TCM Prescription: Huo Pu Xia Ling Decoction



Prescription Description
Prescription IDTCMF2871
Pinyin NameHuo Pu Xia Ling Tang
Chinese Name藿朴夏苓汤
English NameHuo Pu Xia Ling Decoction
Function Description湿之化气, 为阴中之阳, 氤氲浊腻, 故兼证最多, 变迁最幻, 愈期最缓其见证也, 面色混浊如油腻, 口气浊腻不知味, 或生甜水, 舌苔白腻, 膜原邪重则舌苔满布, 厚如积粉, 板贴不松, 脉息模糊不清, 或沉细似伏, 断续不匀, 神多沉困嗜睡斯时也, 邪在气分, 即当分别湿多热多
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH519 Pogostemon cablin 杜藿香 TCMH519 ITSAJ4146-14
TCMH291 Cortex magnoliae officinalis 川朴 TCMH291 ITSAM1591-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH256 Wolfiporia cocos 赤茯苓 TCMH256 GBPOL314-13
TCMH2322 Prunus armeniaca 杏仁 TCMH2322 ITSAJ4486-14
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH53 Amomum kravanh 白豆蔻 TCMH53 KT898257
TCMH2671 Polyporus umbellatus 猪苓 TCMH2671 NOBAS3307-16
TCMH416 Glycine max 淡香豉 TCMH416 ITSAJ4675-14
TCMH1057 Alisma orientale 建泽泻 TCMH1057 KC573871
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.8454
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.8839
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HMGCR, PIM1, PPARA, TYR, XDH 9.85285
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 7.73921
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 7.14864
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.83523
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 6.72812
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, AXL, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 6.39046
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TYR, XDH 6.22746
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 6.06624
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 5.80969
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, HMGCR, HSD17B1, HSD17B2, MET, PPARA 5.66658
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.64457
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.27419
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 5.25678
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.79194
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.68016
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 4.53382
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.51539
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.51539
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.47648
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.33482
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.29683
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, SRC 4.279
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.279
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA3, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 4.279
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.19741
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 4.14596
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 4.12637
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.93143
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.93143
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.91693
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.89859
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, FABP4, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TYR 3.8138
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.76852
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.72973
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 3.67965
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.67284
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67284
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.66251
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, SRC, TYR 3.66055
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, F2, FABP3, FLT3, HMGCR, PPARA, SRC 3.62258
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, ESR1, F2, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.60216
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.50184
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.4173
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.4141
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, HMGCR, KDR, MET, MMP12, PPARA 3.37755
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, MMP12, MMP2, PPARA, PTPN1, SRC 3.36071
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 3.34326
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TYR 3.3334
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.31049
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 3.2977
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, ESR2, F2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.27421
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.18599
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.18284
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17152
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, AXL, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC 3.07847
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.062
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CNR1, CSNK2A1, CYP1B1, ESRRA, F2, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 3.05829
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.86676
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84378
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.84261
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, F2, HMGCR, KDR, SRC 2.83326
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.78119
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7639
[BP] GO:0009115 None AOX1, XDH 2.75946
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, F2, MMP12, PPARA 2.74527
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.69812
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.66878
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.62469
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, HMGCR, MET, PPARA 2.62469
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 2.62469
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, PPARA 2.62469
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, F2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.62406
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.58902
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, F2, FLT3, HMGCR, KDR, MET, PTPN1, SRC, XDH 2.58842
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.58758
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.55207
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, F2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 2.55103
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.50248
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA 2.48787
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR 2.46472
[BP] GO:0046110 None AOX1, XDH 2.38363
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38363
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 2.38348
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC 2.37586
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, F2, KDR, SRC 2.36887
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.35824
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 2.35824
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.35599
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.34611
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.34611
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.29315
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.27015
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23989
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18601
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.18343
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.18264
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.18133
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.18133
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.18133
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.18133
[BP] GO:0006145 None AOX1, XDH 2.16495
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.16495
[BP] GO:0038171 None CNR1, CNR2 2.16495
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16495
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 2.15436
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, ESRRB, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.14665
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, MET 2.12982
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.12955
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.07983
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.06654
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.04829
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.04829
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.04633
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.0318
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.02277
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.02277
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02277
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.87605
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 1.70639
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, AOX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 1.20202
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, AOX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 1.06542
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F2, FLT3, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 1.01617
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 21.0921
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 17.9039
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.8839
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3687
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 10.6738
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 10.3423
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 10.3129
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.23964
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 6.21407
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 5.79618
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 5.14513
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD17B1, HSD17B2, XDH 4.24747
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 4.12637
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93143
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93143
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.87571
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.71952
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.67284
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.64044
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, SRC, XDH 3.57667
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57667
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.56651
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.17152
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.13989
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.13575
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, MET, PPARA 3.04327
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.97919
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.79092
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.76218
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75946
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.6558
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.62469
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, MET, PPARA 2.52402
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, PPARA 2.52402
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.42348
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, MET, PPARA 2.38363
[MF] GO:0004949 None CNR1, CNR2 2.38363
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.31655
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.18264
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.16495
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, MET, PPARA 2.14665
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.04313
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.01523


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.5507
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4062
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.363
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.6507
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.536
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4681
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.9678
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1056
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP19A1, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 3.5869
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3535
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.6108
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.2557
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8935
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.321
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, F2 2.2057
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.1467
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2057
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2557
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.2057
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1204
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2057
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9751
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.1204
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6538
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1427
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3998
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3558
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3988
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2916
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2832
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0596
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2916
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1225
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.5148
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0187
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0735
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2916
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2258
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0187
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9751
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9751
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.841
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.971
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9543
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.862
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8668
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8745
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8259
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.753
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8176
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8529
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.706
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.6803
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8139
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3007
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0484
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3671
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5343
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3659
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3986
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3891
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3984
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3891
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4442
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5343
Platelet activation_Homo sapiens_hsa04611 SRC 0.4878
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.432
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5091
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5343
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4701
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4742
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4622
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.466
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5091
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5308
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5308
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4878
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5324
Gap junction_Homo sapiens_hsa04540 SRC 0.5343
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5343
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4742
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5343
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5308
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5277
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4878
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5343
Axon guidance_Homo sapiens_hsa04360 MET 0.4831
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4938
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5343
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5324
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5324
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5091
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5648
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5308
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5324
Peroxisome_Homo sapiens_hsa04146 XDH 0.5343
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.5444
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5943
Glioma_Homo sapiens_hsa05214 IGF1R 0.5943
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5814
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5974
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5938
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5943
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5933
Shigellosis_Homo sapiens_hsa05131 SRC 0.5943
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5943
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6492
Malaria_Homo sapiens_hsa05144 MET 0.6609
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.659
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6718
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6741
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6803
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6803
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7051
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8176
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.797
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8176
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8256
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8256
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8441
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0991
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8642
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2832


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)