TCM Prescription: Rheumatalgia-Relieving Plaster



Prescription Description
Prescription IDTCMF2397
Pinyin NameZhui Feng Gao
Chinese Name追风膏
English NameRheumatalgia-Relieving Plaster
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH857 Radix knoxiae 红大戟 TCMH857
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH293 Manis pentadactyla 穿山甲 TCMH293 GBMA15413-17
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8826
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9419
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR, XDH 9.04625
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1 8.94344
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 8.6779
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 8.4414
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.00611
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, KDR, MET, MIF, POLA1, POLB, PPARA, SLC1A1, SRC, XDH 7.95606
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 7.8507
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 6.84323
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.80748
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, MET, MIF, PPARA, TBXAS1 6.54252
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, TBXAS1 6.54252
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 5.94026
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.88362
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 5.83747
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HCAR2, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 5.81597
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HCAR2, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 5.7942
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.72029
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, SRC, TYR 5.69376
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.55817
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, SRC, TYR 5.51187
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.49466
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PPARA, TBXAS1 5.40541
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.37286
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.16314
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, POLA1, POLB, SRC 5.16131
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.14491
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.01447
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 4.85884
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.85884
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, POLA1, POLB, PTPN1, SRC, TOP2A 4.75506
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 4.75506
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.7015
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, SRC, TYR 4.6657
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.57423
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.57423
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.5121
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC 4.47549
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.37072
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, ERBB2, FLT3, GRM1, KDR, MET, MIF, PTPN1, SRC, XDH 4.35662
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 4.30402
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 4.30402
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 4.27784
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC 4.25453
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TOP2A, TYR, XDH 4.2514
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC 4.2514
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 4.24941
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.18171
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 4.15558
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.13997
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD17B2, KDR, POLB, PPARA, SRC, TYR 4.02963
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC 4.01174
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 3.92916
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TOP2A, XDH 3.92916
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TOP2A, TYR 3.88775
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 3.84597
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.77989
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.77989
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 3.77379
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC 3.67785
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.66104
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC 3.65841
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GLO1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, SRC, TOP2A, TYR 3.65318
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 3.59549
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, SRC, TBXAS1, TOP2A, TYR, XDH 3.59374
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, ERBB2, FLT3, GRM1, KDR, MIF, PTPN1, SRC, XDH 3.58792
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.56477
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.55919
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.5456
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.5456
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TOP2A, TYR, XDH 3.54341
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, XDH 3.52633
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC 3.48303
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC 3.47865
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 3.47865
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.42712
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, POLA1, SRC, TYR 3.41122
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.3764
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, IGF1R, MIF, PTPN1, SRC 3.36204
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC 3.32359
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, ERBB2, PPARA 3.3101
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.2384
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, MIF, PTPN1, SRC 3.23743
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.23743
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC 3.18947
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.11187
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.107
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.107
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HCAR2, KDR, MIF, SRC 3.107
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, EGFR, ERBB2, FLT3, GRM1, IGF1R, KDR, MIF, PTPN1, SRC, XDH 3.07531
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.0686
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 3.06352
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.00274
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.97817
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 2.97817
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 2.90524
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC 2.8769
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.87465
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.86236
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 2.85827
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GRIK5, GRM5, HCAR2, MIF, MMP12, MMP9, PPARA, PTPN1, SRC 2.8519
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MIF, MMP9, SRC 2.79672
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79672
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.77166
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.77166
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.75186
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TYR 2.74078
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PTPN1, SRC 2.72486
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, PPARA, SRC 2.72467
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 2.71415
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.66905
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 2.66077
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.6478
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 2.58546
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.56837
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, MIF, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TOP2A 2.5196
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, MIF, PTPN1, SRC 2.47322
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 2.4651
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.4535
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PTPN1, SRC 2.44853
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.44456
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.41423
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, GRM1, MMP2, POLB, PPARA, SRC, TYR 2.41396
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.40112
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, SRC, TYR 2.3883
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.3883
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PTPN1, SRC 2.37809
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.37809
[BP] GO:0099566 None GRM1, GRM5 2.37809
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.37809
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.37809
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SRC 2.3605
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.35673
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.35204
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, EGFR, ERBB2, KDR, MIF, PTPN1, SRC 2.32086
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SRC 2.31069
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 2.2793
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.27901
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.25712
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.2555
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.25212
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, IGF1R, MIF, PTPN1, SRC 2.24438
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.21121
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.21121
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.21121
[BP] GO:0042391 None ADORA1, CACNA1C, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.16084
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.15732
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC 2.15215
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET 2.14323
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.14323
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.14323
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14323
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.13606
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.13106
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, XDH 2.13106
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12557
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR 2.12504
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.11104
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.11017
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC, XDH 2.07787
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, EGFR, ERBB2, HCAR2, MIF, MMP12, PTPN1, SRC 2.04789
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.0457
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.0457
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.03494
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.01337
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, EGFR, GRIK5, HCAR2, MIF, MMP12, SRC 2.00653
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 4.35116
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 3.40508
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.36204
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ALOX15, AXL, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC 3.16783
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.07531
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.07531
[CC] GO:0044456 None ACHE, ADORA1, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.53281
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.31722
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.21627
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TBXAS1, TYR 2.13748
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, PIM1, POLA1, PTPN1, SRC, TBXAS1, TOP2A, TYR, XDH 2.00458
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 2.00094
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.1644
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 13.6322
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 12.8499
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9419
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TOP2A, TYR, XDH 10.6173
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 9.90557
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, SRC, TBXAS1, TOP2A, TYR, XDH 8.52086
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.29009
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.75276
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.60063
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.56493
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.99831
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TOP2A, TYR, XDH 5.93847
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.88847
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TOP2A, TYR, XDH 5.66948
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.30343
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 5.28677
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.20172
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.19811
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.00156
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.6657
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 4.45964
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.35662
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.35662
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.2514
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.92916
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 3.78504
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.77989
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 3.61992
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 3.27631
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.23743
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.23743
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.07531
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.05863
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.95334
[MF] GO:0008389 None CYP2A13, CYP2A6 2.77166
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.75186
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.71147
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC 2.3883
[MF] GO:0099583 None GRM1, GRM5 2.37809
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.37184
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.37184
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.37184
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.21973
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.15215
[MF] GO:0004971 None GRIA2, GRIA4 2.14323


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.6889
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 8.0317
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8834
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.8765
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.8765
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, GRM1, GRIA4 6.2511
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.3525
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1309
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5819
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3525
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 4.3092
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.9863
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR 3.7447
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.4296
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.622
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.7305
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.9642
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.4296
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.4296
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.4296
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 3.1884
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9352
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.3621
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.3558
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.9087
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.487
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3241
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.0588
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.3976
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3245
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.2256
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9718
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.2569
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1779
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2197
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2507
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 1.9547
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.9718
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.8851
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7994
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.7247
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.8167
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, CACNA1C 1.7528
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.6183
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5427
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR, IGF1R 1.5904
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4426
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, EGFR, IGF1R 1.2528
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0083
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.065
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0827
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 1.0083
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0117
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8453
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.959
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.1957
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8989
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6366
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8713
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7293
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9662
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.8453
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6212
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9735
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1437
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1553
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2395
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3078
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2391
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3188
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3259
Tuberculosis_Homo sapiens_hsa05152 SRC 0.335
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3604
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3256
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3505
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3675
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.3547
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3794
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.397
Measles_Homo sapiens_hsa05162 CSNK2A1 0.402
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3977
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.397
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4055
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4275
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4275
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.4473
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4313
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4495
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4275
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4426
Axon guidance_Homo sapiens_hsa04360 MET 0.4224
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4289
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4313
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3251
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4734
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4734
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4737
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4734
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4778
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4825
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4628
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4823
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4777
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4825
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4825
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4776
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4781
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5013
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4825
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4841
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4901
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4825
Peroxisome_Homo sapiens_hsa04146 XDH 0.4891
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5181
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5002
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4891
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5161
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5201
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.426
Bile secretion_Homo sapiens_hsa04976 CA2 0.5191
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5385
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5161
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5415
Shigellosis_Homo sapiens_hsa05131 SRC 0.54
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5427
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5802
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.622
Malaria_Homo sapiens_hsa05144 MET 0.6332
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6366
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6733
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.845
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.7528
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8642
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8094
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7924
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7452
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7007
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0103
DNA replication_Homo sapiens_hsa03030 POLA1 0.7338
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8453
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8453
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3525
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9935


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)