Prescription Description
| Prescription ID | TCMF1358 |
| Pinyin Name | Wu Mei Wan |
| Chinese Name | 乌梅丸 |
| English Name | Pill of Mume; Mume Pill |
| Function Description | 蛔厥, 脘腹阵痛, 烦闷呕吐, 时发时止, 得食则吐, 甚则吐蛔, 手足厥冷, 或久痢不止, 胃腑发咳, 现用于胆道蛔虫病产后冷热痢 |
| Indications | Enteritis, Dysentery |
| Disease ICD-11 Category |
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎
]; |
| Human Tissues Associated with Indication | Large Intestine, Stomach |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2191 | Prunus mume | 乌梅 | TCMH2191 | ITSAN1052-14 |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH623 | Aconitum carmichaeli | 附子 | TCMH623 | ITSAH2410-14 |
| TCMH761 | Cinnamomum cassia | 桂枝 | TCMH761 | GQ255631 |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH949 | Phellodendron amurense | 黄柏 | TCMH949 | ITSAM1586-14 |
| TCMH1059 | Glycine max | 姜 | TCMH1059 | ITSAJ4675-14 |
| TCMH972 | Coptis chinensis | 黄连 | TCMH972 | ITSAO4469-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH924 | Zanthoxylum bungeanum | 花椒 | TCMH924 | ITSAJ4650-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
Showing 1 to 10 of 99 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
Showing 1 to 10 of 60 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 4.55496 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.17763 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9 | 2.48524 |
| [BP] GO:0001659 | None | ADORA1, ADRB1, DRD1, DRD2 | 3.33069 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC | 2.62204 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.68894 |
| [BP] GO:0001763 | morphogenesis of a branching structure | BCL2, DRD2, ESR1, MET, SRC | 2.05313 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, KDR, MMP9, SRC, XDH | 2.03051 |
| [BP] GO:0001963 | None | DRD1, DRD2, DRD3 | 2.7923 |
| [BP] GO:0001975 | None | CNR2, DRD1, DRD2, DRD3 | 3.56812 |
Showing 1 to 10 of 397 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.397 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R | 5.5105 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5464 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, ADRB1, CACNA1C | 1.4402 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.7587 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.7201 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.5086 |
| Alzheimer's disease_Homo sapiens_hsa05010 | CACNA1C | 0.3603 |
| Amphetamine addiction_Homo sapiens_hsa05031 | CACNA1C, DRD1 | 1.3022 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4412 |
Showing 1 to 10 of 149 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples