TCM Prescription: Bai Hua Ding Chuan Pills



Prescription Description
Prescription IDTCMF3160
Pinyin NameBai Hua Ding Chuan Wan
Chinese Name百花定喘丸
English NameBai Hua Ding Chuan Pills
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2728 Aster tataricus 紫菀 TCMH2728 ITSAI2445-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, TRPV1 11.429
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 9.60438
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 9.34155
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GLO1, MIF, PIM1, PPARA, TYR, XDH 8.84657
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SLC1A1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.68399
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1132
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 7.78652
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.74269
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.58758
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 7.20259
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.95792
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MET, MIF, PPARA 6.75995
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.6424
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.50108
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, SRC, TRPV1, TYR 6.31219
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 6.03711
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PPARA 5.87882
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 5.87882
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 5.78924
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.69419
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.67655
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, SRC, TERT, TRPV1, TYR 5.67655
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, SRC, TRPV1, TYR 5.67655
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.21094
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 5.21094
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.21094
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.20783
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.20783
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.20783
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.13615
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.00628
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.95553
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.82185
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.80815
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.73595
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.72617
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TERT, TRPV1 4.72617
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PTPN1, SRC, TERT, TOP2A, TRPV1 4.62239
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.61662
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.60768
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 4.60235
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.58242
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT 4.54793
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 4.517
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.517
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.49455
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.33834
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.282
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TRPV1 4.09659
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 4.09613
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, SRC, TRPV1 4.07081
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TERT, TRPV1 4.05621
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.03206
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, SRC, TRPV1, TYR 4.03206
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TYR 4.03206
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.99254
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.98109
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT 3.97152
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.91175
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, MIF 3.8392
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 3.78912
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.75307
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 3.74852
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF 3.74234
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.64118
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.61304
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 3.58632
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS2, TOP2A, TYR 3.56971
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.46291
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.43182
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.43182
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42684
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, SRC, TYR 3.36518
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.28975
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.26923
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.25313
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.22696
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, SRC, TRPV1 3.1855
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.15397
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.12126
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 3.11621
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.11621
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 3.01521
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 3.00502
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, FLT3, NR3C1, SRC, TRPV1 3.00256
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.00163
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.99488
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TRPV1, TYR 2.97292
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, SRC, TERT, TOP2A, TRPV1, TYR 2.96002
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.94416
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.94416
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.93335
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 2.92569
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.88938
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.8328
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 2.83137
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, SRC, TRPV1 2.82995
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.80643
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF 2.79398
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.79398
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.79398
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, GRM1, KDR, MET, MIF, PTPN1, SRC, XDH 2.77646
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.76146
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.71786
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.71359
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.71359
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.71359
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.71359
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, SRC, TRPV1 2.69183
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.6876
[BP] GO:0032845 None ADORA1, MIF, SRC, TNKS, TNKS2, TRPV1 2.67452
[BP] GO:0042391 None ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.66381
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 2.6443
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, KDR, MIF, PTPN1, SRC, XDH 2.63243
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CYP19A1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 2.63073
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TERT 2.60263
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.60054
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.57315
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.54711
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 2.53224
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, MIF, PTPN1, SRC 2.5284
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 2.52758
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.46873
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TRPV1 2.4256
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.4256
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.39596
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.376
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 2.34134
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT, TNKS 2.33793
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.33793
[BP] GO:0099566 None GRM1, GRM5 2.31668
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.31668
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.30976
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.30976
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.30976
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.30976
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.30213
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.30042
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.29759
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.28044
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.26334
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.23507
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.19822
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, IGF1R, KDR, MIF, PTPN1, SRC, XDH 2.19532
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 2.18323
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.17252
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, MIF, SRC, TERT 2.168
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.16195
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.16195
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.16195
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, MMP2, PPARA, SRC, TERT, TRPV1, TYR 2.15534
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.14666
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.14151
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.14151
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.12271
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.11938
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PTPN1, SRC, TNKS 2.11738
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 2.11527
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.11527
[BP] GO:0070213 None TNKS, TNKS2 2.11527
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.11527
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11527
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.11527
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11527
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.0872
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.08489
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.07258
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06975
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.06896
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.05362
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.05045
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, GRM5, IGF1R, MMP2, SRC, TRPV1 2.04548
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SRC, TERT, TRPV1 4.09613
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 4.0332
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 3.97152
[CC] GO:0044456 None ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC, TRPV1 3.51925
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.1855
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, TRPV1 3.08856
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, SRC, TRPV1 3.0456
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TUBB3 2.99488
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, TRPV1 2.79398
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.79398
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, BACE1, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NR3C1, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.72538
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, GRIA2, HSD11B1, HSD17B2, PTPN1 2.19532
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.12271
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, IGF1R, KDR, MET, PTPN1, PTPRS, SLC1A1, SRC, TRPV1, TYR 2.11527
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.11527
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.07856
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.07856
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 13.3894
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 12.1226
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.64035
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 8.68399
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.08401
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.99272
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 7.78652
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.69402
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.70333
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.53545
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.03711
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.03711
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.83272
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.76514
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.14536
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 4.98463
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.96697
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 4.77266
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.47741
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.31515
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, TNKS 4.18918
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.76976
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A, TRPV1 3.2659
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.1855
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.11621
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.0259
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 2.89896
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 2.79398
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78237
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.71359
[MF] GO:0008389 None CYP2A13, CYP2A6 2.71359
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.4256
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 2.34134
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.31668
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.31668
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.31668
[MF] GO:0099583 None GRM1, GRM5 2.31668
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 2.30976
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 2.30976
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.29759
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.29759
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.24643
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 2.22523
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.22523
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.205
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.11527
[MF] GO:0004971 None GRIA2, GRIA4 2.11527
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.11527
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.05362


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8834
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.734
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8918
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.0825
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, NR3C1, GRM1, GRIA4 7.0989
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8918
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.8884
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.4514
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.066
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7948
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.1311
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.1506
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.6312
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.1311
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0586
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.5514
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, GRM1 2.7009
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.5396
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET, CDC25B 2.4097
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.4097
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.058
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 1.8874
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5722
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1561
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.058
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9439
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.0322
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7846
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.6882
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.6728
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6728
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.0124
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6232
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3704
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9435
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9767
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9355
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9435
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9516
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2847
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1862
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.244
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.838
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2802
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1571
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1862
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8844
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0904
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1832
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.838
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.7926
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2617
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8386
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7768
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7342
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.66
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7528
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.66
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.6269
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3742
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.66
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2198
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2198
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2755
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2652
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2745
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3003
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2858
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.292
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6882
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3002
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3311
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.292
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3352
Platelet activation_Homo sapiens_hsa04611 SRC 0.3754
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3553
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3519
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4237
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3324
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3519
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3903
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3311
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3519
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.359
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3754
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3903
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4237
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3769
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3754
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4237
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4088
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4117
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3754
Axon guidance_Homo sapiens_hsa04360 MET 0.371
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3769
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4117
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4237
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4237
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4216
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4237
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5328
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4237
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4237
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4216
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4216
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4216
Peroxisome_Homo sapiens_hsa04146 XDH 0.4237
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4593
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.454
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4237
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.465
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4832
Glioma_Homo sapiens_hsa05214 IGF1R 0.4832
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4825
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4832
Shigellosis_Homo sapiens_hsa05131 SRC 0.4832
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.6232
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.527
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6728
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5513
Malaria_Homo sapiens_hsa05144 MET 0.5615
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6107
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8801
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5989
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6269
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6994
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2037
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6799
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7528
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7435
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8817
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9412


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)