TCM Prescription: Er Bao Ointment



Prescription Description
Prescription IDTCMF3846
Pinyin NameEr Bao Gao
Chinese Name儿宝膏
English NameEr Bao Ointment
Function Description疳病
IndicationsInfantile malnutrition disorder
Disease ICD-11 Category SE37 [Infantile malnutrition disorder (TM1), 疳病 (TM1) ];
Human Tissues Associated with IndicationSpleen, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2059 Radix pseudostellariae 太子参 TCMH2059
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH45 Lablab purpureus 白扁豆 TCMH45 ITSAM881-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.82923
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 8.84882
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 8.47522
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, IDO1, MPO, PIM1, PPARA, PTGS2, TYR, XDH 8.28223
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 7.83562
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.19365
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD17B2, MET, PPARA, PTGS2, TRPV1 7.01447
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 6.8003
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 6.8003
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH 6.4899
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 6.26389
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.14576
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TYR, XDH 6.06788
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PTGS2, RORC, SRC, TRPV1, TYR 5.93442
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 5.89102
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 5.65943
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 5.64366
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.64209
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, PTGS2, SRC, TRPV1 5.58186
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.41457
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC 5.38763
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, FABP4, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 5.28821
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.25473
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1 5.23851
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.21683
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 5.13538
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, MMP1, MMP2, MMP9, MPO, SRC, XDH 5.13434
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 5.12524
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.06066
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B2 4.81974
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.7992
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.62148
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IDO1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 4.49847
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR6, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.4561
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.45001
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.45001
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR6, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.45001
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC, TRPV1 4.41848
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 4.41848
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.25543
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2 4.23347
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, RORC, SRC, TRPV1 4.13566
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR 4.0898
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.01655
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 4.00051
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 3.86167
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B2, KDR, MET, PPARA, PTGS2, SRC, TRPV1, XDH 3.8526
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, PPARA, PTGS2 3.8526
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.80589
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F10, FLT3, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.80017
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.72194
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.7058
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 3.70578
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.65592
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.65592
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.62923
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.60641
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, PTGS2, SRC, TRPV1 3.59776
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGS2 3.58383
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.58383
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 3.56823
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 3.53987
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.51408
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TRPV1 3.39679
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.39172
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, F10, FLT3, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.32254
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.32254
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.3019
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 3.29653
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 3.2697
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, MPO 3.26659
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2296
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.2296
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 3.20647
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.17334
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.16566
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, MPO, PTGS2, SRC, TRPV1, TYR 3.11049
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, MMP2, MPO, PPARA, PTGS2, SRC, TRPV1, TYR 3.05171
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC 3.01781
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 3.01433
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 3.00679
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, XDH 2.98204
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS2, SRC 2.94065
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CYP1B1, ESRRA, F10, FABP4, FLT3, HTR6, IDO1, KDR, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 2.93835
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.90634
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC, TRPV1 2.88481
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.88262
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.87121
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.87003
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.86351
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.85925
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85925
[BP] GO:0009115 None AOX1, XDH 2.85925
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC, TRPV1 2.82395
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.80421
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.74622
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.72941
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.72815
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.70661
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.70309
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.7021
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B2 2.65065
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.63377
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.63377
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.61303
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.61175
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.61175
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 2.61175
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, SRC, TRPV1 2.61164
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.58859
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F10, FLT3, HTR6, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.56322
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.54885
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.5466
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.53901
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.53901
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, MPO, PTGS2, SRC, TRPV1, TYR 2.53712
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.51989
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.51989
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 2.50213
[BP] GO:0046110 None AOX1, XDH 2.47039
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47039
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TRPV1 2.46836
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TRPV1 2.44288
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.43145
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.43145
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.4232
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.40851
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.39477
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.35096
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.32683
[BP] GO:0030335 positive regulation of cell migration BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.30699
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.30615
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30144
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.29593
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 2.29593
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.25189
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.22988
[BP] GO:2000147 positive regulation of cell motility BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.22404
[BP] GO:0006145 None AOX1, XDH 2.22404
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22404
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.16032
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 2.15288
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.14948
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.13925
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.13925
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.13925
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.13057
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.12747
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.10763
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.10501
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.07322
[BP] GO:0040017 positive regulation of locomotion BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.06705
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP2, PPARA, PTGS2, PTPN1, SRC 2.05652
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.05372
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, PTGS2, SRC 2.03033
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.02089
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MPO 2.02089
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM2, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, IDO1, KDR, MET, MMP9, PIM1, PTGS2, SRC, TRPV1, XDH 2.02089
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, HTR6, IDO1, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.01392
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.01086
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, ESRRB, HCAR2, IDO1, KDR, MET, MMP9, PIM1, PTGS2, SRC, TRPV1 2.01014
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.01014
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.01014
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.01014
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, IDO1, MPO, SRC, XDH 2.00933
[CC] GO:0044432 endoplasmic reticulum part BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HSD17B2, PTGS2, PTPN1 2.12995
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, FLT3, FUT7, HCAR2, HSD17B2, HTR6, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, TRPV1, TYR 1.99763
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, FLT3, FUT7, HCAR2, HSD17B2, HTR6, IGF1R, KDR, MET, MMP2, PIM1, PTGS2, PTPN1, SRC, TRPV1, TYR 1.97145
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.93039
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, CHRM2, F10, FLT3, HTR6, IGF1R, KDR, MET, TRPV1 1.70961
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.5196
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0954
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 8.48684
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2, SRC 8.06758
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2, SRC 7.83562
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, TRPV1, TYR, XDH 7.71635
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 7.71543
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, TRPV1, TYR, XDH 7.27834
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.86967
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 6.76654
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.63527
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC 6.16649
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.14576
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.82557
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.46058
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.46058
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.46058
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.25473
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2, SRC, XDH 5.25473
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TYR 5.14804
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.09598
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.18079
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 4.17785
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.7058
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.5928
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.58939
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 3.56823
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 3.39679
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.2296
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, PPARA, RORC, TRPV1 3.17428
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.17334
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 3.07947
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 3.03956
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 3.01781
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.86195
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85925
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85925
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.66788
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B2, XDH 2.24218
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22404
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.16204
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.13057
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0444
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.0358


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6592
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.2803
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.4653
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 4.7361
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.4653
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.62
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9094
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5837
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 3.8365
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.0171
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1864
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.7474
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.529
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.3648
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4564
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, PPARA 2.7844
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.7778
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.9622
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, ADORA3, ADORA1, TRPV1 2.2458
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3977
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4856
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, IGF1R 1.8959
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2458
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.2617
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.8874
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2824
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8874
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.8228
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2 1.8228
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6809
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7778
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5782
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4962
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1868
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4549
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3525
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1868
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3342
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1775
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.143
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.085
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.143
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.1967
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3504
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.437
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2667
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.085
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.085
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1114
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.4064
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.1685
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9201
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0563
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.856
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0563
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0563
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8377
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6 0.8063
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6007
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6929
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8085
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8589
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7828
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2899
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2 0.3555
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3542
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8228
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4042
Purine metabolism_Homo sapiens_hsa00230 XDH 0.394
Platelet activation_Homo sapiens_hsa04611 SRC 0.472
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3773
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.4042
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4514
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4355
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4322
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.472
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4514
Tight junction_Homo sapiens_hsa04530 SRC 0.4514
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4584
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.472
Phagosome_Homo sapiens_hsa04145 MPO 0.429
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.472
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4584
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.472
Axon guidance_Homo sapiens_hsa04360 MET 0.4672
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0243
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5458
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5278
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5278
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5345
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7778
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5418
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5345
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5278
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5458
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5418
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5345
Gap junction_Homo sapiens_hsa04540 SRC 0.5458
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5458
Peroxisome_Homo sapiens_hsa04146 XDH 0.5501
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5852
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5857
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5645
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6117
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5924
Glioma_Homo sapiens_hsa05214 IGF1R 0.6117
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6123
Bile secretion_Homo sapiens_hsa04976 CA2 0.5918
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6108
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6117
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6117
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6117
Shigellosis_Homo sapiens_hsa05131 SRC 0.6117
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.672
Malaria_Homo sapiens_hsa05144 MET 0.6828
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6885
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6855
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7978
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8303
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8392
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8392
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8586
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8377
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.856
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.085
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3342


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)