TCM Prescription: Qi Protection Double Solution Decoction



Prescription Description
Prescription IDTCMF2108
Pinyin NameWei Qi Shuang Jie Tang
Chinese Name
English NameQi Protection Double Solution Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1652 Paris polyphylla 七叶一枝花 TCMH1652 ITSAH2421-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH805 Calcitum 寒水石 TCMH805
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2442 Radix rumicis japonici 羊蹄根 TCMH2442
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTGS2 10.7401
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FDPS, FUT7, GBA2, IDO1, PPARA, PTGS2, TYR, XDH 10.1326
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 9.76301
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.70368
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.89254
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.28353
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IDO1, PTGS2, TYR 7.18079
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, PPARA, PTGS2, TYR 7.17664
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.05376
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.98565
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TYR, XDH 6.75774
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, IDO1, PPARA, PTGS2, TYR 6.39391
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F3, FABP3, FABP4, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTGS2, TNKS, TNKS2, XDH 5.589
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, GBA2, PPARA, PTGS2 5.589
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, IDO1, PPARA, PTGS2, TYR 5.39795
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, HSD11B2, PTGS2, TYR 5.36626
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.2396
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.22018
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, FDPS, GBA2, TYR 5.08656
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TYR, XDH 5.0701
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.0701
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.01141
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA, PTGS2 5.01141
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.99692
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 4.90213
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.56953
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PPARA, PTGS2 4.55877
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38701
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 4.33597
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.33597
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD17B2, PPARA, PTGS2, PTPRS, TNKS2, TYR 4.29131
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 4.16251
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, GBA2, GSK3B, HSD11B1, HSD17B2, PPARA, PTGS2, PTPRS, TYR 4.15748
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.07651
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, PPARA, PTGS2 4.04033
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.94256
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PPARA, PTGS2, TYR 3.89421
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, PTPRS, TYR 3.88333
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TYR, XDH 3.84418
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.7546
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA 3.74899
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.6905
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PPARA, PTGS2, TYR 3.50518
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PPARA, PTGS2, TYR 3.43805
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 3.43805
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.326
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TYR, XDH 3.25058
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.21588
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21588
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, DHFR, FDPS, IDO1, PTGS2 3.19681
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, PTGS2 3.04022
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, PTGS2 3.02654
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.98105
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.96243
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, IDO1, PPARA, PTGS2, PTPN1, PTPRS, XDH 2.93392
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, DHFR, FDPS, TYR 2.93006
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.93006
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89357
[BP] GO:0009115 None AOX1, XDH 2.78341
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, XDH 2.66031
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.64651
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.64651
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.49353
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, XDH 2.46633
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, IDO1, PTGS2, XDH 2.42597
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GSK3B, IDO1, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.35886
[BP] GO:0046110 None AOX1, XDH 2.35824
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.35824
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.35824
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, PTGS2 2.34533
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32163
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.28823
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F3, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, IDO1, PPARA, PTGS2, PTPN1, TYR 2.2456
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH 2.21708
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21471
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.16526
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16523
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, PTGS2, TNKS, TNKS2 2.15822
[BP] GO:0070213 None TNKS, TNKS2 2.10918
[BP] GO:0006145 None AOX1, XDH 2.10918
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.10918
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, PTGS2 2.06007
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.05217
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F3, FABP4, GSK3B, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, XDH 2.05077
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, FABP3, FABP4, FDPS, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TYR, XDH 2.63305
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2 1.69864
[CC] GO:0099055 None ADORA1, PTPRS 1.52404
[CC] GO:0099699 None ADORA1, PTPRS 1.52404
[CC] GO:0099240 None ADORA1, PTPRS 1.52404
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3337
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS, TYR, XDH 10.1849
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FDPS, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, TYR, XDH 10.1849
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 10.1326
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, GSK3B, HSD17B1, IDO1, PPARA, PTGS2, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, TYR, XDH 7.25774
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.8993
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.79983
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.89777
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 5.08656
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.72926
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B2, HSD17B1, IDO1, PTGS2, XDH 4.53365
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, IDO1, PPARA, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 4.29131
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.25336
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS 4.11974
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.05485
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.05485
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, IDO1, PPARA, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 3.94578
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.81794
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.78327
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.73082
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.68945
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.65012
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.65012
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.59451
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.59451
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4776
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2 3.43805
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.35707
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2 3.26928
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 3.0151
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.86313
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.84888
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.81412
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78341
[MF] GO:0003845 None HSD11B1, HSD11B2 2.78341
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.35824
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.10918


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 10.1812
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.9183
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 10.0835
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1 8.838
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.8595
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.8595
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.658
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.517
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, CYP1B1, PTGS2, CDC25B 2.8529
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.3422
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, ESR1, ESR2 2.1568
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2244
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.9614
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1807
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9151
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.7873
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, PTGS2 1.7873
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7438
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.6413
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.7373
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 1.2637
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, CDK6, BCL2, PTGS2 1.1852
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.3429
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3696
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2686
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2 1.1372
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.0692
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7891
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7873
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.0692
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0046
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0692
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2637
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2637
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7438
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.942
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, ESR1 0.9767
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9767
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.9735
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9126
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, BCL2 0.8834
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.8911
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.8979
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.8979
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB 0.8979
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.8834
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7873
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8576
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7395
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8386
Influenza A_Homo sapiens_hsa05164 FDPS, GSK3B 0.8184
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7469
Focal adhesion_Homo sapiens_hsa04510 GSK3B, BCL2 0.7469
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.2281
HTLV-I infection_Homo sapiens_hsa05166 FDPS, GSK3B 0.6465
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6264
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3122
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.421
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3781
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4108
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.3781
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4641
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4015
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4481
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4641
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4419
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4108
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.421
Oxytocin signaling pathway_Homo sapiens_hsa04921 PTGS2 0.4369
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4419
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B 0.4015
Axon guidance_Homo sapiens_hsa04360 GSK3B 0.4872
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4856
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5586
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.5364
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5558
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5533
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B 0.5776
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5533
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5619
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5558
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5735
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5619
Gap junction_Homo sapiens_hsa04540 TUBB3 0.5776
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5776
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6264
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6264
Melanoma_Homo sapiens_hsa05218 CDK6 0.6264
Peroxisome_Homo sapiens_hsa04146 XDH 0.5906
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6264
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6304
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6258
Glioma_Homo sapiens_hsa05214 CDK6 0.631
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6264
VEGF signaling pathway_Homo sapiens_hsa04370 PTGS2 0.6455
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.605
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6317
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6264
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6686
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6811
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6702
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6702
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.683
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6979
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6851
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6955
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6979
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6979
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7469
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7055
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0557
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7729
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8164
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8297
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8529
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8447
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8979
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9133
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8911
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2637


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)