Prescription Description
| Prescription ID | TCMF1328 |
| Pinyin Name | Shen Kang Ning Pian |
| Chinese Name | 肾康宁片 |
| English Name | Tablet for Chronic Nephritis |
| Function Description | 腰酸, 疲乏, 畏寒及夜尿增多 |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | Bladder, Kidney |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH2473 | Leonurus japonicus | 益母草 | TCMH2473 | ITSAN1807-14 |
| TCMH623 | Aconitum carmichaeli | 附子 | TCMH623 | ITSAH2410-14 |
| TCMH2056 | Cynomorium songaricum | 锁阳 | TCMH2056 | ITSAO3649-14 |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
Showing 1 to 10 of 101 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1207 | Legionella pneumophila |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
Showing 1 to 10 of 46 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.66413 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC | 2.19909 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A3, SLC6A4 | 4.24693 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3, SLC6A4 | 5.20604 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT | 4.31405 |
| [BP] GO:0001763 | morphogenesis of a branching structure | BCL2, DRD2, ESR1, MET, SRC | 2.07576 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PTPN1, SRC, XDH | 2.98401 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH | 3.4728 |
| [BP] GO:0001975 | None | DRD2, DRD3, DRD4 | 2.27074 |
| [BP] GO:0002791 | None | ACHE, ADORA1, ADRA2A, DRD2, DRD3, DRD4, MMP12, SRC | 2.10609 |
Showing 1 to 10 of 441 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3597 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.1396 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.528 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3754 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1 | 1.7678 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2, SLC6A3 | 0.7104 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, SLC6A3, GRIA4 | 2.1689 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.412 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.4238 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3874 |
Showing 1 to 10 of 139 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples