TCM Prescription: Powder Containing Nine Drugs; Nine Immortal Powder



Prescription Description
Prescription IDTCMF2138
Pinyin NameJiu Xian San
Chinese Name九仙散
English NamePowder Containing Nine Drugs; Nine Immortal Powder
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, SLC1A1, SRC, TRPV1, XDH 10.5962
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 10.5962
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1, TYR 9.93522
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1, TYR 9.6167
[BP] GO:0007188 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.98652
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1 8.97869
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, IGF1R, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1, TYR 8.8691
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1 8.8691
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, NR3C1, OPRK1, OPRM1, PDE3A, RORC, SRC, TRPV1, TYR 8.8691
[BP] GO:0007187 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.43568
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PDE3A, TRPV1 8.40163
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.39195
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 7.48325
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.48325
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.48325
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.38424
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 7.38424
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.37543
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.37543
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, RORC, SRC, TRPV1, TYR 7.36792
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 7.23547
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TOP2A, TRPV1 7.15235
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FUT7, GLO1, PDE10A, PDE3A, PDE3B, PIM1, TYR, XDH 7.10961
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B, RORC, SRC, TRPV1 7.03626
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FLT3, GRM5, IGF1R, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TRPV1 6.92323
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.92323
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1 6.71986
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, FLT3, NR3C1, OPRM1, PDE3A, RORC, SRC, TRPV1 6.70805
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 6.55356
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.5276
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 6.35221
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, HCAR2, HTR2A, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SRC, XDH 6.12818
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, HCAR2, HTR2A, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SRC, XDH 6.09885
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, TOP2A, TRPV1, XDH 6.06224
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, SRC, TRPV1 5.95775
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HTR1A, TYR 5.95688
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.91131
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, RORC, SRC, TOP2A, TRPV1, XDH 5.9101
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 5.90337
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 5.77086
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, HTR2A, KDR, NR3C1, OPRK1, OPRM1, PDE3A, SRC, TRPV1 5.59938
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, TOP2A, TRPV1, XDH 5.49711
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, RORC, SLC1A1, SRC, TOP2A, TRPV1, XDH 5.49711
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PDE3A, PIM1, SIGMAR1, SRC, TOP2A, TRPV1, XDH 5.4578
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.45492
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 5.45425
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FLT3, GRM5, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TRPV1, TYR 5.43839
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, OPRM1, TRPV1 5.41902
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.28196
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SIGMAR1, SRC, TRPV1 5.27656
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 5.26868
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.25201
[BP] GO:0042391 None ADORA1, APP, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, OPRD1, OPRM1, SRC, TRPV1 5.22459
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, SRC 5.21001
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.19475
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TOP2A, TRPV1, TYR 5.13193
[BP] GO:0007200 None DRD1, DRD2, GRM5, HTR2A, OPRD1, OPRK1, OPRM1 5.11547
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FLT3, GRM5, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TRPV1, TYR 5.06126
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FLT3, HSD17B2, NR3C1, OPRK1, OPRM1, RORC, SRC, TYR 4.98861
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.98514
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 4.96589
[BP] GO:0007267 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 4.90813
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, MET, SRC, TRPV1 4.89408
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.83712
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC, TRPV1 4.82668
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, NR3C1, OPRM1, SRC, TRPV1 4.7712
[BP] GO:0007154 None ADORA1, AXL, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1, TRPV1 4.7712
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.71662
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.71368
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, GRM1, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, SRC, TRPV1, TYR 4.70809
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.66529
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 4.58406
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.56018
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, HTR2A, KDR, OPRK1, SRC, TRPV1 4.54217
[BP] GO:0051930 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.54215
[BP] GO:0051931 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.54215
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, FLT3, GRM5, IGF1R, MMP2, NR3C1, OPRM1, PDE3A, PDE3B, SRC, TRPV1 4.52206
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.51395
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, OPRM1, TRPV1 4.43234
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, TRPV1, XDH 4.42299
[BP] GO:0023052 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SLC1A1 4.42216
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, GRM5, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 4.28209
[BP] GO:0007626 None APP, DRD1, DRD2, GRM1, GRM5, OPRD1, OPRK1, OPRM1 4.27261
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, GLO1, GRM3, GRM8, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, RORC, SRC, TOP2A, TRPV1, XDH 4.27261
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, HTR2A, KDR, OPRK1, OPRM1, SRC, XDH 4.25341
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, FLT3, GRM1, HTR2A, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 4.25341
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, FABP4, FUT7, MET, PDE3A 4.24636
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.19871
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 4.1911
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, FLT3, GRM1, HTR2A, KDR, MET, OPRK1, OPRM1, SRC, XDH 4.18637
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, GLO1, GRM3, GRM8, HCAR2, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, RORC, SRC, TOP2A, TRPV1, XDH 4.18637
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TRPV1, TYR 4.17808
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, MMP12, MMP9, OPRD1, OPRK1, OPRM1, SRC, TRPV1 4.12483
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, OPRK1, SRC 3.96814
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.95343
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FLT3, NR3C1, OPRK1, PDE3B, SRC, TRPV1 3.94705
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.92109
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 3.90249
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7, TRPV1 3.87259
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.84902
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.84902
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, HTR7, OPRK1, OPRM1, RORC, SRC, TOP2A 3.84902
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CSNK2A1, CYP1B1, DRD2, FLT3, HTR1A, HTR2A, IGF1R, KDR, MMP12, MMP2, MMP9, OPRM1, PIM1, SRC, XDH 3.78984
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, RORC, SIGMAR1, SRC, TOP2A, TYR 3.77149
[BP] GO:0007631 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 3.70959
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, DRD1, DRD2, FABP4, GRIK5, GRM1, GRM5, HTR2A, MET, TRPV1 3.689
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.68247
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.66987
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, FLT3, GRM1, HTR2A, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SRC, XDH 3.66832
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.64909
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.64909
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.6437
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63701
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.61924
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.61227
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, HTR2A, IGF1R, KDR, OPRK1, OPRM1, SRC, XDH 3.59904
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, DRD1, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.59443
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, DRD1, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.59443
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.50986
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC, TRPV1 3.50681
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.49295
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.49295
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.45001
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, GRM1, HCAR2, HTR2A, OPRD1, OPRK1, OPRM1, SLC1A1, TRPV1 3.45001
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.45001
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 3.45001
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, SLC1A1, TRPV1 3.44616
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.40759
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.34126
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, RORC 3.33225
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, TRPV1, TYR 3.33225
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 3.33181
[BP] GO:0007610 None APP, DRD1, DRD2, GRM1, GRM5, HTR1A, HTR2A, OPRD1, OPRK1, OPRM1, TRPV1 3.31293
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, HTR1A, SLC1A1, TRPV1 3.29909
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.26194
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, OPRK1, PDE3B, SRC, TRPV1 3.22748
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.22748
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, OPRD1 3.22748
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, TRPV1, TYR, XDH 3.22239
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.21114
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.20784
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.20784
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20784
[BP] GO:0031644 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 3.1918
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, SRC, TRPV1 3.19146
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.18566
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 3.14813
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.12724
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.09219
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, HCAR2, HTR2A, KDR, MET, MMP12, MMP9, OPRM1, PDE3A, PIM1, SLC1A1, SRC, TRPV1 3.08448
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, OPRM1, SRC 3.08448
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 3.07685
[BP] GO:0070848 response to growth factor APP, KDR, NR3C1, OPRD1, OPRM1, PDE3A, SRC, TRPV1 3.06955
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 3.04724
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 2.99584
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.98802
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.98802
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, MMP12, OPRK1, SRC, TRPV1 2.97582
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, PDE3B, SRC 2.95687
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 2.91516
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PDE3A, PIM1, SRC 2.91437
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90299
[BP] GO:0031635 None OPRK1, OPRM1 2.90299
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.90299
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.90299
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.90299
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SRC, TOP2A, TRPV1, TYR, XDH 2.89975
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, HTR2A, OPRM1, SLC1A1, TRPV1 2.82731
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.81262
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.81262
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, SRC, XDH 2.80139
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.7999
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, DRD2, FLT3, HTR1A, HTR2A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 2.78599
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, FABP4, GRM3, IGF1R, MET, MMP9, OPRM1, PIM1, SRC 2.78296
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.77913
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.77076
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SIGMAR1, SRC, TOP2A, TRPV1, XDH 2.74466
[BP] GO:0030818 None DRD2, GRM3, GRM8, OPRM1 2.74427
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.73648
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.73648
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.7224
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2 2.71879
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, FABP4, FLT3, GRM1, HTR2A, KDR, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, SRC, XDH 2.70113
[BP] GO:0030803 None DRD2, GRM3, GRM8, OPRM1 2.68063
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.65779
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, DRD2, GRM1, HCAR2, HTR2A, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SLC1A1, SRC, TRPV1, XDH 2.63608
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.62978
[BP] GO:0030815 None DRD2, GRM3, GRM8, OPRM1 2.61669
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.61669
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, SLC1A1, TRPV1 2.61669
[BP] GO:0030817 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.60062
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.60062
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.59089
[BP] GO:1900372 None DRD2, GRM3, GRM8, OPRM1 2.59089
[BP] GO:0030809 None DRD2, GRM3, GRM8, OPRM1 2.59089
[BP] GO:0071363 cellular response to growth factor stimulus APP, KDR, NR3C1, OPRD1, PDE3A, SRC, TRPV1 2.57919
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD1, DRD2, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, RORC, SRC, TOP2A, TRPV1, XDH 2.57369
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, SRC, XDH 2.56557
[BP] GO:0030800 None DRD2, GRM3, GRM8, OPRM1 2.56557
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, XDH 2.56557
[BP] GO:0099566 None GRM1, GRM5 2.51012
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.51012
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51012
[BP] GO:0019233 None GRM1, OPRD1, OPRK1, OPRM1 2.48054
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.47805
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, HCAR2, MMP12, OPRK1, SRC, TRPV1 2.47594
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.47594
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.47594
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.43869
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, OPRM1 2.42114
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, OPRK1 2.42114
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.39643
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FLT3, HCAR2, HTR2A, PDE3B, RORC, SRC 2.39307
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP4 2.35659
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35407
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, GRM5, HTR2A, OPRK1 2.34069
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.34069
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, OPRM1, SRC 2.32369
[BP] GO:0030814 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.31108
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.30939
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.30593
[BP] GO:0050995 None ADORA1, HCAR2, PDE3B 2.30593
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.30398
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, DRD1, IGF1R, KDR, MET, MMP9, OPRK1, SRC 2.29315
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.28033
[BP] GO:0030802 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.27107
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.26521
[BP] GO:0007198 None HTR1A, HTR7 2.26521
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.26521
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26521
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26439
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, CYP2D6, DRD2, FABP4, GRM3, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, RORC, SRC, TRPV1, XDH 2.25584
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.24178
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2A 2.21959
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.21959
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.21959
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21959
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, RORC, SRC, TOP2A, TRPV1, XDH 2.21935
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.21334
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.21334
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MMP2, MMP9, OPRD1, OPRK1, OPRM1, SRC, TOP2A, TRPV1 2.20747
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.20576
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CYP19A1, CYP1A1, DRD1, HSD17B2, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC, TOP2A 2.17694
[BP] GO:0048169 None APP, DRD2, GRM5 2.17694
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.16702
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.16702
[BP] GO:1900371 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.14389
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SENP6, SRC, TOP2A, TYR, XDH 2.14271
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, GRM1, GRM5, HTR2A, TRPV1 2.13566
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13566
[BP] GO:0046683 response to organophosphorus APEX1, APP, PDE3A, TRPV1, TYR 2.13566
[BP] GO:0030808 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.13566
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.12219
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.12219
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.10819
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.10032
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.09864
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.09864
[BP] GO:0021853 None DRD1, DRD2 2.09864
[BP] GO:1904936 None DRD1, DRD2 2.09864
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.09864
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.09864
[BP] GO:0042321 None ADORA1, DRD2 2.09864
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM5, HTR2A, TRPV1 2.09864
[BP] GO:0019725 cellular homeostasis APEX1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM5, HTR2A, TRPV1 2.09834
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP4, FUT7, PDE10A, PDE3A, PDE3B, XDH 2.09478
[BP] GO:1900543 None DRD2, GRM3, GRM8, OPRM1 2.09451
[BP] GO:0008306 None APP, DRD1, DRD2, OPRK1 2.09451
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.09329
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.08578
[BP] GO:0045980 None DRD2, GRM3, GRM8, OPRM1 2.07443
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, OPRK1 2.07144
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.06838
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.06838
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.05584
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, RORC, SIGMAR1, SRC, TYR 2.04808
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, GRM1, GRM5, HTR2A, TRPV1 2.02905
[BP] GO:0019098 None APP, DRD1, OPRK1 2.02905
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.02905
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SLC1A1, SRC, TRPV1 7.6448
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, TRPV1 7.61025
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, TRPV1 7.30415
[CC] GO:0044456 None ACHE, ADORA1, APP, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 6.71938
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, SRC, TRPV1 6.43661
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, SLC1A1, SRC, TRPV1 6.392
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, SIGMAR1, SLC1A1, SRC, TRPV1, TYR 6.35221
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SLC1A1, SRC, TRPV1, TYR 5.26164
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 5.08565
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 5.08565
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, SIGMAR1, TRPV1 4.71415
[CC] GO:0043005 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 4.53246
[CC] GO:0097458 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, PDE10A, SIGMAR1, SRC, TRPV1 4.12483
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.98414
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.98414
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3, OPRM1 3.689
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC, TRPV1 3.53084
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD1, DRD2, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SLC1A1, TRPV1, TYR 3.49295
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.40759
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.33225
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.26057
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.22748
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.07029
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CYP3A4, DRD1, DRD2, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SLC1A1, TRPV1, TYR 2.99584
[CC] GO:0045211 None GRIA2, GRIA4, GRIK5, GRM3, OPRD1, SIGMAR1, TRPV1 2.91844
[CC] GO:0032589 None ADORA1, OPRD1, OPRM1, TRPV1 2.8462
[CC] GO:0098793 None ADORA1, APP, DRD2, GRIK5, OPRD1, OPRK1 2.5705
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, KDR, OPRM1, PDE3B, SIGMAR1, XDH 2.55731
[CC] GO:0043204 None DRD2, GRIK5, OPRK1, OPRM1, PDE10A 2.32466
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, RORC, TYR, XDH 10.5962
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.73726
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, RORC, SIGMAR1, TRPV1 9.44488
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR7, OPRM1 9.23709
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 8.8691
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 8.8691
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, RORC, SIGMAR1, TRPV1 8.54806
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, RORC, SIGMAR1, TRPV1 8.32233
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.23576
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SLC1A1, SRC, TOP2A, TRPV1, TYR, XDH 8.19937
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, GLO1, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SLC1A1, TOP2A, TRPV1, TYR, XDH 8.01556
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, RORC, SIGMAR1, TRPV1 7.73191
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.98317
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.80719
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH 6.77041
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.70805
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.44823
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SRC, TOP2A, TYR, XDH 6.43661
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.34582
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.45492
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.38272
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.21001
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, MET, PDE10A, PIM1, SIGMAR1, SRC, TOP2A, TRPV1 5.17819
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, RORC, SLC1A1, TOP2A, TRPV1, TYR, XDH 4.98861
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR 4.89408
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 4.76178
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.29605
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 4.13438
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 3.93852
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR 3.64909
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.40759
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33181
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 3.11676
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, RORC 3.11676
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.09219
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.09219
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97582
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.97391
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 2.95687
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.90299
[MF] GO:0004119 None PDE3A, PDE3B 2.90299
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.81262
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.73648
[MF] GO:0008081 None ADORA1, APEX1, PDE10A, PDE3A, PDE3B 2.73441
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.61669
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.51012
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.51012
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.51012
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.51012
[MF] GO:0099583 None GRM1, GRM5 2.51012
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.47594
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.47594
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.39643
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.37492
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, SRC, XDH 2.31747
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.30593
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.27107
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.26521
[MF] GO:0004971 None GRIA2, GRIA4 2.26521
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.26521
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.21959
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.21959
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.21959
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.20576
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.17694
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.13566
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.09864
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.09864
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09864
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.02905
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.01724


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, GRIA2, GRIK5, HTR1A, OPRK1, OPRM1, TRPV1, HTR2A, NR3C1, GRM1, GRM3, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 16.8271
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.208
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.9337
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8386
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.845
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR7, CYP2D6, ALOX5, ALOX15, HTR1A, ALOX12, HTR2A 6.845
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, GRIA4 6.2057
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4488
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 4.9747
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2A, DRD1, DRD2, GRM1 5.0152
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.2156
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, GRM1 3.6417
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9496
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.1828
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8908
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.6417
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A 2.7003
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.0157
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1, HTR2A 2.6332
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, HTR7, HTR2A, DRD1, GRM1 2.6212
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6212
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.3361
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, GRIA4 2.274
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.005
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1927
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6392
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.3016
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2468
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.2208
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.1957
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1927
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.9314
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.1927
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0157
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1927
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.908
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7635
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6139
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, CYP3A4 2.1686
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.452
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, ADORA1 1.6139
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.291
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8891
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0094
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, IGF1R 1.019
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0627
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0362
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.128
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3125
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8202
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2529
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7828
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7924
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3506
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7956
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8969
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7069
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2377
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1699
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2491
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6772
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3311
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2377
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.2453
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2818
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2719
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.281
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.292
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.298
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3061
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3367
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.298
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3207
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3367
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3674
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3644
Insulin signaling pathway_Homo sapiens_hsa04910 PDE3B 0.3644
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3644
Platelet activation_Homo sapiens_hsa04611 SRC 0.3913
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4098
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.447
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3913
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4098
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3965
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3913
Axon guidance_Homo sapiens_hsa04360 MET 0.3869
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4283
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4311
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.447
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3965
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B 0.4311
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4409
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.447
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.447
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4409
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4409
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.447
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.447
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4409
Peroxisome_Homo sapiens_hsa04146 XDH 0.447
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.488
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.447
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4825
Glioma_Homo sapiens_hsa05214 IGF1R 0.5173
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5173
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5164
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5173
Shigellosis_Homo sapiens_hsa05131 SRC 0.5173
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5098
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6139
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5913
Malaria_Homo sapiens_hsa05144 MET 0.6017
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8002
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6767
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7635
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6772
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7153
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7533
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9948
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7335
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7956
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.761
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7924
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0159
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0422


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)