TCM Prescription: Guogong Wine; Medicated Wine of Guogong



Prescription Description
Prescription IDTCMF1330
Pinyin NameGuo Gong Jiu
Chinese Name国公酒
English NameGuogong Wine; Medicated Wine of Guogong
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
TCMH2551 Polygonatum odoratum 玉竹 TCMH2551 ITSAM921-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1237 Mycobacterium kansasii
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3473
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4493
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.82194
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 7.61194
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, CA1, CSNK2A1, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 7.07337
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, TRPV1 6.60791
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 6.33646
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 6.33646
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, MMP9, PTPN1, SMAD3, SRC, TEK 6.33646
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, MMP9, PTPN1, SMAD3, SRC, TEK 6.32762
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA 6.04844
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.02075
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.02075
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK 5.98447
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK 5.87543
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, EGFR, FABP3, GRM5, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 5.87543
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, FABP3, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TRPV1 5.86892
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.57972
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MCL1, MET, SMAD3, SRC, TRPV1 5.46872
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TRPV1 5.46705
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TRPV1 5.44829
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK 5.37782
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, TRPV1 5.37782
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK 5.37782
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.37782
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1B1, CYP2A13, CYP2A6 5.37782
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.36673
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.35516
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK 5.18595
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.17324
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.13538
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.1161
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 5.08703
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 4.96683
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.9051
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 4.65012
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.61747
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.60022
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, CA1, CA2, CSNK2A1, CYP1B1, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 4.57435
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, CYP1B1, EGFR, GPR35, GRM1, HSPA1A, INSR, KDR, MCL1, MET, PTPN1, SRC, TEK 4.54463
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, CSNK2A1, CYP1B1, DUSP3, EGFR, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PTPN1, SRC, TEK 4.54463
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, CA2, CA9, CYP1A1, CYP1B1, EGFR, FABP4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TRPV1 4.53508
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 4.50818
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, IGF1R, INSR, KDR, PIM1, SRC, TEK 4.50818
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.50818
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, CYP1A1, CYP1B1, EGFR, FABP4, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC, TRPV1 4.46238
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.46238
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, CYP1B1, EGFR, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 4.39459
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, CSNK2A1, CYP1B1, EGFR, GPR35, GRM1, HSPA1A, INSR, KDR, MCL1, MET, MMP9, PTPN1, SMAD3, SRC, TEK 4.36188
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.27238
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.26066
[BP] GO:0042391 None ADORA1, APP, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.22996
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, CYP1A1, CYP1B1, EGFR, FABP4, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, SMAD3, SRC, TRPV1 4.19197
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.1596
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, EGFR, FABP3, INSR, PPARA, SRC, TEK, TRPV1 4.03406
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1B1, CYP2A13, CYP2A6 3.9913
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MCL1, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK 3.88303
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 3.88303
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.87805
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 3.82777
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3, TRPV1 3.76708
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.76708
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.76156
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 3.74748
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, CA2, CYP1A1, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 3.74748
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.7366
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.72677
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.72677
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, APP, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, GRM1, GRM5, GRM8, IGF1R, INSR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1 3.70079
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.6953
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.69308
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.63364
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.59142
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.58658
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, SRC, TRPV1 3.54871
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, CSNK2A1, CYP1B1, EGFR, FABP4, GPR35, GRM1, HSPA1A, INSR, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.52406
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 3.51608
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.51608
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.48206
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 3.44105
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC 3.38207
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK 3.37628
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK 3.37628
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.29967
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.29774
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.28494
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA 3.28494
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.2595
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 3.24294
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK 3.23369
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 3.21372
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK 3.20741
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 3.20234
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.07473
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, GRM1, IGF1R, INSR, KDR, PTPN1, SRC, TEK 3.03133
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, GRM1, IGF1R, INSR, PTPN1, SRC 3.02751
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 3.02304
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 3.02304
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK 3.01267
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.00486
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, SRC, TEK, TRPV1 3.00486
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK 2.99029
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.99029
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP2A6 2.97027
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MCL1, MMP9, PTPN1, SRC 2.9116
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.85389
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MCL1, MET, PPARA, PTPN1, SMAD3 2.8416
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MCL1, MET, PPARA, SMAD3 2.81646
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.77966
[BP] GO:0006468 protein phosphorylation APP, CDC25B, CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.74956
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.73982
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.71815
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.71815
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK 2.71716
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.71716
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, GRM1, INSR, KDR, PTPN1, SRC, TEK 2.69512
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.68831
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.68492
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.68492
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALPL, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 2.67011
[BP] GO:0044057 None ADORA1, ADORA3, EGFR, GPR35, GRM1, HCAR2, SLC1A1, SMAD3, TRPV1 2.66282
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.64009
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1B1, CYP2A13, CYP2A6 2.64009
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.64009
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.60316
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.59475
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.59475
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.59232
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.57962
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK 2.57962
[BP] GO:0051240 positive regulation of multicellular organismal process APP, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 2.57803
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.57339
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.57339
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, SMAD3, SRC, TRPV1 2.55702
[BP] GO:0099566 None GRM1, GRM5 2.54545
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54545
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, CDC25B, CSNK2A1, DUSP3, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK 2.54105
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.53463
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.5282
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, SRC 2.47387
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.47387
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.46692
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 2.35674
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, EGFR, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK 2.35343
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, CA2, CA9, CYP1A1, CYP1B1, EGFR, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.34128
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC 2.33111
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32521
[BP] GO:0061900 None APP, EGFR, TRPV1 2.32521
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, CDC25B, CSNK2A1, DUSP3, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK 2.31989
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.31856
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29305
[BP] GO:0050730 None ADORA1, APP, EGFR, GRM5, PTPN1, SRC 2.25588
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23275
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.23261
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR 2.21328
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP9, PTPN1, SMAD3, SRC 2.20983
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.20133
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MCL1, MET, MMP9, PTPN1, SMAD3, SRC 2.2
[BP] GO:0032844 regulation of homeostatic process ADORA1, CA2, CA7, EGFR, HCAR2, KDR, SRC, TRPV1 2.19938
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.19653
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 2.18829
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, SRC, TRPV1 2.18754
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.1697
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.13911
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.13157
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, INSR, MET, SRC, TEK 2.13057
[BP] GO:0019725 cellular homeostasis APP, CA2, CA7, GPR35, GRIK5, GRM1, GRM5, MCL1, SMAD3, TRPV1 2.13057
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, CSNK2A1, CYP1B1, DUSP3, EGFR, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK 2.12135
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, HCAR2, PPARA, SRC, TEK 2.11509
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, CA2, CYP19A1, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 2.09643
[BP] GO:0007188 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.09179
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.09179
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, CA2, CYP1B1, EGFR, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 2.09179
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK 2.0845
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, EGFR, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK 2.08431
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.07965
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.07965
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.07965
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway HSPA1A, MCL1, MMP9, PTPN1, SRC 2.07965
[BP] GO:0045787 positive regulation of cell cycle APP, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.07965
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, GRM1, IGF1R, INSR, PTPN1, SRC 2.0783
[BP] GO:0016310 phosphorylation APP, CDC25B, CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.07551
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTPN1 2.07423
[BP] GO:1901890 None KDR, SMAD3, TEK 2.07075
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 2.06089
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2 2.05476
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03758
[BP] GO:0007346 regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.03758
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, GRM1, GRM5, INSR, PTPN1, SRC 2.03219
[BP] GO:0042058 None ADORA1, APP, EGFR, MMP9 2.02812
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, GRM1, INSR, PTPN1, SRC 2.02812
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, SRC, TRPV1 2.02812
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HSPA1A, IGF1R, MCL1, MET, MMP9, PTPN1, SRC 2.02307
[BP] GO:0010907 None INSR, PPARA, SRC 2.01196
[BP] GO:0106027 None APP, IGF1R, INSR 2.01196
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 2.0023
[BP] GO:1990535 None APP, INSR 2.0022
[BP] GO:0051234 None ACHE, ADORA1, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, MCL1, MMP9, PPARA, SLC1A1, SRC, TRPV1 2.00193
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.00094
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK 2.00094
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 6.60791
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.37782
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, CA2, CA4, CA9, DUSP3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK, TRPV1 4.46238
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 4.01909
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, CA4, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 3.87805
[CC] GO:0044456 None ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 3.83216
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.66935
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 3.51473
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.48206
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MCL1, MET, PTPN1, SLC1A1, SRC, TEK, TRPV1 3.48206
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALPL, APP, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MCL1, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 3.24294
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.67518
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.56901
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.56901
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.56241
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.54105
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 2.35343
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 2.35343
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.13057
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.10616
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0022
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.9361
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4623
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2506
[MF] GO:0046914 transition metal ion binding APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3 9.62098
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.5692
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.63424
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 5.44829
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1, SMAD3 5.37782
[MF] GO:0043167 ion binding ACHE, ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.37782
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 5.37782
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 5.37782
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 5.25542
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 5.20797
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.96683
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK, TRPV1 4.91298
[MF] GO:0004872 receptor activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 4.85129
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, EGFR, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK, TRPV1 4.64722
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.46238
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13 3.85003
[MF] GO:0004713 protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.6953
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 3.66935
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, SRC 3.44105
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.43295
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.29769
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, SRC 3.28494
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.20041
[MF] GO:0043169 cation binding ACHE, ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TRPV1 3.16389
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 2.9116
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90667
[MF] GO:0046872 metal ion binding ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TRPV1 2.89286
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP2A13 2.89286
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.7914
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.69789
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.67689
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.67496
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.57962
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.57962
[MF] GO:0099583 None GRM1, GRM5 2.54545
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.38737
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.38345
[MF] GO:0004971 None GRIA2, GRIA4 2.29305
[MF] GO:0051425 None APP, INSR 2.29305
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.18829
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.13213
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11509
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 2.10037
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.07075
[MF] GO:0005506 iron ion binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 2.06564
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR 2.03758
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.02812
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0022


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.4725
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.6908
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, GRM1, GRIA4 7.9311
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.4665
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.5581
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.1944
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 5.1764
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.5774
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.5167
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 4.3756
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.0174
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B, MCL1 3.67
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.4138
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, MCL1, IGF1R 3.412
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.4257
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.0952
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A1, CYP1B1 3.3717
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4138
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.9147
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 3.1026
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, PPARA, GRIA4 2.8483
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.8365
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A1, CYP1B1 3.1987
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.902
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.5399
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.4191
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4853
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.9329
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.332
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.3952
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0488
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3722
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP19A1 2.5122
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8665
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7185
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5791
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4409
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.4089
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9, MET, IGF1R 1.4089
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4167
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 1.0776
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.201
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2116
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4089
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.1603
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1721
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1603
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.171
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, AKR1B10, CYP1A1, ALPL, AKR1B1, CYP19A1 0.9638
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4347
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4088
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1996
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.4088
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2923
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0276
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.015
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0341
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9638
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MET, EGFR 1.4088
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9905
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9735
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.015
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A1 1.4089
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9638
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9179
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.959
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.959
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9638
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.9076
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.9076
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5701
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7508
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7183
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2863
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7185
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3546
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3994
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3786
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.371
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.7185
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3883
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3907
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3994
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3783
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.427
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4549
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4671
Platelet activation_Homo sapiens_hsa04611 SRC 0.4913
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5117
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4913
Axon guidance_Homo sapiens_hsa04360 MET 0.4831
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4995
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5117
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5358
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5286
Toxoplasmosis_Homo sapiens_hsa05145 HSPA1A 0.4995
Serotonergic synapse_Homo sapiens_hsa04726 APP 0.5117
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5358
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8979
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5479
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5566
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5476
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5724
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5522
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5578
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5717
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5574
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5571
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6101
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6114
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6089
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.614
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5974
Bile secretion_Homo sapiens_hsa04976 CA2 0.6126
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7775
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6286
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6 0.6153
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6302
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6356
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6302
Shigellosis_Homo sapiens_hsa05131 SRC 0.6302
Acute myeloid leukemia_Homo sapiens_hsa05221 PIM1 0.6647
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8665
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6672
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6878
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6698
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6908
Malaria_Homo sapiens_hsa05144 MET 0.7022
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7058
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0889
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6 0.7183
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7708
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8102
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8554
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9076
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9076
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9076
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0776
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6 1.4089


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)