TCM Prescription: Zuogui Decoction



Prescription Description
Prescription IDTCMF1829
Pinyin NameZuo Gui Yin
Chinese Name左归饮
English NameZuogui Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 11.9619
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 11.9619
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A3, SRC, TYR 10.4773
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A3, SRC, TYR 9.22215
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 8.84866
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A3, SRC, TNKS2, TYR 8.39046
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A3, SRC, TYR 8.32725
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 8.15801
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.92215
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FLT3, HSD11B2, RORC, SLC6A3, SRC, TYR 7.6188
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, XDH 7.25049
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 7.1692
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.1446
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.1446
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.07032
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.07032
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.92119
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, SRC, TYR 6.91404
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.90987
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.79903
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.70229
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.70229
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.26808
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.25779
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.10142
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.10142
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, HSD11B2, KDR, SLC6A2, SLC6A3, SRC 6.028
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 6.028
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.99219
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD2, DRD3, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 5.8818
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.88106
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.85396
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 5.81155
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 5.74958
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.7439
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.7439
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, GBA2, HMGCR, SLC6A3, TYR 5.6901
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 5.65516
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.59632
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.3793
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A3, SRC, TNKS2, TYR 5.22122
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 5.20973
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 5.20716
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.14572
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.12162
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.05538
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 5.0484
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, ESR1, GRM5 4.93085
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.84687
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TYR 4.83456
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.82543
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SLC6A3, SRC, TYR 4.75926
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 4.74476
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRM5, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.73924
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRM5, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.6805
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.61729
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.54146
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.53884
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD4, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 4.52964
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, PPARA, RORC, SRC 4.52892
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 4.5254
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 4.50946
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC 4.50824
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.46177
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.44509
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 4.41917
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.41917
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.402
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.38944
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.36548
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35017
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 4.34475
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.29878
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HMGCR, PIM1, PPARA, TYR, XDH 4.27766
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.22279
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 4.21674
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.19414
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.17453
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.17453
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.14367
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 4.05976
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 4.04589
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.01518
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 4.00176
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 3.97249
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.97001
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.97001
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.97001
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.94777
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.927
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.83184
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 3.79508
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TNKS2, XDH 3.79508
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 3.79508
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.76288
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.76288
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.72478
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.72478
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.70386
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 3.69898
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.69675
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.69264
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.6645
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 3.63561
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.62177
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.62016
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.62016
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.54511
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC 3.53521
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.49807
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2, TNKS, TNKS2 3.47358
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 3.47029
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 3.47029
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.46075
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 3.44493
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.44493
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, F3, MET, SLC6A3, XDH 3.42322
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.41295
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.41295
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA 3.38857
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.38213
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.3681
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.3681
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.36704
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.36148
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.3363
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.33393
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.30785
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, DRD4, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.29026
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 3.27719
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.25842
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 3.23709
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, GRM1, HMGCR, HSD11B2, MMP2, PPARA, SRC, TYR 3.23466
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 3.23466
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.19189
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, SLC6A3, TNKS2 3.19189
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.19189
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 3.19189
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.18216
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.16008
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.16008
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16008
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.15322
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.15322
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.15322
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 3.15322
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.14469
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 3.06512
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.05608
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.04416
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.03803
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PTPN1, SRC, TNKS, XDH 3.00977
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.98898
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.96702
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.94788
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1 2.93898
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 2.93865
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.92858
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.92774
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.90908
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 2.90774
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, XDH 2.89349
[BP] GO:0009115 None AOX1, XDH 2.86113
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, DRD3, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC 2.8584
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85358
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.85358
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.85358
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, HSD11B2, SLC6A3, SRC, TYR 2.85281
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.85069
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.85069
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, DRD4, MMP9 2.81452
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 2.78041
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 2.76963
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76573
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.76573
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.74894
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.74736
[BP] GO:0042391 None ADORA1, BCL2, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.71772
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.70383
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A3 2.6789
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.67429
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.64429
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.62715
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 2.62715
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 2.62715
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60716
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.60716
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 2.6017
[BP] GO:1900542 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, PPARA 2.57556
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.55321
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.54609
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 2.53938
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53735
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.53735
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DRD2, DRD3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, SLC6A3, SRC, XDH 2.52156
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, SLC1A1, SLC6A3, XDH 2.52156
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.52156
[BP] GO:0006140 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, PPARA 2.51048
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, SLC6A3 2.48915
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.47282
[BP] GO:0099566 None GRM1, GRM5 2.47282
[BP] GO:0051944 None DRD2, DRD4 2.47282
[BP] GO:0046110 None AOX1, XDH 2.47282
[BP] GO:0060160 None DRD2, DRD3 2.47282
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47282
[BP] GO:0051586 None DRD2, DRD4 2.47282
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.47282
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5 2.44835
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC 2.4473
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.4473
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.44513
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.44406
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.42508
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42508
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.42488
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.42488
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.41492
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PPARA, PTPN1, SRC 2.39785
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.394
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.38778
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC, TNKS 2.37841
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.3754
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.3754
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.3754
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.3754
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.3754
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.34296
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.34296
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, XDH 2.32309
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A3 2.32309
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.32309
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32309
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.27244
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26338
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.26331
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, DRD2, DRD4, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MMP9, PTPN1, SRC, TNKS, XDH 2.25989
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.24923
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.24718
[BP] GO:0070213 None TNKS, TNKS2 2.2385
[BP] GO:0006145 None AOX1, XDH 2.2385
[BP] GO:0051582 None DRD2, DRD4 2.2385
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2385
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.2385
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DRD2, DRD4, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 2.23775
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.2358
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.2358
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.23417
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.2332
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.2332
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.2332
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2332
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.22104
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.22104
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, HMGCR, PPARA, SLC6A3 2.21322
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, DRD4 2.19191
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.18714
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18659
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CHRM1, DRD2, DRD3, DRD4, GRM5, MMP9 2.17872
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.17722
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.17232
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, SLC1A1 2.16582
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.15806
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.15711
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.15711
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.1555
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.14019
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.13895
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.10358
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1002
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.1002
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.1002
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.1002
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.09402
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.094
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.094
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.08909
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, XDH 2.08318
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, SLC6A3, TYR 2.08318
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.08318
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.08318
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.08318
[BP] GO:0046541 None CHRM1, CHRM3 2.08318
[BP] GO:0043696 None CDK6, ESRRB 2.08318
[BP] GO:0043697 None CDK6, ESRRB 2.08318
[BP] GO:0010641 None F3, SRC 2.08318
[BP] GO:0007598 None F10, F3 2.08318
[BP] GO:0042321 None ADORA1, DRD2 2.08318
[BP] GO:0090325 None DRD2, DRD3 2.08318
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07337
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.07276
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.07059
[BP] GO:0007589 None CHRM1, CHRM3, SLC6A3, XDH 2.07059
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.06536
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.03475
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.02646
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.00203
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 7.12621
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 6.31133
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 6.17132
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR 5.85804
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.85804
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 5.5701
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.39203
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 5.33904
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 4.91207
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 4.2632
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.82802
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.82802
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.6645
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 3.36817
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.36148
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.32799
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.12699
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TYR 3.04242
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.65111
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.3754
[CC] GO:0031233 None CA4, F10, F3 2.3754
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC 2.33061
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.2332
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TYR 2.21622
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.20768
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.07059
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.01368
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.01368
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 10.4773
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 10.4773
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 10.4773
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 9.92935
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.81049
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 9.51068
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 8.56118
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98749
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 7.82569
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.97849
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.97849
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.63869
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.25779
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.0949
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.94625
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TYR, XDH 5.67286
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 5.53399
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.317
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.03798
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.03798
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.96028
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC 4.77887
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.6429
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.61729
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.50824
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 4.16968
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.1694
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.98272
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.81988
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.63391
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.62016
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TYR, XDH 3.47963
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.45464
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.44558
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.43236
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.41295
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.38213
[MF] GO:0051721 None BCL2, HMGCR, PTPN1, SLC6A3 3.3363
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.32799
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.28742
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 3.24928
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.23709
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.14966
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.93865
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.89819
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.89322
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86113
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86113
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, SRC, XDH 2.85358
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.67651
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.64429
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.57348
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, PTPN1, SLC6A3 2.49902
[MF] GO:0005330 None SLC6A2, SLC6A3 2.47282
[MF] GO:0099583 None GRM1, GRM5 2.47282
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.42508
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.42508
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.3754
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.32309
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2385
[MF] GO:0004971 None GRIA2, GRIA4 2.2385
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SRC 2.23417
[MF] GO:0019903 protein phosphatase binding BCL2, HMGCR, MET, PTPN1, SLC6A3 2.2332
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, DRD4, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, TYR, XDH 2.15562
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.1002
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08318
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.07337


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 12.2366
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0009
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.7091
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6334
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.5444
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 4.7493
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.1888
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.421
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.9003
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.9003
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 3.9083
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9083
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.2942
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.0249
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7865
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7752
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.0249
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.4944
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.7632
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5113
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.959
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0106
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.5113
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.7042
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2963
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.7841
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.2277
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.2157
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.0465
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0557
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1486
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.0557
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0572
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0625
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0176
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7673
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0122
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3062
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4791
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2155
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9622
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.246
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1758
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2405
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.211
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9996
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9889
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0404
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1593
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.11
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8428
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9634
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9686
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0195
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0754
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.937
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2211
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9784
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1552
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9666
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.863
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0725
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.863
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1511
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.863
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7899
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8422
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.1357
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8011
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3062
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7836
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8422
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7841
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7836
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.212
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6912
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6566
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6566
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6003
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5947
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2872
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2941
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3063
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.316
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2937
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3493
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3342
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3458
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3614
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3614
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3598
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3722
Platelet activation_Homo sapiens_hsa04611 SRC 0.3924
Axon guidance_Homo sapiens_hsa04360 MET 0.3847
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3945
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3924
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4183
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4152
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4455
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4453
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4494
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4666
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4577
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4573
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4666
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4661
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4666
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4666
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4872
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4666
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4666
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4666
Peroxisome_Homo sapiens_hsa04146 XDH 0.4675
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4666
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5119
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.524
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.539
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.539
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5258
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.539
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.539
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6889
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5794
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5391
Shigellosis_Homo sapiens_hsa05131 SRC 0.539
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.539
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5391
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5704
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5658
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6447
Malaria_Homo sapiens_hsa05144 MET 0.6103
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6182
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6142
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6182
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6182
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6704
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8948
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7547
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7724
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7724
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7875
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7635
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7836
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8413
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8861
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9634
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0005
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2087


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)