Prescription Description
| Prescription ID | TCMF1357 |
| Pinyin Name | Tian Ma Wan |
| Chinese Name | 天麻丸 |
| English Name | Tianma Pills; Gastrodia Tuber Bolus |
| Function Description | 肝疳, 风疳, 疳眼 |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | Liver |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2090 | Gastrodia elata | 天麻 | TCMH2090 | |
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH517 | Angelica pubescens | 独活 | TCMH517 | ITSAF170-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH170 | Dioscorea hypoglauca | 萆薢 | TCMH170 | GBVU109-13, GBVT4961-13 |
| TCMH623 | Aconitum carmichaeli | 附子 | TCMH623 | ITSAH2410-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 112 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 55 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.4368 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.02692 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK | 3.38246 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD3, EGFR, GRIK5, INSR, SLC1A1, SMAD3 | 3.37491 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 2.47206 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.66326 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.82924 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.86554 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR | 2.05059 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.9098 |
Showing 1 to 10 of 317 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3549 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.9626 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.536 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1 | 1.7592 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.7077 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3334 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.2827 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.8925 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6223 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5191 |
Showing 1 to 10 of 148 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples