Prescription Description
| Prescription ID | TCMF2035 |
| Pinyin Name | He Che Da Zao Wan |
| Chinese Name | 河车大造丸 |
| English Name | Heche Dazao Pills |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2710 | Homo sapiens | 紫河车 | TCMH2710 | |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH2084 | Asparagus cochinchinensis | 天冬 | TCMH2084 | ITSAJ4142-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH949 | Phellodendron amurense | 黄柏 | TCMH949 | ITSAM1586-14 |
| TCMH746 | Carapax et plastrum testudinis | 龟甲 | TCMH746 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT1 | EHMT2 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Transferase | Q96KQ7 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT105 | SLC15A2 | Solute carrier family 15 member 2 | Transporter | Q16348 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
Showing 1 to 10 of 282 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1174 | Mycobacterium bovis BCG |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1177 | Haemophilus influenzae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
Showing 1 to 10 of 172 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000122 | None | AR, AURKB, DNMT1, DNMT3B, DRD3, EHMT1, EHMT2, ESR1, ESR2, ESRRA, FBP1, HSPA1A, NR1H4, NR3C1, PPARA, PPARD, PPARG, RARA, RARB, RARG, RORC, RXRA, SMAD3, SMYD2, THRA, THRB, VDR | 5.49562 |
| [BP] GO:0000187 | activation of MAPK activity | ADRA2B, CHRNA7, DRD4, GRM1, INSR, MAPK14, PTPN1, S1PR2 | 2.47376 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, AKR1C3, AVPR1A, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, NR1H4, PPARG, PTGER2, PTGER4, PTGES, PTGFR, PTGS2, RARA, RARG, RORB, RXRA, SLC6A4, SRC | 9.40976 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK, THRA | 2.32373 |
| [BP] GO:0001504 | None | SLC1A1, SLC22A3, SLC6A2, SLC6A3, SLC6A4 | 4.54793 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, ADORA2A, AGTR2, CHRNA3, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, GPER1, GRIK5, HRH3, HSPA8, HTR1A, INSR, MAOA, MAOB, PTGS2, RORA, SLC1A1, SLC22A2, SLC22A3, SLC6A2, SLC6A3, SLC6A4, SMAD3 | 16.2972 |
| [BP] GO:0001508 | None | ATP1A1, CACNA1C, CACNA2D1, DRD1, GPER1, KCNH2 | 2.44434 |
| [BP] GO:0001516 | None | MIF, PTGES, PTGS1, PTGS2 | 3.57151 |
| [BP] GO:0001659 | None | ADORA1, ADRB1, ADRB2, DRD1, DRD2, HTR2A | 4.51376 |
| [BP] GO:0001662 | None | DRD1, DRD4, HTR1A, HTR2C | 2.23189 |
Showing 1 to 10 of 1,092 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, RARA, PIM1, PPARD | 2.0499 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 5.1338 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | RXRB, RXRA, PPARA, RXRG | 1.8147 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | CACNA2D1, AGTR1, ADRB1, ATP1A1, CACNA1C, AGTR2, ADRB2, ADRA1B, MAPK14, ADRA1A | 4.6615 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.4162 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1, AGTR1, MAPK14, F3 | 2.6313 |
| Alcoholism_Homo sapiens_hsa05034 | ADORA2A, MAOB, MAOA, DRD1, DRD2, SLC6A3 | 1.5864 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | AGTR1, CACNA1C | 0.5345 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR, ATP1A1, NR3C2 | 2.6038 |
| Alzheimer's disease_Homo sapiens_hsa05010 | CACNA1C | 0.0742 |
Showing 1 to 10 of 194 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples