TCM Prescription: Added Flavor Dang Gui Drink



Prescription Description
Prescription IDTCMF2510
Pinyin NameJia Wei Dang Gui Yin
Chinese Name加味当归饮
English NameAdded Flavor Dang Gui Drink
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 14.3696
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.7127
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1308
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 10.158
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.1343
[BP] GO:0018108 peptidyl-tyrosine phosphorylation CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.1343
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.1343
[BP] GO:0018212 peptidyl-tyrosine modification CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.0916
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, NISCH, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.21632
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.06552
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, GBA2, HSPA1A, NISCH, PIK3CA, PPARA, PTGS1, PTGS2, TYR, XDH 9.02931
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.85026
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.66291
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.49723
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.44333
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FDPS, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 8.37262
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.37262
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 8.16349
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.13283
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.13283
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FDPS, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.91895
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.85628
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, KIT, PPARA, PTGS2, SRC, TEK 7.74594
[BP] GO:0006468 protein phosphorylation BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, SRC, TEK, TNKS 7.70466
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.69115
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FDPS, FUT7, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.49424
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.44429
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.43476
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.38562
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.35817
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 7.31498
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGS2, RORC, SRC, TYR 7.2159
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 7.12598
[BP] GO:0016310 phosphorylation BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK, TNKS 6.93794
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.79013
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 6.76539
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 6.72469
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 6.58907
[BP] GO:0046777 protein autophosphorylation CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, SRC, TEK 6.58907
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 6.57339
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 6.56413
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.51876
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 6.4907
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TEK, TYR 6.39756
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.30106
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.29297
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.21029
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.18673
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.18604
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.1385
[BP] GO:0018193 peptidyl-amino acid modification BCL2, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS 5.9632
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.84896
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, BCL2, CDC25B, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.77376
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.76505
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.75357
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.73586
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC 5.73528
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.70926
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.70926
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.68234
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC 5.67189
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.65218
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.59744
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.59744
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.58619
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 5.56025
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.5525
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, DYRK3, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.50781
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.48645
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.42095
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, DYRK3, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.35782
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.31323
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.28209
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 5.27296
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.27296
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.27296
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.27273
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PTGS2, TEK 5.27187
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.20739
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.15865
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.14675
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, KIT, PPARA, PTGS2, RORC, SRC, TEK 5.08912
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.07703
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 4.85919
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 4.74576
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.60986
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.60986
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.5913
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.55164
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.48658
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.48602
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.48015
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.44634
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.43235
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 4.39366
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, DYRK3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.3788
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 4.37171
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.36966
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 4.36221
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.33974
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.33729
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.32408
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.32187
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.24286
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.23323
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.19873
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 4.13396
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, DYRK3, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.11297
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.10045
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 4.10045
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC 4.0933
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.95238
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 3.89586
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.89506
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.89506
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.8777
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2 3.8777
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.85991
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.84476
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.76122
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.76122
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, MAOA, TYR 3.75247
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.73435
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.70245
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 3.69567
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.69363
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.69363
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.68096
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 3.66924
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 3.65215
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, BCL2, CA1, CSNK2A1, DYRK2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.62674
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.51806
[BP] GO:0019538 protein metabolic process ACHE, ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.51806
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.51806
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.51806
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.50592
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.49652
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.45379
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.44288
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.44115
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.43851
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, RORC, SRC 3.42973
[BP] GO:0008217 None ADORA1, HSD11B2, NISCH, PPARA, PTGS1, PTGS2, SMAD3 3.42599
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 3.42599
[BP] GO:0008283 cell proliferation ACHE, BCL2, CLK1, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIK3CB, SRC, TEK, TYR 3.3947
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.3947
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.34104
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 3.33629
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.33222
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.3029
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.25112
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.24614
[BP] GO:0032787 None ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA, PTGS1, PTGS2 3.23001
[BP] GO:0006464 cellular protein modification process ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.19985
[BP] GO:0036211 protein modification process ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.19985
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 3.18676
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.18343
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.17192
[BP] GO:0044267 cellular protein metabolic process ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.16039
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.15216
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.12168
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.12168
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.10087
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.10087
[BP] GO:0003006 developmental process involved in reproduction ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC 3.0931
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.0931
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.08201
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.07802
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.07802
[BP] GO:0044093 positive regulation of molecular function ADORA1, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.06808
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 3.05542
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HASPIN, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.0524
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.04818
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 3.0334
[BP] GO:0045913 None DYRK2, ESRRB, INSR, PPARA, SRC 3.01838
[BP] GO:0010638 positive regulation of organelle organization ALOX15, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.00261
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.98608
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.977
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.96954
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.94577
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.94577
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 2.93833
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 2.91804
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, MAOA 2.91146
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.90845
[BP] GO:0006979 response to oxidative stress AKR1B1, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 2.88733
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 2.87841
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.87841
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.86665
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.85647
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 2.85086
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.84142
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.84142
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.8348
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 2.8348
[BP] GO:0009115 None AOX1, XDH 2.8348
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 2.82587
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, DYRK1A, DYRK3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 2.82587
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.80784
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.79888
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, HSD11B2, HSPA1A, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 2.79025
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78427
[BP] GO:0051338 regulation of transferase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.75928
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, BCL2, CA2, CA7, CYP19A1, DYRK2, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 2.73492
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.73386
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 2.71073
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.70169
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.70122
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70122
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.6993
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, DYRK1B, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.69639
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.68989
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.68989
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.68989
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.68699
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.68107
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.65981
[BP] GO:0051347 positive regulation of transferase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.63917
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 2.62508
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.62508
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.62014
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.54785
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.54739
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.54691
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.54635
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.54635
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.54023
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 2.53802
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, KIT, NISCH, PTGS2 2.53185
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, KIT, NISCH, PTGS2 2.53185
[BP] GO:0022414 reproductive process AKR1B1, ALPL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, PTGS2, SRC 2.4794
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 2.43622
[BP] GO:0009891 positive regulation of biosynthetic process DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2 2.43622
[BP] GO:0046110 None AOX1, XDH 2.43424
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43424
[BP] GO:0043412 macromolecule modification ALPL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.43424
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.41501
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.4091
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.4091
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.40779
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.40626
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FDPS, KIT, MET, PIK3CA, PIK3CB 2.40165
[BP] GO:0035556 intracellular signal transduction AKR1B1, BCL2, CYP1B1, DYRK2, EGFR, HASPIN, IGF1R, INSR, KDR, KIT, MET, NISCH, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.39119
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.38547
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, PTGS2, SRC 2.3801
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.37814
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.37193
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.36799
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.36799
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.36479
[BP] GO:0009892 negative regulation of metabolic process ADORA1, BCL2, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.36054
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.35986
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.35308
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.34369
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.34369
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.32574
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.30331
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.29583
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GPR35, HASPIN, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.29555
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.29555
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.29172
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.29172
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.25664
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.25664
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, KIT, MET, PIK3CA, PIK3CB 2.25152
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.23854
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9 2.23577
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.22539
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.22539
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.22368
[BP] GO:0000302 response to reactive oxygen species AKR1B1, BCL2, CYP1B1, EGFR, MMP9, SRC 2.22368
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.21485
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.21485
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK 2.21485
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, PTGS2, SMAD3 2.1981
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.1981
[BP] GO:0070213 None TNKS, TNKS2 2.1981
[BP] GO:0006145 None AOX1, XDH 2.1981
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1981
[BP] GO:0044092 negative regulation of molecular function ADORA3, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS 2.19705
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1968
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.19473
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.18834
[BP] GO:0034502 protein localization to chromosome ESR1, HASPIN, TNKS, TNKS2 2.16974
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 2.15532
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.14931
[BP] GO:0050900 leukocyte migration FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.14931
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1468
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1468
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.12397
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.1201
[BP] GO:0031328 positive regulation of cellular biosynthetic process DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2 2.10977
[BP] GO:0051894 None KDR, SMAD3, TEK 2.09589
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09589
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC 2.08523
[BP] GO:0048608 reproductive structure development BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.07009
[BP] GO:0050927 None F3, KDR, SMAD3 2.04738
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.03303
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.03276
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.02627
[BP] GO:0043467 regulation of generation of precursor metabolites and energy DYRK2, ESRRB, INSR, PIK3CA, PPARA 2.01937
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2 2.01638
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.01638
[BP] GO:0043696 None CDK6, ESRRB 2.01638
[BP] GO:0043697 None CDK6, ESRRB 2.01638
[BP] GO:0010641 None F3, SRC 2.01638
[BP] GO:0007598 None F10, F3 2.01638
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.01638
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.01638
[BP] GO:0050926 None F3, KDR, SMAD3 2.01638
[BP] GO:0005979 None DYRK2, ESRRB, INSR 2.01638
[BP] GO:1903393 None KDR, SMAD3, TEK 2.01638
[BP] GO:0010962 None DYRK2, ESRRB, INSR 2.01638
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.01525
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.00675
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.00594
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.00594
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 3.16317
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 2.71029
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.64719
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.63917
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.47313
[CC] GO:0031233 None CA4, F10, F3 2.29555
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, BCL2, CA4, CA5A, CA5B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FDPS, FLT3, FUT7, GBA2, HASPIN, HSPA1A, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, NUAK1, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.21741
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.09564
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FDPS, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH 17.4844
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 16.8944
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.6371
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 16.1462
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[MF] GO:0004713 protein tyrosine kinase activity CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.1767
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS 9.54336
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.06552
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.88142
[MF] GO:0004672 protein kinase activity CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, SRC, TEK 7.80108
[MF] GO:0008144 drug binding ACHE, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, SRC, TEK 7.66583
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH 7.44429
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 7.43476
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH 7.2159
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.03245
[MF] GO:0016301 kinase activity CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 6.84435
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.42812
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.29297
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.95514
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.77376
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 5.77046
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.71853
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.47252
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.35591
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.27072
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.12264
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.11275
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.94613
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.94613
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.8278
[MF] GO:0043168 anion binding ALOX15, AOX1, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, SRC, TEK, XDH 4.7881
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.74576
[MF] GO:0036094 small molecule binding ADORA1, AOX1, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, SRC, TEK, XDH 4.72811
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.6885
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.56069
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.49994
[MF] GO:0140096 catalytic activity, acting on a protein CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PTPN1, SRC, TEK 4.46035
[MF] GO:0000166 nucleotide binding AOX1, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, SRC, TEK, XDH 4.33974
[MF] GO:1901265 nucleoside phosphate binding AOX1, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, SRC, TEK, XDH 4.33974
[MF] GO:0005524 ATP binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 4.05743
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, PPARA, RORC 3.8998
[MF] GO:0032559 adenyl ribonucleotide binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 3.8998
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 3.89586
[MF] GO:0030554 adenyl nucleotide binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 3.87245
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC 3.83879
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.76718
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.69363
[MF] GO:0004674 protein serine/threonine kinase activity CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIK3CA 3.4282
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC 3.41212
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 3.38848
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.38775
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.27807
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.17036
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.17036
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.16317
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.06916
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 3.06619
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.99085
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, NISCH, NQO2, PTGS2, SMAD3, TYR, XDH 2.98342
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.97924
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.94577
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.87031
[MF] GO:0035639 purine ribonucleoside triphosphate binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.87031
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8348
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8348
[MF] GO:0003845 None HSD11B1, HSD11B2 2.8348
[MF] GO:0008389 None CYP2A13, CYP2A6 2.8348
[MF] GO:0004872 receptor activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 2.77366
[MF] GO:0032555 purine ribonucleotide binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.75092
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, SMAD3, TEK 2.72636
[MF] GO:0017076 purine nucleotide binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.71514
[MF] GO:0032553 ribonucleotide binding CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.70934
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.58161
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.43424
[MF] GO:0016740 transferase activity CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FDPS, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK, TNKS, TNKS2 2.36978
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.34304
[MF] GO:0097367 carbohydrate derivative binding ADORA1, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.32748
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1981
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.07346
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.01937
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01638
[MF] GO:0043559 insulin binding IGF1R, INSR 2.01638


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6124
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.6535
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, KIT, BCL2, MET 7.6704
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.9465
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.2884
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.6704
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.6525
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.1462
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.5435
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOA, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.8489
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 5.6949
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.3672
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.1236
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.5505
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 5.4097
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.3165
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.8459
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2707
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.7525
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIK3CB, F3 4.5882
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.5882
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2478
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.1905
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4634
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2384
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.3599
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.377
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.3429
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.0113
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.1866
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7924
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.8514
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.3964
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.233
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 3.0314
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.4025
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.9618
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PIK3CB, EGFR 2.9454
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.7873
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIK3CB 3.3964
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.2649
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 3.0431
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.6949
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 3.1276
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.808
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2071
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6467
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6981
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4684
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4752
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9618
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.4144
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1276
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.9905
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.4089
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX15, PTGS2, PTGS1 2.4617
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4144
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3749
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB, HSPA1A 2.4144
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4144
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.3558
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.2577
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0842
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.971
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.2011
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, AOX1, PIK3CB 2.0261
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB, HSPA1A 1.8814
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8557
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.7038
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6455
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4224
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8611
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2725
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2793
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2779
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2779
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4372
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, PIK3CA, PIK3CB 1.4152
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3194
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.803
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.7724
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5952
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3591
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3929
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7428
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5619
Axon guidance_Homo sapiens_hsa04360 MET 0.3715
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.369
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3794
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8492
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1726
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.8435
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7122
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6803
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4443
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8259
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8456
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4443
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2025
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4578
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8182
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4568
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8435
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.4317
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4703
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9897
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4768
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4909
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0223
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4756
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0002
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0223
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.066
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1782
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0299
Peroxisome_Homo sapiens_hsa04146 XDH 0.4924
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0834
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0967
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0967
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.502
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5171
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5311
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.529
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5409
Bile secretion_Homo sapiens_hsa04976 CA2 0.5387
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5433
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.2673
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5514
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2265
Shigellosis_Homo sapiens_hsa05131 SRC 0.56
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5629
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1726
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2744
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5844
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2444
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3662
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3062
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6444
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.649
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3754
Malaria_Homo sapiens_hsa05144 MET 0.6538
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6538
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.4152
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6607
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6556
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8564
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6607
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.56
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7122
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5467
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7622
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8435
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.808
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8489
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8251
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8456
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8611
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.803
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7212
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8182
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8435
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8748
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0304
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9073
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0002
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9872
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.066
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2384
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3754


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)