Prescription Description
| Prescription ID | TCMF1157 |
| Pinyin Name | Yao Tong Wan |
| Chinese Name | 腰痛丸 |
| English Name | Yao Tong Pills |
| Function Description | 腰痛 |
| Indications | Lumbago disorder |
| Disease ICD-11 Category |
SC61 [Lumbago disorder (TM1), 腰痛 (TM1)
]; |
| Human Tissues Associated with Indication | Kidney |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH526 | Eucommia ulmoides | 杜仲叶 | TCMH526 | ITSAM1588-14 |
| TCMH693 | Cudrania cochinchinensis | 狗脊 | TCMH693 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH1753 | Boswellia carterii | 乳香 | TCMH1753 | |
| TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
| TCMH2334 | Dipsacus japonicus | 续断 | TCMH2334 | ITSAC1509-14 |
| TCMH258 | Paeonia obovata | 赤芍 | TCMH258 | GBVX7902-15 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH1742 | Cinnamomum cassia | 肉桂 | TCMH1742 | GQ255631 |
| TCMH2129 | Eupolyphaga sinensis | 土鳖虫 | TCMH2129 | GBMIN33972-13 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 118 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
Showing 1 to 10 of 61 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.23556 |
| [BP] GO:0000904 | cell morphogenesis involved in differentiation | AR, AXL, MET, SRC, TEK | 2.45923 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC | 2.51931 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 4.25886 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, SLC1A1, SMAD3 | 3.98717 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 3.09209 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.51336 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, RORC, SMAD3, SRC | 2.20522 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.29911 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.55842 |
Showing 1 to 10 of 402 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3164 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.8035 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5133 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3402 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1 | 2.4938 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR, NR3C2 | 1.5417 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.2419 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, PPARG, IGF1R | 1.4897 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.38 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1, HSPA1A | 1.9311 |
Showing 1 to 10 of 154 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples