Prescription Description
| Prescription ID | TCMF100 |
| Pinyin Name | Niu Huang Qing Gong Wan |
| Chinese Name | 牛黄清宫丸 |
| English Name | Niu Huang Qing Gong Pills |
| Function Description | 痛眩晕, 惊悸不安及小儿急热惊风 |
| Indications | Inducible palpitation disorder, Vertigo disorder, Convulsions |
| Disease ICD-11 Category |
SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; 8A68.Z [Type of seizure, unspecified, 癫痫发作类型，未特指的 ]; |
| Human Tissues Associated with Indication | Heart, Brain |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1716 | Calculus bovis artificiosus | 人工牛黄 | TCMH1716 | |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH1276 | Nelumbo nucifera | 莲子心 | TCMH1276 | ITSAI3109-14 |
| TCMH2086 | Trichosanthes kirilowii | 天花粉 | TCMH2086 | ITSAO4359-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH1272 | Forsythia suspensa | 连翘 | TCMH1272 | ITSAJ4444-14 |
| TCMH2532 | Curcuma aromatica | 郁金 | TCMH2532 | ITSAF2298-14 |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
| TCMH2329 | Realgar | 雄黄 | TCMH2329 | |
| TCMH1999 | Bubalus bubalis | 水牛角浓缩粉 | TCMH1999 | GBMA0080-06 |
| TCMH2682 | Cinnabaris | 朱砂 | TCMH2682 | |
| TCMH183 | Dryobalanops aromatica | 冰片 | TCMH183 | GBVK4926-11 |
| TCMH1127 | Lonicera japonica | 金银花 | TCMH1127 | ITSAI3881-14 |
| TCMH1717 | Moschus moschiferus | 人工麝香 | TCMH1717 | GBMA2112-09 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
Showing 1 to 10 of 161 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1177 | Haemophilus influenzae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1186 | Plasmodium yoelii yoelii |
Showing 1 to 10 of 94 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000122 | None | AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, MMP12, NR1H4, NR3C1, PPARA, RELA, RORC, THRA, THRB | 2.26864 |
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC | 3.38515 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTGES, PTGS2, RELA, SRC | 3.80257 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9, THRA | 2.65689 |
| [BP] GO:0001516 | None | PTGES, PTGS1, PTGS2 | 2.63942 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT | 3.8019 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 | 4.998 |
| [BP] GO:0001817 | regulation of cytokine production | ADRA2A, AXL, CYP1B1, DRD2, HTR2B, MAP3K7, MMP12, NR1H4, PTGS2, PTPRS, RELA, SRC | 2.14122 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FABP4, FLT3, GPER1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.51105 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GPER1, HMGCR, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 8.50448 |
Showing 1 to 10 of 610 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.584 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA | 6.3262 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R | 4.6574 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA, RELA | 1.0774 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, CACNA1C, PIK3CB | 1.7503 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA | 4.9108 |
| Alcoholism_Homo sapiens_hsa05034 | MAP2K1, MAOA, DRD2 | 0.9694 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.4052 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB, NR3C2 | 3.6112 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP, CACNA1C | 1.0278 |
Showing 1 to 10 of 190 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples