Prescription Description
| Prescription ID | TCMF1047 |
| Pinyin Name | Shu Dan Jiao Nang |
| Chinese Name | 舒胆胶囊 |
| English Name | Shu Dan Capsule |
| Function Description | 胁痛 |
| Indications | Hypochondrium pain disorder, Cholecystitis |
| Disease ICD-11 Category |
SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1)
]; DC12 [Cholecystitis, 胆囊炎 ]; |
| Human Tissues Associated with Indication | Liver, Gallbladder |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
| TCMH2630 | Citrus aurantium | 枳实 | TCMH2630 | ITSAA1279-14 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH2494 | Artemisia capillaris | 茵陈蒿 | TCMH2494 | ITSAN1371-14 |
| TCMH1114 | Herba glechomae longitubae | 金钱草 | TCMH1114 | |
| TCMH228 | Bupleurum chinense | 柴胡 | TCMH228 | ITSAM2218-14 |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 | |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH189 | Mentholum | 薄荷脑 | TCMH189 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 123 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
Showing 1 to 10 of 74 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC | 3.09201 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, AKR1C3, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 3.07358 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.16864 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, PTGS2 | 2.20321 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 3.16146 |
| [BP] GO:0001662 | None | BCL2, DRD1, HTR1A, HTR2C | 3.19853 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT | 4.57246 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 | 8.1328 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, APP, BCL2, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 4.29236 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, APP, BCL2, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 4.72612 |
Showing 1 to 10 of 544 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6639 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, KIT, PIM1, PIK3CB | 4.4156 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 2.8781 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5315 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB, ADRA1A | 1.9485 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 4.4145 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6639 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB | 2.6139 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6834 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9935 |
Showing 1 to 10 of 159 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples