TCM Prescription: Lonicera Poison Relieving Pills



Prescription Description
Prescription IDTCMF2153
Pinyin NameYin Qiao Jie Du Wan
Chinese Name银翘解毒丸
English NameLonicera Poison Relieving Pills
Function Description流行性感冒, 头疼咳嗽, 咽喉肿痛, 四肢疲乏
IndicationsCommon cold disorder, Common cold, Influenza, Upper respiratory infection(uri)
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
1E32 [Influenza, virus not identified, 季节性流行性感冒,病毒尚未鉴定 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患,未特指的 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH396 Semen sojae praeparata 淡豆豉 TCMH396
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 12.3109
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 11.549
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET 11.2571
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TYR 8.89149
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, RORC, SRC, TYR 8.80841
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 8.64089
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH 8.51018
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, RORC, SRC, TYR 8.23733
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 8.20233
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 7.81406
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.80719
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.79572
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.71873
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 7.20472
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, RORC, SRC, TYR 7.05306
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SRC, TYR 7.03844
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 7.03844
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 7.02677
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 6.95365
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, RORC, SRC 6.80795
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, SRC, TNKS, TNKS2, XDH 6.80433
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, HMGCR, PIM1, TYR, XDH 6.7918
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.73715
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, RORC, SRC, TNKS2, TYR 6.57315
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.23952
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.22284
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR3C1, SRC 6.14265
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1 5.96698
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.96226
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, SRC 5.96039
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 5.96039
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC 5.94555
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, SRC, TYR 5.75232
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SRC 5.72158
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, RORC, SRC 5.60594
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.60594
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.60594
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, XDH 5.5835
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.53445
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET 5.5276
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.52384
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, RORC, SRC, TYR 5.38853
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC 5.3423
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SRC, TNKS2, TYR 5.30857
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 5.14621
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, XDH 5.08807
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.02871
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.0073
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.98159
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC 4.85624
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 4.71371
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.71371
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.6698
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.61364
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, TYR 4.60941
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.51482
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.43924
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 4.39788
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.38517
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 4.3267
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC 4.31272
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PGR, SRC 4.30171
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.30171
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.30171
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 4.27728
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.25182
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.24733
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.24733
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, PGR, RORC, SRC 4.19769
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.13942
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HMGCR, KDR, SRC, TNKS, TNKS2 4.1175
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, SRC 4.00509
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.96556
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 3.93883
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.91422
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.91255
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.82235
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC 3.80874
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.79787
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.78849
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.77503
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.77168
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.71118
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.70593
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.68142
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC 3.68142
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.67531
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TYR 3.6375
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.55929
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.47474
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.47474
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.40359
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.38789
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.35483
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.35409
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.35182
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.35163
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.33531
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2 3.30462
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 3.28722
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.28252
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, KIT, PGR, RORC, SRC 3.22794
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 3.22591
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, NR3C1, SRC 3.22591
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22591
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.21115
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC 3.18028
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.17331
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.16334
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 3.14914
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.11226
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.11226
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.11172
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 3.09973
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.08366
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.00525
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.99412
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 2.99412
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.99412
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.92725
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9 2.92678
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91391
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.9038
[BP] GO:0009115 None AOX1, XDH 2.87001
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.84241
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 2.84241
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.83594
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83075
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, RORC, SRC, TNKS, TNKS2 2.81602
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.80863
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, RORC, SRC, TNKS, TNKS2 2.70551
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.69339
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, KIT, MMP2, SRC, TYR 2.66921
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC, TNKS2, XDH 2.66771
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66771
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.65669
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 2.65669
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.64984
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR3C1, RORC, SRC 2.63705
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.61637
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60074
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.60074
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.59798
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, KIT, RORC, SRC 2.58799
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC 2.56014
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTPN1, SRC, TNKS, XDH 2.5432
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2 2.5432
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.53965
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.53841
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.53547
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.53547
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.53547
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.53104
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, XDH 2.52026
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.52026
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.5197
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TNKS, XDH 2.50147
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.49633
[BP] GO:0060748 None AR, PGR 2.49633
[BP] GO:0046110 None AOX1, XDH 2.49633
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49633
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.49147
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.47057
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.4555
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, SRC 2.44495
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, PIM1 2.44343
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.42461
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, RORC, SRC, TNKS, TNKS2 2.41744
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.39889
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.3803
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.37579
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MMP2, MMP9, RORC 2.35018
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.34931
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33421
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3 2.33284
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.32802
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.29482
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.29268
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.28649
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28649
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PTPN1, SRC, XDH 2.28649
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.28573
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.26687
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.26286
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.26025
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, NR3C1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.26025
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.26025
[BP] GO:0070213 None TNKS, TNKS2 2.26025
[BP] GO:0006145 None AOX1, XDH 2.26025
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26025
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25853
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25564
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC, XDH 2.25549
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25488
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.23783
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, SRC 2.23581
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, ESR1, KIT, PGR, SRC 2.22914
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.21035
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.19584
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, SRC, TYR 2.1882
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.16926
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.16926
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, PIM1, PTPN1, SRC, TNKS, XDH 2.16406
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.13176
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1 2.12983
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.1257
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.11628
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.11628
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC, TNKS 2.11587
[BP] GO:0050678 None AR, CDK6, F3, KDR, MMP12, PGR, XDH 2.10785
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GBA2, SRC, XDH 2.10518
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.09983
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.09516
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.09512
[BP] GO:0043696 None CDK6, ESRRB 2.09512
[BP] GO:0043697 None CDK6, ESRRB 2.09512
[BP] GO:0010641 None F3, SRC 2.09512
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.09512
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.09086
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.07306
[BP] GO:0040007 None APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.07306
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR3C1, NR3C2, PGR, RORC, TYR, XDH 2.06315
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS 2.05685
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.05578
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.05524
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.04229
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.03848
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.03757
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TNKS 2.03757
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.03147
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.03147
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.03147
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.02729
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02729
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.80188
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTPN1 3.35157
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2 3.01679
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 2.53547
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.24414
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TNKS, TYR, XDH 18.8105
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 12.3109
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 11.3138
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.2866
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 9.15923
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, RORC, TNKS 8.89149
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.20233
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 7.86886
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.70482
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.38793
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.03844
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 6.84849
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.84849
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.84849
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 6.70566
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, XDH 5.96039
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.69063
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.4288
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.08807
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, TYR 5.08807
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, SRC, XDH 4.86618
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.81795
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.37345
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 4.30505
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.27728
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 4.24759
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 4.13942
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.1175
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 3.99677
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, TYR 3.83609
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 3.58897
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.51687
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.45629
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.40359
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.35157
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, F3, HMGCR, KIT, MET, NR3C1, PGR, PTPN1, SRC, TNKS2 3.31571
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP3A4 3.18028
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 3.09233
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.98547
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.94593
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87001
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87001
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PGR, TYR, XDH 2.81663
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.80805
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.53689
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.53547
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, XDH 2.52026
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.50564
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.49633
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, XDH 2.47057
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.38894
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26025
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.26025
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.26025
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.21035
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.11845
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.09512
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09512
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09512


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.6851
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0709
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.9442
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2226
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0078
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.8256
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 5.1612
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3717
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.5653
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3717
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8554
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.09
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.4568
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0812
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.6536
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.2688
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5242
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.3599
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.4603
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1825
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.172
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3408
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.528
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.1742
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1684
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1662
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9796
Prostate cancer_Homo sapiens_hsa05215 AR, BCL2, IGF1R 1.9458
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.8431
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.1684
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.172
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.7181
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.5311
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.671
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6792
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.406
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1024
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0434
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9842
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.406
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3239
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3578
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0277
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1314
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 0.9531
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1211
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2014
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2591
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9842
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.093
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9646
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9646
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9646
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3759
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3043
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8952
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9531
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8752
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9531
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8851
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3536
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6653
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6653
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7899
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7491
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2557
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.304
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3394
Purine metabolism_Homo sapiens_hsa00230 XDH 0.352
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3618
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.3231
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3618
Apoptosis_Homo sapiens_hsa04210 BCL2 0.404
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3393
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.6718
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3772
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.404
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3958
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4027
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4015
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4144
Platelet activation_Homo sapiens_hsa04611 SRC 0.4375
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4395
Axon guidance_Homo sapiens_hsa04360 MET 0.4269
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4671
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4671
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5134
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5017
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5054
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5054
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5133
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5054
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5134
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5134
Gap junction_Homo sapiens_hsa04540 SRC 0.5134
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5134
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7192
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5589
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8265
Peroxisome_Homo sapiens_hsa04146 XDH 0.5229
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.558
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5373
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5891
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5891
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5891
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5933
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5891
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5763
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8431
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5891
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5891
Shigellosis_Homo sapiens_hsa05131 SRC 0.5891
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6156
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7836
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7181
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9889
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.648
Malaria_Homo sapiens_hsa05144 MET 0.659
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6653
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6621
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6653
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.803
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.819
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8529
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8108
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8431
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8983
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9566
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0212
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3119


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)