TCM Prescription: Liver Soothing and Sclerma Removing Recipe



Prescription Description
Prescription IDTCMF2378
Pinyin NameShu Gan Xiao He Fang
Chinese Name
English NameLiver Soothing and Sclerma Removing Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1178 Citrus reticulata 橘核 TCMH1178 ITSAA1245-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH1346 Cornu cervi degelatinatum 鹿角霜 TCMH1346
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 15.1656
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 15.1656
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, RELA, SMAD3, SRC, TEK, XDH 12.732
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MAOA, MCL1, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 12.3096
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.1893
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, RELA, SRC, TEK, TRPV1, TYR 11.8101
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MCL1, MMP2, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TRPV1, TYR 11.7056
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 11.5683
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, PTPN1, RELA, SRC, TEK, XDH 11.5391
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 11.1769
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES, TRPV1 10.9877
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.9877
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGES, RELA, SRC, TEK, TRPV1, TYR 10.9877
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8746
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 10.8746
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.8684
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.2219
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.0397
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0397
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 10.0343
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, INSR, MMP2, PPARA, RELA, SMAD3, SRC, TEK, TRPV1 9.99385
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 9.70775
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TNKS2, TOP1, TRPV1, TYR 9.49021
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, INSR, PPARA, RELA, SRC, TEK, TRPV1 9.28123
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2, TRPV1 9.00587
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, RELA, SMAD3, SRC, TEK, TYR 8.98834
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FDPS, FUT7, GBA2, HSD17B3, HSPA1A, HTR2B, PIM1, PPARA, PTGES, TYR, XDH 8.81921
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PTGES, RELA, SRC, TYR 8.5964
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, RELA, TEK 8.56644
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 8.2623
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MET, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 8.02089
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 7.94522
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 7.85464
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 7.75211
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 7.73927
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 7.68662
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.68662
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD11B2, HTR2A, HTR2B, KDR, RELA, SRC, TOP1, TRPV1 7.65708
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, INSR, KDR, MAP2K1, MCL1, MMP9, PIM1, PPARA, RELA, SIGMAR1, SMAD3, SRC, TEK, TYR 7.57843
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 7.56211
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 7.56211
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.56211
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 7.50975
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 7.3893
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, INSR, KDR, MAP2K1, MCL1, MET, MMP2, MMP9, PIM1, PPARA, RELA, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TYR 7.23999
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FDPS, GBA2, HSD17B3, HTR1A, MAOA, TYR 7.2048
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, MCL1, MET, SMAD3, SRC, TRPV1 7.09537
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, RELA, SMAD3, SRC, TEK, TRPV1, TYR 6.83688
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 6.82509
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.82256
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.82256
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.80218
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.72485
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SMAD3, SRC, TEK, TRPV1 6.69118
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3, TRPV1 6.60386
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC 6.58876
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 6.55606
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.53081
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 6.52183
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 6.51358
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4172
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4172
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.3643
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 6.36324
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.35797
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.35304
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 6.35036
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 6.34798
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TOP1, XDH 6.34056
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 6.34056
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 6.34056
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.21914
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.16956
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 6.12127
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.10307
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 6.0843
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 6.03071
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.02741
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.01507
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 5.98068
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.95407
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.95287
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.93752
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TOP1, XDH 5.93752
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 5.92541
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 5.86984
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.83858
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.83197
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.82238
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.7454
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, MAP2K1, PTPN1, SRC, TEK 5.74366
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 5.70925
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, XDH 5.70332
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 5.70332
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.64219
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.61904
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 5.59394
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.55476
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.50716
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.50716
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.4982
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.39665
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.38046
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TRPV1, TYR 5.36222
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 5.3619
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.32672
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MCL1, MET, MMP9, PTPN1, RELA, SRC, XDH 5.30933
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.30524
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.29125
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RELA, SMAD3, SRC, TRPV1 5.29061
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 5.26165
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2, TRPV1 5.26165
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PPARA, PTGES 5.25384
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 5.22471
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 5.21253
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.21033
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MAP2K1, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 5.21033
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.21033
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.21033
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.20572
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, MAP2K1, SRC, TEK 5.19933
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.17184
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.17034
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, MAOA, SMAD3, TRPV1 5.17034
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.1613
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.1015
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, NUAK1, PTPN1, RELA, SRC, TEK 5.1015
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.084
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.082
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.0764
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.0764
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 5.0764
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.07055
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 5.07055
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.037
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.02674
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RELA, SMAD3, SRC, TRPV1 4.99481
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TRPV1, TYR 4.95566
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS, TNKS2, TRPV1 4.90697
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 4.88289
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.87988
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.86743
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR 4.76606
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.75652
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC, TOP1 4.75652
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TRPV1 4.74407
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, TNKS, TNKS2 4.71317
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.6976
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.6976
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.65292
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.65292
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HTR2A, HTR2B, PPARA, SRC, TEK 4.61792
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TNKS, TOP1 4.5766
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, TEK 4.5701
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.54686
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.54581
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.54581
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.53313
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 4.53313
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.53159
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.53069
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS, TNKS2, TRPV1 4.52988
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 4.52123
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.51459
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.49644
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.47208
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.39968
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.36845
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, TNKS 4.364
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MCL1, MET, PPARA, PTPN1, RELA, SMAD3 4.35974
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.35013
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35013
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.343
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.27526
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, SMAD3, SRC, TNKS, TNKS2 4.25135
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 4.25135
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 4.23395
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, RELA, SRC 4.21719
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.20188
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HTR2B, MCL1, MET, PPARA, RELA, SMAD3 4.20188
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MAP2K1, MET, PIM1, SRC, TEK, TYR 4.19824
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 4.19239
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, HSD11B2, PPARA, SMAD3 4.18745
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.18745
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, TRPV1 4.18745
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.18745
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 4.18629
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 4.18629
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.17766
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TNKS 4.17481
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 4.17041
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 4.1674
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RELA, SRC, TRPV1 4.16521
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.14345
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.14115
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 4.13023
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.12836
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 4.09477
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, MMP12, SMAD3, SRC, TRPV1 4.09433
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 4.09049
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FDPS 4.08929
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.07271
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MAP3K7, MCL1, MET, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.06738
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.06738
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 4.06541
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.03916
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, RELA, SRC, TEK, TRPV1 4.02632
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC, TRPV1 4.00413
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, TNKS 4.00413
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, RELA, SRC, TRPV1 3.98915
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, RELA, SRC 3.97387
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.96966
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, MCL1, SMAD3, TRPV1 3.96486
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 3.95926
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.9588
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 3.95158
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.94963
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 3.94749
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, MAP2K1, PTGES, SMAD3, XDH 3.88666
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.88666
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, TRPV1 3.84093
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 3.82331
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 3.82068
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, TRPV1 3.82068
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, SRC 3.79383
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.79383
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.79383
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, RELA, SRC 3.76656
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.75498
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 3.73667
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.73467
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FDPS 3.69399
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC, TRPV1 3.69399
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 3.69294
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.68508
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CYP1A1, DRD3, EGFR, FDPS, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MAP2K1, MET, MMP1, MMP12, RELA, SMAD3, SRC, TOP1 3.66452
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.6201
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.61575
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.58944
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, TRPV1 3.5796
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 3.56903
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES 3.56594
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.53172
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 3.50651
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA, TRPV1 3.50408
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.44286
[BP] GO:0050678 None AR, CDK6, EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 3.44286
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.43395
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42716
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.42716
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 3.4205
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.38123
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, HTR2A, MMP9 3.37651
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, RELA, SMAD3, SRC, TRPV1 3.37651
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.36783
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.36783
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.36257
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.35562
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.31455
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS 3.31455
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SRC 3.30901
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.28402
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.2688
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.26525
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, MMP9 3.24241
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.2363
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CACNA1C, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, SMAD3, TRPV1 3.23176
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TRPV1 3.22093
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.21306
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MCL1, MMP9, PTPN1, RELA, SRC 3.21056
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.1985
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.18202
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.18114
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.18114
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.18114
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.18114
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.18114
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.18114
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.18114
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.16384
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK, TRPV1, TYR 3.15291
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, RELA, TYR 3.15291
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.15291
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.13972
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, MCL1, RELA, SRC 3.13972
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, INSR, PPARA, TRPV1 3.08477
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.08464
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.08353
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, SRC, TNKS 3.07864
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, INSR, KDR, MAP2K1, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 3.07791
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC, TRPV1 3.07631
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.06259
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS, TNKS2 3.06039
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.03386
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.02764
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 2.99551
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MCL1, MET, NUAK1, PTPN1, XDH 2.98477
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 2.97835
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.97834
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.96368
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.96368
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3, TNKS2 2.96368
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.96368
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 2.94063
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.9347
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.93378
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.9332
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, DRD2, EGFR, ESR1, HTR2B, INSR, MET, MMP2, RELA, SMAD3, SRC, TEK 2.93253
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.92664
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.91869
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 2.91837
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 2.91837
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.90885
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK, TRPV1 2.90796
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.8873
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES 2.88195
[BP] GO:0009115 None AOX1, XDH 2.87407
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, RELA, SRC, TRPV1 2.86483
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 2.85655
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, CACNA1C, DRD1, GPR35, KDR, SRC, TRPV1 2.82052
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 2.81137
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC, TRPV1 2.81124
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.79546
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.79218
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.79218
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 2.79218
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR2B, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.77878
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76915
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.76915
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.76915
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.7673
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.72544
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.72381
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.71725
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.70591
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP12, MMP9, SRC, TEK 2.69861
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK 2.68786
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67859
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.67859
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.67859
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP12, MMP9, SRC, TEK 2.67368
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SMAD3, SRC, TNKS2 2.65933
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.65674
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, DRD3, EGFR, HSD11B2, HTR2A, MMP12, PTGES, RELA, SMAD3, SRC, TRPV1, TYR 2.63213
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MAP3K7, MMP12, MMP2, PTPN1, RELA, SMAD3, SRC 2.62868
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.62346
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 2.61285
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.60934
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.60934
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, RELA, SRC, TRPV1 2.60934
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.59854
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.59854
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.59854
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.59854
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS 2.59854
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, RELA, TYR 2.58352
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, RELA, SRC, TRPV1, TYR 2.58352
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.57817
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.57817
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.55919
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA, TOP1 2.55378
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.54712
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 2.5463
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.54158
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.54158
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HTR2B, KDR, MAP2K1, MCL1, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.53936
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.52752
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.52752
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52752
[BP] GO:0070920 None EGFR, ESR1, MAP2K1 2.52752
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.52752
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.52427
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.51774
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC 2.51414
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.49817
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC, TEK, TRPV1 2.487
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.487
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, TRPV1 2.48151
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.48151
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, TRPV1 2.48151
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 2.48151
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC, TRPV1 2.48151
[BP] GO:0033590 None EGFR, RELA 2.47845
[BP] GO:0046110 None AOX1, XDH 2.47845
[BP] GO:0060160 None DRD2, DRD3 2.47845
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47845
[BP] GO:0002520 None CACNA1C, SMAD3 2.47845
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.46171
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.46015
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.45336
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.44752
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.44613
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, FDPS, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, RELA, SMAD3, SRC, TOP1 2.43417
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.42712
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.40608
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.40125
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.39503
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.39503
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.39503
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 2.39305
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.39198
[BP] GO:0048589 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SMAD3, TNKS2 2.36492
[BP] GO:0051254 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS 2.3636
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.33351
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.33351
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33351
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.33351
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MCL1, MMP9, PTPN1, RELA, SMAD3, SRC 2.3222
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.29127
[BP] GO:2001236 regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, MCL1, RELA, SRC 2.29127
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.27141
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.27141
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.27141
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, RELA, SMAD3, TEK 2.27117
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SRC 2.25341
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.24858
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.24441
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.24441
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.24265
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.24265
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.22947
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, DRD2, HSPA1A, HTR2B, MAP3K7, MMP12, RELA, SMAD3, SRC 2.22448
[BP] GO:0070213 None TNKS, TNKS2 2.22448
[BP] GO:0006145 None AOX1, XDH 2.22448
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22448
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.22353
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.22353
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.22353
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, HTR2A, PTPN1, SRC 2.22295
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, MAP2K1, RELA 2.22295
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.21779
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.21464
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, DRD3, INSR, PIM1, TNKS2 2.21225
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.19895
[BP] GO:0032922 None DRD2, DRD3, PPARA, TOP1 2.19895
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.19412
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.18872
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, BCL2, DRD2, EGFR, MET, SRC, TEK 2.18872
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CACNA1C, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.18758
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.18758
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.18758
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, XDH 2.18496
[BP] GO:0045893 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS 2.18496
[BP] GO:1903508 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS 2.18496
[BP] GO:1902680 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TNKS 2.182
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, SRC, TNKS, TOP1 2.182
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.18151
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.18151
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HSD11B2, RELA, SRC, TRPV1, TYR 2.16771
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, MAP2K1, TEK, TYR 2.15829
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.15681
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, TRPV1 2.15681
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.15681
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.15681
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.15299
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.1369
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.1369
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.13448
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.13448
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13448
[BP] GO:0043412 macromolecule modification ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.12156
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, MAP3K7, RELA 2.12031
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.11873
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.10936
[BP] GO:0051894 None KDR, SMAD3, TEK 2.08437
[BP] GO:0061900 None APP, EGFR, TRPV1 2.08437
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08437
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.08437
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTPN1, SMAD3, SRC, XDH 2.08437
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.07717
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.05878
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, RELA, TYR 2.05878
[BP] GO:0021853 None DRD1, DRD2 2.05878
[BP] GO:0043696 None CDK6, ESRRB 2.05878
[BP] GO:0043697 None CDK6, ESRRB 2.05878
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.05878
[BP] GO:0010641 None F3, SRC 2.05878
[BP] GO:0090325 None DRD2, DRD3 2.05878
[BP] GO:0007598 None F10, F3 2.05878
[BP] GO:0071502 None HTR2B, TRPV1 2.05878
[BP] GO:1904936 None DRD1, DRD2 2.05878
[BP] GO:0042321 None ADORA1, DRD2 2.05878
[BP] GO:0010513 None HTR2A, HTR2B 2.05878
[BP] GO:0050708 None ACHE, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.05186
[BP] GO:0050927 None F3, KDR, SMAD3 2.04584
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, HSPA1A, MAP3K7, MMP12, MMP2, PTPN1, RELA, SRC 2.04577
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.04527
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.04198
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.04198
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F10, FABP3, HSPA1A, HTR2A, HTR2B, MCL1, MMP12, MMP9, PPARA, SIGMAR1, SRC, TNKS, TNKS2, TRPV1, XDH 2.03754
[BP] GO:0007267 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.03345
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.02653
[BP] GO:0050926 None F3, KDR, SMAD3 2.00285
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00285
[BP] GO:1903393 None KDR, SMAD3, TEK 2.00285
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.00285
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 5.93752
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP2, PIM1, PTGES, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR 5.72247
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 4.65292
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 4.59251
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR5A, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, PIM1, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 4.53313
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MCL1, MET, PTGES, PTPN1, SIGMAR1, SRC, TEK, TRPV1, TYR 4.23181
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SRC, TEK, TRPV1 4.18629
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, SIGMAR1 4.09049
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, SIGMAR1 3.77399
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.36783
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSD17B3, HSPA1A, HTR5A, KDR, MAP2K1, PTPN1, SIGMAR1, XDH 3.08084
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B3, HSPA1A, HTR2A, HTR5A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SHBG, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.79218
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK, TRPV1 2.41362
[CC] GO:0045121 membrane raft ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.35641
[CC] GO:0098857 membrane microdomain ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.33685
[CC] GO:0043226 organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B3, HSPA1A, HTR2A, HTR5A, HTR6, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SHBG, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.33351
[CC] GO:0031233 None CA4, F10, F3 2.27141
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC, TRPV1 2.18496
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MCL1, MET, PTGES, SIGMAR1, TEK, TRPV1, TYR 2.18151
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.6528
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 15.6528
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 15.6528
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTPN1, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 10.1538
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 9.99407
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.99385
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK, TRPV1 9.75142
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, PPARA, SIGMAR1, SMAD3, TEK, TRPV1 9.52914
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CDK6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK, TRPV1 8.85933
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP1, TRPV1 8.76194
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.73043
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK, TRPV1 8.53002
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.79482
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS 7.69339
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.49265
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.92509
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.67478
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 6.51358
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 6.51358
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.50901
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.50855
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.50855
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4172
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4172
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.29257
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.14507
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.99105
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.91752
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 5.7454
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 5.53011
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.52439
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.47729
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.45886
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 5.43838
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.41886
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.3501
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 4.98242
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.77149
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.77149
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.66039
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, SHBG 4.64912
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.64332
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.60898
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.56447
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.53313
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.39968
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.36245
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.21737
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, HSD17B1, PTGES, SRC, XDH 4.19824
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.1265
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.09049
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG, TRPV1 4.06738
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RELA, SHBG, SMAD3, SRC, TEK, TOP1, TRPV1, XDH 3.97576
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC 3.96966
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC 3.92423
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 3.82068
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.26924
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.21306
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.8975
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87407
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87407
[MF] GO:0008389 None CYP2A13, CYP2A6 2.87407
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.86483
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.77845
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.76915
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MAP3K7, MCL1, MET, MMP9, RELA, SMAD3, TRPV1, TYR, XDH 2.73618
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, RELA, SRC, TEK, TOP1, TRPV1, XDH 2.6933
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TOP1, TRPV1, XDH 2.59854
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 2.56725
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.51414
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 2.3941
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, SHBG, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 2.39224
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 2.27399
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.27141
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 2.27141
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 2.24508
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22448
[MF] GO:0005497 None AR, SHBG 2.22448
[MF] GO:0051425 None APP, INSR 2.22448
[MF] GO:0019904 None APP, AR, BCL2, DRD3, ESRRA, HSPA1A, INSR, MCL1, PPARA, RELA, SRC, TOP1 2.2038
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.18872
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA1A, AXL, BCL2, DRD2, EGFR, MCL1, RELA, SMAD3, TYR 2.18151
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, RELA, TOP1 2.1489
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 2.13715
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 2.1369
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.12757
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05878
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05878
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.05878
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.02277


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.9031
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 10.751
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 9.3462
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR1A, TRPV1, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 8.6242
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5715
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.5789
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, MMP9, EGFR, RELA, IGF1R, AR, CDK6, BCL2, MET 6.0457
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.2172
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, MAP2K1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, PPARA, RELA 6.1041
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 5.543
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.1041
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.0361
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.1574
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, RELA, MCL1, IGF1R 5.1221
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2A, DRD1, DRD2, EGFR 5.543
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.1011
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOA, HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 4.9439
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, BCL2, TEK, EGFR, RELA, IGF1R 5.136
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.9289
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B, MCL1 4.9048
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, EGFR, RELA, IGF1R 4.4981
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SMAD3, SRC, BCL2, MMP9, RELA 4.3421
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3, RELA 4.2142
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.688
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 3.7607
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9378
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, SMAD3, EGFR, RELA 3.9776
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5381
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, EGFR, IGF1R 3.8533
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.8383
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 3.8986
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.3889
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, CACNA1C, ADRA1A 3.1156
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9303
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA, HSPA1A 2.9237
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.9176
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2, DRD3 2.813
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, EGFR, IGF1R 2.9237
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.0995
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA, HSPA1A 2.7359
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, EGFR, IGF1R 2.7711
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 2.8941
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, TRPV1, HTR2A 2.3539
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, SMAD3, RELA 2.7908
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.225
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9237
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.3325
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.1875
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 2.8798
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA, HSPA1A 2.0547
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.1939
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA, RELA 2.2003
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.4299
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8652
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA, MCL1 1.8904
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, ADRA1A, IGF1R 2.0434
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 1.7326
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, ESRRB, IGF1R 1.8755
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.7326
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, RELA, HSPA1A 1.6105
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.5947
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5645
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 1.67
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.6021
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.495
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3735
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.6776
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.5117
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.3823
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2449
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.0274
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1111
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6, EGFR 2.1111
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 1.9333
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3555
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.3735
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2917
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9825
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2827
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3512
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.2917
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, INSR 1.2565
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.2419
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3183
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, INSR, EGFR 1.2309
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3183
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1817
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, BCL2 2.0145
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C, ADRA1A 1.2139
Axon guidance_Homo sapiens_hsa04360 MET 0.3326
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.2005
Platelet activation_Homo sapiens_hsa04611 SRC 0.343
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3626
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6139
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0706
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0389
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4006
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6148
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4006
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, EGFR 0.9278
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, RELA 0.7734
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 0.9586
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4006
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4115
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4138
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4104
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7222
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4115
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0351
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7338
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.424
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.424
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4226
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4312
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4282
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.424
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4297
Peroxisome_Homo sapiens_hsa04146 XDH 0.4329
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4362
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8245
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4329
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.447
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4489
Pertussis_Homo sapiens_hsa05133 RELA 0.4556
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9278
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4577
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 0.9066
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 0.9248
Bile secretion_Homo sapiens_hsa04976 CA2 0.4672
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4577
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.4774
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9821
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4748
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9867
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.0351
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0004
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.497
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0706
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1144
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0645
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1144
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1394
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.1777
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1394
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1777
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2158
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1817
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1817
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.2917
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RELA 1.1817
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2419
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.2585
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2248
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.58
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.2005
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5847
Malaria_Homo sapiens_hsa05144 MET 0.5897
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5947
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6411
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.345
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3648
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.4799
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6511
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.5482
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6428
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.7135
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7675
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7435
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6021
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5302
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7675
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7675
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7959
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8309
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7838
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8245
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8545
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9412
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9278
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9772
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0048
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2585


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)