TCM Prescription: Ligusticum Chuanxiong Powder to be Taken with Green Tea



Prescription Description
Prescription IDTCMF2724
Pinyin NameChuan Xiong Cha Tiao San
Chinese Name川芎茶调散
English NameLigusticum Chuanxiong Powder to be Taken with Green Tea
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, PPARA 9.95193
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.70274
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.62842
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 8.01937
[BP] GO:0042221 response to chemical ABCB1, ADORA2A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PPARA, RORC, TERT, TYR 7.6204
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, KIT, MMP2, PPARA, RORC, TYR 7.49293
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, RORC, TYR 7.30127
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.07849
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, KIT, MMP12, MMP2, MMP9, TERT, XDH 7.00466
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, TYR 7.00466
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, RORC, TYR 7.00466
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 7.00466
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 7.0042
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.0042
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, MMP2, PPARA 6.86136
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, PPARA, TERT, TNKS, TNKS2, XDH 6.82571
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.47298
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 6.12722
[BP] GO:0044281 small molecule metabolic process ADORA2A, AKR1B1, AKR1B10, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, PPARA, TYR, XDH 6.02773
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KIT, MMP2, MMP9, PPARA, RORC, TERT, TNKS2, TYR 6.0276
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.93646
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA 5.89594
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 5.80773
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KIT, PPARA, TYR 5.71088
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.45389
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KIT, MMP9, PPARA, RORC, TYR 5.38073
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KIT, MMP9, TERT 4.96084
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 4.96084
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APP, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 4.93299
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 4.90986
[BP] GO:0044237 cellular metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APP, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, KIT, MMP1, MMP2, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 4.88647
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 4.87427
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.7537
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, KIT, PPARA 4.75272
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.66532
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, TERT 4.58338
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 4.47813
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, KIT, MMP12, MMP2, MMP9, TERT 4.44894
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, KIT, MMP12, MMP2, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 4.40217
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.39996
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, KIT, MMP2, MMP9, RORC, TERT 4.39996
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34812
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APP, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 4.28416
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, KIT, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TYR 4.21871
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 4.19415
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 4.10784
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, TNKS, TNKS2 4.01835
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, EGFR, KIT 3.82612
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, EGFR, KIT 3.82612
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, XDH 3.72641
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, ADRB1, AKR1B1, AKR1B10, ALPL, APP, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, RORC, TNKS2, TYR 3.69693
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, KIT, MMP9, TERT 3.69693
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, KIT, MMP9, TERT 3.68543
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.64008
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APP, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HCAR2, KIT, MMP12, MMP9, PPARA, PTPN1, TERT 3.64008
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.64008
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.57099
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57099
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, KIT, MMP2, RORC 3.56502
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.54285
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.54285
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KIT, MMP9, PTPN1, XDH 3.40544
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KIT, MMP9, PTPN1, XDH 3.40544
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.37882
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, KIT, MMP9, TERT 3.37378
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, KIT, MMP12, MMP2, MMP9, PPARA, PTPN1, TERT, TNKS, TNKS2, XDH 3.31718
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.27479
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CYP19A1, DYRK1A, EGFR, ESR1, F3, FABP4, MMP12, MMP2, PPARA, PTPN1, TERT, XDH 3.27479
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, EGFR 3.25299
[BP] GO:0048143 None ADORA2A, APP, EGFR 3.24118
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.24118
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CYP1A1, EGFR, HSD11B2, KIT, MMP2, PPARA, TERT, TYR 3.22217
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.17701
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7 3.1651
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 3.16318
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, RORC 3.15646
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.12708
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12708
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.12708
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.05586
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.00741
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, KIT, MMP9, PTPN1, TERT, TNKS, XDH 2.95793
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.91578
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7 2.91578
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 2.90047
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 2.89531
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.84984
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.82068
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81087
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.81087
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, BCL2, CA2, CYP19A1, EGFR, ERBB2, HCAR2, MMP12, TERT 2.78178
[BP] GO:0009115 None AOX1, XDH 2.7734
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, KIT, MMP9, PPARA, PTPN1, TERT, XDH 2.75236
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, KIT, PTPN1, XDH 2.74309
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, KIT, MMP2, MMP9, PTPN1, RORC, TERT 2.71617
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ADRB1, ALPL, APP, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KIT, MMP2, MMP9, RORC, TERT 2.70873
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.70806
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP1B1, ERBB2, FABP3, TERT, XDH 2.68762
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CDK6, CYP19A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, MMP12, MMP9, PPARA, PTPN1, TERT, XDH 2.68723
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, ADRB1, APP, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HCAR2, KIT, MMP12, MMP9, TERT, TNKS2, XDH 2.68723
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, HCAR2, MMP12, MMP9, PPARA, PTPN1, TERT 2.67008
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.67008
[BP] GO:0003014 None ADORA1, ADORA2A, AKR1B1, BCL2, HSD11B2 2.66758
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.64869
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.62813
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC 2.62813
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.61453
[BP] GO:0070920 None EGFR, ESR1, TERT 2.59919
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.59919
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, KIT, MMP9, PTPN1, TERT, XDH 2.5965
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, TERT 2.5661
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.5661
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9 2.56551
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, ADRB1, APP, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, KIT, MMP9, PTPN1, TERT, TNKS, XDH 2.5594
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, TERT 2.55609
[BP] GO:0042493 response to drug ABCB1, ADORA2A, AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2 2.55594
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC 2.55474
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, ADRB1, APP, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2 2.55327
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.55184
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.5475
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.51685
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, KIT, MMP9, PPARA, PTPN1, XDH 2.51685
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, TERT 2.51685
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2 2.51261
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.50373
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.48981
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, KIT, MMP9, PPARA, PTPN1, XDH 2.48546
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, MMP2, PPARA, TYR 2.45971
[BP] GO:0046110 None AOX1, XDH 2.42295
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42295
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, KIT, MMP9, TERT 2.415
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.40377
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.40377
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, KIT, PTPN1, TERT, TNKS, XDH 2.39841
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.38632
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.37943
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, KIT, MMP9, PTPN1, XDH 2.35088
[BP] GO:0034502 protein localization to chromosome ESR1, TERT, TNKS, TNKS2 2.3476
[BP] GO:0046777 protein autophosphorylation CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, KIT 2.34557
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, TERT 2.33766
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, KIT, MMP9, PTPN1, XDH 2.32734
[BP] GO:0008283 cell proliferation ABCB1, ACHE, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, TYR 2.32734
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.2999
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR 2.29934
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, ALPL, AOX1, APP, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.29917
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.28528
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, CACNA1C, EGFR, ERBB2, HCAR2, MMP12, PTPN1 2.2623
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.26163
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.25804
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23657
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, CACNA1C 2.23307
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, MMP2, PPARA, TYR 2.23002
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.21968
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.21968
[BP] GO:0070213 None TNKS, TNKS2 2.20076
[BP] GO:0006145 None AOX1, XDH 2.20076
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20076
[BP] GO:0061900 None ADORA2A, APP, EGFR 2.20076
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.20076
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, KIT, MMP9, PTPN1, XDH 2.19043
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.19043
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, KIT, MMP9, PPARA, PTPN1, XDH 2.19043
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.19043
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, MMP9, PTPN1, TERT, XDH 2.19043
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, ADRB1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, KIT, MMP9, PPARA, PTPN1, TERT, TNKS, XDH 2.19043
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, ADRB1, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, KIT, MMP12, MMP9, PTPN1, TERT, TNKS, TNKS2, XDH 2.18308
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2 2.1463
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, BCL2, CA2, CDK6, CYP19A1, ERBB2, ESR1, ESRRA, HCAR2, KIT, MMP12, MMP2, PTPN1 2.1259
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, KIT, MMP9, PTPN1, XDH 2.11822
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, APP, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, KIT, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 2.09871
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2 2.09025
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.06617
[BP] GO:1901360 None ACHE, ADORA2A, AKR1B1, AKR1B10, AOX1, APP, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, RORC, TERT, TYR, XDH 2.06103
[BP] GO:0032880 regulation of protein localization ACHE, ADORA2A, APP, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, HCAR2, MMP12, PTPN1, TERT 2.05868
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, XDH 2.05666
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1 2.03806
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3 2.03511
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APP, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, MMP12, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 2.0299
[BP] GO:0043696 None CDK6, ESRRB 2.0299
[BP] GO:0043697 None CDK6, ESRRB 2.0299
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.0299
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, KIT, MMP9, PTPN1, XDH 2.0278
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, KIT, MMP2, MMP9, PPARA, PTPN1, TERT 2.00646
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.00014
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 3.28993
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.43422
[CC] GO:0099056 None ADORA1, ADORA2A 2.42295
[CC] GO:0098889 None ADORA1, ADORA2A 2.42295
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2 2.42168
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ALPL, APP, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, KIT, MMP2, PTPN1, TERT, TNKS, TNKS2, TYR 2.30447
[MF] GO:0046914 transition metal ion binding AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TYR, XDH 15.4026
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.94602
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PTPN1, TERT, TNKS, TNKS2, TYR, XDH 8.94489
[MF] GO:0043167 ion binding ABCB1, ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 8.39533
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 7.95723
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.73306
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.39367
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 6.2606
[MF] GO:0046872 metal ion binding ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 5.92236
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.57624
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.38073
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.27331
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.23696
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.23696
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.23696
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.20423
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.96084
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.83366
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.75272
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.9831
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.71028
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.54285
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.39309
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.31379
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.28993
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.28141
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KIT 3.24118
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, XDH 3.20096
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.154
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.08527
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, PPARA, RORC 3.02628
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.99659
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, PPARA, RORC 2.8493
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 2.80386
[MF] GO:0042802 identical protein binding ACHE, ADORA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, KIT, MMP9, TERT, TYR, XDH 2.78121
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7734
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7734
[MF] GO:0008389 None CYP2A13, CYP2A6 2.7734
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.71617
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, PPARA, RORC 2.51875
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.48941
[MF] GO:0019899 enzyme binding ADORA2A, ADRB1, APP, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, KIT, PPARA, PTPN1, TNKS2 2.38729
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.38632
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, ERBB2, FLT3, KIT 2.28509
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20076
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3 2.16247
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, PPARA, RORC 2.13709
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0299


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2788
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.1884
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3205
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, ERBB2, MMP9, EGFR 5.2385
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, ERBB2, BCL2, CYP1B1, MMP9, EGFR, CDC25B 5.189
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.909
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.0829
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2385
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, MMP9, EGFR 4.3006
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, EGFR, ESR2 3.7812
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0387
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA2A, ADORA1, ADRB1, CACNA1C, PPARA 3.417
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, EGFR 3.277
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2989
Calcium signaling pathway_Homo sapiens_hsa04020 ADORA2A, ERBB2, ADRB1, CACNA1C, EGFR 2.7222
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, ERBB2, EGFR 3.1619
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, ERBB2, MMP9, ESR1, EGFR 2.5054
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2548
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.3221
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.3221
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 1.9884
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.1535
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.173
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR 1.8502
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.116
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.7319
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2, CACNA1C, EGFR 1.8386
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.6676
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR 1.7312
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.4085
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6115
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA2A, ADORA3, ADORA1, ADRB1 1.4085
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.189
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.4085
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.3026
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, BCL2, EGFR 1.2142
Focal adhesion_Homo sapiens_hsa04510 ERBB2, BCL2, EGFR 1.1573
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, KIT, EGFR 1.1171
Glioma_Homo sapiens_hsa05214 CDK6, EGFR 1.2585
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT 1.3368
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.9834
Melanoma_Homo sapiens_hsa05218 CDK6, EGFR 1.2145
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2142
Endocytosis_Homo sapiens_hsa04144 KIT, ADRB1, EGFR 0.9772
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4024
ErbB signaling pathway_Homo sapiens_hsa04012 ERBB2, EGFR 1.1083
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, EGFR 0.9662
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3185
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0296
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1083
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2145
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9834
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0981
Gap junction_Homo sapiens_hsa04540 ADRB1, EGFR 1.1083
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1083
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0795
Serotonergic synapse_Homo sapiens_hsa04726 APP, CACNA1C 0.9763
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8722
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A, CACNA1C 0.9427
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT, EGFR 0.8353
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4603
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8831
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9492
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9303
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8063
Oxytocin signaling pathway_Homo sapiens_hsa04921 CACNA1C, EGFR 0.8063
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6635
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7319
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.7275
Ras signaling pathway_Homo sapiens_hsa04014 KIT, EGFR 0.6144
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6546
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2569
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 EGFR 0.3092
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3194
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3564
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3658
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3489
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3564
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.3564
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.4184
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4184
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4184
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4184
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4006
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4184
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR 0.4214
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4184
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4288
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4686
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4511
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7047
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4537
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4592
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6432
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8989
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.4968
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4537
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4965
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4965
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.501
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.501
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5096
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5007
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4965
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.521
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5099
GABAergic synapse_Homo sapiens_hsa04727 CACNA1C 0.5102
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5102
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5402
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.521
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5102
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5158
Peroxisome_Homo sapiens_hsa04146 XDH 0.521
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5242
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5402
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5235
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.521
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5488
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5539
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5525
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5402
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5501
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 EGFR 0.5513
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5553
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5693
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6375
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6572
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6572
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6572
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6572
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6635
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6635
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7062
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8142
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7902
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8063
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8063
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8182
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7983
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8142
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.942
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.994
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2412


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)