TCM Prescription: Chen Xiang Powder



Prescription Description
Prescription IDTCMF3187
Pinyin NameChen Xiang San
Chinese Name沉香散
English NameChen Xiang Powder
Function Description腹胀
IndicationsDyspepsia, Enteritis
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, POLB, PPARA, PTGS2, RORC, SRC, TYR 12.5518
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGS2, TBXAS1 12.4197
[BP] GO:0042221 response to chemical ABCB1, ABCG2, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, MPO, POLB, PPARA, PTGS2, RORC, SRC, TERT, TYR 11.5705
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MPO, POLB, PPARA, PTGS2, RORC, SRC, TYR 11.4459
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 11.228
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, POLA1, POLB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 10.9499
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.7826
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 9.72822
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.21119
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.19031
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.99305
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, HMGCR, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 8.84233
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 8.63087
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 8.09332
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 7.83739
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.65825
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, MPO, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TYR 7.61169
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TERT, TNKS2, TYR 7.58995
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.53356
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.50274
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.32605
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PPARA, PTGS2, TBXAS1 7.31998
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, HMGCR, HTR6, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.28526
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 7.28316
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 7.28316
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.23051
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 7.23051
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.21751
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 7.19211
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, EGFR, HCAR2, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 7.0855
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 7.03494
[BP] GO:0042493 response to drug ABCB1, ABCG2, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KDR, POLB, PTGS2, SRC 6.95253
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 6.9137
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 6.74878
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.74019
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT 6.63788
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, POLB, PPARA, SRC, TYR 6.59319
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, HMGCR, HTR6, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 6.58815
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5467
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.53326
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PIM1, SRC 6.53115
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 6.47277
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 6.31831
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 6.27658
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 6.12566
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, PTGS2, SRC 6.09598
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.09445
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 6.07624
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1 5.997
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.84765
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.78344
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, KIT, MMP2, MPO, POLB, PPARA, PTGS2, SRC, TERT, TYR 5.72933
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 5.72933
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.69605
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.68107
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.64594
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SRC, TERT 5.63485
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1 5.63485
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.61996
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 5.61996
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 5.45244
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1 5.42009
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT 5.34473
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.3003
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.21843
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.21685
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PTGS2, RORC, SRC 5.14257
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.14257
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 5.0791
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TERT 5.02455
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, PTGS2, RORC, SRC 4.98286
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.97666
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.97666
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.93172
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, EGFR, KIT, PTGS2 4.87204
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, EGFR, KIT, PTGS2 4.87204
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.85495
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.83082
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.83082
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.70388
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, TNKS2, XDH 4.70388
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, MET, PIM1, POLA1, SRC, TYR 4.67655
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH 4.674
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 4.65609
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.64352
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 4.57761
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.55064
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DYRK1A, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.45375
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.44542
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, POLA1, POLB, PTGS2, PTPN1, RORC, SRC, TERT 4.43529
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.401
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.38518
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1 4.38106
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, KIT, MET, SRC 4.30292
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.29491
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, KIT, MET, SRC, XDH 4.29491
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.29491
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 4.29094
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1 4.25782
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 4.2517
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, RORC, SRC 4.21484
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.20306
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, XDH 4.19681
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC, TERT 4.12739
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.11955
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PTGS2, TNKS, TNKS2 4.07602
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2, TBXAS1 4.0751
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.0751
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.05056
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, MPO, POLB, PTGS2, TERT 4.01161
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.95168
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.93218
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.93218
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.91455
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 3.90519
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PPARA, PTGS2, TBXAS1 3.88605
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, XDH 3.87952
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 3.82144
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.82144
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 3.77881
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.76542
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.73011
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.72745
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, IDO1, KIT, MMP12, MPO, PTGS2, SRC, TYR 3.72745
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.70161
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, TYR 3.70161
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.67792
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.67273
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.66292
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.60825
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, MPO, PTGS2, SRC 3.58363
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.578
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.578
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 3.56594
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.54621
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.53156
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, IDO1, MPO 3.52058
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 3.51586
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.51153
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.51153
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.48891
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 3.4537
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.44422
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.44422
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.44146
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.37571
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.33739
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.33329
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.33329
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS 3.30622
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.30123
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.2947
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.25955
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.23624
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.19273
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 3.18485
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.18485
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2 3.18439
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.16025
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HMGCR, IDO1, KDR, KIT, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TNKS2, XDH 3.15601
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.14708
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.11903
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.10069
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, EGFR, ERBB2, HCAR2, HMGCR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 3.08791
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 3.08516
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 3.06287
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.05887
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05887
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, IDO1, KIT, MMP2, MMP9, MPO, POLA1, POLB, PPARA, PTGS2, PTPN1, SRC, TERT 3.05446
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 3.04485
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.03338
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.02434
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.02379
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.01025
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.98537
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.98161
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.97263
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 2.96924
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.96621
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 2.96617
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 2.96038
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.96008
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.95188
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.93916
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.93654
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.93569
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 2.92099
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT 2.92068
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.91997
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, HCAR2, MMP12, PTGS2, SRC, TERT 2.9175
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.88283
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.8762
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.85115
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.85115
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.85106
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.84903
[BP] GO:0009115 None AOX1, XDH 2.8176
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2 2.80219
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.79197
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ERBB2, ESR1, ESRRA, HCAR2, IDO1, KIT, MMP12, MMP2, PTPN1, SRC 2.77495
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.7647
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76362
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2 2.66877
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66346
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.65887
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 2.64046
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.63653
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CACNA1C, CNR1, CSNK2A1, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC, TERT 2.63177
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.62648
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.6249
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HMGCR, KIT, PTGS2, TYR 2.61565
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, PPARA 2.61086
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.61086
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.61057
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.58524
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KIT, MMP2, PTGS2, SRC 2.5785
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.5785
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.5785
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.55564
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, SRC, TNKS, TNKS2 2.55398
[BP] GO:0050999 None CNR1, CNR2, EGFR, TERT 2.5446
[BP] GO:0009968 negative regulation of signal transduction BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.52952
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, HMGCR, IDO1, KDR, KIT, PIM1, PTGS2, SRC, TERT, XDH 2.52137
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51309
[BP] GO:0070920 None EGFR, ESR1, TERT 2.51309
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.50093
[BP] GO:0008217 None ADORA1, ADRB1, CNR1, HSD11B2, PPARA, PTGS2 2.48604
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, ERBB2, FABP3, IDO1, PTGS2, TERT, XDH 2.47635
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, MET 2.45893
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CNR1, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.45189
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.44511
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44065
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2 2.4392
[BP] GO:0046110 None AOX1, XDH 2.40936
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40936
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, HMGCR, PTGS2, SRC 2.40769
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.40634
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.40634
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.39795
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.37827
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CDK6, CNR1, CNR2, CYP19A1, ERBB2, IDO1, MMP12 2.36933
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.36863
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.36526
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.34222
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.33184
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.33184
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.32944
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.3178
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31741
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DYRK1A, EGFR, HSD11B2, IDO1, KDR, MET, MMP1, MMP12, MPO, POLA1, SRC 2.31024
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.30326
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.27446
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.26609
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, EGFR, HMGCR, KIT, POLB, PTGS2, TYR 2.2613
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TYR 2.25952
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, KIT, PIM1, PTGS2, SRC, TERT 2.25812
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, F3, KDR, KIT, PTGS2, TERT, XDH 2.23617
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, XDH 2.23223
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.22576
[BP] GO:0032768 None CNR1, CNR2, EGFR, TERT 2.22576
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.21864
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.20899
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.20899
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.20317
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, KIT, PTPN1, SRC, TERT, TNKS, XDH 2.20103
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.18658
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC, TNKS 2.18649
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DYRK1A, EGFR, HMGCR, IGF1R, MET, PTGS2, PTPN1, TERT, XDH 2.18608
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.17178
[BP] GO:0070213 None TNKS, TNKS2 2.17178
[BP] GO:0006145 None AOX1, XDH 2.17178
[BP] GO:0038171 None CNR1, CNR2 2.17178
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17178
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, IDO1, MPO, PTGS2 2.16913
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.16913
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.16913
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16913
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.16913
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.16351
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, PTGS2 2.13617
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.13582
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, PTGS2, SRC 2.13467
[BP] GO:0051223 None ACHE, APP, CACNA1C, CNR1, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.1203
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.11822
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11822
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11523
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.10991
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MPO 2.10991
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.10991
[BP] GO:0050729 positive regulation of inflammatory response CNR1, EGFR, FABP4, IDO1, PTGS2 2.10991
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.09634
[BP] GO:0007187 None ADORA1, ADRB1, CHRM2, CNR1, CNR2, HTR6 2.09634
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, MET, PPARA 2.09634
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, HMGCR 2.09634
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, EGFR, HCAR2, HMGCR, MMP12, SRC 2.09634
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, KIT, PTPN1, SRC 2.08797
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.08252
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.06668
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.04235
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.03584
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.02871
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.02871
[BP] GO:0050890 None ADORA1, APP, CNR1, EGFR, HMGCR, KIT, PTGS2 2.01952
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.00591
[BP] GO:0006940 None ADORA1, CHRM2, KIT, PTGS2 2.00591
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, EGFR, ERBB2, HMGCR, KDR, PTPN1, SRC 2.00335
[BP] GO:0043696 None CDK6, ESRRB 2.0023
[BP] GO:0043697 None CDK6, ESRRB 2.0023
[BP] GO:0010641 None F3, SRC 2.0023
[BP] GO:0007598 None F10, F3 2.0023
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.0023
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1, TBXAS1 4.77891
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 4.42096
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2, TBXAS1 3.68983
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, KIT, MET, PTGS2, PTPN1, SRC, TBXAS1, TYR 3.578
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, EGFR, ERBB2, ESR1, F10, F3, FLT3, GBA2, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT 3.31958
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, MPO, PIM1, POLA1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 3.14377
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, EGFR, ERBB2, F10, F3, FLT3, HTR6, IGF1R, KDR, KIT, MET, PTGS2, SRC 2.88024
[CC] GO:0031233 None CA4, F10, F3 2.26026
[CC] GO:0043226 organelle ABCB1, ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HTR6, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.22939
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 2.22355
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, CHRM2, CNR1, CNR2, F10, F3, FLT3, HTR6, IGF1R, KDR, MET 2.0791
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.06651
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 15.3096
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 14.3231
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 13.628
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.62493
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC, TBXAS1 9.34491
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 9.34491
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC, TBXAS1 9.05751
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 8.71239
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 8.27055
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 7.99361
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.95062
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, XDH 7.28316
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.95253
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 6.88912
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.66317
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.38419
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 6.3603
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TBXAS1, TYR 6.35488
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.2368
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.97851
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.95197
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.78344
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.70481
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 5.69058
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA, RORC 5.59242
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CDK6, CHRM2, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA, RORC 5.07236
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.07236
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR, KIT 5.05463
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.87833
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.87833
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA, RORC 4.73081
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.45079
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.27115
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, PPARA, RORC 4.07564
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.98906
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.93488
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, HMGCR, KIT, MET, POLA1, POLB, PPARA, PTGS2, PTPN1, SRC, TNKS2 3.92999
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TERT, TYR, XDH 3.8852
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.84223
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, POLA1, POLB, SRC, TERT 3.80078
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, ADRB1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, XDH 3.78735
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.77881
[MF] GO:1901363 heterocyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, XDH 3.578
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25489
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.1991
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, XDH 3.18485
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.18439
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1 3.15856
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.15139
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.14708
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.96617
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.85343
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, XDH 2.83252
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, XDH 2.83086
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8176
[MF] GO:0003845 None HSD11B1, HSD11B2 2.8176
[MF] GO:0008389 None CYP2A13, CYP2A6 2.8176
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, CNR1, CNR2, EGFR, ERBB2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET 2.78448
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, CNR1, CNR2, EGFR, ERBB2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET 2.78448
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5446
[MF] GO:0043168 anion binding ABCB1, ABCG2, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MPO, PIM1, SRC, XDH 2.44065
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.40936
[MF] GO:0004949 None CNR1, CNR2 2.40936
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.28789
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRB1, AOX1, AXL, BCL2, EGFR, ERBB2, FLT3, HMGCR, KIT, PTGS2, TERT, TYR, XDH 2.27446
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.26026
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17178
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17178
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17178
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, F3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC 2.11523
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.0825
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0023
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0023
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, KDR, KIT 2.00229


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.8022
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.7645
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.2995
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 7.556
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, ERBB2, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 7.0235
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.2483
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 5.852
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.402
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.3699
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.3699
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.613
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.066
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 4.3896
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, ADRB1, CACNA1C, PPARA 3.7635
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 4.0574
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.7452
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0945
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, MET, EGFR, IGF1R 3.6459
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KIT, KDR, BCL2, MET, EGFR, IGF1R 3.1961
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4, ABCG2 3.9598
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R 3.1689
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, ERBB2, ADRB1, CACNA1C, EGFR 3.1689
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, ALOX5, CACNA1C, PTGS2 3.1689
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CNR2, CNR1, ADORA3, ADORA1, ADRB1 3.0171
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1, PTGS2 3.1961
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.914
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.5532
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3743
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 2.9469
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.5309
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2, CACNA1C 2.2726
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9469
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.3682
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.3682
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, EGFR, IGF1R 2.0144
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9446
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, PTGS2, EGFR 1.8499
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.794
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.1438
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0597
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 1.7823
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1331
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.0144
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.0142
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.0217
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9355
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.0504
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9872
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.7572
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.763
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3682
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.6254
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 1.7518
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7071
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.2255
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4445
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.172
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.1106
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.9314
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 0.8993
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.7742
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8831
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8193
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8176
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8732
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.937
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7812
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7716
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7812
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.937
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7812
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.9314
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7696
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.7392
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7392
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0127
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7305
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7696
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2662
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7233
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5976
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2902
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7174
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT, EGFR 0.7135
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2658
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5414
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.594
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0089
Phagosome_Homo sapiens_hsa04145 MPO 0.316
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3194
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3378
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3378
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.4553
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.336
Axon guidance_Homo sapiens_hsa04360 MET 0.3612
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.3588
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3744
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.369
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3744
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3859
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4113
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4219
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4219
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4267
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4317
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4317
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.431
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4317
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4378
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4387
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4396
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4553
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2989
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4396
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4499
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2162
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4553
Peroxisome_Homo sapiens_hsa04146 XDH 0.4553
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4779
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4618
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4553
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4779
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4779
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4852
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.4969
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4779
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4969
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.487
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4969
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.4947
Shigellosis_Homo sapiens_hsa05131 SRC 0.4969
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5114
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4969
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5025
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5667
Malaria_Homo sapiens_hsa05144 MET 0.5786
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5834
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5829
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.4295
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5829
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5834
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5926
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6375
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7071
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6726
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5991
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7392
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7203
DNA replication_Homo sapiens_hsa03030 POLA1 0.6655
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.66
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5827
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7135
Base excision repair_Homo sapiens_hsa03410 POLB 0.6923
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8598
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7233
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7392
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7174
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7392
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7804
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.066
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8327
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9161
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2162


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)