Prescription Description
| Prescription ID | TCMF2 |
| Pinyin Name | Dan Yi Pian |
| Chinese Name | 丹益片 |
| English Name | Dan Yi Tablets |
| Function Description | 活血化瘀, 清热利湿的功效, 慢性非细菌性前列腺炎 |
| Indications | Chronic prostatitis |
| Disease ICD-11 Category |
GA91.0 [Chronic prostatitis, 慢性前列腺炎
]; |
| Human Tissues Associated with Indication | Prostate |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
| TCMH2473 | Leonurus japonicus | 益母草 | TCMH2473 | ITSAN1807-14 |
| TCMH1393 | Verbena officinalis | 马鞭草 | TCMH1393 | ITSAJ4412-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH949 | Phellodendron amurense | 黄柏 | TCMH949 | ITSAM1586-14 |
| TCMH109 | Pulsatilla chinensis | 白头翁 | TCMH109 | ITSAJ4425-14 |
| TCMH2161 | Vaccaria segetalis | 王不留行 | TCMH2161 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
Showing 1 to 10 of 95 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1218 | Staphylococcus aureus |
Showing 1 to 10 of 58 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC | 2.09164 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A4 | 2.56396 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, GRIK5, SLC1A1, SLC6A2, SLC6A4 | 3.38827 |
| [BP] GO:0001666 | response to hypoxia | CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT | 2.53858 |
| [BP] GO:0006082 | organic acid metabolic process | ABCG2, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR | 2.17498 |
| [BP] GO:0006140 | None | ADRA2A, DRD1, DRD2, ESRRB, GRM3, GRM8, PPARA | 2.68564 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.24162 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.24162 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.68564 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC | 2.2618 |
Showing 1 to 10 of 292 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCG2 | 0.6321 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3657 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.1592 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5074 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1, F3 | 1.8239 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.691 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, DRD1, GRIA4 | 2.2138 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4173 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.5952 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, CYP2C19 | 1.3247 |
Showing 1 to 10 of 131 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples