TCM Prescription: Qiju Dihuang Pills; Lycium Chrysanthemum Rehmannia Pill



Prescription Description
Prescription IDTCMF1325
Pinyin NameQi Ju Di Huang Wan
Chinese Name杞菊地黄丸
English NameQiju Dihuang Pills; Lycium Chrysanthemum Rehmannia Pill
Function Description肝肾阴亏, 眩晕耳鸣, 羞明畏光, 迎风流泪, 视物昏花
IndicationsTinnitus disorder, Vertigo disorder
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
Human Tissues Associated with IndicationBrain, Liver
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 10.6331
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 9.76632
[BP] GO:0007188 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 7.81728
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.48649
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.48649
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.43033
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.43033
[BP] GO:0007187 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 7.36294
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 7.05682
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.75918
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75918
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.41232
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.39595
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.30111
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.30111
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, FABP3, GRIK5, GRM5, HMGCR, IGF1R, MMP2, MMP9, RORC, SLC6A3, SRC 6.22385
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.89889
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.82522
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, KDR, SLC6A2, SLC6A3, SRC 5.80062
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, RORC, SLC6A3, SRC 5.71858
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 5.60393
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.56509
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.56509
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 5.32404
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, MMP9, RORC, SLC6A2, SLC6A3, SRC 5.26207
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1 5.18038
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.18038
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.88067
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.76318
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SLC6A2, SLC6A3, SRC, TNKS2 4.65655
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, CDK6, DRD2, DRD3, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 4.61177
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, MET 4.55069
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.50149
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.48232
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.37767
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, RORC, SLC6A3, SRC 4.36323
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1 4.29106
[BP] GO:0007267 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.27047
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APEX1, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC 4.22693
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 4.2241
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 4.20543
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.17826
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 4.17103
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, SLC1A1, SLC6A2, SLC6A3 4.15922
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 4.11672
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 4.11104
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1 4.1056
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.07931
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.06352
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.02955
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.02955
[BP] GO:0032502 developmental process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, KDR, MET, MMP2, MMP9, PHF8, PIM1, RORC, SLC6A3, SRC, TNKS2, TOP2A 4.01427
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.99924
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 3.99448
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.91546
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM5 3.9014
[BP] GO:0023052 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.86087
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.84513
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HMGCR, PIM1, XDH 3.82478
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.81331
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.81331
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.7732
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 3.73398
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2, TNKS, TNKS2 3.66021
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.65022
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.65022
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2 3.63345
[BP] GO:0007154 None AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.62817
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, SLC6A3 3.56436
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.52058
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, CDK6, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, F10, IGF1R, KDR, MET, MMP9, SRC 3.52058
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 3.50425
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, PHF8, XDH 3.49992
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.49103
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, GRM1, GRM3, GRM5, GRM8 3.47635
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.45843
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.41377
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.41377
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.41377
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 3.40096
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.37306
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.27506
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1 3.25917
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.24637
[BP] GO:0019220 regulation of phosphate metabolic process CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.23291
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.23075
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.20638
[BP] GO:0019216 regulation of lipid metabolic process CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, RORC, SRC 3.20638
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, MET 3.20638
[BP] GO:0051174 regulation of phosphorus metabolic process CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.19804
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.17656
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8 3.15862
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD2, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 3.15857
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.15857
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.15857
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15857
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.14712
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8 3.14712
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.12795
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TOP2A 3.11012
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.10504
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, RORC, SRC, TOP2A 3.1004
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.0482
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.03514
[BP] GO:0060078 None DRD4, GRIA2, GRIA4, GRIK5, GRM5 3.03514
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1 3.03514
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.02627
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.02564
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.01865
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.003
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.99201
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, MET, SRC, XDH 2.99201
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.98086
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 2.96626
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 2.96626
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HMGCR, HSD11B1, HSD17B1 2.96573
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, SLC6A3, SRC 2.93363
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, SLC1A1, SLC6A3, XDH 2.9186
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, F10, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.90137
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.87088
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 2.86958
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 2.83052
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.82495
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.77719
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.72007
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.71233
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.69543
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A3 2.69351
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 2.68814
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, SLC6A3, SRC 2.63416
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.62609
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.62417
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.61623
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.61186
[BP] GO:0042752 None DRD2, DRD3, DRD4, RORC, TOP2A 2.61186
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 2.57658
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, APEX1, AURKB, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.55972
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.55126
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.55126
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.50134
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.50134
[BP] GO:0006810 None ACHE, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.50134
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.49514
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 2.48777
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, RORC, SRC 2.48063
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PTPN1, XDH 2.47484
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PTPN1, XDH 2.47078
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.46526
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.46526
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.45777
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.45777
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.45777
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.45777
[BP] GO:0099566 None GRM1, GRM5 2.45777
[BP] GO:0051944 None DRD2, DRD4 2.45777
[BP] GO:0060160 None DRD2, DRD3 2.45777
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45777
[BP] GO:0051586 None DRD2, DRD4 2.45777
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.45777
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.41879
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.39173
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.39056
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.36069
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A3, SRC 2.36069
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.36069
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.34063
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.34063
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A3 2.33809
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.33809
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC 2.33627
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.33627
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.31115
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31115
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.30077
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.29075
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.29075
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.29075
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.29075
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.28575
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.28575
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.26956
[BP] GO:0051234 None ACHE, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.26352
[BP] GO:0051179 None ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.26198
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.25567
[BP] GO:0050878 regulation of body fluid levels AKR1B1, CHRM1, CHRM3, DRD2, F10, MET, SLC6A3, XDH 2.2525
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.25206
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.25206
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25206
[BP] GO:0044057 None ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 2.25153
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TNKS2, XDH 2.23891
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23847
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.23847
[BP] GO:0070213 None TNKS, TNKS2 2.23847
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.23847
[BP] GO:0051582 None DRD2, DRD4 2.23847
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23847
[BP] GO:0045859 regulation of protein kinase activity CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.23553
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.23214
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1 2.23144
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, PIM1, SRC 2.23124
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.23124
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.23124
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.23124
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.22694
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22694
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD2, DRD3, KDR, SRC 2.20868
[BP] GO:0001934 positive regulation of protein phosphorylation CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.20442
[BP] GO:0010562 positive regulation of phosphorus metabolic process CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.20439
[BP] GO:0045937 positive regulation of phosphate metabolic process CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.20439
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.20232
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.19736
[BP] GO:0040014 regulation of multicellular organism growth DRD2, DRD3, SLC6A3, TNKS2 2.19736
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3 2.19736
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.1927
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.17526
[BP] GO:0090087 None ACHE, CA2, CHRM1, DRD2, DRD3, DRD4, HCAR2, HMGCR, MMP12, PTPN1, SRC 2.15814
[BP] GO:0080090 regulation of primary metabolic process ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.15098
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.14692
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14692
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.14692
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.14692
[BP] GO:0050708 None ACHE, DRD2, DRD3, DRD4, HCAR2, HMGCR, MMP12, SRC 2.14147
[BP] GO:0007589 None CHRM1, CHRM3, SLC6A3, XDH 2.13973
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, HMGCR, MMP12, SRC 2.12062
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC, TNKS 2.10733
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.10733
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 2.10496
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.10087
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, SRC 2.08486
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.0819
[BP] GO:0046541 None CHRM1, CHRM3 2.0814
[BP] GO:0090325 None DRD2, DRD3 2.0814
[BP] GO:0042327 positive regulation of phosphorylation CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.06869
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, CDC25B, DRD2, DRD3, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.05191
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.05045
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.04897
[BP] GO:0051049 regulation of transport ACHE, AXL, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HMGCR, MMP12, MMP9, PTPN1, SRC 2.04897
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.0373
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.0373
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.0373
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.03456
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.03456
[BP] GO:0043549 regulation of kinase activity CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.03456
[BP] GO:0032845 None DRD2, HMGCR, SRC, TNKS, TNKS2 2.03456
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.0023
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 6.57995
[CC] GO:0044456 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 6.10352
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.7388
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.70531
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 5.62736
[CC] GO:0005886 plasma membrane ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, F10, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 5.56693
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 5.25489
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP2, PHF8, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2 4.43994
[CC] GO:0043005 None CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 4.00934
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.85343
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.40096
[CC] GO:0042995 cell projection AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.30494
[CC] GO:0014069 None CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.12795
[CC] GO:0099572 None CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.12795
[CC] GO:0120025 None AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.04372
[CC] GO:0044425 membrane part ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, IGF1R, KDR, MET, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 2.61186
[CC] GO:0098793 None CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 2.60176
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.43406
[CC] GO:0097458 None CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC 2.26702
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.13973
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1 2.01137
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 10.6331
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.76632
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, TNKS, XDH 7.92212
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.92212
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 7.56896
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 7.48649
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.69001
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, RORC 6.37151
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.32196
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.32196
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.30111
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.26477
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, RORC 6.04901
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, RORC 5.62736
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, SLC6A3, SRC, TOP2A 5.56509
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, XDH 5.5049
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.25489
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, RORC 4.97724
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PTPN1, RORC, TNKS 4.55353
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.50149
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, PHF8, XDH 4.34806
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 4.24055
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.01427
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, XDH 3.99448
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.85921
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.65022
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 3.59963
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.52798
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.47442
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.41377
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.40096
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, XDH 3.25917
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1 3.25917
[MF] GO:0004930 None ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 3.03016
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.99686
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.96626
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.96269
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.69543
[MF] GO:0005330 None SLC6A2, SLC6A3 2.45777
[MF] GO:0099583 None GRM1, GRM5 2.45777
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.45204
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.45204
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.45204
[MF] GO:0004971 None GRIA2, GRIA4 2.23847
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.23214
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.21038
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.10733
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.09584
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SLC6A3, SRC 2.07407
[MF] GO:0051721 None HMGCR, PTPN1, SLC6A3 2.07231
[MF] GO:0004629 None CHRM1, CHRM3, CHRM5 2.0023


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, DRD2, DRD3, DRD4, GRIA4 11.7747
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4224
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7844
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.3263
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0261
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.1328
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1328
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1328
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.4837
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.512
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9638
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8864
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3171
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, DRD2, GRIA4 3.3353
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.6158
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.6718
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.6718
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.8052
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6676
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, CDC25B 2.5864
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CBR1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1B1, HMGCR, CYP19A1, XDH 2.4458
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4458
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, MET, IGF1R 2.3451
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.4364
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6718
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2168
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3059
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.2127
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2168
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1681
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9462
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7924
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.19
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4639
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.403
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0393
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2677
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.291
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3265
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.908
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0575
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.014
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1225
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1979
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0302
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0393
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2521
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3084
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.164
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.249
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8844
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2677
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0388
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.2874
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8348
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.908
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8447
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8844
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2228
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8153
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8248
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6891
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6112
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2427
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3075
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3336
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3181
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3247
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5897
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3334
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3617
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3247
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.347
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3617
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3904
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3905
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3904
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4424
Platelet activation_Homo sapiens_hsa04611 SRC 0.4256
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4424
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3 0.4268
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4289
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4256
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4876
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4583
Axon guidance_Homo sapiens_hsa04360 MET 0.4181
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4289
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4399
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4876
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4876
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4725
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4876
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4876
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4799
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4876
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4799
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4876
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4799
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5131
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4876
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4876
Peroxisome_Homo sapiens_hsa04146 XDH 0.4876
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5137
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4877
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4876
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5327
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5327
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5327
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7924
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5253
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5253
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5327
Shigellosis_Homo sapiens_hsa05131 SRC 0.5327
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5715
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5715
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6676
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5979
Malaria_Homo sapiens_hsa05144 MET 0.6085
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.756
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6227
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9905
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6737
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7605
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7406
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.776
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8091
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.768
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7994
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8462
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0625


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)