Prescription Description
| Prescription ID | TCMF14 |
| Pinyin Name | Fen Qing Wu Lin Wan |
| Chinese Name | 分清五淋丸 |
| English Name | Fen Qing Wu Lin Pills |
| Function Description | 小便黄赤, 尿频尿急, 尿道灼热涩痛 |
| Indications | Urethritis, Cystitis |
| Disease ICD-11 Category |
GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征
]; GC00 [Cystitis, 膀胱炎 ]; |
| Human Tissues Associated with Indication | Bladder |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1531 | Akebia quinata | 木通 | TCMH1531 | ITSAJ4440-14 |
| TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH2671 | Polyporus umbellatus | 猪苓 | TCMH2671 | NOBAS3307-16 |
| TCMH949 | Phellodendron amurense | 黄柏 | TCMH949 | ITSAM1586-14 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
| TCMH177 | Polygonum aviculare | 萹蓄 | TCMH177 | ITSAG3700-14 |
| TCMH1706 | Dianthus superbus | 瞿麦 | TCMH1706 | ITSAJ4556-14 |
| TCMH2624 | Anemarrhena asphodeloides | 知母 | TCMH2624 | GBVA3255-11, GBVU1201-13 |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH933 | Talcum | 滑石 | TCMH933 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
Showing 1 to 10 of 131 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
Showing 1 to 10 of 86 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.81867 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.1017 |
| [BP] GO:0001662 | None | BCL2, DRD1, HTR1A, HTR2C | 3.02109 |
| [BP] GO:0001666 | response to hypoxia | BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT | 3.38549 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 4.18198 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH | 4.7075 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH | 5.35635 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SRC | 2.16491 |
| [BP] GO:0002031 | None | DRD2, HTR1B, HTR2B | 2.90745 |
| [BP] GO:0002209 | None | BCL2, DRD1, HTR1A, HTR2C | 3.02109 |
Showing 1 to 10 of 509 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6358 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, KIT, PIM1, PIK3CB | 4.2755 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 3.8289 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4994 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PRKCA, PIK3CB | 1.9024 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.7142 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB, F3 | 5.3167 |
| Alcoholism_Homo sapiens_hsa05034 | MAOB, DRD1, DRD2 | 1.0966 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.4573 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PRKCA, PIK3CB | 3.7447 |
Showing 1 to 10 of 179 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples