Prescription Description
| Prescription ID | TCMF2251 |
| Pinyin Name | Shi Wei San |
| Chinese Name | 石韦散 |
| English Name | Powder of Pyrrosiae |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1953 | Pyrrosia lingua | 石韦 | TCMH1953 | GBVQ3369-13 |
| TCMH1706 | Dianthus superbus | 瞿麦 | TCMH1706 | ITSAJ4556-14 |
| TCMH501 | Semen malvae verticillatae | 冬葵子 | TCMH501 | |
| TCMH258 | Paeonia obovata | 赤芍 | TCMH258 | GBVX7902-15 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH1531 | Akebia quinata | 木通 | TCMH1531 | ITSAJ4440-14 |
| TCMH2161 | Vaccaria segetalis | 王不留行 | TCMH2161 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH933 | Talcum | 滑石 | TCMH933 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 109 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 62 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.34691 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 4.37855 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 4.08317 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.58729 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.06254 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.06842 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.52054 |
| [BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.68146 |
| [BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 3.01257 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, MMP2, PTPN1, SMAD3, SRC | 3.07493 |
Showing 1 to 10 of 363 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3411 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.1152 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5487 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3623 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.5931 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.5758 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3274 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.8877 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6325 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5237 |
Showing 1 to 10 of 146 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples