TCM Prescription: Brain Strengthening Decoction



Prescription Description
Prescription IDTCMF2300
Pinyin NameJian Nao An Shen Tang
Chinese Name健脑安神
English NameBrain Strengthening Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2491 Alpinia oxyphylla 益智仁 TCMH2491 ITSAJ4276-14
TCMH2702 Concha mauritiae arabicae 紫贝齿 TCMH2702
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH743 Plastrum testudinis 龟板 TCMH743
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA 7.70083
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.31885
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GLO1, HMGCR, PIM1, PPARA, TYR, XDH 7.06489
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 6.6124
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.4803
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC, TOP2A, XDH 6.40268
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.25573
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR 6.22127
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, HMGCR, HSD17B1, HSD17B2 6.15526
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.15526
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 5.98084
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC, TOP2A, XDH 5.76076
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 5.59447
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 5.38597
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 5.10849
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.04506
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.85399
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, SRC, TOP2A, TYR, XDH 4.8356
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.81653
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, SRC 4.80646
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 4.61052
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2 4.51396
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 4.39771
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 4.39771
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.393
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 4.34961
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC 4.03563
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, SRC, TYR 4.03005
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 4.02221
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 4.02158
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 3.97438
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 3.93427
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.90646
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.86646
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.86646
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.86646
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79668
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.62182
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, SRC 3.62182
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.62182
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.5744
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD17B1, HSD17B2 3.54485
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.48051
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.48051
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC 3.43063
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.34344
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, SRC, TYR 3.29222
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, HMGCR, KDR, MET, MMP9, SRC, XDH 3.2789
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, HMGCR, KDR, MET, MMP9, SRC, XDH 3.26644
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2537
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 3.09526
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR 3.06996
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 3.00948
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93068
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.90709
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.9052
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.88465
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85305
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.79935
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.79163
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.77493
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.76308
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.73819
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.73724
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.73724
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72036
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 2.70523
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD17B1, HSD17B2 2.70109
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.69623
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.69472
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.64739
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 2.64739
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, SRC 2.64017
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.62828
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 2.58295
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.58176
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, SRC 2.58176
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR 2.506
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TOP2A, TYR 2.49709
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.48478
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.48478
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45046
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.43449
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.43241
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.39359
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.38259
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, SRC 2.37467
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.36067
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 2.35575
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34043
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 2.32234
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HMGCR 2.32234
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.30355
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30355
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 2.30218
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 2.28528
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.26961
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.26961
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.26023
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 2.24041
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 2.23796
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.23796
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23796
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 2.21896
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.2077
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TOP2A 2.19304
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.1846
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, HMGCR, SRC 2.1846
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.17419
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, TYR 2.14546
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, TYR 2.11037
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.07997
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 2.07817
[BP] GO:0046541 None CHRM1, CHRM3 2.06593
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.02804
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.01272
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC 2.11037
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3 1.86929
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, MET, SRC 1.7579
[CC] GO:0032279 None CHRM2, CHRM3 1.70729
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GLO1, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TYR 1.68192
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2246
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, SRC, TOP2A, TYR, XDH 9.65525
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 9.65525
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 7.49474
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.31885
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71319
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.4803
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 6.0222
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.88049
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.80588
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, PPARA 4.34854
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FDPS, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TOP2A, TYR, XDH 4.33221
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.21597
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.86646
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.68396
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66674
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 3.48051
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.4749
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FDPS, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TOP2A, TYR, XDH 3.44058
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 3.39972
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.2789
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.11601
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.05094
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 3.01617
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.94079
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.94079
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.88359
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.8123
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.8069
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8069
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HMGCR, HSD17B1, HSD17B2 2.58553
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.58176
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.57013
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.47152
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.34662
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, SRC, XDH 2.34043
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.30506
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.26646
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23796
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.19304
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.1846
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.12838
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.12838
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06593
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R 2.06257


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.125
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7418
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.6499
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.7602
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, AKR1B1, HMGCR, TYR, CYP19A1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.0027
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.0796
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.9606
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1556
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.4684
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4684
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1 3.3143
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5016
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 3.0321
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3306
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.9255
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.5882
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0321
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.2665
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.3499
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 2.1573
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2665
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.1573
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.1051
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8002
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.6064
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4777
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4776
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4352
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2794
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3974
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.4352
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3631
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3857
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1632
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3974
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1462
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4093
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2269
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3857
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3311
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.194
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0681
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9374
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0681
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0641
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0474
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9666
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8526
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1573
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5629
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5629
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.3269
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5629
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5629
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5629
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3989
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4306
Gap junction_Homo sapiens_hsa04540 SRC 0.5629
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5591
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3977
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5629
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5591
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4607
Influenza A_Homo sapiens_hsa05164 FDPS 0.4306
Platelet activation_Homo sapiens_hsa04611 SRC 0.5143
Peroxisome_Homo sapiens_hsa04146 XDH 0.5629
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4212
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5384
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4688
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5384
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4943
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4869
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4306
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5613
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4983
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5571
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5629
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5629
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4869
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4607
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6115
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5542
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5629
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5143
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5571
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4983
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4212
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5629
Glioma_Homo sapiens_hsa05214 IGF1R 0.6115
Axon guidance_Homo sapiens_hsa04360 MET 0.5068
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.521
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5613
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5613
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5361
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6182
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6002
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6115
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6115
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6002
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6183
Shigellosis_Homo sapiens_hsa05131 SRC 0.6115
Malaria_Homo sapiens_hsa05144 MET 0.6872
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6975
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.1586
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6992
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7498
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8248
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7908
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8187
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8309
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.813
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7865
Base excision repair_Homo sapiens_hsa03410 APEX1 0.808
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8526
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8526
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3143


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)