1 2.04215
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.8281
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCG, XDH 16.8281
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 11.1777
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.814
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7085
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FDPS, FLT3, GLO1, HMGCR, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, XDH 9.73361
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FDPS, GLO1, IDO1, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, TOP2A, TRPV1, XDH 8.91965
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.33203
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.25384
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.14827
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FDPS, GLO1, IDO1, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, TOP2A, TRPV1, XDH 8.02493
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NR3C1, PPARA, PRKCA, PRKCB, PRKCG 8.02493
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 8.02493
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.81892
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 7.53589
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD17B1, IDO1, XDH 7.07795
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 7.04494
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PRKCE, PTAFR, TRPV1 6.93966
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.89995
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.84128
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 6.84128
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.37805
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, SRC 6.28879
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, SRC 6.06658
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.99527
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR, TRPV1 5.93761
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR, TRPV1 5.93761
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.36796
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.81593
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.60189
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.46696
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.39857
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, IDO1, SRC, XDH 4.38682
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.03082
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.80875
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 3.59882
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1 3.47484
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.42379
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1 3.42222
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3774
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.30882
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.27654
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.24061
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PTAFR, TRPV1 3.126
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.07802
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.96855
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.94879
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1, XDH 2.94059
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.93285
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89262
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.89262
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89262
[MF] GO:0035403 None PRKCA, PRKCB 2.89262
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.86744
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.8293
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1 2.80635
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 2.77214
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.70476
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.586
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.56145
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.47894
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.47894
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.47894
[MF] GO:0099583 None GRM1, GRM5 2.47894
[MF] GO:0004699 None PRKCD, PRKCE 2.47894
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43674
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43674
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.43674
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.3987
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.3376
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA 2.2949
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23917
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.23917
[MF] GO:0004971 None GRIA2, GRIA4 2.23917
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.23917
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1 2.23915
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 2.22774
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.22458
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.16736
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.1471
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.12921
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.10865
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.07684
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07684
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.07684


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.2697
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, PTAFR, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 12.743
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 10.8523
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.1078
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM3, GRM5, CHRM1, PRKCB, CHRM5, PTAFR, PRKCA, GRM1 7.6546
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA, ALOX12, TRPV1 7.3714
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R 7.3239
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM3, CHRM1, PRKCB, CHRM5, PRKCA 7.0364
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.7924
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.4959
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4789
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, GRM1, ESR2 6.0927
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1, GRIA4 6.0927
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 6.0927
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 5.8761
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PRKCB, MMP2, PRKCE, PRKCD, PIM1, PRKCA 4.8771
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.2275
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, GRM1 5.2066
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH, IDO1 4.3974
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, ALOX15, PRKCA, ALOX12 4.6582
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA 4.7042
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 4.5424
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 4.3902
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, ADORA3, PRKCE, ADORA1, PRKCA 4.5237
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, MMP9, MET, IGF1R 4.2301
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, PRKCA, MET, IGF1R 4.3648
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, KDR, PRKCA, MET, IGF1R 4.2566
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, CHRM3, PRKCB, CA2, PRKCA 4.3902
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PIM1, CYP1B1, PRKCA, MMP9, MET 4.2537
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 4.0779
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 4.0135
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 4.0446
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA, ESR1 3.6057
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, CHRM3, PRKCB, CA2, PRKCA 4.0135
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.5864
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.6057
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R 3.2962
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.4734
Hepatitis B_Homo sapiens_hsa05161 PRKCG, PRKCB, SRC, PRKCA, MMP9 3.2754
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, PRKCA, GRM1 3.2948
Glioma_Homo sapiens_hsa05214 PRKCG, PRKCB, PRKCA, IGF1R 3.5261
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 4.3902
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1979
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.2269
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.335
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.6022
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA 3.124
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, PRKCA, MET, IGF1R 2.4883
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.5864
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 4.0135
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.5261
Insulin secretion_Homo sapiens_hsa04911 PRKCG, CHRM3, PRKCB, PRKCA 3.1547
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.228
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, PRKCA, IGF1R 2.8831
Insulin resistance_Homo sapiens_hsa04931 PRKCB, PRKCE, PRKCD, PPARA 2.8049
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 3.0727
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.1129
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4439
Salivary secretion_Homo sapiens_hsa04970 PRKCG, CHRM3, PRKCB, PRKCA 3.1019
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.4127
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA 2.2758
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0909
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.596
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.6262
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2161
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, PRKCE, ADORA1 1.4139
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2788
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA 1.9654
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA 0.9987
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9638
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2774
Influenza A_Homo sapiens_hsa05164 FDPS, PRKCB, PRKCA 1.3762
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2895
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2993
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3087
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.9654
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3081
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA 1.959
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.9784
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3398
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.355
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3514
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.3121
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3655
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3769
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3812
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.9017
Platelet activation_Homo sapiens_hsa04611 SRC 0.4015
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD 0.4036
Axon guidance_Homo sapiens_hsa04360 MET 0.3937
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4015
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9496
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4276
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4062
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4623
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4547
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4706
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4702
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.326
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4831
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4831
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4831
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4831
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4831
Peroxisome_Homo sapiens_hsa04146 XDH 0.4954
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB 1.1563
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.5148
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.5402
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.2412
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.5402
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.3371
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.3598
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5561
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.3371
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5487
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5638
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5682
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5682
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2858
Shigellosis_Homo sapiens_hsa05131 SRC 0.5659
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PRKCB, PRKCA 2.595
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3515
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3835
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5919
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6084
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6115
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3765
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6373
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6373
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5144
Malaria_Homo sapiens_hsa05144 MET 0.6451
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.505
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6749
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.614
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCE, PRKCD 1.6258
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.8242
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7183
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PRKCB, PRKCA 3.022
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8184
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7567
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7881
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7964
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.767
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.3268
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8576
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2046
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3854
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.2372


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)