TCM Prescription: Huazheng Huisheng Tablets



Prescription Description
Prescription IDTCMF2636
Pinyin NameHua Zheng Hui Sheng Pian
Chinese Name化症回生片
English NameHuazheng Huisheng Tablets
Function Description症积, 产后瘀血, 少腹疼痛拒按, 适用于属血瘀气滞型的原发性支气管肺癌及原发性肝癌等
IndicationsBlood stasis pattern, Qi stagnation pattern, Malignant neoplasm of liver
Disease ICD-11 Category SF01 [Blood stasis pattern (TM1), 血瘀证 (TM1) ];
SE91 [Qi stagnation pattern (TM1), 气滞证 (TM1) ];
2C12.0 [Malignant neoplasm of liver, 肝恶性肿瘤 ];
Human Tissues Associated with IndicationLiver, Lung, Blood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH2013 Hirudo medicinalis 水蛭 TCMH2013 GBAN0017-06
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2044 Caesalpinia sappan 苏木 TCMH2044 ITSAJ4578-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH2668 Anemone raddeana 竹节香附 TCMH2668
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.3874
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4721
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALDH2, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, MIF, PIM1, PPARA, TYR, XDH 11.1071
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.30326
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.60769
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HSD17B2, MET, MIF, PPARA 5.99473
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.80479
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 5.65823
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.5411
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.51934
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.39157
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 5.37109
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, SRC, TYR 5.26146
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 5.03942
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 4.74028
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 4.65051
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B2, KDR, MET, MIF, PPARA, SRC, XDH 4.52056
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC, XDH 4.40071
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 4.40071
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.32852
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 4.32852
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, SRC, XDH 4.10123
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.08521
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, MIF, PPARA 4.03198
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, SRC, TYR, XDH 4.03198
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 3.82964
[BP] GO:0009056 catabolic process ACHE, ADORA1, ALDH2, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.82133
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.73856
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.73856
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALDH2, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, TYR, XDH 3.54256
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, SRC, XDH 3.4541
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, HCAR2, KDR, MIF, SRC 3.31439
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC 3.31439
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 3.29786
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28301
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B2 3.25267
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC 3.21898
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B2 3.11718
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SRC, TYR 3.06512
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP9, SRC, XDH 3.05529
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP9, SRC, XDH 3.03909
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.97061
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.97061
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.95228
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, IGF1R, KDR, MET, MIF, MMP9, PIM1, SRC 2.93843
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.8849
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.87749
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.84348
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.84148
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.84148
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.84148
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CNR1, CYP1A1, CYP1A2, CYP1B1, FLT3, SRC, TYR 2.83984
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, KDR, SRC 2.79847
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.7979
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA6, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP2, MMP9, PPARA, SRC, TYR 2.79292
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.77415
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.69225
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.66484
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, ALPL, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR 2.65624
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.64804
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.60715
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.60049
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.5415
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 2.53573
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, SRC, XDH 2.52271
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.4449
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.44298
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44298
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, MET, MIF, PIM1, SRC, TYR 2.42718
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.41421
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.41421
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CYP1A2, FABP3, FLT3, PPARA, SRC 2.41421
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35986
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, IGF1R, KDR, MIF, MMP9, PIM1, SRC 2.33327
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 2.31945
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.31945
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31945
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, XDH 2.31892
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.30332
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.22837
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 2.21602
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.21602
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21602
[BP] GO:0038171 None CNR1, CNR2 2.21602
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21602
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.21602
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.16672
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.16672
[BP] GO:1901575 None ACHE, ADORA1, ALDH2, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, XDH 2.16672
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.16384
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.14609
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.14609
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, SRC 2.08271
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CNR1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PPARA, SRC 2.08201
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, CNR1, FABP3, FABP4, FLT3, MET, SRC 2.07744
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.047
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TYR 1.35775
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, SRC, TYR 1.17738
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9 1.12075
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC 1.03673
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CNR1, CNR2, FLT3, IGF1R, KDR, MET 0.922987
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.9826
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 13.0237
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6248
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3629
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, SRC, TYR, XDH 9.50923
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.55555
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.30326
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 6.31733
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.64222
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.58153
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.49443
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.83379
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA 4.71566
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.65469
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 4.63055
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.40071
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.40071
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALDH2, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, TYR, XDH 4.37986
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 4.22833
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.82133
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.4541
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.35212
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.34043
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, XDH 3.28301
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.93348
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.84148
[MF] GO:0008389 None CYP2A13, CYP2A6 2.83482
[MF] GO:0004949 None CNR1, CNR2 2.44298


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.6124
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.1203
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.269
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8611
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1 4.5253
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.1307
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.6876
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.5253
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, ALDH2, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, AKR1B1, TYR, CYP19A1, XDH 3.8407
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.9965
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.7523
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4022
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.668
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4719
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.1444
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.3365
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3043
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0725
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8245
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1 1.7768
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.6876
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.4459
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5186
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5186
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.3479
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4927
Glycerolipid metabolism_Homo sapiens_hsa00561 ALDH2, AKR1B1 1.5054
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4459
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.8245
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2052
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4351
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.2052
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4459
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2672
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6666
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4459
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 ALDH2, AKR1B1 1.8204
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3698
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9796
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0882
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0908
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9735
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1214
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8881
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5907
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5907
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5907
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5907
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5907
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5907
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6426
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5907
Gap junction_Homo sapiens_hsa04540 SRC 0.5907
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5907
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4156
Glioma_Homo sapiens_hsa05214 IGF1R 0.6426
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5907
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5746
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6426
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4263
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5746
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6321
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5907
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5907
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4678
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5746
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6271
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5907
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5879
Platelet activation_Homo sapiens_hsa04611 SRC 0.5585
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.5024
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.5107
Peroxisome_Homo sapiens_hsa04146 XDH 0.5907
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4678
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5907
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6426
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5907
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4543
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5291
Tight junction_Homo sapiens_hsa04530 SRC 0.5328
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5638
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.5024
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6321
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.545
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5585
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6426
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5585
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.545
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5746
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5638
Axon guidance_Homo sapiens_hsa04360 MET 0.5538
Bile secretion_Homo sapiens_hsa04976 CA2 0.6321
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.6426
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6426
Shigellosis_Homo sapiens_hsa05131 SRC 0.6426
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6921
Malaria_Homo sapiens_hsa05144 MET 0.702
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.7009
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.7031
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7314
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7632
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8539
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.857
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8539
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8486
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8539
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8784
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8784
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8784
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8921
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0093
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0819


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)