TCM Prescription: Pill for Controlling Fluid



Prescription Description
Prescription IDTCMF2207
Pinyin NameGong Ti Wan
Chinese Name巩堤丸
English NamePill for Controlling Fluid
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH2491 Alpinia oxyphylla 益智仁 TCMH2491 ITSAJ4276-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1176 Allium tuberosum 韭子 TCMH1176 ITSAJ4084-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 16.3048
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NR3C1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 13.4865
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PPARG, TRPV1 12.2473
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NR3C1, PPARA, PPARG, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 11.6664
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD17B2, HSP90AB1, IGF1R, INSR, NR3C1, PPARA, PPARG, SLC6A3, SRC, TEK, TRPV1, TYR 10.888
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SLC6A3, SRC, TEK, TRPV1, TYR 10.5547
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC, TRPV1 10.4031
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1 10.3016
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 9.27731
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 9.15937
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, XDH 8.68603
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, XDH 8.66366
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PPARG, SMAD3, TRPV1 8.66127
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.40519
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 8.37058
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 8.37058
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.79827
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, PPARA, PPARG, SLC6A3, SRC, TEK, TRPV1, TYR 7.72246
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1, TRPV1 7.69392
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, PPARG, TYR, XDH 7.69392
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 7.66415
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 7.64524
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 7.45028
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 7.45028
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.32539
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, PPARA, PPARG, SLC6A3, SRC, TEK, TRPV1, TYR 7.27952
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 7.24834
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, HSP90AB1, KDR, NR3C1, PPARG, SLC6A2, SLC6A3, SRC, TRPV1 7.15885
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.08999
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG 7.01954
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, PPARG, SRC, TEK, TRPV1 6.99802
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.95526
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, NR3C1, PPARG, SMAD3, SRC, TRPV1 6.91954
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NR3C1, PPARG, SMAD3, SRC, TRPV1 6.84772
[BP] GO:0007193 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 6.81526
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PPARG, SMAD3, SRC, TEK, XDH 6.79681
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD2, DRD3, EGFR, GRM1, HSP90AA1, HSP90AB1, HSPA1A, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR 6.79279
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 6.78421
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, XDH 6.72396
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 6.70369
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, XDH 6.62281
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 6.59799
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, NR3C1, NUAK1, PPARA, PPARG, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 6.59354
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 6.52967
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR 6.41944
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1, TRPV1 6.41377
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, SLC6A3, SRC 6.38292
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.3645
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 6.32435
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.30967
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, DRD2, DRD3, DRD4, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.30967
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, DRD4, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 6.27506
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.26226
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 6.23448
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 6.18302
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, PIM1, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 6.15721
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.13575
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PPARG, TYR, XDH 6.07102
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.05292
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, SLC6A3, TYR 6.03092
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.02415
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 5.93501
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 5.91985
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TRPV1 5.87726
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, INSR, MMP12, PPARA, PPARG, SMAD3, SRC, TRPV1 5.86816
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.85411
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 5.85141
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.83357
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PPARG, SRC, TYR 5.80133
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, EGFR, HSPA1A, SLC6A3 5.77869
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.72888
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.72888
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 5.72888
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, HCAR2, HSP90AB1, INSR, MMP12, PPARG, SMAD3, SRC, TRPV1 5.65908
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.60323
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, XDH 5.59241
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 5.53434
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 5.42243
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 5.40678
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NR3C1, NUAK1, PPARG, SMAD3, SRC, TRPV1 5.4007
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 5.39642
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 5.38996
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.37949
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD2, DRD3, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PPARG, SLC6A3, SMAD3, TEK 5.35993
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC, TEK 5.35921
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HSP90AA1, KDR, SLC6A3, SRC 5.29141
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, XDH 5.26135
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 5.25161
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, PIM1, PPARA, PPARG, SRC 5.21633
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, TRPV1 5.19614
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.17467
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 5.17467
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 5.13748
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 5.13543
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 5.12422
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FLT3, GRM1, INSR, KDR, SRC, TEK, XDH 5.12422
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 5.11968
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, SRC, TEK, XDH 5.08454
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, SMAD3, SRC, TEK 5.04529
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 5.04448
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, XDH 5.00027
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PPARG, SRC, TEK, TRPV1 4.99119
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.97429
[BP] GO:0009410 None DRD2, DRD3, DRD4, EGFR, HSP90AB1, NR3C1, PPARG, SLC6A3 4.9637
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD2, DRD3, PPARA, PPARG, SLC6A3, SMAD3, TEK 4.89747
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 4.87178
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.86542
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 4.85978
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, PPARG, SRC 4.83761
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, SMAD3, SRC, TEK 4.83618
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.81896
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, PIM1, PPARG, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1 4.79898
[BP] GO:0007188 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.77368
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TYR 4.76596
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 4.72976
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, PIM1, PPARG, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 4.72976
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 4.69732
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.62351
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARG 4.60606
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 4.5923
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 4.56181
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.53661
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, PPARG, SMAD3, TEK 4.50011
[BP] GO:0042391 None ADORA1, APP, DRD4, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.47053
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.47035
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.43646
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TYR, XDH 4.42711
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD2, DRD4, EGFR 4.36906
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.36906
[BP] GO:0072507 divalent inorganic cation homeostasis APP, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.30123
[BP] GO:0007187 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.30093
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HSP90AA1, SLC1A1, SLC6A2, SLC6A3, TRPV1 4.28342
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, SRC, TEK 4.256
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3, TYR 4.256
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, SMAD3, SRC, TEK, XDH 4.256
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, SMAD3, SRC, TEK, XDH 4.256
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK 4.22709
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.22159
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.19073
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.19073
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.17385
[BP] GO:0007154 None ADORA1, AXL, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1, SLC6A2, TEK, TRPV1 4.15236
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.15044
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.15044
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, NR3C1, PPARG, SRC, TRPV1 4.13857
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, SMAD3, SRC, TEK, XDH 4.06987
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.06195
[BP] GO:0040008 regulation of growth ALOX12, APP, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SLC6A3, SMAD3 4.06121
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 4.06121
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1, XDH 4.03901
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.02558
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, PPARG, SMAD3, SRC, TEK, XDH 3.99627
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PPARG, SRC, TEK 3.99271
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.98566
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.96953
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, SRC, TRPV1 3.96182
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC, TRPV1 3.95518
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.95518
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.95518
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.95518
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP12, PPARA, PPARG, SMAD3, SRC, TEK 3.95284
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, SRC 3.94191
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.93471
[BP] GO:0043279 None DRD2, DRD3, HSP90AB1, PPARG, SLC6A3, TRPV1 3.93471
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AB1, INSR, SRC 3.93471
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, SRC, TEK, XDH 3.92723
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.92723
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, PPARG, SMAD3, SRC, TEK, XDH 3.91184
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, NR3C1, PPARG, SMAD3, SRC, TRPV1 3.8924
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, SRC, TEK 3.8823
[BP] GO:0007268 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.87481
[BP] GO:0098916 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.87481
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD2, DRD3, EGFR, HCAR2, KDR, SRC, TRPV1 3.86504
[BP] GO:0006874 cellular calcium ion homeostasis APP, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.85266
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TYR 3.85215
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.85087
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, SRC, TRPV1 3.84824
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.83797
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.83223
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3, PPARG 3.82829
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.81914
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 3.81485
[BP] GO:0099536 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.81485
[BP] GO:0099537 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.81485
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.7977
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.7977
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, PPARA, SRC, TEK, XDH 3.79638
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, PPARG 3.79571
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, SRC, TEK, XDH 3.79571
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.78955
[BP] GO:0055074 calcium ion homeostasis APP, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.7656
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.73811
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.72006
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, SRC, TEK, XDH 3.70559
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, PPARG, SMAD3, SRC, TEK, XDH 3.69619
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, SLC6A3, TYR 3.67292
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.65626
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.65602
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.62679
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.62679
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, SLC6A3 3.62157
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 3.60018
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, SRC, TEK, XDH 3.59187
[BP] GO:0007267 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.56986
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.56594
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, SLC1A1, SMAD3, TRPV1 3.56419
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.55886
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.54949
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.53311
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PPARG, SMAD3, SRC, XDH 3.51871
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.51675
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PPARG, SMAD3, SRC, XDH 3.50384
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PPARG, SRC 3.50094
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, SRC 3.49119
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, DRD2, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, TEK 3.47691
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1 3.47531
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 3.45489
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 3.45362
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 3.43914
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, SRC 3.43546
[BP] GO:0007610 None APP, DRD2, DRD3, DRD4, EGFR, GRM1, GRM5, INSR, PPARA, SLC6A3, TRPV1 3.43031
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.42483
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 3.40462
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD2, MET, TRPV1 3.40462
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 3.40462
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 3.40462
[BP] GO:0042220 None DRD2, DRD3, HSP90AB1, SLC6A3 3.40462
[BP] GO:0055065 metal ion homeostasis APP, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.40453
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.39162
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, SRC, TEK 3.38491
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.37396
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, DRD2, DRD3, DRD4, HSP90AA1, HSP90AB1, HSPA1A, SLC1A1, SLC6A3, TRPV1, XDH 3.36852
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.36777
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.36777
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.36777
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.36777
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.36716
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.36716
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.36517
[BP] GO:0019725 cellular homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 3.36356
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1, XDH 3.32956
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC, TEK 3.32956
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.30853
[BP] GO:0046942 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1, TRPV1 3.30447
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 3.30172
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 3.29548
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.29227
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC 3.28874
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.28472
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.28314
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.2603
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, KDR, SRC, TEK 3.25849
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.25364
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, DRD3, DRD4, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 3.23964
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, KDR, SRC, TEK 3.23285
[BP] GO:0015849 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1, TRPV1 3.23077
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 3.22619
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.22619
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.21734
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 3.21734
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.21308
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 3.21268
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.20709
[BP] GO:0023052 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.20481
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA, PPARG 3.19803
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1, TRPV1 3.18994
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.16558
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 3.14231
[BP] GO:0006875 cellular metal ion homeostasis APP, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.11814
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC 3.11163
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, PPARG, SRC 3.11163
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, PPARA, PPARG, SMAD3, SRC, TEK 3.10757
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.10104
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PPARG, SRC 3.09848
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, SMAD3, TEK 3.08157
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, TYR 3.08157
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.08157
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.08157
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.08157
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.08122
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 3.08122
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.07311
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 3.06548
[BP] GO:0045934 None AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 3.03804
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 3.03804
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, PPARG, SRC, TRPV1 3.0353
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SRC, TRPV1 3.02756
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DRD4, DUSP3, EGFR, FLT3, GRM1, HSP90AB1, IGF1R, INSR, SRC 3.01171
[BP] GO:0014074 response to purine-containing compound APP, PPARG, SLC6A3, TEK, TRPV1, TYR 2.9912
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.99062
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.99062
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.98461
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, HSP90AA1, HSP90AB1, HSPA1A, NUAK1, PPARA, PPARG, SLC6A2, SMAD3, SRC, TEK, TRPV1 2.97957
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, ESR1, ESR2, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1, XDH 2.96161
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.96161
[BP] GO:0060359 None DRD2, DRD3, DRD4, HSP90AB1, SLC6A3 2.95846
[BP] GO:0008217 None ADORA1, DRD2, DRD3, PPARA, PPARG, SMAD3 2.95261
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.9526
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, SRC 2.94715
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR, HCAR2 2.92267
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, SMAD3, SRC 2.90924
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.90924
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, INSR, SLC6A3, TRPV1, TYR 2.88497
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.88108
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 2.86942
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, INSR, PPARA 2.83357
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.83068
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.83068
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.83068
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.83068
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.80027
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, PPARG, SRC, TRPV1 2.795
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP12, SLC6A3, SRC, XDH 2.7872
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, HSP90AA1, MMP12, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.78386
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3 2.77657
[BP] GO:0006140 None DRD2, DRD3, DRD4, GRM3, GRM8, INSR, PPARA 2.76594
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.76049
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.76049
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.76049
[BP] GO:0032409 None APP, DRD2, DRD3, DRD4, GPR35, GRM5, PPARG 2.75874
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, SRC, TEK, XDH 2.75689
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP12, PPARG, SMAD3, SRC 2.72239
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 2.71235
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 2.71235
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.71235
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.71235
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.71235
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.71235
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.7076
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.69383
[BP] GO:0051098 regulation of binding APP, AURKB, HSP90AB1, MET, PPARA, PPARG, SMAD3, SRC 2.68768
[BP] GO:0099566 None GRM1, GRM5 2.68768
[BP] GO:0051944 None DRD2, DRD4 2.68768
[BP] GO:0060160 None DRD2, DRD3 2.68768
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.68768
[BP] GO:0051586 None DRD2, DRD4 2.68768
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, INSR, SLC6A3, SRC, TEK, TRPV1, TYR 2.68404
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SRC 2.6773
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, SRC 2.65517
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.65247
[BP] GO:0045927 positive regulation of growth ALOX12, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.65001
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC 2.65001
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.64865
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, DRD4, EGFR, FLT3, GRM1, HSP90AB1, INSR, SRC 2.63545
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.62832
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.62832
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.62347
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, PPARA, SMAD3, SRC, TEK 2.61692
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.60742
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, HSP90AB1, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.60453
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.59073
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.59073
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, HSP90AB1, INSR, KDR, PIM1, PPARG, SLC6A3, SMAD3, SRC, TEK 2.58911
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, HSP90AB1, MET, PPARA, SMAD3 2.58154
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, DRD4, EGFR, FLT3, GRM1, INSR, SRC 2.57209
[BP] GO:0072347 None DRD2, DRD3, HSP90AB1, SLC6A3 2.54775
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.54775
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, PPARA, SMAD3, SRC, TEK 2.544
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.53152
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.51535
[BP] GO:0045936 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, XDH 2.50839
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, SLC6A3 2.50756
[BP] GO:0010563 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, XDH 2.50415
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR 2.50238
[BP] GO:0050890 None ADORA1, APP, DRD2, DRD3, EGFR, GRM5, INSR 2.49984
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR, XDH 2.48743
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 2.47861
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.47805
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.47805
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CYP19A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.47429
[BP] GO:0043434 None FABP3, INSR, PPARA, PPARG, SRC, TEK, TRPV1 2.44594
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.4455
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.43887
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.43887
[BP] GO:0051582 None DRD2, DRD4 2.43887
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.43887
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.43887
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PPARG, TRPV1, TYR 2.43657
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.43657
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.43657
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.43657
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43657
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.43378
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.42774
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.42669
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.40135
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 2.40135
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.40061
[BP] GO:0031327 None AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 2.39013
[BP] GO:0051894 None KDR, SMAD3, TEK 2.39013
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.39013
[BP] GO:0061900 None APP, EGFR, TRPV1 2.39013
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.39013
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.39006
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, HSPA1A, PIM1, PPARG 2.38758
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC 2.38758
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.3568
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PPARG, SMAD3, SRC, XDH 2.34613
[BP] GO:0048169 None APP, DRD2, GRM5 2.34256
[BP] GO:0009890 None AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 2.33367
[BP] GO:0040014 regulation of multicellular organism growth APP, DRD2, DRD3, SLC6A3 2.31986
[BP] GO:0043393 regulation of protein binding APP, AURKB, HSP90AB1, MET, PPARA, SRC 2.31322
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.29921
[BP] GO:0035304 regulation of protein dephosphorylation ADORA1, DRD2, HSP90AB1, NUAK1 2.29921
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.29921
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.29921
[BP] GO:1903393 None KDR, SMAD3, TEK 2.29921
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.29921
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, DRD2, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 2.29921
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, HSP90AB1, SMAD3, SRC 2.2915
[BP] GO:0046683 response to organophosphorus APP, SLC6A3, TEK, TRPV1, TYR 2.2915
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.2915
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, SRC, XDH 2.29061
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.28477
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FABP3, FABP4, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SMAD3, SRC, TRPV1 2.28358
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 2.28358
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DRD2, DUSP3, MMP12, PPARG 2.27247
[BP] GO:0090325 None DRD2, DRD3 2.26741
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.26741
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.26741
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.26741
[BP] GO:0042321 None ADORA1, DRD2 2.26741
[BP] GO:0010891 None PPARA, PPARG 2.26741
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.26741
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, XDH 2.25021
[BP] GO:0051223 None ACHE, APP, DRD2, DRD3, DRD4, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 2.24298
[BP] GO:0000122 None AURKB, DRD3, ESR1, ESR2, HSPA1A, MMP12, NR3C1, PPARA, PPARG, SMAD3, TRPV1 2.23409
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TYR, XDH 2.23122
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.2281
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.2281
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.22563
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.22563
[BP] GO:0031099 regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.22183
[BP] GO:0007612 None APP, DRD2, DRD3, GRM5, INSR 2.22183
[BP] GO:0043627 response to estrogen CA2, ESR1, PPARG, TEK 2.20874
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, SLC6A3, XDH 2.20684
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PPARG, SRC 2.19288
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, NR3C1, SRC 2.19288
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, DRD4, EGFR, GRM1, INSR, SRC 2.19059
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.19045
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.18939
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.18939
[BP] GO:0032868 None FABP3, INSR, PPARA, PPARG, SRC 2.18672
[BP] GO:0030534 None APP, DRD2, DRD3, DRD4, PPARA 2.17408
[BP] GO:0032413 None DRD2, DRD3, DRD4, GPR35 2.17408
[BP] GO:0050708 None ACHE, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, SRC 2.17408
[BP] GO:0032412 None APP, DRD2, DRD3, DRD4, GPR35, GRM5 2.16997
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.1642
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, DRD4, GPR35 2.16304
[BP] GO:0051952 None ADORA1, DRD2, DRD3, DRD4 2.1567
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.15533
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.15533
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.15533
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.15395
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PPARG, SRC 2.13947
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.13947
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ALOX12, APP, AXL, DRD2, DRD3, EGFR, GPR35, HSP90AB1, PPARG, SMAD3, TEK, XDH 2.13441
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CYP1A1, EGFR, PPARG, SRC, TRPV1, TYR 2.13441
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CYP1A1, DRD3, DUSP3, INSR 2.13441
[BP] GO:0010887 None PPARA, PPARG 2.13441
[BP] GO:0010871 None PPARA, PPARG 2.13441
[BP] GO:1990535 None APP, INSR 2.13441
[BP] GO:0032415 None DRD3, DRD4 2.13441
[BP] GO:0051934 None SLC6A2, SLC6A3 2.13441
[BP] GO:0021984 None DRD2, SLC6A3 2.13441
[BP] GO:0090494 None SLC6A2, SLC6A3 2.13441
[BP] GO:0090493 None SLC6A2, SLC6A3 2.13441
[BP] GO:0051583 None SLC6A2, SLC6A3 2.13441
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.13441
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.13441
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.13263
[BP] GO:0022898 None APP, DRD2, DRD3, DRD4, GPR35, GRM5 2.13263
[BP] GO:1901890 None KDR, SMAD3, TEK 2.13263
[BP] GO:0001659 None ADORA1, DRD2, TRPV1 2.13263
[BP] GO:0045744 None DRD2, DRD3, MET 2.13263
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.13263
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.13263
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, SMAD3, SRC, TRPV1 2.12585
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, SRC 2.10441
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FABP3, FABP4, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, SMAD3, SRC, TRPV1 2.09813
[BP] GO:0050678 None EGFR, KDR, MMP12, PPARG, SMAD3, TEK, XDH 2.09626
[BP] GO:0070201 None ACHE, APP, DRD2, DRD3, DRD4, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 2.09626
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.09626
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.09626
[BP] GO:0035303 None ADORA1, DRD2, HSP90AB1, NUAK1, SMAD3 2.08338
[BP] GO:0009266 None ADORA1, HSP90AA1, HSPA1A, PPARG, TRPV1 2.07198
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, MMP12, SRC 2.07198
[BP] GO:0007611 None APP, DRD2, DRD3, EGFR, GRM5, INSR 2.07198
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.06408
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.06408
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.06408
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.06408
[BP] GO:0010907 None INSR, PPARA, SRC 2.06408
[BP] GO:0106027 None APP, IGF1R, INSR 2.06408
[BP] GO:0032410 None DRD2, DRD3, DRD4, GPR35 2.04736
[BP] GO:1904063 None DRD2, DRD3, DRD4, GPR35 2.04736
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, DRD2, FABP3, HSPA1A, PPARG, SMAD3, XDH 2.0331
[BP] GO:0045892 None AURKB, DRD3, ESR1, ESR2, FABP4, HSPA1A, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TRPV1 2.02118
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, HSPA1A, SLC6A3, XDH 2.01763
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, SRC 2.01723
[BP] GO:0090647 None APP, GRM5 2.01723
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP3A4 2.01723
[BP] GO:0032226 None DRD2, DRD4 2.01723
[BP] GO:0098810 None SLC6A2, SLC6A3 2.01723
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.01723
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.01621
[BP] GO:0032870 cellular response to hormone stimulus EGFR, ESR1, FLT3, INSR, NR3C1, PPARG, SRC 2.01621
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, MET, PPARG 2.01099
[BP] GO:0021885 forebrain cell migration AXL, DRD2, EGFR 2.00158
[BP] GO:0001890 placenta development HSD17B2, HSP90AB1, PPARG 2.00158
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TRPV1 8.12425
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, SLC1A1, SRC, TEK, TRPV1 7.66415
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, PIM1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1 7.34667
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 6.93877
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TRPV1, TYR 6.81526
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PIM1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 6.66324
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 6.61617
[CC] GO:0044456 None ACHE, ADORA1, APP, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC, TRPV1 5.22931
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 4.399
[CC] GO:0098794 None ADORA1, APP, DRD2, DRD4, GRIA2, GRIA4, GRM3 3.82829
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD2, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 3.65602
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.54694
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.40462
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.37396
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, HSP90AB1, TEK 3.36517
[CC] GO:0043005 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.32639
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 3.32403
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 3.32403
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.22619
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.22619
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.14231
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1, TYR 3.11814
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 3.08976
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 3.08122
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, HSP90AB1, MET, SLC6A2, SLC6A3, TEK 2.77276
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 2.68768
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1, TYR 2.67003
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 2.66936
[CC] GO:0097458 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, SLC6A2, SLC6A3, SRC, TRPV1 2.6467
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, SLC6A2, SLC6A3, SRC, TEK 2.6152
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 2.43887
[CC] GO:0031256 None ADORA1, HSP90AA1, INSR, SRC, TRPV1 2.06346
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP12, NR3C1, PIM1, PPARA, PPARG, SMAD3, TYR, XDH 11.69
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR, XDH 10.5628
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 10.3456
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0732
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD2, DRD3, DRD4, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SRC, TEK, TRPV1 9.72755
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 9.21238
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, SMAD3, TEK, TRPV1 9.07189
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 8.95503
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.37058
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.28449
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 8.12425
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 8.12425
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.89811
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.40739
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.01954
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.71788
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.47156
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.39887
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.39887
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, ESR1, ESR2, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1, TYR, XDH 6.26226
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.20576
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.85141
[MF] GO:0030594 None DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.80621
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.60323
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.5023
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.33567
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, SRC, TEK, TYR, XDH 5.13543
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.12422
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.7928
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.79238
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.75445
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.65426
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1, TYR, XDH 4.42711
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, SLC6A3, SMAD3, SRC 4.18349
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.0646
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 4.03737
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.96182
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, PPARA, SLC6A3, SMAD3, SRC 3.92723
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PPARG, SMAD3, TRPV1, TYR, XDH 3.88664
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 3.64167
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, PPARG 3.6326
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.62679
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.61022
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.48172
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.48172
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SLC1A1, SRC, TEK, TRPV1, XDH 3.47531
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38029
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, TRPV1 3.30846
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 3.27613
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP12, NR3C1, PPARA, PPARG, SMAD3 3.24401
[MF] GO:0019899 enzyme binding APP, AURKB, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, GRM5, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK 3.22664
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SLC1A1, SRC, TEK, TRPV1, XDH 3.22619
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.16558
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.13227
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.13227
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.08157
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.08157
[MF] GO:0008389 None CYP2A13, CYP2A6 3.08157
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1 2.99551
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.96161
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.95846
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.89633
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.78128
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.78128
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG 2.75689
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG 2.75689
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.75648
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, SLC6A3, SMAD3 2.75256
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.68768
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.68768
[MF] GO:0005330 None SLC6A2, SLC6A3 2.68768
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.68768
[MF] GO:0099583 None GRM1, GRM5 2.68768
[MF] GO:0005102 receptor binding ADORA1, APP, DRD2, DRD3, EGFR, ESR1, ESR2, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARG, SLC6A3, SMAD3, SRC 2.68404
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.64865
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.64865
[MF] GO:0019904 None APP, DRD3, DRD4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARA, PPARG, SRC 2.62347
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.43887
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.43887
[MF] GO:0004971 None GRIA2, GRIA4 2.43887
[MF] GO:0051425 None APP, INSR 2.43887
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.43887
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD17B1, HSD17B2 2.43887
[MF] GO:0004930 None ADORA1, ADORA3, DRD2, DRD3, DRD4, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.43081
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.36625
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.35032
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.29921
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.2915
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.26741
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.26741
[MF] GO:0043559 insulin binding IGF1R, INSR 2.26741
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.26741
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.26741
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.26741
[MF] GO:0019900 None AURKB, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, SMAD3, SRC 2.20566
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.18939
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.18939
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.17408
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.1579
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.1567
[MF] GO:0005329 None SLC6A2, SLC6A3 2.13441
[MF] GO:0050543 None FABP3, PPARG 2.13441
[MF] GO:0004064 arylesterase activity CA1, CA2 2.13441
[MF] GO:0097718 None HSP90AA1, HSP90AB1, HSPA1A 2.13263
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.09626
[MF] GO:0035257 None ESR1, FLT3, PPARG, SMAD3, SRC 2.09626
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.01723
[MF] GO:0001609 None ADORA1, ADORA3 2.01723
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.01621
[MF] GO:0019901 None DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, SMAD3, SRC 2.01621


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 11.1137
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.3501
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0874
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.9322
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.2018
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.2752
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8687
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.845
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.845
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.9133
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.7685
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.0917
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.8502
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.5733
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.4747
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1, EGFR 3.7905
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, PPARG, MET, EGFR, IGF1R 3.23
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, DRD2, PPARA, GRIA4 3.23
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.23
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.5733
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.239
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0344
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.1526
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.23
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.7981
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARG, PPARA 3.1585
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6187
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6008
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.4505
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.4909
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3369
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1929
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2621
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.1695
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1695
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MET, IGF1R 1.8908
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1695
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1287
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.7991
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1214
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6853
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, IGF1R 1.7991
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.8318
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1618
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.154
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3734
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.5482
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.5439
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 2.048
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, EGFR 1.2483
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2483
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.2483
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.1987
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0575
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.8755
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1 0.9614
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9087
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.0233
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9961
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0521
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7833
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8665
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7883
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8665
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7833
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7833
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8595
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7833
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7833
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC 0.7683
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2731
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2483
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.759
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.132
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3208
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7409
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2161
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.628
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2457
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6146
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6757
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5924
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2774
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1987
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3023
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3118
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3112
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3118
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3021
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3203
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3369
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3443
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3728
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3821
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.3208
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.384
Platelet activation_Homo sapiens_hsa04611 SRC 0.399
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.399
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.399
Axon guidance_Homo sapiens_hsa04360 MET 0.394
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4281
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4552
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4479
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4552
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4552
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4638
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4634
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4726
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4815
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4731
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4681
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.4731
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4731
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4807
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4731
Peroxisome_Homo sapiens_hsa04146 XDH 0.4815
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4731
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5186
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5171
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5308
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5494
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.5618
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5514
Shigellosis_Homo sapiens_hsa05131 SRC 0.5514
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5514
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5578
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.573
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5741
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5894
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6061
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5924
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6096
Malaria_Homo sapiens_hsa05144 MET 0.6169
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6207
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6247
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6861
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.721
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.764
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.759
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7833
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7515
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.721
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7433
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.714
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1784
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7833
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0011
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7833
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9731


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)