Prescription Description
| Prescription ID | TCMF1325 |
| Pinyin Name | Qi Ju Di Huang Wan |
| Chinese Name | 杞菊地黄丸 |
| English Name | Qiju Dihuang Pills; Lycium Chrysanthemum Rehmannia Pill |
| Function Description | 肝肾阴亏, 眩晕耳鸣, 羞明畏光, 迎风流泪, 视物昏花 |
| Indications | Tinnitus disorder, Vertigo disorder |
| Disease ICD-11 Category |
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; |
| Human Tissues Associated with Indication | Brain, Liver |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH1181 | Chrysanthemum morifolium | 菊花 | TCMH1181 | KX675020 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH1862 | Cornus officinalis | 山茱萸 | TCMH1862 | ITSAO2979-14 |
| TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 | |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 99 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1207 | Legionella pneumophila |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 55 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.50134 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A3 | 2.55126 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 | 4.20543 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH | 2.20442 |
| [BP] GO:0001975 | None | DRD2, DRD3, DRD4 | 2.14692 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 2.23214 |
| [BP] GO:0006584 | None | AKR1B1, DRD2, DRD3, DRD4, SLC6A3 | 4.02955 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, MET | 4.55069 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.50134 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1 | 2.23144 |
Showing 1 to 10 of 317 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3265 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.1328 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.014 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2, SLC6A3 | 0.6891 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, SLC6A3, GRIA4 | 2.2127 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | HMGCR, IGF1R | 0.8844 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.5979 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5 | 1.2874 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4181 |
| Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.164 |
Showing 1 to 10 of 130 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples