Natural Product: NPC474104

Natural Product ID:  NPC474104
Common Name:   Kazinol T
IUPAC Name:   4-[3-[7-hydroxy-2-(2-hydroxypropan-2-yl)-4-(3-methylbut-2-enyl)-2,3-dihydro-1-benzofuran-5-yl]propyl]-6-(2-methylbut-3-en-2-yl)benzene-1,3-diol
Synonyms:   kazinol T
Molecular Formula:   C30H40O5
Standard InCHIKey:  PGDXKQIJKHBXCK-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C30H40O5/c1-8-29(4,5)23-14-20(24(31)17-25(23)32)11-9-10-19-15-26(33)28-22(21(19)13-12-18(2)3)16-27(35-28)30(6,7)34/h8,12,14-15,17,27,31-34H,1,9-11,13,16H2,2-7H3
Canonical SMILES:  C=CC(c1cc(CCCc2cc(O)c3c(c2CC=C(C)C)CC(O3)C(O)(C)C)c(cc1O)O)(C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO16111 Broussonetia kazinoki Species Moraceae Eukaryota PMID[19046886]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 > 200000 nM 20573514
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 = 103100 nM Open TG-GATES in vivo data: Organ Weight

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC474104 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9489 High Similarity NPC234568
0.9489 High Similarity NPC198038
0.9366 High Similarity NPC473876
0.9281 High Similarity NPC87725
0.9281 High Similarity NPC263261
0.922 High Similarity NPC473845
0.922 High Similarity NPC50250
0.9143 High Similarity NPC35216
0.9137 High Similarity NPC32630
0.911 High Similarity NPC160196
0.9103 High Similarity NPC195561
0.9091 High Similarity NPC260397
0.9091 High Similarity NPC233980
0.9085 High Similarity NPC280092
0.9085 High Similarity NPC45257
0.9085 High Similarity NPC63879
0.9085 High Similarity NPC12641
0.9085 High Similarity NPC93323
0.9085 High Similarity NPC473108
0.9071 High Similarity NPC184797
0.9071 High Similarity NPC160283
0.9071 High Similarity NPC309124
0.9071 High Similarity NPC254759
0.9065 High Similarity NPC477938
0.9051 High Similarity NPC475840
0.9044 High Similarity NPC15543
0.9041 High Similarity NPC2745
0.9028 High Similarity NPC474397
0.9028 High Similarity NPC21776
0.9028 High Similarity NPC16269
0.9021 High Similarity NPC221318
0.9014 High Similarity NPC258083
0.9014 High Similarity NPC102044
0.9014 High Similarity NPC47633
0.9014 High Similarity NPC85264
0.9007 High Similarity NPC265075
0.9 High Similarity NPC236306
0.9 High Similarity NPC70682
0.9 High Similarity NPC260741
0.9 High Similarity NPC292882
0.9 High Similarity NPC232164
0.9 High Similarity NPC473739
0.8993 High Similarity NPC177160
0.8993 High Similarity NPC10737
0.8993 High Similarity NPC227503
0.8993 High Similarity NPC263367
0.8993 High Similarity NPC29799
0.8993 High Similarity NPC474639
0.8993 High Similarity NPC209985
0.8993 High Similarity NPC230734
0.8993 High Similarity NPC54743
0.8993 High Similarity NPC477939
0.8993 High Similarity NPC156502
0.8993 High Similarity NPC234952
0.8986 High Similarity NPC49603
0.8986 High Similarity NPC187616
0.8986 High Similarity NPC80918
0.8986 High Similarity NPC193026
0.8986 High Similarity NPC188578
0.898 High Similarity NPC157783
0.8973 High Similarity NPC158784
0.8971 High Similarity NPC126836
0.8966 High Similarity NPC212142
0.8951 High Similarity NPC469795
0.8944 High Similarity NPC107161
0.8944 High Similarity NPC204347
0.8944 High Similarity NPC2613
0.8944 High Similarity NPC41782
0.8944 High Similarity NPC59841
0.8944 High Similarity NPC475891
0.8921 High Similarity NPC151224
0.8921 High Similarity NPC256262
0.8921 High Similarity NPC112246
0.8921 High Similarity NPC470356
0.8921 High Similarity NPC474206
0.8921 High Similarity NPC112939
0.8921 High Similarity NPC473413
0.8921 High Similarity NPC94750
0.8921 High Similarity NPC121812
0.8921 High Similarity NPC134968
0.8913 High Similarity NPC158331
0.8912 High Similarity NPC302915
0.8905 High Similarity NPC469907
0.8897 High Similarity NPC212015
0.8897 High Similarity NPC101376
0.8889 High Similarity NPC252131
0.8889 High Similarity NPC469557
0.8889 High Similarity NPC181615
0.8881 High Similarity NPC81638
0.8881 High Similarity NPC477616
0.8873 High Similarity NPC247291
0.8873 High Similarity NPC311530
0.8865 High Similarity NPC471183
0.8857 High Similarity NPC162659
0.8857 High Similarity NPC472334
0.8857 High Similarity NPC248727
0.8857 High Similarity NPC302701
0.8857 High Similarity NPC16435
0.8857 High Similarity NPC126101
0.8857 High Similarity NPC470802
0.8857 High Similarity NPC472336
0.8857 High Similarity NPC269091
0.8857 High Similarity NPC306441
0.8857 High Similarity NPC270456
0.8857 High Similarity NPC265433
0.8851 High Similarity NPC325860
0.8849 High Similarity NPC317380
0.8849 High Similarity NPC117048
0.8849 High Similarity NPC287745
0.8849 High Similarity NPC124085
0.8841 High Similarity NPC470752
0.8841 High Similarity NPC175067
0.8841 High Similarity NPC204215
0.8836 High Similarity NPC473408
0.8832 High Similarity NPC472338
0.8828 High Similarity NPC324492
0.8828 High Similarity NPC317053
0.8828 High Similarity NPC211758
0.8828 High Similarity NPC87794
0.8824 High Similarity NPC28765
0.8803 High Similarity NPC27495
0.8803 High Similarity NPC259519
0.8803 High Similarity NPC109240
0.8794 High Similarity NPC176051
0.8794 High Similarity NPC103976
0.8794 High Similarity NPC474282
0.8794 High Similarity NPC326797
0.8794 High Similarity NPC107551
0.8794 High Similarity NPC56329
0.8794 High Similarity NPC35550
0.8794 High Similarity NPC211549
0.8794 High Similarity NPC242715
0.8794 High Similarity NPC102904
0.8786 High Similarity NPC234333
0.8786 High Similarity NPC158142
0.8786 High Similarity NPC164787
0.8786 High Similarity NPC47398
0.8786 High Similarity NPC241241
0.8786 High Similarity NPC10314
0.8786 High Similarity NPC200557
0.8786 High Similarity NPC472337
0.8786 High Similarity NPC294884
0.8786 High Similarity NPC61946
0.8786 High Similarity NPC313081
0.8786 High Similarity NPC69029
0.8786 High Similarity NPC260898
0.8786 High Similarity NPC126409
0.8786 High Similarity NPC108198
0.8786 High Similarity NPC99572
0.8777 High Similarity NPC474453
0.8777 High Similarity NPC229442
0.8777 High Similarity NPC168059
0.8777 High Similarity NPC32778
0.8777 High Similarity NPC11060
0.8777 High Similarity NPC26394
0.8777 High Similarity NPC85435
0.8768 High Similarity NPC309787
0.8768 High Similarity NPC472597
0.8767 High Similarity NPC328567
0.8767 High Similarity NPC320671
0.8767 High Similarity NPC327412
0.8767 High Similarity NPC320970
0.8759 High Similarity NPC90645
0.8759 High Similarity NPC180953
0.875 High Similarity NPC163508
0.875 High Similarity NPC82679
0.875 High Similarity NPC124452
0.875 High Similarity NPC469630
0.875 High Similarity NPC324112
0.875 High Similarity NPC293054
0.875 High Similarity NPC169474
0.875 High Similarity NPC236791
0.875 High Similarity NPC210355
0.875 High Similarity NPC282000
0.875 High Similarity NPC470699
0.875 High Similarity NPC246620
0.875 High Similarity NPC74817
0.875 High Similarity NPC173203
0.875 High Similarity NPC159968
0.8741 High Similarity NPC471389
0.8741 High Similarity NPC71046
0.8741 High Similarity NPC471414
0.8733 High Similarity NPC157333
0.8732 High Similarity NPC319647
0.8732 High Similarity NPC245207
0.8732 High Similarity NPC184613
0.8732 High Similarity NPC19869
0.8732 High Similarity NPC127218
0.8732 High Similarity NPC220344
0.8732 High Similarity NPC25966
0.8732 High Similarity NPC243996
0.8732 High Similarity NPC275061
0.8732 High Similarity NPC132804
0.8723 High Similarity NPC327735
0.8723 High Similarity NPC202846
0.8723 High Similarity NPC133025
0.8723 High Similarity NPC3049
0.8723 High Similarity NPC262585
0.8723 High Similarity NPC20829
0.8723 High Similarity NPC143139

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC474104 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8623 High Similarity NPD3027 Phase 3
0.8571 High Similarity NPD1612 Clinical (unspecified phase)
0.8571 High Similarity NPD1613 Approved
0.8417 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.8345 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.8227 Intermediate Similarity NPD4625 Phase 3
0.8169 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.8056 Intermediate Similarity NPD3620 Phase 2
0.8056 Intermediate Similarity NPD4060 Phase 1
0.8056 Intermediate Similarity NPD3619 Clinical (unspecified phase)
0.8042 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.8028 Intermediate Similarity NPD4908 Phase 1
0.7925 Intermediate Similarity NPD6234 Discontinued
0.7914 Intermediate Similarity NPD1610 Phase 2
0.7898 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.7872 Intermediate Similarity NPD6696 Suspended
0.7834 Intermediate Similarity NPD1934 Approved
0.7799 Intermediate Similarity NPD3882 Suspended
0.7762 Intermediate Similarity NPD6917 Clinical (unspecified phase)
0.7755 Intermediate Similarity NPD5735 Approved
0.7754 Intermediate Similarity NPD1548 Phase 1
0.7748 Intermediate Similarity NPD6674 Discontinued
0.7748 Intermediate Similarity NPD5698 Clinical (unspecified phase)
0.7746 Intermediate Similarity NPD8651 Approved
0.7722 Intermediate Similarity NPD37 Approved
0.7716 Intermediate Similarity NPD7199 Phase 2
0.7708 Intermediate Similarity NPD2861 Phase 2
0.7708 Intermediate Similarity NPD3018 Phase 2
0.7697 Intermediate Similarity NPD7228 Approved
0.7688 Intermediate Similarity NPD4965 Approved
0.7688 Intermediate Similarity NPD4967 Phase 2
0.7688 Intermediate Similarity NPD4966 Approved
0.7676 Intermediate Similarity NPD4749 Approved
0.7676 Intermediate Similarity NPD3600 Clinical (unspecified phase)
0.7664 Intermediate Similarity NPD7157 Approved
0.7647 Intermediate Similarity NPD5283 Phase 1
0.763 Intermediate Similarity NPD228 Approved
0.7622 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7616 Intermediate Similarity NPD5762 Approved
0.7616 Intermediate Similarity NPD5763 Approved
0.7576 Intermediate Similarity NPD2489 Approved
0.7576 Intermediate Similarity NPD27 Approved
0.7562 Intermediate Similarity NPD2801 Approved
0.7558 Intermediate Similarity NPD7906 Approved
0.7552 Intermediate Similarity NPD2983 Phase 2
0.7552 Intermediate Similarity NPD5327 Phase 3
0.7552 Intermediate Similarity NPD2982 Phase 2
0.755 Intermediate Similarity NPD6099 Approved
0.755 Intermediate Similarity NPD6100 Approved
0.7545 Intermediate Similarity NPD5844 Phase 1
0.7535 Intermediate Similarity NPD3705 Approved
0.7529 Intermediate Similarity NPD7311 Approved
0.7529 Intermediate Similarity NPD7310 Approved
0.7529 Intermediate Similarity NPD7312 Approved
0.7529 Intermediate Similarity NPD7313 Approved
0.7516 Intermediate Similarity NPD2563 Approved
0.7516 Intermediate Similarity NPD2560 Approved
0.7485 Intermediate Similarity NPD3818 Discontinued
0.7485 Intermediate Similarity NPD7309 Approved
0.7483 Intermediate Similarity NPD2981 Phase 2
0.7483 Intermediate Similarity NPD7095 Approved
0.747 Intermediate Similarity NPD6166 Phase 2
0.747 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.747 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7469 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7468 Intermediate Similarity NPD1653 Approved
0.7467 Intermediate Similarity NPD6353 Approved
0.7447 Intermediate Similarity NPD1357 Approved
0.7439 Intermediate Similarity NPD5494 Approved
0.7438 Intermediate Similarity NPD6072 Discontinued
0.7432 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7431 Intermediate Similarity NPD4379 Clinical (unspecified phase)
0.7427 Intermediate Similarity NPD4577 Approved
0.7427 Intermediate Similarity NPD4578 Approved
0.741 Intermediate Similarity NPD2969 Approved
0.741 Intermediate Similarity NPD2970 Approved
0.741 Intermediate Similarity NPD6671 Approved
0.74 Intermediate Similarity NPD6355 Discontinued
0.7399 Intermediate Similarity NPD4663 Approved
0.7396 Intermediate Similarity NPD7074 Phase 3
0.7368 Intermediate Similarity NPD5588 Approved
0.7355 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7355 Intermediate Similarity NPD4109 Clinical (unspecified phase)
0.7355 Intermediate Similarity NPD3892 Phase 2
0.7355 Intermediate Similarity NPD4110 Phase 3
0.7355 Intermediate Similarity NPD6331 Phase 2
0.7353 Intermediate Similarity NPD3021 Approved
0.7353 Intermediate Similarity NPD3022 Approved
0.7351 Intermediate Similarity NPD4097 Suspended
0.7349 Intermediate Similarity NPD6071 Discontinued
0.7349 Intermediate Similarity NPD6232 Discontinued
0.7349 Intermediate Similarity NPD3051 Approved
0.7346 Intermediate Similarity NPD7819 Suspended
0.7342 Intermediate Similarity NPD5261 Clinical (unspecified phase)
0.7337 Intermediate Similarity NPD7054 Approved
0.7333 Intermediate Similarity NPD1558 Phase 1
0.7333 Intermediate Similarity NPD4140 Approved
0.7325 Intermediate Similarity NPD1511 Approved
0.7321 Intermediate Similarity NPD7473 Discontinued
0.7319 Intermediate Similarity NPD7843 Approved
0.7317 Intermediate Similarity NPD7075 Discontinued
0.7312 Intermediate Similarity NPD6055 Clinical (unspecified phase)
0.7303 Intermediate Similarity NPD4537 Clinical (unspecified phase)
0.7303 Intermediate Similarity NPD4536 Approved
0.7303 Intermediate Similarity NPD4538 Approved
0.7301 Intermediate Similarity NPD6374 Clinical (unspecified phase)
0.7294 Intermediate Similarity NPD7472 Approved
0.7285 Intermediate Similarity NPD3657 Discovery
0.7285 Intermediate Similarity NPD5124 Phase 1
0.7285 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.7283 Intermediate Similarity NPD8054 Approved
0.7283 Intermediate Similarity NPD8053 Approved
0.7279 Intermediate Similarity NPD2684 Approved
0.7273 Intermediate Similarity NPD2029 Clinical (unspecified phase)
0.7261 Intermediate Similarity NPD7124 Phase 2
0.7261 Intermediate Similarity NPD5058 Phase 3
0.7246 Intermediate Similarity NPD7229 Phase 3
0.7239 Intermediate Similarity NPD1465 Phase 2
0.7239 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.7233 Intermediate Similarity NPD1512 Approved
0.7233 Intermediate Similarity NPD1940 Clinical (unspecified phase)
0.7226 Intermediate Similarity NPD2424 Discontinued
0.7212 Intermediate Similarity NPD7975 Clinical (unspecified phase)
0.7212 Intermediate Similarity NPD7832 Clinical (unspecified phase)
0.7212 Intermediate Similarity NPD7831 Phase 2
0.7212 Intermediate Similarity NPD7833 Phase 2
0.7211 Intermediate Similarity NPD3094 Phase 2
0.7209 Intermediate Similarity NPD7240 Approved
0.7206 Intermediate Similarity NPD290 Approved
0.7205 Intermediate Similarity NPD4005 Discontinued
0.7197 Intermediate Similarity NPD2677 Approved
0.7197 Intermediate Similarity NPD5307 Clinical (unspecified phase)
0.7195 Intermediate Similarity NPD3817 Phase 2
0.7195 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7186 Intermediate Similarity NPD8127 Discontinued
0.7184 Intermediate Similarity NPD7090 Clinical (unspecified phase)
0.7172 Intermediate Similarity NPD422 Phase 1
0.7172 Intermediate Similarity NPD1091 Approved
0.7172 Intermediate Similarity NPD3092 Approved
0.717 Intermediate Similarity NPD7447 Phase 1
0.717 Intermediate Similarity NPD4160 Clinical (unspecified phase)
0.717 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7162 Intermediate Similarity NPD4624 Approved
0.7161 Intermediate Similarity NPD3540 Phase 1
0.716 Intermediate Similarity NPD4675 Approved
0.716 Intermediate Similarity NPD4380 Phase 2
0.716 Intermediate Similarity NPD4678 Approved
0.7153 Intermediate Similarity NPD4626 Approved
0.7143 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD5960 Phase 3
0.7134 Intermediate Similarity NPD6658 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD3750 Approved
0.7134 Intermediate Similarity NPD7466 Approved
0.7134 Intermediate Similarity NPD5929 Approved
0.7134 Intermediate Similarity NPD4628 Phase 3
0.7126 Intermediate Similarity NPD4666 Phase 3
0.7124 Intermediate Similarity NPD2157 Approved
0.7113 Intermediate Similarity NPD7340 Approved
0.711 Intermediate Similarity NPD6559 Discontinued
0.711 Intermediate Similarity NPD7251 Discontinued
0.7107 Intermediate Similarity NPD7041 Phase 2
0.7107 Intermediate Similarity NPD7213 Phase 3
0.7107 Intermediate Similarity NPD7040 Clinical (unspecified phase)
0.7107 Intermediate Similarity NPD7212 Phase 2
0.7105 Intermediate Similarity NPD2238 Phase 2
0.7097 Intermediate Similarity NPD3539 Phase 1
0.7086 Intermediate Similarity NPD6798 Discontinued
0.7083 Intermediate Similarity NPD5691 Approved
0.7083 Intermediate Similarity NPD6959 Discontinued
0.7078 Intermediate Similarity NPD6111 Discontinued
0.707 Intermediate Similarity NPD4237 Approved
0.707 Intermediate Similarity NPD4236 Phase 3
0.707 Intermediate Similarity NPD3060 Approved
0.7069 Intermediate Similarity NPD7808 Phase 3
0.7067 Intermediate Similarity NPD5752 Clinical (unspecified phase)
0.7066 Intermediate Similarity NPD5709 Phase 3
0.7063 Intermediate Similarity NPD2533 Approved
0.7063 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7063 Intermediate Similarity NPD2532 Approved
0.7063 Intermediate Similarity NPD2534 Approved
0.7055 Intermediate Similarity NPD6599 Discontinued
0.7052 Intermediate Similarity NPD6797 Phase 2
0.7051 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.7051 Intermediate Similarity NPD1375 Discontinued
0.7051 Intermediate Similarity NPD7266 Discontinued
0.7051 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.7048 Intermediate Similarity NPD7768 Phase 2
0.7047 Intermediate Similarity NPD6584 Phase 3
0.7032 Intermediate Similarity NPD6028 Clinical (unspecified phase)
0.7032 Intermediate Similarity NPD6029 Clinical (unspecified phase)
0.7021 Intermediate Similarity NPD1398 Phase 1
0.7014 Intermediate Similarity NPD3091 Approved
0.7014 Intermediate Similarity NPD7741 Discontinued
0.7012 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7011 Intermediate Similarity NPD2493 Approved
0.7011 Intermediate Similarity NPD2494 Approved
0.7006 Intermediate Similarity NPD7037 Approved
0.7006 Intermediate Similarity NPD1549 Phase 2
0.7006 Intermediate Similarity NPD4055 Discovery
0.7 Intermediate Similarity NPD4357 Discontinued

Structure

External Identifiers

PubChem CID   44569311
ChEMBL   CHEMBL461632
ZINC  

Physicochemical Properties

Molecular Weight:  480.29
ALogP:  1.9467
MLogP:  4.21
XLogP:  6.446
# Rotatable Bonds:  19
Polar Surface Area:  90.15
# H-Bond Aceptor:  1
# H-Bond Donor:  4
# Rings:  3
# Heavy Atoms:  35

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs