TCM Prescription: Decoction for Pus Drainage and Relieving Pain



Prescription Description
Prescription IDTCMF2064
Pinyin NameTuo Li Ding Tong Tang
Chinese Name托里定痛汤
English NameDecoction for Pus Drainage and Relieving Pain
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 10.8478
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 9.78145
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.67539
[BP] GO:0044281 small molecule metabolic process AKR1B1, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, PDE10A, PDE3A, PDE3B, PPARA, XDH 7.65964
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, PDE3A, PPARA 6.84612
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AR, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 6.4685
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HSD11B1, HSD17B1, HTR1A, HTR2A, OPRK1 6.18119
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.06797
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.88228
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AR, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, FABP3, FABP4, HCAR2, HSD11B1, HSD17B1, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, XDH 5.82849
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.82849
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.82849
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.7268
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 5.66213
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.61725
[BP] GO:0014070 response to organic cyclic compound AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, NR3C1, OPRK1, OPRM1, PDE3A 5.55426
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.3711
[BP] GO:0007188 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.29793
[BP] GO:0010033 response to organic substance AKR1B1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 5.18398
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.07485
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD17B1 5.0312
[BP] GO:0042221 response to chemical AKR1B1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, HTR2A, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 5.0312
[BP] GO:0007187 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.83162
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HTR2A, NR3C1, OPRK1, OPRM1, PDE3A 4.66829
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 4.65552
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.47495
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.43014
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, XDH 4.40736
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, HTR2A, MMP9, OPRK1, OPRM1, XDH 4.36793
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, HTR2A, MMP9, OPRK1, OPRM1, XDH 4.34875
[BP] GO:0009725 response to hormone AKR1B1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, NR3C1, OPRK1, PDE3B, PPARA 4.34745
[BP] GO:0007200 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 4.34745
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1 4.33592
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, PDE3A, PPARA 4.28436
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 4.10445
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.10445
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.04057
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.94654
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, OPRM1, PPARA 3.82958
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1 3.74645
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.62955
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, HTR7, OPRK1, OPRM1, PGR, PPARA 3.6257
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AR, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B 3.6077
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, HTR2A, OPRM1, PPARA 3.58773
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 3.51572
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HTR2A 3.45223
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, PPARA 3.45223
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.42184
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, DRD1, DRD2, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA 3.37874
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.37628
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 3.32248
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 3.28431
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 3.28431
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A 3.28287
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25796
[BP] GO:0071310 cellular response to organic substance AKR1B1, AR, BCL2, CYP1A1, CYP1B1, DRD1, FABP4, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B 3.25486
[BP] GO:0033993 response to lipid AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, NR3C1, OPRK1, OPRM1 3.23576
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, BCL2, CSNK2A1, CYP1B1, DRD2, FABP3, HTR1A, HTR2A, MMP2, MMP9, OPRM1, PGR, XDH 3.16693
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, FABP3, HCAR2, HTR1A, HTR2A, MMP1, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PGR, PPARA, XDH 3.16491
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MMP9 3.152
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.12939
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A 3.12939
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 3.12433
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AR, BCL2, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HTR1A, MMP1, MMP2, MMP9, NR3C1, NR3C2, PDE10A, PDE3A, PDE3B, PGR, PPARA, SENP6, XDH 3.09347
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HCAR2, HTR2A, OPRK1 3.08882
[BP] GO:0007267 None ADORA1, AR, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PGR 2.99941
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.97783
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, OPRD1, PPARA 2.97342
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.973
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AR, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, MMP2, MMP9, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PPARA, SIGMAR1 2.96514
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, OPRK1 2.94223
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.91898
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, OPRD1, PPARA 2.91612
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.91612
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.91612
[BP] GO:0031635 None OPRK1, OPRM1 2.88422
[BP] GO:1901575 None ACHE, ADORA1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, PDE10A, PDE3A, PDE3B, XDH 2.85766
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.84288
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, HTR1A 2.82218
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2 2.7976
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, XDH 2.78551
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 2.78551
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.77174
[BP] GO:0009636 response to toxic substance AKR1B1, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, OPRD1, OPRK1 2.77174
[BP] GO:0007610 None BCL2, DRD1, DRD2, HTR1A, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 2.73732
[BP] GO:0050994 None ADORA1, HCAR2, PDE3B, PPARA 2.73603
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, OPRD1, PPARA 2.73412
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.73124
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.73124
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.71576
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A 2.70643
[BP] GO:0023052 None ADORA1, AR, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PGR 2.70192
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.69244
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AR, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F10, FABP3, FABP4, HTR1A, HTR2A, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 2.69197
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.68752
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.68752
[BP] GO:0007154 None ADORA1, AR, BCL2, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PGR 2.67826
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, HTR2A 2.67826
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, HTR2A 2.67826
[BP] GO:0051049 regulation of transport ACHE, ADORA1, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, HCAR2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, PPARA 2.66099
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AR, BCL2, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FABP3, FABP4, FUT7, HSD17B1, HTR1A, MMP1, MMP2, NR3C1, NR3C2, PDE10A, PDE3A, PDE3B, PGR, PPARA, SENP6, XDH 2.65815
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A 2.64811
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, FABP3, FABP4, HCAR2, HTR1A, HTR2A, MMP1, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PGR, PPARA, XDH 2.63934
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A 2.61746
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.6073
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, HTR1A, HTR2A, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, XDH 2.59006
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.58623
[BP] GO:0055114 oxidation-reduction process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, XDH 2.58518
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.57044
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.57044
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 2.5573
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.5573
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.54576
[BP] GO:0060748 None AR, PGR 2.54405
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54405
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, HTR1A, HTR2A, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, XDH 2.53344
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.50973
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, PDE10A, PDE3A, PDE3B, XDH 2.50973
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, BCL2, DRD1, DRD2, FABP3, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, XDH 2.50973
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, BCL2, DRD1, DRD2, FABP3, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, XDH 2.50973
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, CYP1B1, DRD1, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B 2.50721
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA 2.50721
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2A 2.49278
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.48355
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AR, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F10, FABP4, HTR1A, HTR2A, HTR7, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PPARA 2.48355
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FABP3, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 2.48355
[BP] GO:0050995 None ADORA1, HCAR2, PDE3B 2.4813
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.47764
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.42649
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.39146
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 2.39146
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.39146
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.39146
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.39146
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.39146
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, HTR2A, MMP9 2.38352
[BP] GO:0031644 None ADORA1, OPRD1, OPRK1, OPRM1 2.38352
[BP] GO:0071407 cellular response to organic cyclic compound AR, CYP1A1, CYP1B1, DRD1, NR3C1, OPRM1, PDE3A 2.37201
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, OPRD1, PPARA, SIGMAR1 2.36742
[BP] GO:0010959 None ADORA1, BCL2, DRD1, DRD2, HTR2A, OPRD1, OPRK1 2.34777
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AR, BCL2, CYP1B1, DRD2, F10, HTR2A, OPRK1, OPRM1, XDH 2.34029
[BP] GO:0007198 None HTR1A, HTR7 2.33139
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33139
[BP] GO:0009410 None DRD1, DRD2, NR3C1, OPRK1, OPRM1 2.33139
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, HCAR2, HTR2A, PDE3B, PPARA 2.29787
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AR, BCL2, CSNK2A1, CYP1B1, DRD2, F10, HTR2A, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, XDH 2.27802
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A 2.27802
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, FABP3, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA 2.2665
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.22455
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.22455
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, HCAR2, HTR2A, OPRD1, OPRK1, OPRM1 2.18783
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.1823
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA 2.16627
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, OPRK1, OPRM1 2.15585
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1 2.15585
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.15585
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.15585
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.15585
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.15585
[BP] GO:0021853 None DRD1, DRD2 2.15585
[BP] GO:1904936 None DRD1, DRD2 2.15585
[BP] GO:0042321 None ADORA1, DRD2 2.15585
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.12334
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.12334
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.12157
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA 2.10927
[BP] GO:0051716 cellular response to stimulus AKR1B1, AR, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B 2.10333
[BP] GO:0043278 None DRD2, OPRK1, OPRM1 2.09928
[BP] GO:0014072 None DRD2, OPRK1, OPRM1 2.09928
[BP] GO:0042596 None BCL2, DRD1, HTR1A 2.09928
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, AR, BCL2, CYP1B1, DRD2, FABP3, OPRM1, XDH 2.09245
[BP] GO:0060359 None DRD1, DRD2, OPRK1, OPRM1 2.08305
[BP] GO:2001023 None DRD1, DRD2, HTR2A, OPRK1 2.06642
[BP] GO:0046058 None PDE10A, PDE3A, PDE3B 2.06642
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.0581
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, MMP9, OPRK1 2.03789
[BP] GO:0019933 None DRD1, DRD2, OPRM1, PDE3A 2.03778
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, DRD1, DRD2, HTR2A, MMP9, OPRK1, OPRM1, PDE3B, XDH 2.02891
[BP] GO:0021843 None DRD1, DRD2 2.02891
[BP] GO:0021830 None DRD1, DRD2 2.02891
[BP] GO:0021826 None DRD1, DRD2 2.02891
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.02891
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, DRD1, DRD2, HTR2A, MMP9, OPRK1, OPRM1, PDE3B, XDH 2.02052
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1 2.02052
[BP] GO:0007626 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.01114
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PPARA 2.01114
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, BCL2, DRD1, DRD2, FABP4, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, PPARA, XDH 2.01058
[BP] GO:0006810 None ACHE, ADORA1, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, HTR2A, MMP9, OPRD1, OPRM1, PPARA, SIGMAR1, XDH 2.00283
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, HSD11B1, NR3C2, SIGMAR1 3.09134
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, F10, HSD11B1, NR3C2, SIGMAR1 2.51232
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, AR, BCL2, CA12, CA14, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FUT7, HCAR2, HSD11B1, HTR1A, HTR2A, HTR7, MMP2, NR3C2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PGR, SIGMAR1 2.28198
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AR, BCL2, CA1, CA2, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HTR2A, MMP2, MMP9, NR3C1, NR3C2, OPRM1, PDE10A, PDE3A, PDE3B, PGR, SENP6, SIGMAR1, XDH 2.16236
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, BCL2, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FUT7, HCAR2, HSD11B1, HTR1A, HTR2A, HTR7, NR3C2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1 1.87205
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 15.4972
[MF] GO:0046914 transition metal ion binding AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, XDH 12.4828
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 10.0294
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 8.94042
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.94042
[MF] GO:0043169 cation binding ACHE, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, HTR1A, HTR2A, HTR7, MMP1, MMP2, MMP9, NR3C1, NR3C2, PDE10A, PDE3A, PDE3B, PGR, PPARA, XDH 8.59333
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.31644
[MF] GO:0043167 ion binding ACHE, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, F10, FABP3, FABP4, HSD17B1, HTR1A, HTR2A, HTR7, MMP1, MMP2, MMP9, NR3C1, NR3C2, PDE10A, PDE3A, PDE3B, PGR, PPARA, XDH 6.90845
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA 6.62896
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 5.88228
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.74908
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.61725
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.3923
[MF] GO:0005506 iron ion binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.2252
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.80169
[MF] GO:0046872 metal ion binding AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, MMP1, MMP2, MMP9, NR3C1, NR3C2, PDE10A, PDE3A, PDE3B, PGR, PPARA, XDH 4.73606
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.69358
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, SIGMAR1 4.66829
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.65983
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.46378
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.19551
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, SIGMAR1 4.04323
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, SIGMAR1 3.86903
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.83979
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA 3.79457
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, SIGMAR1 3.52256
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 3.25486
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, FUT7, HSD11B1, HSD17B1, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SENP6, XDH 3.20315
[MF] GO:0016491 oxidoreductase activity AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, XDH 3.19974
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.16491
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.16491
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.152
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR 3.13777
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, XDH 3.03424
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.91612
[MF] GO:0004119 None PDE3A, PDE3B 2.88422
[MF] GO:0008389 None CYP2A13, CYP2A6 2.88422
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.84288
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.73603
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.63417
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.4813
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.39146
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.39146
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.39146
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.34859
[MF] GO:0008289 lipid binding AR, F10, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA 2.17578
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, NR3C1 2.12211
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.10284
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.10284
[MF] GO:0008081 None ADORA1, PDE10A, PDE3A, PDE3B 2.03778
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02891
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, HTR2A, PDE10A, PPARA, SIGMAR1 2.01058


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 17.3273
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, ADORA3, ADORA1, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, NR3C1, DRD2 8.4074
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.702
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA 6.1737
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7724
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 5.8265
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.0316
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, CYP19A1 4.0965
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A 3.2639
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5832
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, HTR1A, HTR2A 2.908
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.963
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, BCL2, ADORA1 2.823
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.963
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.6499
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.5106
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 2.3212
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.5106
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.4582
Pathways in cancer_Homo sapiens_hsa05200 AR, MMP1, MMP2, BCL2, MMP9 1.8794
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, OPRM1, MMP9 2.069
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CYP2A6, FUT7, HSD17B1, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH 1.8468
Gap junction_Homo sapiens_hsa04540 HTR2A, DRD1, DRD2 2.1954
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1 1.4357
Prostate cancer_Homo sapiens_hsa05215 AR, BCL2 1.1521
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2 1.108
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, PGR 1.108
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.046
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 1.108
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1317
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6142
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, CYP1B1, MMP9 0.9948
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6505
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR 0.9948
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9772
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0105
Hepatitis B_Homo sapiens_hsa05161 BCL2, MMP9 0.9038
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.914
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8207
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7713
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9 0.7713
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5516
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.543
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5751
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5842
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HTR2A 0.5337
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5084
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5084
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.543
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.521
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4598
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5766
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4598
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4876
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5447
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4598
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.5751
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.543
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.488
Insulin signaling pathway_Homo sapiens_hsa04910 PDE3B 0.4598
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5354
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 BCL2 0.2332
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4484
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4598
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6071
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4503
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4598
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2 0.4376
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5567
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4191
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5354
Peroxisome_Homo sapiens_hsa04146 XDH 0.5516
Bile secretion_Homo sapiens_hsa04976 CA2 0.5766
Rap1 signaling pathway_Homo sapiens_hsa04015 DRD2 0.369
Ras signaling pathway_Homo sapiens_hsa04014 HTR7 0.3501
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3785
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4075
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4075
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4032
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6191
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6698
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7713
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8207
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8207
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.7518
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8207
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7783
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8182
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8459
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 0.8867
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8404


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)