TCM Prescription: Jianbu Pills



Prescription Description
Prescription IDTCMF1375
Pinyin NameJian Bu Wan
Chinese Name健步丸
English NameJianbu Pills
Function Description肝肾不足, 腰膝酸软, 下肢痿弱, 步履艰难
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH136 Os pardi 豹骨 TCMH136
TCMH743 Plastrum testudinis 龟板 TCMH743
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0776
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0998
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 9.76378
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 8.27586
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.53997
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FDPS, FUT7, PDE5A, PIM1, PPARA 7.42401
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 6.81934
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.74871
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 6.69466
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 6.69466
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.27031
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, CA12, CA2, CA7, CYP19A1, CYP1B1, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, MAOB, MCL1, PPARA, SLC1A1, TRPV1 5.08753
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, PPARA, TRPV1 4.81111
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.55873
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.55873
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.54497
[BP] GO:0007188 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 4.071
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1B1, CYP2A13, CYP2A6 3.90944
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, MAOB, SLC1A1, TRPV1 3.85749
[BP] GO:0007187 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 3.67008
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.48722
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.48722
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MCL1, PPARA, SLC1A1, TRPV1 3.45903
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.45903
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.45903
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, MAOB 3.45028
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.42299
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.32258
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.27472
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRM1, HCAR2, MCL1, MMP9, PDE5A, PTPN1 3.26285
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRM1, HCAR2, MCL1, MMP9, PDE5A, PTPN1 3.24739
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.15404
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP2A6, CYP3A4, FDPS 3.02282
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, GRIK5, GRM1, GRM5, TRPV1 3.02282
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, PPARA 2.93646
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, GRIK5, GRM1, GRM5, MCL1, TRPV1 2.88386
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.86819
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.86819
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 2.82263
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, MAOB 2.76862
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2, MAOB 2.73282
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRIK5, GRM5, HCAR2, MAOB, MMP9, PPARA, PTPN1, TRPV1 2.62631
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FABP3, FABP4, GRIK5, GRM1, GRM5, HCAR2, MAOB, MCL1, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TRPV1 2.61825
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FABP3, GRIK5, GRM1, GRM5, HCAR2, MAOB, MCL1, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, TRPV1 2.6087
[BP] GO:0006810 None ACHE, ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, GRIA2, GRIA4, GRIK5, MCL1, MMP9, PPARA, SLC1A1, TRPV1 2.58928
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, CA1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MCL1, MMP2, MMP9, PTPN1, TRPV1 2.5837
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA9, CYP1B1, DRD1, DRD2, FABP3, GRIK5, GRM5, MAOB, MMP2, MMP9, PPARA, TRPV1 2.5527
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, TRPV1 2.53528
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, TRPV1 2.49804
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.49804
[BP] GO:0099566 None GRM1, GRM5 2.36787
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36787
[BP] GO:0019373 epoxygenase P450 pathway CYP1B1, CYP2A13, CYP2A6 2.36192
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.35385
[BP] GO:0007267 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.33436
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MCL1, MMP9, PDE5A, PTPN1 2.33353
[BP] GO:0051234 None ACHE, ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, GRIA2, GRIA4, GRIK5, MCL1, MMP9, PPARA, SLC1A1, TRPV1 2.31006
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MAOB, MMP1, MMP2, MMP9, PDE5A 2.29259
[BP] GO:1900542 None DRD1, DRD2, GRM3, GRM8, PDE5A, PPARA 2.29028
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MCL1, MMP9, PDE5A, PTPN1 2.2775
[BP] GO:0030799 None DRD1, DRD2, GRM3, GRM8, PDE5A 2.25476
[BP] GO:0051049 regulation of transport ACHE, ADORA1, CA2, CA7, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, MAOB, MMP9, PPARA, PTPN1, TRPV1 2.24697
[BP] GO:0006140 None DRD1, DRD2, GRM3, GRM8, PDE5A, PPARA 2.23931
[BP] GO:1900543 None DRD2, GRM3, GRM8, PPARA 2.23117
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FABP4, GRM1, GRM5, GRM8, MCL1, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, TRPV1 2.22322
[BP] GO:0045980 None DRD2, GRM3, GRM8, PPARA 2.21518
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1B1, CYP3A4, DRD2, HCAR2 2.18692
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, FABP3, GRM1, GRM5, TRPV1 2.17109
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.16444
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.16444
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, GRM1, HCAR2, PDE5A, SLC1A1, TRPV1 2.15719
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, MAOB 2.11976
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.09909
[BP] GO:0007154 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TRPV1 2.09909
[BP] GO:0023052 None ADORA1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.08287
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.05898
[BP] GO:0042391 None ADORA1, DRD1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 2.02998
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, MMP9, PDE5A, PPARA, PTPN1 2.02025
[BP] GO:0021853 None DRD1, DRD2 2.00644
[BP] GO:0007598 None F10, F3 2.00644
[BP] GO:1904936 None DRD1, DRD2 2.00644
[BP] GO:0042321 None ADORA1, DRD2 2.00644
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC1A1, TRPV1 5.08753
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.54511
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.51981
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.40028
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, DRD1, DRD2, F10, F3, GRIA2, GRM1, GRM3, GRM5, GRM8, SLC1A1, TRPV1 2.59598
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5 2.5837
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5 2.5837
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.53528
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.50509
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA4, CA9, DRD1, DRD2, F10, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MMP2, PIM1, PTPN1, SLC1A1, TRPV1 2.46972
[CC] GO:0031233 None CA4, F10, F3 2.40465
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MAOB, MCL1, PTPN1, SLC1A1, TRPV1 2.27901
[CC] GO:0098794 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.16041
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, CA2, CA4, CA9, DRD1, DRD2, F10, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC1A1, TRPV1 2.15719
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 2.10191
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 2.10191
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.6711
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1909
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9759
[MF] GO:0046914 transition metal ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1 9.12632
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 9.06433
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.37939
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.23276
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1 5.14629
[MF] GO:0043169 cation binding ACHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, FDPS, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TRPV1 5.08753
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.06352
[MF] GO:0043167 ion binding ACHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, FDPS, MAOB, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TRPV1 3.90944
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP2A13, CYP3A4 3.70928
[MF] GO:0046872 metal ion binding CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, FDPS, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SLC1A1, TRPV1 3.45903
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, TRPV1 3.45903
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, TRPV1 3.24739
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, TRPV1 3.24739
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP2A13, CYP2A6, CYP3A4 3.20973
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, FDPS, FUT7, MAOB, MMP1, MMP2, MMP9, PDE5A, PIM1, PTPN1 3.13647
[MF] GO:0004872 receptor activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, TRPV1 2.93531
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 2.86819
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, TRPV1 2.80847
[MF] GO:0019825 oxygen binding CYP19A1, CYP1B1, CYP2A13, CYP3A4 2.80847
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.71936
[MF] GO:0008389 None CYP2A13, CYP2A6 2.71936
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, DRD1, DRD2, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, TRPV1 2.54812
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.46897
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.46897
[MF] GO:0020037 heme binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 2.40465
[MF] GO:0099583 None GRM1, GRM5 2.36787
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.33436
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 2.29309
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.16444
[MF] GO:0004971 None GRIA2, GRIA4 2.16444
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 2.13091
[MF] GO:0005506 iron ion binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 2.08646


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.3913
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, DRD1, DRD2, GRM1, GRIA4 10.0975
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 8.0849
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 5.5891
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, DRD1, DRD2, PPARA, GRIA4 5.084
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, GRIA4 3.6682
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 3.5916
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1B1, CYP3A4 3.5458
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5916
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 3.1179
Gap junction_Homo sapiens_hsa04540 GRM5, DRD1, DRD2, GRM1 3.3135
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1B1, CYP3A4 3.3924
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.6236
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.0419
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, CDC25B, MCL1 2.4456
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.5177
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1B1, CYP3A4, CYP19A1 2.6249
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP3A4 2.4873
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 2.0999
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, GRM1 2.1036
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CYP2A6, FUT7, AKR1B10, MAOB, AKR1B1, CYP3A4, CYP19A1 1.6205
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.6276
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.6205
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, DRD1, GRM1 1.6205
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6205
Ovarian steroidogenesis_Homo sapiens_hsa04913 CYP1B1, CYP19A1 1.6805
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6205
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1 1.6205
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.8377
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1B1 1.8377
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.3142
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4 1.7354
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3384
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.2138
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0122
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP3A4 1.5696
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.4431
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8931
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1573
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.5198
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1607
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.0442
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.9825
Pathways in cancer_Homo sapiens_hsa05200 MMP1, MMP2, MMP9 0.9215
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1793
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9759
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9 0.8579
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5794
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 TRPV1 0.5754
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5959
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5754
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5479
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5479
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4923
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MCL1 0.25
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5699
Hepatitis B_Homo sapiens_hsa05161 MMP9 0.4823
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1 0.5003
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4753
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3285
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5794
Influenza A_Homo sapiens_hsa05164 FDPS 0.4312
Rap1 signaling pathway_Homo sapiens_hsa04015 DRD2 0.3842
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5003
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4923
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.3285
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5754
Purine metabolism_Homo sapiens_hsa00230 PDE5A 0.4312
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.4094
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5153
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4284
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6345
Serotonergic synapse_Homo sapiens_hsa04726 MAOB 0.5479
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5754
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5794
Adherens junction_Homo sapiens_hsa04520 PTPN1 0.6345
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6428
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6716
Acute myeloid leukemia_Homo sapiens_hsa05221 PIM1 0.7113
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7501
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.7493
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8345
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.8742
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9169
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP3A4 0.9285
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9574
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.95
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9825
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 1.0011
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0917
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6 1.5319


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)