Prescription Description
| Prescription ID | TCMF1046 |
| Pinyin Name | Shu Gan Ping Wei Wan |
| Chinese Name | 舒肝平胃丸 |
| English Name | Shu Gan Ping Wei Pills |
| Function Description | 积滞, 胃脘痛 |
| Indications | Stomach ache disorder, Dyspepsia |
| Disease ICD-11 Category |
SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1)
]; MD92 [Dyspepsia, 消化不良 ]; |
| Human Tissues Associated with Indication | Intestine, Stomach, Spleen |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH890 | Cortex magnoliae officinalis | 厚朴 | TCMH890 | ITSAM1591-14 |
| TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
| TCMH211 | Atractylodes lancea | 苍术 | TCMH211 | ITSAN4439-14 |
| TCMH1072 | Semen arecae preparata | 焦槟榔 | TCMH1072 | ITSAA732-14 |
| TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 | |
| TCMH552 | Rhizoma pinelliae preparata | 法半夏 | TCMH552 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 88 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
Showing 1 to 10 of 72 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC | 2.32278 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC | 2.03033 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.16118 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 3.03548 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 | 7.92964 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 | 2.32278 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 | 2.51374 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.23592 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.78066 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.85705 |
Showing 1 to 10 of 194 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3456 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.165 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5804 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.4259 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | BCL2, PIM1, F3 | 1.7397 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7231 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4634 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6574 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.4382 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, TBXAS1 | 1.3108 |
Showing 1 to 10 of 132 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples