Natural Product: NPC293044

Natural Product ID:  NPC293044
Common Name:   Mooloolabene D
IUPAC Name:   [(1S,5aR,7R,7aS,11aR,11bR,13aS,13bR)-1-acetyloxy-8,8,11a,13a-tetramethyl-3,5,5a,7,7a,9,10,11,11b,12,13,13b-dodecahydro-1H-phenanthro[2,1-e][2]benzofuran-7-yl] acetate
Synonyms:   Mooloolabene D
Molecular Formula:   C28H40O5
Standard InCHIKey:  JCJGAZKXOUBQBW-GNVPTIMCSA-N
Standard InCHI:  InChI=1S/C28H40O5/c1-16(29)32-22-14-19-20-9-8-18-15-31-25(33-17(2)30)23(18)27(20,5)13-10-21(19)28(6)12-7-11-26(3,4)24(22)28/h8,14,20-25H,7,9-13,15H2,1-6H3/t20-,21-,22+,23+,24-,25-,27-,28+/m0/s1
Canonical SMILES:  CC(=O)O[C@@H]1OCC2=CC[C@@H]3[C@]([C@@H]12)(C)CC[C@H]1C3=C[C@H]([C@@H]2[C@]1(C)CCCC2(C)C)OC(=O)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO20034 Hyattella intestinalis Species Spongiidae Eukaryota Inner Gneerings, a group of shoals off Mooloolaba (Australia) 2005-JUL PMID[17125226]
NPO19595 Lathyrus chloranthus Species Fabaceae Eukaryota UNPD*
NPO21265 Teucrium webbianum Species Lamiaceae Eukaryota UNPD*
NPO16397 Didymocarpus oblonga Species Gesneriaceae Eukaryota UNPD*
NPO21592 Urtica circularis Species Urticaceae Eukaryota UNPD*
NPO12814 Daphne retusa Species Thymelaeaceae Eukaryota UNPD*
NPO19293 Tabebuia cassinoides Species Bignoniaceae Eukaryota UNPD*
NPO19439 Calea zacatechichi Species Asteraceae Eukaryota UNPD*
NPO17690 Sideritis sventenii Species Lamiaceae Eukaryota UNPD*
NPO18198 Selaginella willdenowii Species Selaginellaceae Eukaryota UNPD*
NPO19735 Euonymus pellucidifolius Species Celastraceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT168 Cell Line P388 Mus musculus IC50 = 3 ug/ml 17125226

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC293044 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9639 High Similarity NPC118266
0.9111 High Similarity NPC94905
0.9111 High Similarity NPC8954
0.8681 High Similarity NPC88507
0.8621 High Similarity NPC472442
0.8617 High Similarity NPC161527
0.8617 High Similarity NPC219285
0.8617 High Similarity NPC228251
0.8617 High Similarity NPC477971
0.8617 High Similarity NPC477968
0.8617 High Similarity NPC477972
0.8617 High Similarity NPC20113
0.8605 High Similarity NPC472440
0.8602 High Similarity NPC257726
0.8602 High Similarity NPC204054
0.8587 High Similarity NPC471372
0.8587 High Similarity NPC471362
0.8587 High Similarity NPC472189
0.8523 High Similarity NPC173917
0.8495 Intermediate Similarity NPC311166
0.8495 Intermediate Similarity NPC171598
0.8478 Intermediate Similarity NPC477722
0.8471 Intermediate Similarity NPC473685
0.8404 Intermediate Similarity NPC98112
0.8404 Intermediate Similarity NPC472188
0.8352 Intermediate Similarity NPC469403
0.8333 Intermediate Similarity NPC144069
0.8316 Intermediate Similarity NPC471366
0.8316 Intermediate Similarity NPC476800
0.8316 Intermediate Similarity NPC472186
0.8316 Intermediate Similarity NPC318917
0.8315 Intermediate Similarity NPC286153
0.8298 Intermediate Similarity NPC112654
0.828 Intermediate Similarity NPC104925
0.828 Intermediate Similarity NPC298973
0.828 Intermediate Similarity NPC469697
0.8261 Intermediate Similarity NPC65513
0.8247 Intermediate Similarity NPC134077
0.8229 Intermediate Similarity NPC472187
0.8229 Intermediate Similarity NPC473545
0.8229 Intermediate Similarity NPC473204
0.8191 Intermediate Similarity NPC230347
0.8191 Intermediate Similarity NPC100892
0.8191 Intermediate Similarity NPC135224
0.8191 Intermediate Similarity NPC275310
0.8191 Intermediate Similarity NPC286612
0.8191 Intermediate Similarity NPC477970
0.8191 Intermediate Similarity NPC477969
0.8144 Intermediate Similarity NPC63249
0.8125 Intermediate Similarity NPC473154
0.8119 Intermediate Similarity NPC112457
0.8105 Intermediate Similarity NPC73858
0.8105 Intermediate Similarity NPC162346
0.8085 Intermediate Similarity NPC189513
0.8068 Intermediate Similarity NPC471218
0.8061 Intermediate Similarity NPC471363
0.8061 Intermediate Similarity NPC238397
0.8043 Intermediate Similarity NPC470819
0.8043 Intermediate Similarity NPC470734
0.8043 Intermediate Similarity NPC177141
0.8041 Intermediate Similarity NPC477716
0.8041 Intermediate Similarity NPC477721
0.8021 Intermediate Similarity NPC477719
0.8021 Intermediate Similarity NPC76266
0.8021 Intermediate Similarity NPC477718
0.8 Intermediate Similarity NPC474013
0.798 Intermediate Similarity NPC471364
0.798 Intermediate Similarity NPC120009
0.798 Intermediate Similarity NPC127933
0.798 Intermediate Similarity NPC134270
0.798 Intermediate Similarity NPC132395
0.798 Intermediate Similarity NPC7644
0.798 Intermediate Similarity NPC475889
0.798 Intermediate Similarity NPC7613
0.798 Intermediate Similarity NPC471365
0.7979 Intermediate Similarity NPC163902
0.7979 Intermediate Similarity NPC471571
0.7979 Intermediate Similarity NPC246860
0.7978 Intermediate Similarity NPC324243
0.7978 Intermediate Similarity NPC469
0.7959 Intermediate Similarity NPC477717
0.7957 Intermediate Similarity NPC273199
0.7957 Intermediate Similarity NPC470817
0.7955 Intermediate Similarity NPC25554
0.7935 Intermediate Similarity NPC474629
0.7935 Intermediate Similarity NPC477128
0.7935 Intermediate Similarity NPC472809
0.7935 Intermediate Similarity NPC472810
0.7931 Intermediate Similarity NPC17550
0.7931 Intermediate Similarity NPC242767
0.7931 Intermediate Similarity NPC44083
0.7931 Intermediate Similarity NPC153987
0.7912 Intermediate Similarity NPC471369
0.79 Intermediate Similarity NPC264867
0.79 Intermediate Similarity NPC470321
0.79 Intermediate Similarity NPC81567
0.79 Intermediate Similarity NPC473207
0.79 Intermediate Similarity NPC222161
0.79 Intermediate Similarity NPC201880
0.7895 Intermediate Similarity NPC128488
0.7895 Intermediate Similarity NPC304968
0.7889 Intermediate Similarity NPC471367
0.7889 Intermediate Similarity NPC96055
0.7872 Intermediate Similarity NPC234335
0.7872 Intermediate Similarity NPC177641
0.7872 Intermediate Similarity NPC329842
0.7872 Intermediate Similarity NPC472811
0.7857 Intermediate Similarity NPC146188
0.7849 Intermediate Similarity NPC473647
0.7841 Intermediate Similarity NPC233332
0.7841 Intermediate Similarity NPC469802
0.7835 Intermediate Similarity NPC239547
0.7835 Intermediate Similarity NPC91197
0.7835 Intermediate Similarity NPC125551
0.7835 Intermediate Similarity NPC96597
0.7835 Intermediate Similarity NPC309503
0.7835 Intermediate Similarity NPC155319
0.7826 Intermediate Similarity NPC166857
0.7822 Intermediate Similarity NPC172867
0.7822 Intermediate Similarity NPC127790
0.7822 Intermediate Similarity NPC252296
0.7812 Intermediate Similarity NPC473369
0.7812 Intermediate Similarity NPC281134
0.781 Intermediate Similarity NPC157441
0.7802 Intermediate Similarity NPC42586
0.7802 Intermediate Similarity NPC473251
0.7802 Intermediate Similarity NPC119001
0.7789 Intermediate Similarity NPC472812
0.7778 Intermediate Similarity NPC121072
0.7778 Intermediate Similarity NPC21064
0.7778 Intermediate Similarity NPC132386
0.7766 Intermediate Similarity NPC469595
0.7766 Intermediate Similarity NPC212679
0.7766 Intermediate Similarity NPC220454
0.7766 Intermediate Similarity NPC159876
0.7753 Intermediate Similarity NPC108476
0.7745 Intermediate Similarity NPC109376
0.7745 Intermediate Similarity NPC88013
0.7745 Intermediate Similarity NPC184512
0.7745 Intermediate Similarity NPC125423
0.7742 Intermediate Similarity NPC93411
0.7742 Intermediate Similarity NPC473879
0.7732 Intermediate Similarity NPC319692
0.7732 Intermediate Similarity NPC164750
0.7732 Intermediate Similarity NPC325960
0.7717 Intermediate Similarity NPC102996
0.7717 Intermediate Similarity NPC471368
0.7717 Intermediate Similarity NPC244174
0.7714 Intermediate Similarity NPC12046
0.7714 Intermediate Similarity NPC194951
0.7708 Intermediate Similarity NPC470255
0.7708 Intermediate Similarity NPC324078
0.77 Intermediate Similarity NPC154452
0.7692 Intermediate Similarity NPC71626
0.7692 Intermediate Similarity NPC319238
0.7692 Intermediate Similarity NPC318515
0.7684 Intermediate Similarity NPC474631
0.7684 Intermediate Similarity NPC165904
0.7684 Intermediate Similarity NPC49420
0.7684 Intermediate Similarity NPC120539
0.7684 Intermediate Similarity NPC179517
0.7684 Intermediate Similarity NPC477122
0.7677 Intermediate Similarity NPC324841
0.767 Intermediate Similarity NPC135015
0.767 Intermediate Similarity NPC217921
0.767 Intermediate Similarity NPC48548
0.767 Intermediate Similarity NPC470024
0.767 Intermediate Similarity NPC128795
0.767 Intermediate Similarity NPC224660
0.767 Intermediate Similarity NPC311223
0.7667 Intermediate Similarity NPC122945
0.7667 Intermediate Similarity NPC286786
0.7667 Intermediate Similarity NPC109938
0.766 Intermediate Similarity NPC174765
0.766 Intermediate Similarity NPC473058
0.7653 Intermediate Similarity NPC10057
0.7653 Intermediate Similarity NPC97867
0.7647 Intermediate Similarity NPC218158
0.764 Intermediate Similarity NPC269791
0.764 Intermediate Similarity NPC195424
0.7634 Intermediate Similarity NPC102640
0.7629 Intermediate Similarity NPC474909
0.7629 Intermediate Similarity NPC472441
0.7624 Intermediate Similarity NPC254202
0.7609 Intermediate Similarity NPC35933
0.7604 Intermediate Similarity NPC267266
0.7604 Intermediate Similarity NPC169343
0.7604 Intermediate Similarity NPC277721
0.7604 Intermediate Similarity NPC166346
0.76 Intermediate Similarity NPC285231
0.76 Intermediate Similarity NPC473384
0.76 Intermediate Similarity NPC21568
0.76 Intermediate Similarity NPC280991
0.7596 Intermediate Similarity NPC206618
0.7596 Intermediate Similarity NPC316974
0.7596 Intermediate Similarity NPC40728
0.7582 Intermediate Similarity NPC474193
0.7582 Intermediate Similarity NPC12283
0.7582 Intermediate Similarity NPC477124
0.7582 Intermediate Similarity NPC49208

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC293044 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7849 Intermediate Similarity NPD6051 Approved
0.7333 Intermediate Similarity NPD6686 Approved
0.7312 Intermediate Similarity NPD6400 Clinical (unspecified phase)
0.7283 Intermediate Similarity NPD4752 Clinical (unspecified phase)
0.7245 Intermediate Similarity NPD6399 Phase 3
0.7188 Intermediate Similarity NPD7513 Clinical (unspecified phase)
0.7158 Intermediate Similarity NPD6684 Approved
0.7158 Intermediate Similarity NPD7521 Approved
0.7158 Intermediate Similarity NPD7334 Approved
0.7158 Intermediate Similarity NPD7146 Approved
0.7158 Intermediate Similarity NPD5330 Approved
0.7158 Intermediate Similarity NPD6409 Approved
0.7059 Intermediate Similarity NPD7638 Approved
0.7054 Intermediate Similarity NPD7328 Approved
0.7054 Intermediate Similarity NPD7327 Approved
0.7018 Intermediate Similarity NPD8033 Approved
0.7018 Intermediate Similarity NPD7503 Approved
0.701 Intermediate Similarity NPD6672 Approved
0.701 Intermediate Similarity NPD5737 Approved
0.701 Intermediate Similarity NPD6903 Approved
0.7 Intermediate Similarity NPD7901 Clinical (unspecified phase)
0.7 Intermediate Similarity NPD7900 Approved
0.6991 Remote Similarity NPD7516 Approved
0.699 Remote Similarity NPD7640 Approved
0.699 Remote Similarity NPD7639 Approved
0.693 Remote Similarity NPD8294 Approved
0.693 Remote Similarity NPD8377 Approved
0.6916 Remote Similarity NPD6412 Phase 2
0.6893 Remote Similarity NPD4225 Approved
0.6875 Remote Similarity NPD1694 Approved
0.687 Remote Similarity NPD8379 Approved
0.687 Remote Similarity NPD8378 Approved
0.687 Remote Similarity NPD8296 Approved
0.687 Remote Similarity NPD8380 Approved
0.687 Remote Similarity NPD8335 Approved
0.6832 Remote Similarity NPD7748 Approved
0.68 Remote Similarity NPD5693 Phase 1
0.6796 Remote Similarity NPD7902 Approved
0.6703 Remote Similarity NPD7339 Approved
0.6703 Remote Similarity NPD6942 Approved
0.6639 Remote Similarity NPD7507 Approved
0.6636 Remote Similarity NPD8132 Clinical (unspecified phase)
0.6634 Remote Similarity NPD7515 Phase 2
0.6633 Remote Similarity NPD6098 Approved
0.663 Remote Similarity NPD3701 Clinical (unspecified phase)
0.6602 Remote Similarity NPD6356 Clinical (unspecified phase)
0.66 Remote Similarity NPD6080 Approved
0.66 Remote Similarity NPD6673 Approved
0.66 Remote Similarity NPD6904 Approved
0.6598 Remote Similarity NPD3668 Phase 3
0.6598 Remote Similarity NPD4786 Approved
0.6596 Remote Similarity NPD7645 Phase 2
0.6562 Remote Similarity NPD3667 Approved
0.6549 Remote Similarity NPD8133 Approved
0.6526 Remote Similarity NPD7525 Registered
0.6522 Remote Similarity NPD8039 Approved
0.6522 Remote Similarity NPD7115 Discovery
0.6514 Remote Similarity NPD6008 Approved
0.6512 Remote Similarity NPD5325 Clinical (unspecified phase)
0.6476 Remote Similarity NPD6083 Phase 2
0.6476 Remote Similarity NPD6084 Phase 2
0.6475 Remote Similarity NPD7319 Approved
0.6471 Remote Similarity NPD8034 Phase 2
0.6471 Remote Similarity NPD6411 Approved
0.6471 Remote Similarity NPD6050 Approved
0.6471 Remote Similarity NPD7637 Suspended
0.6471 Remote Similarity NPD8035 Phase 2
0.646 Remote Similarity NPD6882 Approved
0.6442 Remote Similarity NPD5695 Phase 3
0.6436 Remote Similarity NPD7285 Clinical (unspecified phase)
0.6429 Remote Similarity NPD7338 Clinical (unspecified phase)
0.64 Remote Similarity NPD3573 Approved
0.6389 Remote Similarity NPD7632 Discontinued
0.6373 Remote Similarity NPD5692 Phase 3
0.6373 Remote Similarity NPD5207 Approved
0.6364 Remote Similarity NPD5739 Approved
0.6364 Remote Similarity NPD6675 Approved
0.6364 Remote Similarity NPD7128 Approved
0.6364 Remote Similarity NPD6402 Approved
0.6337 Remote Similarity NPD5208 Approved
0.6327 Remote Similarity NPD6695 Phase 3
0.6311 Remote Similarity NPD5694 Approved
0.6306 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6303 Remote Similarity NPD8517 Approved
0.6303 Remote Similarity NPD8515 Approved
0.6303 Remote Similarity NPD8513 Phase 3
0.6303 Remote Similarity NPD8516 Approved
0.6275 Remote Similarity NPD6101 Approved
0.6275 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6263 Remote Similarity NPD3133 Approved
0.6263 Remote Similarity NPD3666 Approved
0.6263 Remote Similarity NPD3665 Phase 1
0.6262 Remote Similarity NPD5696 Approved
0.626 Remote Similarity NPD7736 Approved
0.625 Remote Similarity NPD6881 Approved
0.625 Remote Similarity NPD7320 Approved
0.625 Remote Similarity NPD6899 Approved
0.625 Remote Similarity NPD5779 Approved
0.625 Remote Similarity NPD5778 Approved
0.625 Remote Similarity NPD2685 Clinical (unspecified phase)
0.6239 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6238 Remote Similarity NPD4751 Clinical (unspecified phase)
0.6237 Remote Similarity NPD4785 Approved
0.6237 Remote Similarity NPD6924 Approved
0.6237 Remote Similarity NPD4784 Approved
0.6237 Remote Similarity NPD6926 Approved
0.6228 Remote Similarity NPD8413 Clinical (unspecified phase)
0.6226 Remote Similarity NPD7732 Phase 3
0.62 Remote Similarity NPD7520 Clinical (unspecified phase)
0.62 Remote Similarity NPD6082 Clinical (unspecified phase)
0.6198 Remote Similarity NPD8328 Phase 3
0.6196 Remote Similarity NPD4243 Approved
0.6195 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6195 Remote Similarity NPD6372 Approved
0.6195 Remote Similarity NPD6373 Approved
0.619 Remote Similarity NPD6001 Approved
0.6179 Remote Similarity NPD8293 Discontinued
0.6174 Remote Similarity NPD6053 Discontinued
0.617 Remote Similarity NPD8264 Approved
0.6161 Remote Similarity NPD5697 Approved
0.6161 Remote Similarity NPD5701 Approved
0.6154 Remote Similarity NPD5281 Approved
0.6154 Remote Similarity NPD5284 Approved
0.614 Remote Similarity NPD5955 Clinical (unspecified phase)
0.614 Remote Similarity NPD6883 Approved
0.614 Remote Similarity NPD7290 Approved
0.614 Remote Similarity NPD7102 Approved
0.6139 Remote Similarity NPD3618 Phase 1
0.6117 Remote Similarity NPD5328 Approved
0.6116 Remote Similarity NPD6370 Approved
0.6111 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6106 Remote Similarity NPD6011 Approved
0.6105 Remote Similarity NPD6933 Approved
0.6087 Remote Similarity NPD6617 Approved
0.6087 Remote Similarity NPD8130 Phase 1
0.6087 Remote Similarity NPD6649 Approved
0.6087 Remote Similarity NPD6847 Approved
0.6087 Remote Similarity NPD6869 Approved
0.6087 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6087 Remote Similarity NPD6650 Approved
0.6082 Remote Similarity NPD6929 Approved
0.6082 Remote Similarity NPD4195 Approved
0.6078 Remote Similarity NPD7750 Discontinued
0.6078 Remote Similarity NPD7524 Approved
0.6075 Remote Similarity NPD5349 Clinical (unspecified phase)
0.6066 Remote Similarity NPD6067 Discontinued
0.6061 Remote Similarity NPD5209 Approved
0.6055 Remote Similarity NPD6648 Approved
0.6053 Remote Similarity NPD6014 Approved
0.6053 Remote Similarity NPD6013 Approved
0.6053 Remote Similarity NPD6012 Approved
0.6038 Remote Similarity NPD5707 Approved
0.6036 Remote Similarity NPD6052 Approved
0.6034 Remote Similarity NPD8297 Approved
0.602 Remote Similarity NPD5790 Clinical (unspecified phase)
0.602 Remote Similarity NPD6930 Phase 2
0.602 Remote Similarity NPD4695 Discontinued
0.602 Remote Similarity NPD7509 Discontinued
0.602 Remote Similarity NPD6931 Approved
0.6016 Remote Similarity NPD7492 Approved
0.6 Remote Similarity NPD6079 Approved
0.6 Remote Similarity NPD5344 Discontinued
0.5981 Remote Similarity NPD1698 Clinical (unspecified phase)
0.5981 Remote Similarity NPD5654 Approved
0.598 Remote Similarity NPD5279 Phase 3
0.598 Remote Similarity NPD4519 Discontinued
0.598 Remote Similarity NPD4623 Approved
0.5979 Remote Similarity NPD7322 Clinical (unspecified phase)
0.5978 Remote Similarity NPD6923 Approved
0.5978 Remote Similarity NPD6922 Approved
0.5977 Remote Similarity NPD1145 Discontinued
0.5968 Remote Similarity NPD6616 Approved
0.5966 Remote Similarity NPD6009 Approved
0.5962 Remote Similarity NPD4753 Phase 2
0.595 Remote Similarity NPD6054 Approved
0.595 Remote Similarity NPD6059 Approved
0.5943 Remote Similarity NPD4202 Approved
0.5935 Remote Similarity NPD7122 Discontinued
0.5926 Remote Similarity NPD7614 Phase 1
0.592 Remote Similarity NPD7078 Approved
0.5914 Remote Similarity NPD7144 Approved
0.5914 Remote Similarity NPD7143 Approved
0.5905 Remote Similarity NPD7838 Discovery
0.5905 Remote Similarity NPD46 Approved
0.5905 Remote Similarity NPD5785 Approved
0.5905 Remote Similarity NPD6698 Approved
0.59 Remote Similarity NPD4223 Phase 3
0.59 Remote Similarity NPD4221 Approved
0.5882 Remote Similarity NPD5329 Approved
0.5876 Remote Similarity NPD5776 Phase 2
0.5876 Remote Similarity NPD6925 Approved
0.5872 Remote Similarity NPD4755 Approved
0.5872 Remote Similarity NPD5959 Approved
0.5859 Remote Similarity NPD4821 Approved
0.5859 Remote Similarity NPD4820 Approved
0.5859 Remote Similarity NPD7332 Phase 2
0.5859 Remote Similarity NPD4748 Discontinued
0.5859 Remote Similarity NPD4819 Approved
0.5859 Remote Similarity NPD7514 Phase 3
0.5859 Remote Similarity NPD4822 Approved

Structure

External Identifiers

PubChem CID   11994178
ChEMBL   CHEMBL511608
ZINC  

Physicochemical Properties

Molecular Weight:  456.29
ALogP:  1.5701
MLogP:  3.99
XLogP:  6.655
# Rotatable Bonds:  10
Polar Surface Area:  61.83
# H-Bond Aceptor:  5
# H-Bond Donor:  0
# Rings:  5
# Heavy Atoms:  33

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
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