NPASS Natural Product

Natural Product: NPC232533

Natural Product ID:	NPC232533
Common Name:	Morphine
IUPAC Name:	(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Synonyms:	Avinza; Depodur; Infumorph; Kadian; Morphine
Molecular Formula:	C17H19NO3
Standard InCHIKey:	BQJCRHHNABKAKU-KBQPJGBKSA-N
Standard InCHI:	InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
Canonical SMILES:	O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
First Find Year:
Max Developmental Stage:
Synthetic Gene Cluster:	;

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Reference
NPO5177	Lecanora conizaeoides	Species	Lecanoraceae	Eukaryota	UNPD*
NPO6887	Lytanthus salicinus	NA	NA	NA	UNPD*
NPO7312	Aplidium multiplicatum	Species	Polyclinidae	Eukaryota	UNPD*
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	UNPD*
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	UNPD*
NPO12250	Strychnos fendleri	Species	Loganiaceae	Eukaryota	UNPD*
NPO2498	Kochia trichophylla	Species	Chenopodiaceae	Eukaryota	UNPD*
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	UNPD*
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	UNPD*
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	UNPD*
NPO7543	Haplopappus venetus	Species	Asteraceae	Eukaryota	UNPD*
NPO4797	Gavia immer	Species	Gaviidae	Eukaryota	UNPD*
NPO12952	Cabucala madagascariensis	Species	Apocynaceae	Eukaryota	UNPD*
NPO4758	Radix stephaniae cepharanthae	Species	Lymnaeidae	Eukaryota	TCMSP*
NPO29665	Papaveris pericarpium	NA	NA	NA	TCMSP*
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	TM-MC*
NPO2466	Aloe microstigma	Species	Asphodelaceae	Eukaryota	UNPD*
NPO21463	Aruncus dioicus	Species	Rosaceae	Eukaryota	UNPD*
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	PMID[23517479]
NPO12735	Halimeda macroloba	Species	Halimedaceae	Eukaryota	UNPD*
NPO18636	Hesperocyparis macrocarpa	Species	Cupressaceae	Eukaryota	UNPD*
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	PMID[15019787]
NPO3983	Piper futokadsura	Species	Piperaceae	Eukaryota	UNPD*
NPO664	Potentilla multifida	Species	Rosaceae	Eukaryota	UNPD*
NPO9398	Cortinarius rubellus	Species	Cortinariaceae	Eukaryota	UNPD*
NPO10672	Vitex megapotamica	Species	Lamiaceae	Eukaryota	UNPD*
NPO7884	Centaurea amara	Species	Asteraceae	Eukaryota	UNPD*
NPO11515	Streptomyces plumbeus	Species	Streptomycetaceae	Bacteria	UNPD*
NPO10176	Chrozophora prostrata	Species	Euphorbiaceae	Eukaryota	UNPD*
NPO6011	Pleurotus citrinopileatus	Species	Pleurotaceae	Eukaryota	UNPD*
NPO2917	Artemisia oranensis	Species	Asteraceae	Eukaryota	UNPD*
NPO26231	Vicia villosa	Species	Fabaceae	Eukaryota	UNPD*
NPO9576	Bufo bufo	Species	Bufonidae	Eukaryota	UNPD*
NPO10043	Phebalium ozothamnoides	Species	Rutaceae	Eukaryota	UNPD*

Biological Activity

Activity Type	# Activity
EC50	39
ED50	253
IC50	105
Kd	2
Ki	201
LD50	2
Others	204
Potency	1

Activity Type	# Activity
Individual Protein	341
Organism	357
Others	77
Protein Family	32

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	Ki	=	32.5	nM	9572880
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	4.2	nM	6288945
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	27	nM	6288945
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.3	mg/kg	2170652
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.1	nM	2170652
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.68	mg/kg	2170652
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.11	mg/kg	2170652
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.77	mg/kg	2170652
NPT2	Others	Unspecified		IC50	=	54.7	nM	10891118
NPT2863	Protein Family	Opioid receptor	Mus musculus	IC50	=	258	nM	10891118
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.8	mg/kg	6708055
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.2	mg/kg	6708055
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1	mg/kg	6708055
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.9	mg/kg	2831363
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	5.7	nM	2831363
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	167	nM	2831363
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	0.88	nM	11425545
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	11425545
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	24	nM	11425545
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.11	ug	10479285
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	10	mg/kg	1847432
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.811	umol/kg	12657261
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.319	umol/kg	12657261
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.339	umol/kg	1652025
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.81	umol/kg	1652025
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	32.58	umol/kg	1652025
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	301	nM	1652025
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.3	nM	1652025
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	456	nM	1652025
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	68.2	nM	7205890
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	492	nM	7205890
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.8	umol/kg	3669010
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.4	mg/kg	6600791
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.4	mg/kg	6600791
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	23	mg/kg	6600791
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	4.5	nM	6600791
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	73	nM	6600791
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	6283082
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	10	nM	6106064
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	250	nM	6106064
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	Ratio	=	25		6106064
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	6106064
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	0.78	nM	12643945
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	4.8	nM	12643945
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.9	umol/kg	7205892
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.72	umol/kg	7205892
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.68	mg/kg	6249930
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.8	mg/kg	6249930
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	11	nM	6249930
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	38	nM	7932535
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	1870	nM	7932535
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	375	nM	7932535
NPT296	Individual Protein	Sigma opioid receptor	Homo sapiens	Ki	>	100000	nM	7932535
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.98	mg/kg	7932535
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	79	nM	7932535
NPT2	Others	Unspecified		Ratio	=	38		7932535
NPT938	Organism	Cavia porcellus	Cavia porcellus	Kd	=	6.31	nM	9276018
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	71.6	nM	1967312
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	736	nM	1967312
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.85	mg/kg	1967312
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	7.71	nM	1967312
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	629.51	nM	1967312
NPT3603	Individual Protein	Kappa opioid receptor	Mus musculus	Ki	=	1549.49	nM	1967312
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.8	mg/kg	6259354
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	16	mg/kg	6259354
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	22	nM	6259354
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LD50	=	530	mg/kg	6259354
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	151	nM	12930147
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	64	nM	12930147
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3	nM	12930147
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	3	nM	12930147
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	456	nM	12930147
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	299	nM	12930147
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	86	nM	2567782
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	1.8	nM	2567782
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ratio	=	0.021		2567782
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	29	nM	3020245
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	79.8	nM	6207298
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	244	nM	6207298
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.8	nM mouse-1	6207298
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	1.94	nM	8642567
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	684	nM	8642567
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	271	nM	8642567
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	2.84		8642567
NPT2	Others	Unspecified		Ratio	=	0.396		8642567
NPT938	Organism	Cavia porcellus	Cavia porcellus	Activity	=	8.2		1361580
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	7365738
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	0.88	nM	15055988
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	15055988
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	24	nM	15055988
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.04		15055988
NPT5131	Others	Opioid receptors; delta & kappa	Homo sapiens	Ratio	=	5.8		15055988
NPT1774	Protein Family	Sodium channel alpha subunits; brain (Types I, II, III)	Homo sapiens	Inhibition	=	5.3	%	2579237
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	90	nM	10843229
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.8	nM	10843229
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.02		10843229
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1	mg/kg	6248644
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	6248644
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg/kg	6248644
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	Ratio	=	3		8394935
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	130	nM	10.1016/S0960-894X(01)80277-8
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	8.5	nM	10.1016/S0960-894X(01)80277-8
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	IC50	=	430	nM	10.1016/S0960-894X(01)80277-8
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	3361582
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.5	mg/kg	3361582
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.9	mg/kg	3361582
NPT2	Others	Unspecified		Ratio	=	0.6		3361582
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	0.88	nM	11000010
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	11000010
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	24	nM	11000010
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	0.13	nM	2754695
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	0.14	nM	7739011
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	7.37	nM	7739011
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	1.82	nM	7739011
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	65	nM	2872334
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3030	umol/kg	2872334
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.9	umol/kg	2872334
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	1.94	nM	7739011
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	684	nM	7739011
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.5	mg/kg	7241506
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.42	mg/kg	7241506
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	500	nM	7241506
NPT32	Organism	Mus musculus	Mus musculus	LD50	=	531	mg/kg	7241506
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	17	nM	9651168
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	150	nM	9651168
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	260	nM	9651168
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.4	ug	9651168
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	17.9	mg/kg	9719602
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.9	mg/kg	9719602
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	9719602
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.9	mg/kg	9719602
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	157	nM	14998329
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	11	nM	14998329
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	188	nM	14998329
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.07		14998329
NPT2	Others	Unspecified		Ratio	=	1.2		14998329
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	90	nM	11425550
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.8	nM	11425550
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.02		11425550
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	12.42	umol/kg	6268787
NPT938	Organism	Cavia porcellus	Cavia porcellus	Potency	=	1000000000	nM	6268787
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	69.7	nM	6268787
NPT32	Organism	Mus musculus	Mus musculus	Kd	>	1000	nM	6268787
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	2390	nM	1659636
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	1659636
NPT32	Organism	Mus musculus	Mus musculus	EC50	=	19700	nM	12570383
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	51	nM	12570383
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	90	nM	12570383
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1	nM	12570383
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol/kg	6864732
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.3	mg/kg	9046345
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	87.2	%	11960505
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	100	%	11960505
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.467	nM	11960505
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	416.87	nM	11960505
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	467.74	nM	11960505
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	57.3	nM	7154002
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	75	nM	6312044
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.70E-06	M kg-1	6312044
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	58.6	nM	1433221
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	644	nM	1433221
NPT2	Others	Unspecified		Ratio	=	11		1433221
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.0056	mg/kg	1433221
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	IC50	=	150	nM	12502358
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	IC50	=	1705.1	nM	12502358
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	IC50	=	0.57	nM	12502358
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ratio	=	265		12502358
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	70	nM	2828622
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	IC50	=	309	nM	2828622
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.15	nM	2828622
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	280	nM	2828622
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	130		2828622
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	292	nM	6310111
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1420	nM	6310111
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	24	nM	6245210
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.85	mg/kg	15163203
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.9	mg/kg	15163203
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	15163203
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	70	%	15012991
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.8	nM	10841790
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	2.92	nM	6090663
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	IC50	=	1420	nM	6090663
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	12954070
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	217	nM	12954070
NPT3601	Individual Protein	Kappa opioid receptor	Rattus norvegicus	Ki	=	113	nM	12954070
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.85	mg/kg	12954070
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.92	mg/kg	12954070
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	12954070
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	86	nM	2832603
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.8	nM	2832603
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.02		2832603
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.5	mg/kg	10782691
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	28.9	mg/kg	10782691
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.4	mg/kg	10782691
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15	mg/kg	10782691
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	160	nM	2876106
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3	umol/kg	2876106
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	23	nM	2876106
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.3		3023611
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	5.8		3023611
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.23		3023611
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.52	mg/kg	2999399
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	8.6	nM	2999399
NPT2	Others	Unspecified		Ratio	=	8.5		2999399
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.5	mg/kg	2999404
NPT2	Others	Unspecified		Ratio	=	500		2999404
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol/kg	6166748
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19.3	umol/kg	6166748
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	8.14	nM	7739013
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	684	nM	7739013
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	69.1	nM	7739013
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol/kg	7310822
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19	umol/kg	7310822
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	33.1	nM	6827557
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	194	nM	6827557
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.79	mg/kg	6181259
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.8	mg/kg	1846921
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	151	nM	1846921
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.3	nM	1846921
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	460	nM	1846921
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	1900	nM	10.1016/S0960-894X(00)80398-4
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	38	nM	10.1016/S0960-894X(00)80398-4
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	51	nM	10.1016/S0960-894X(00)80398-4
NPT296	Individual Protein	Sigma opioid receptor	Homo sapiens	Ki	>	10000	nM	10.1016/S0960-894X(00)80398-4
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.98	mg/kg	10.1016/S0960-894X(00)80398-4
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.8	mg/kg	10.1016/S0960-894X(00)80398-4
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.9	mg/kg	10.1016/S0960-894X(00)80398-4
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	54	mg/kg	10.1016/S0960-894X(00)80398-4
NPT2	Others	Unspecified		Ratio	=	4		6312042
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	24	nM	6312042
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol/kg	6767032
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19.3	umol/kg	6767032
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.47	mg/kg	1310115
NPT4389	Protein Family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	28	nM	1310115
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	4	nM	2887656
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	IC50	=	185	nM	2887656
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	530	nM	2887656
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3090	pM mouse-1	2887656
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.8	umol/kg	2887656
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Ratio	=	46		2887656
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	2390	nM	1846918
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	1846918
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	200	nM	6313921
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	77	nM	6313921
NPT5130	Individual Protein	Mu opioid receptor	Bos taurus	Ki	=	0.9	nM	8642554
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	132	nM	8642554
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	330	nM	8642554
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	10.6		1671414
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.4	umol/kg	1671414
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.9	umol/kg	1671414
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	1.6	nM	1671414
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	3.96	nM	12372519
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	52.14	nM	12372519
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	113.3	nM	12372519
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	umol/kg	12372519
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.6	umol/kg	12372519
NPT5130	Individual Protein	Mu opioid receptor	Bos taurus	Activity	=	67		7515442
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Activity	=	62		7515442
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Activity	=	31		7515442
NPT2	Others	Unspecified		ED50	=	1.339	umol/kg	1323679
NPT2	Others	Unspecified		ED50	=	9.81	umol/kg	1323679
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	14.4	umol/kg	1323679
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	301	nM	1323679
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.3	nM	1323679
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	456	nM	1323679
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	21.6	nM	8960554
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.27	nM	8960554
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.47	mg/kg	8393489
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	Inhibition	=	1	%	6315939
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	Inhibition	=	2	%	6315939
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	3.9	nM	1851843
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	205	nM	1851843
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	38	nM	1851843
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.02		1851843
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	14.6		12620082
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.2	mg/kg	1311764
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.2	mg/kg	1311764
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	ug	1311764
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	710	nM	9873603
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	6.51	nM	9873603
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	110	nM	9873603
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	EC50	=	21.3	nM	9873603
NPT5130	Individual Protein	Mu opioid receptor	Bos taurus	Ki	=	0.5	nM	1315868
NPT5130	Individual Protein	Mu opioid receptor	Bos taurus	Ki	=	2.5	nM	1315868
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	280	nM	1315868
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	49	nM	1315868
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	33	nM	1315868
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	38	nM	9873439
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	1870	nM	9873439
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	510	nM	9873439
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.3	mg/kg	12408719
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15	mg/kg	12408719
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.7	mg/kg	12408719
NPT2	Others	Unspecified		Ratio	=	15		12408719
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.2	umol/kg	3981537
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.46	mg/kg	2863378
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.06	mg/kg	2863378
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.5	mg/kg	2863378
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	31.2	mg/kg	2863378
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	0.027	nM	2863378
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	6424	nM	8390575
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	36	nM	8390575
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.0056		8390575
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	1	nM	8390575
NPT938	Organism	Cavia porcellus	Cavia porcellus	Ki	=	0.13	nM	8390575
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	0.09	nM	8390575
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.99	mg/kg	8390575
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Activity	=	1220	nM	8390575
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	70	nM	6276540
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	390	nM	6276540
NPT2	Others	Unspecified		Ratio	=	0.18		6276540
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.2	nM	9288177
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.9	nM	9288177
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	1.7	mg/kg	10.1016/S0960-894X(01)80179-7
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	3.4	mg/kg	10.1016/S0960-894X(01)80179-7
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.34	umol/kg	7932577
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.8	umol/kg	7932577
NPT3603	Individual Protein	Kappa opioid receptor	Mus musculus	Ki	=	301	nM	7932577
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.86	umol/kg	7932577
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	17	nM	12166947
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	150	nM	12166947
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	260	nM	12166947
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	58.8	nM	12166947
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	644	nM	12166947
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	15	nM	12166947
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	50000	nM	12699389
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	3.7	nM/mg*min	12699389
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Inhibition	=	2	%	12699389
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	IC50	>	50000	nM	12699389
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	IC50	>	50000	nM	12699389
NPT1456	Individual Protein	P-glycoprotein 1	Mus musculus	IC50	>	50000	nM	12699389
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	1		12699389
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	1.5		12699389
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	2.4		12699389
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.67	umol/kg	6708052
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1		6708052
NPT2863	Protein Family	Opioid receptor	Mus musculus	ED50	=	6.13	umol/kg	2213833
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	58.6	nM	4009598
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3030	pM mouse-1	4009598
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.9	umol/kg	4009598
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	140	nM	1714957
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1722	nM	1714957
NPT2	Others	Unspecified		Ratio	=	12.5		1714957
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	12699394
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	217	nM	12699394
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	113	nM	12699394
NPT2	Others	Unspecified		Ratio	=	17.3		12699394
NPT2	Others	Unspecified		Ratio	=	33.1		12699394
NPT2	Others	Unspecified		ED50	=	1.9	mg/kg	12699394
NPT5342	Protein Family	Opioid receptors; mu and delta	Mus musculus	ED50	=	0.4	mg/kg	12699394
NPT2863	Protein Family	Opioid receptor	Mus musculus	ED50	=	0.85	mg/kg	12699394
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.26	mg/kg	6248645
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.36	mg/kg	6103962
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.8	mg/kg	6103962
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	8.1	mg/kg	6103962
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	25	mg/kg	6103962
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	20	mg/kg	6103962
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2	nM	8064796
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.46	mg/kg	6292420
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.06	mg/kg	6292420
NPT2863	Protein Family	Opioid receptor	Mus musculus	IC50	=	27	nM	6292420
NPT2762	Organism	Monkey	Cercopithecidae	ED50	=	1.2	mg/kg	1433169
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol/kg	7192744
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19.3	umol/kg	7192744
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	3	nM	10.1016/0960-894X(95)00077-7
NPT3601	Individual Protein	Kappa opioid receptor	Rattus norvegicus	Ki	=	27	nM	10.1016/0960-894X(95)00077-7
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	15	nM	10.1016/0960-894X(95)00077-7
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.6	mg/kg	10.1016/0960-894X(95)00077-7
NPT2	Others	Unspecified		Ki	=	6.55	nM	15664820
NPT2	Others	Unspecified		Ki	=	217	nM	15664820
NPT2	Others	Unspecified		Ratio	=	33.1		15664820
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	Ki	=	1.8	nM	15482911
NPT2	Others	Unspecified		Ki	=	90	nM	15482911
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	Ratio	=	0.02		15482911
NPT2	Others	Unspecified		Ki	=	1100	nM	15509180
NPT2	Others	Unspecified		Ki	=	140000	nM	15509180
NPT2	Others	Unspecified		Ki	=	47000	nM	15509180
NPT2	Others	Unspecified		EC50	=	15.6		15509180
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg/kg	16033256
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.8	mg/kg	16033256
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	16033256
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	16033285
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	217	nM	16033285
NPT3601	Individual Protein	Kappa opioid receptor	Rattus norvegicus	Ki	=	113	nM	16033285
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.85	mg/kg	16033285
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.9	mg/kg	16033285
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	16033285
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	15857143
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.622	umol/kg	15857143
NPT32	Organism	Mus musculus	Mus musculus	Ratio	=	1.1		15857143
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	217	nM	15857143
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	113	nM	15857143
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	311	nM	15857143
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	1600	nM	15857143
NPT2	Others	Unspecified		Ratio	=	5.1		15857143
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	6690	nmol/kg	15857143
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	127.4	nM	15857121
NPT98	Individual Protein	HERG	Homo sapiens	IC50	=	1000000	nM	15911273
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	0.88	nM	16392810
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	16392810
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	24	nM	16392810
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio Ki	=	0.04		16392810
NPT5131	Others	Opioid receptors; delta & kappa	Homo sapiens	Ratio Ki	=	5.8		16392810
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Activity	=	62	%	16913723
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	EC50	=	484	nM	16913723
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Activity	=	103	%	16913723
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	EC50	=	316	nM	16913723
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Activity	=	93	%	16913723
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	15.6	nM	16913723
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	16913723
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	46.9	nM	16913723
NPT5343	Individual Protein	Nociceptin receptor	Cavia porcellus	Ki	=	13.9	nM	16777416
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	33.9	nM	16777416
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	58	nM	16777416
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	2.5	nM	16777416
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	1.1	nM	16913723
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	ED50	=	37	nM	17625813
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	1.1	nM	17887741
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	46.9	nM	17887741
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	17887741
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	15.6	nM	17887741
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	EC50	=	484	nM	17887741
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	316	nM	17887741
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.8	mg/kg	17887741
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.98	mg/kg	17887741
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg/kg	17887741
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Activity	=	93	%	17887741
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Activity	=	62	%	17887741
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Activity	=	103	%	17887741
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.56	mg/kg	17218099
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.73	mg/kg	17218099
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.1	mg/kg	17531479
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	27.3	mg/kg	17531479
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.8	mg/kg	17531479
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	50.7	%	17587585
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.98	mg/kg	17962026
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg/kg	17962026
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.8	mg/kg	17962026
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.6	mg/kg	17962026
NPT2	Others	Unspecified		EC50	=	23.6	nM	17962026
NPT2	Others	Unspecified		EC50	=	142	nM	17962026
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	EC50	=	395	nM	17962026
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	0.67	mg/kg	18160299
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	6	nM	17616524
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	4	nM	17616524
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	6.4	nM	17616524
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	7	nM	17616524
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15	nM	18294843
NPT2	Others	Unspecified		Ratio Ki	=	61		18311899
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	65.5	nM	18311899
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	104.57	nM	18311899
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	1.7	nM	18311899
NPT2	Others	Unspecified		Ratio Ki	=	38		18311899
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.92	mg/kg	18311899
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg/kg	18311899
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.85	mg/kg	18311899
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	9770	nM	18370374
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	112200	nM	18370374
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	29300	nM	18370374
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	155000	nM	18370374
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.95	nmol	17389363
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.085	nmol	17389363
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.36	umol/kg	17389363
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.7	nmol	17389363
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.088	nmol	17389363
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.47	umol/kg	17389363
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	IC50	=	1.27	nM	18337104
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	<	500	nM	18337104
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	<	500	nM	18337104
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	0.88	nM	19027293
NPT2	Others	Unspecified		Ki	=	140	nM	19027293
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	24	nM	19027293
NPT2	Others	Unspecified		Ratio Ki	=	6		19027293
NPT2	Others	Unspecified		Ratio Ki	=	0.037		19027293
NPT2	Others	Unspecified		Ki	=	2	nM	14738380
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	28000	nM	18788725
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	Inhibition	=	67.9	%	18788725
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.59	mg/kg	19199782
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	40	%	19289283
NPT3603	Individual Protein	Kappa opioid receptor	Mus musculus	IC50	=	145.1	nM	18829333
NPT2	Others	Unspecified		Ratio	=	0.06		18829333
NPT2	Others	Unspecified		Ratio	=	0.14		18829333
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.58	mg/kg	18829333
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.26	mg/kg	18829333
NPT2	Others	Unspecified		Ratio	=	0.25		18829333
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	18.4	umol/kg	10514316
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.4	umol/kg	10514316
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	IC50	=	213.1	nM	18990576
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	>	1000	nM	18990576
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	IC50	=	1.271	nM	18990576
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	15.6	nM	19253983
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	EC50	=	316	nM	19253983
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	EC50	=	484	nM	19253983
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Activity	=	93	%	19253983
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Activity	=	103	%	19253983
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Activity	=	62	%	19253983
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	92.9	%	18922604
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	87.45	%	18922604
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.9	mg/kg	19788200
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.5	mg/kg	19788200
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.1	ug	19788200
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.55	nM	19627147
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	ED50	=	37	nM	20055417
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	ED50	=	316	nM	20055417
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	ED50	=	1140	nM	20055417
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.5	umol/kg	19800791
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3.1	umol/kg	19800791
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	577	%	19736007
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	147	%	19679482
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	177.6	%	19679482
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	122.7	%	19679482
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	64.9	%	19679482
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	36.7	%	19679482
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.9	%	19679482
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	6.9	nM	19932964
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	116.8	nM	19932964
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	76.9	nM	19932964
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	EC50	=	123.5	nM	19932964
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Activity	=	209	%	19932964
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	38	%	20020710
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	77	%	20020710
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.9	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	36.7	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	64.9	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	177.6	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	122.7	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	147	%	20176491
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	78.9	%	19327871
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	74.7	%	19327871
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	57.8	%	19327871
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.1	%	19327871
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	0.85	%	20022146
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	EC50	=	85.5	nM	20413312
NPT2	Others	Unspecified		Ratio IC50	=	71.6		20413312
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	IC50	=	404	nM	20413312
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	IC50	=	5.64	nM	20413312
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	33.7	nM	20478711
NPT2	Others	Unspecified		Ratio Ki	=	0.02		20478711
NPT2	Others	Unspecified		Activity	=	22.9	%	18193048
NPT2	Others	Unspecified		Inhibition	=	25	%	18193048
NPT2	Others	Unspecified		Activity	=	8.1	%	18193048
NPT2	Others	Unspecified		EC50	=	3	nM	18193048
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	>	10000	nM	20580236
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	>	10000	nM	20580236
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	>	10000	nM	20580236
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	109000	nM	20580236
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.7	mg/kg	20599386
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	21235243
NPT2	Others	Unspecified		Ki	=	217	nM	21235243
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	113	nM	21235243
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	6.053	umol/kg	21235243
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	7.626	umol/kg	21235243
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	13.29	umol/kg	21235243
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	FC	=	1		21235243
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Activity	=	93	%	21235243
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Activity	=	103	%	21235243
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Activity	=	62	%	21235243
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	EC50	=	15.6	nM	21235243
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	316	nM	21235243
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	EC50	=	484	nM	21235243
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.3	mg/kg	21546249
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	142.2	%	21474215
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	175.78	%	21474215
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	139.03	%	21474215
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	98.78	%	21474215
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	64.55	%	21474215
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	57.43	%	21474215
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	2.2	nM	21481987
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	1.8	nM	21481987
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.98	nM	21641219
NPT2	Others	Unspecified		Ki	=	325	nM	21641219
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	54.3	nM	21641219
NPT2	Others	Unspecified		Ratio Ki	=	27.4		21641219
NPT2	Others	Unspecified		Ratio Ki	=	164		21641219
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	mg/kg	21641219
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.1	nM	21641798
NPT2	Others	Unspecified		Ki	=	140	nM	21641798
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	46.9	nM	21641798
NPT2	Others	Unspecified		Ratio Ki	=	0.02		21641798
NPT2	Others	Unspecified		Ratio Ki	=	3		21641798
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	4.6	nM	21621410
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.52	nM	21621410
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	1.92	nM	21621410
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.55	nM	21684752
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	21570305
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.4	mg/kg	21689868
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.44	mg/kg	21864951
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.5	mg/kg	21864951
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	mg/kg	21889335
NPT901	Individual Protein	UDP-glucuronosyltransferase 1-1	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT702	Individual Protein	UDP-glucuronosyltransferase 1-6	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT703	Individual Protein	UDP-glucuronosyltransferase 1-9	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	2536	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	2968	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	3719	pm/min/mg	10836148
NPT704	Individual Protein	UDP-glucuronosyltransferase 2B15	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT902	Individual Protein	UDP-glucuronosyltransferase 1A4	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT699	Individual Protein	UDP-glucuronosyltransferase 1-10	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT695	Individual Protein	UDP-glucuronosyltransferase 1-8	Homo sapiens	Activity	=	35	pm/min/mg	10836148
NPT694	Individual Protein	UDP-glucuronosyltransferase 1-3	Homo sapiens	Activity	=	21	pm/min/mg	10836148
NPT695	Individual Protein	UDP-glucuronosyltransferase 1-8	Homo sapiens	Activity	=	15	pm/min/mg	10836148
NPT696	Individual Protein	UDP-glucuronosyltransferase 2A1	Homo sapiens	Activity	=	73	pm/min/mg	10836148
NPT700	Individual Protein	UDP-glucuronosyltransferase 2B10	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT701	Individual Protein	UDP-glucuronosyltransferase 2B4	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	0	pm/min/mg	10836148
NPT697	Individual Protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	160	pm/min/mg	10836148
NPT2	Others	Unspecified		Ki	=	900000	nM	15781124
NPT2	Others	Unspecified		Ki	=	3600000	nM	15781124
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	mg/kg	22341895
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	22341895
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	605	nM	22341895
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	299	nM	22341895
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.2	nM	24900459
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	3.7	nM	24900459
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	140	nM	22439881
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	24	nM	22439881
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	0.88	nM	22439881
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	2	%	12699389
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.6	mg/kg	22386241
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.15	mg/kg	22386241
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	13.5	mg/kg	22386241
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.57	mg/kg	22386241
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.96	mg/kg	22386241
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	0.14	nM	22680612
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	295	nM	22680612
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	13.3	nM	22680612
NPT2	Others	Unspecified		Ratio Ki	=	2107		22680612
NPT2	Others	Unspecified		Ratio Ki	=	95		22680612
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.6	umol/kg	22680612
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	36.7	%	22680612
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	20.7	umol/kg	22680612
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	IC50	=	4.3	nM	22995061
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.6	umol/kg	23102273
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	66	%.min	23102273
NPT32	Organism	Mus musculus	Mus musculus	FC	=	44		23016952
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	100	%	23043264
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	67	%	23043420
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.4	mg/kg	23010454
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.4	mg/kg	23010454
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	100	%	10.1007/s00044-011-9619-z
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	92.5	%	10.1007/s00044-011-9619-z
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	100	%	10.1007/s00044-012-0449-4
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	68.02	%	10.1007/s00044-012-0449-4
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	171	nM	23419026
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	60.9	nM	23419026
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	EC50	=	194	nM	23419026
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.3	nM	23419026
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	97.21	%	23734744
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	94	%	23734744
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	98.3	%	23734744
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	299	nM	23618710
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	605	nM	23618710
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	23618710
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	100	%	23517479
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	70	%	23517479
NPT2	Others	Unspecified		Ratio Ki	>	100		23517479
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	468	nM	23517479
NPT2	Others	Unspecified		Ki	=	417	nM	23517479
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.5	nM	23517479
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	605	nM	23880358
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	299	nM	23880358
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	23880358
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	Inhibition	=	97	%	23880538
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Inhibition	=	91	%	23880538
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Inhibition	=	90	%	23880538
NPT3603	Individual Protein	Kappa opioid receptor	Mus musculus	Inhibition	=	71	%	23880538
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Inhibition	=	69	%	23880538
NPT2	Others	Unspecified		Ratio EC50	=	10		23880538
NPT2	Others	Unspecified		Ratio EC50	=	1		23880538
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	EC50	=	500	nM	23880538
NPT3603	Individual Protein	Kappa opioid receptor	Mus musculus	EC50	=	400	nM	23880538
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	EC50	=	400	nM	23880538
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	50	nM	23880538
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	EC50	=	30	nM	23880538
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.96	mg/kg	24103580
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	501.19	nM	24063433
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	39.81	nM	24063433
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	IC50	=	2.5	nM	24171469
NPT3606	Individual Protein	Kappa-type opioid receptor	Cricetulus griseus	Inhibition	=	100	%	24183585
NPT3606	Individual Protein	Kappa-type opioid receptor	Cricetulus griseus	Inhibition	=	95	%	24183585
NPT3607	Individual Protein	Delta-type opioid receptor	Cricetulus griseus	Inhibition	=	95	%	24183585
NPT3607	Individual Protein	Delta-type opioid receptor	Cricetulus griseus	Inhibition	=	72	%	24183585
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Inhibition	=	98	%	24183585
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Inhibition	=	81	%	24183585
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.2	mg/kg	24360563
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	109618
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	EC50	=	3	nM	109618
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.1	mg/kg	423201
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	<	40	mm	309950
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	>	34	mm	309950
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	>	50	mm	309950
NPT2	Others	Unspecified		ID50	=	68.2	nM	73588
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	EC50	=	3	nM	73588
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.26	mg/kg	73588
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	73588
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.17	mg/kg	73588
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	408488
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	408488
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.68	mg/kg	691001
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.8	mg/kg	691001
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	209187
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	209187
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	413922
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	mg/kg	41949
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	3.9	mg/kg	41949
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.3	mg/kg	41949
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	0.026	nmol	845862
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	0.031	nmol	845862
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	3.32	umol/kg	845862
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.5	mg/kg	13216
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1	mg/kg	37335
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	8.9	mg/kg	37335
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.2	%	853506
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	70	%	853506
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	80	%	853506
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	Activity	=	155	%	853506
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	10	mg/kg	853506
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	Activity	=	3	nM	16133
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.47	mg/kg	660593
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.43	mg/kg	817026
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.57	mg/kg	817026
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	15.9	mg/kg	817026
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.26	mg/kg	845878
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AD50	=	29	mg/kg	31481
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AD50	=	13	mg/kg	31481
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	915912
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.43	mg/kg	1263200
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ratio	=	1		1263200
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	15.9	mg/kg	1263200
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	199728
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	199728
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	ED50	=	3	nM	199728
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	10	nM	207868
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	IC50	=	250	nM	207868
NPT3590	Protein Family	Opioid receptor	Rattus norvegicus	Ratio IC50	=	25		207868
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.5	umol/kg	207868
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.5	umol/kg	207868
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg/kg	21291
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg/kg	21291
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	21291
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	5.34	mg/kg	21291
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg/kg	814236
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	EC50	=	10	nM	25087049
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.51	mg/kg	24978316
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.8	mg/kg	24978316
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	5.2	nM	25062506
NPT1069	Individual Protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.45	nM	25129170
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	82.5	nM	25129170
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	28.1	nM	25129170
NPT2	Others	Unspecified		Ratio Ki	=	57		25129170
NPT2	Others	Unspecified		Ratio Ki	=	19		25129170
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	IC50	=	29.3	nM	25129170
NPT1167	Individual Protein	Delta opioid receptor	Mus musculus	IC50	=	155	nM	25129170
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	EC50	=	120	nM	25783191
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.24	mg/kg	25783191
NPT1168	Individual Protein	Mu opioid receptor	Mus musculus	Activity	=	1	nM	25783191
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	9.6		25559207
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	22.5	nmol	25559207
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.35	nmol	25559207
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	25599950
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ki	=	605	nM	25599950
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	299	nM	25599950
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.49	nmol	25544687
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	6.25	nmol	25544687
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	377	nmol	25544687
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	22	nM	25494650
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	2.23		25996309
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.91	mg/kg	25996309
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.07	mg/kg	25996309
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.35	nM	25996309
NPT2	Others	Unspecified		Ki	=	2.6	nM	26134550
NPT5344	Individual Protein	Mu opioid receptor-like OR2	Danio rerio	Ki	=	187.4	nM	26134550
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	7.4	nmol	26348111
NPT1075	Individual Protein	Kappa opioid receptor	Cavia porcellus	Ki	=	35	nM	26411794
NPT1074	Individual Protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.9	nM	26411794
NPT3600	Individual Protein	Delta opioid receptor	Rattus norvegicus	Ki	=	2	nM	26411794
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	11		26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.301	nmol	26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.027	nmol	26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.015	nmol	26451468
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	8		26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	28.14	nmol	26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.035	nmol	26451468
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.73	mg/kg	26524472
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.7	mg/kg	26656913
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	0.3431	mg/kg	26599832
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	IC50	=	6.3	nM	26789491
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ki	=	120	nM	26390077
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	0.53	nM	26390077
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ratio	=	3.5		26713106
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ki	=	5.2	nM	10.1039/C5MD00414D
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7	nmol	27035422
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.46	nmol	27035422

Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC232533 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	236
0.1-0.2	1090
0.2-0.3	2768
0.3-0.4	7507
0.4-0.5	5947
0.5-0.6	6556
0.6-0.7	6560
0.7-0.8	202
0.8-0.85	12
0.85-0.9	2
0.9-0.95	3
0.95-1	6

Similarity Score	Similarity Level	Natural Product ID
0.9889	High Similarity	NPC243483
0.9889	High Similarity	NPC97086
0.9779	High Similarity	NPC140577
0.9779	High Similarity	NPC43069
0.967	High Similarity	NPC67346
0.962	High Similarity	NPC126211
0.9462	High Similarity	NPC157958
0.9448	High Similarity	NPC174783
0.9194	High Similarity	NPC311781
0.875	High Similarity	NPC214629
0.8587	High Similarity	NPC298339
0.8486	Intermediate Similarity	NPC115906
0.8308	Intermediate Similarity	NPC254045
0.8308	Intermediate Similarity	NPC201055
0.8308	Intermediate Similarity	NPC64576
0.8308	Intermediate Similarity	NPC151470
0.8196	Intermediate Similarity	NPC66909
0.8177	Intermediate Similarity	NPC196231
0.8115	Intermediate Similarity	NPC162694
0.8103	Intermediate Similarity	NPC279665
0.8081	Intermediate Similarity	NPC244191
0.8043	Intermediate Similarity	NPC124657
0.8	Intermediate Similarity	NPC305847
0.7958	Intermediate Similarity	NPC302449
0.7892	Intermediate Similarity	NPC255607
0.7892	Intermediate Similarity	NPC3375
0.7879	Intermediate Similarity	NPC293624
0.7868	Intermediate Similarity	NPC33256
0.7749	Intermediate Similarity	NPC35680
0.773	Intermediate Similarity	NPC226428
0.773	Intermediate Similarity	NPC475780
0.7696	Intermediate Similarity	NPC476500
0.7677	Intermediate Similarity	NPC94499
0.7663	Intermediate Similarity	NPC323443
0.7663	Intermediate Similarity	NPC180756
0.761	Intermediate Similarity	NPC80472
0.7513	Intermediate Similarity	NPC329969
0.7487	Intermediate Similarity	NPC470324
0.7465	Intermediate Similarity	NPC82056
0.7463	Intermediate Similarity	NPC286135
0.7448	Intermediate Similarity	NPC263212
0.7447	Intermediate Similarity	NPC205167
0.7447	Intermediate Similarity	NPC249274
0.7437	Intermediate Similarity	NPC141440
0.7435	Intermediate Similarity	NPC284842
0.7421	Intermediate Similarity	NPC35345
0.7409	Intermediate Similarity	NPC227683
0.7405	Intermediate Similarity	NPC475718
0.7398	Intermediate Similarity	NPC32154
0.738	Intermediate Similarity	NPC147091
0.7371	Intermediate Similarity	NPC38964
0.7368	Intermediate Similarity	NPC94687
0.7368	Intermediate Similarity	NPC476495
0.7368	Intermediate Similarity	NPC106840
0.7368	Intermediate Similarity	NPC324144
0.7366	Intermediate Similarity	NPC115869
0.7354	Intermediate Similarity	NPC27410
0.7354	Intermediate Similarity	NPC18402
0.7354	Intermediate Similarity	NPC166014
0.7353	Intermediate Similarity	NPC83019
0.7351	Intermediate Similarity	NPC85747
0.7351	Intermediate Similarity	NPC8337
0.7344	Intermediate Similarity	NPC145832
0.7344	Intermediate Similarity	NPC117188
0.7344	Intermediate Similarity	NPC306555
0.7344	Intermediate Similarity	NPC12053
0.7344	Intermediate Similarity	NPC81218
0.7344	Intermediate Similarity	NPC205421
0.7344	Intermediate Similarity	NPC474931
0.7344	Intermediate Similarity	NPC158376
0.7337	Intermediate Similarity	NPC469540
0.7337	Intermediate Similarity	NPC469539
0.733	Intermediate Similarity	NPC13504
0.733	Intermediate Similarity	NPC477563
0.733	Intermediate Similarity	NPC306843
0.733	Intermediate Similarity	NPC253043
0.733	Intermediate Similarity	NPC96603
0.733	Intermediate Similarity	NPC78222
0.733	Intermediate Similarity	NPC212794
0.733	Intermediate Similarity	NPC136508
0.733	Intermediate Similarity	NPC196447
0.7321	Intermediate Similarity	NPC326895
0.7317	Intermediate Similarity	NPC207239
0.7317	Intermediate Similarity	NPC267414
0.731	Intermediate Similarity	NPC27887
0.731	Intermediate Similarity	NPC99179
0.7304	Intermediate Similarity	NPC24228
0.7304	Intermediate Similarity	NPC204580
0.73	Intermediate Similarity	NPC230098
0.7297	Intermediate Similarity	NPC474556
0.7296	Intermediate Similarity	NPC241704
0.7287	Intermediate Similarity	NPC476443
0.7287	Intermediate Similarity	NPC133817
0.7277	Intermediate Similarity	NPC1229
0.7277	Intermediate Similarity	NPC476569
0.7263	Intermediate Similarity	NPC135006
0.7259	Intermediate Similarity	NPC320223
0.7259	Intermediate Similarity	NPC114364
0.7251	Intermediate Similarity	NPC46990
0.7251	Intermediate Similarity	NPC476496
0.7249	Intermediate Similarity	NPC180901
0.7249	Intermediate Similarity	NPC300757
0.7245	Intermediate Similarity	NPC128560
0.7245	Intermediate Similarity	NPC229166
0.7245	Intermediate Similarity	NPC199465
0.7236	Intermediate Similarity	NPC233718
0.7234	Intermediate Similarity	NPC131121
0.7222	Intermediate Similarity	NPC149285
0.7222	Intermediate Similarity	NPC126284
0.7222	Intermediate Similarity	NPC474745
0.7214	Intermediate Similarity	NPC8927
0.7211	Intermediate Similarity	NPC288353
0.7198	Intermediate Similarity	NPC474427
0.7192	Intermediate Similarity	NPC63152
0.7188	Intermediate Similarity	NPC472962
0.7188	Intermediate Similarity	NPC472961
0.7188	Intermediate Similarity	NPC21046
0.7184	Intermediate Similarity	NPC17677
0.7179	Intermediate Similarity	NPC168753
0.7179	Intermediate Similarity	NPC118274
0.7172	Intermediate Similarity	NPC474325
0.7172	Intermediate Similarity	NPC21885
0.7165	Intermediate Similarity	NPC298979
0.7163	Intermediate Similarity	NPC471489
0.7158	Intermediate Similarity	NPC478161
0.7158	Intermediate Similarity	NPC478159
0.7158	Intermediate Similarity	NPC65490
0.7158	Intermediate Similarity	NPC78359
0.7158	Intermediate Similarity	NPC315707
0.7158	Intermediate Similarity	NPC40389
0.7158	Intermediate Similarity	NPC148014
0.715	Intermediate Similarity	NPC116284
0.715	Intermediate Similarity	NPC248642
0.715	Intermediate Similarity	NPC47191
0.7143	Intermediate Similarity	NPC129578
0.7143	Intermediate Similarity	NPC239775
0.7143	Intermediate Similarity	NPC908
0.7143	Intermediate Similarity	NPC138438
0.7143	Intermediate Similarity	NPC186392
0.7136	Intermediate Similarity	NPC474432
0.7136	Intermediate Similarity	NPC475713
0.7135	Intermediate Similarity	NPC228501
0.7129	Intermediate Similarity	NPC228209
0.7128	Intermediate Similarity	NPC41689
0.7128	Intermediate Similarity	NPC164429
0.7128	Intermediate Similarity	NPC470924
0.7123	Intermediate Similarity	NPC207873
0.7123	Intermediate Similarity	NPC100573
0.7121	Intermediate Similarity	NPC237044
0.712	Intermediate Similarity	NPC118804
0.7114	Intermediate Similarity	NPC474746
0.7114	Intermediate Similarity	NPC156576
0.7114	Intermediate Similarity	NPC244903
0.7114	Intermediate Similarity	NPC104682
0.7114	Intermediate Similarity	NPC475981
0.7113	Intermediate Similarity	NPC81247
0.7113	Intermediate Similarity	NPC476573
0.7113	Intermediate Similarity	NPC35627
0.7112	Intermediate Similarity	NPC68967
0.7108	Intermediate Similarity	NPC240808
0.7108	Intermediate Similarity	NPC226708
0.7107	Intermediate Similarity	NPC66341
0.7107	Intermediate Similarity	NPC192135
0.7107	Intermediate Similarity	NPC477020
0.7092	Intermediate Similarity	NPC191012
0.7092	Intermediate Similarity	NPC69712
0.7092	Intermediate Similarity	NPC255787
0.7092	Intermediate Similarity	NPC26240
0.7092	Intermediate Similarity	NPC477562
0.7092	Intermediate Similarity	NPC329911
0.709	Intermediate Similarity	NPC306011
0.709	Intermediate Similarity	NPC472838
0.7085	Intermediate Similarity	NPC148693
0.7085	Intermediate Similarity	NPC118633
0.7085	Intermediate Similarity	NPC294790
0.7083	Intermediate Similarity	NPC4304
0.7081	Intermediate Similarity	NPC316164
0.7077	Intermediate Similarity	NPC210140
0.7074	Intermediate Similarity	NPC472837
0.7071	Intermediate Similarity	NPC131866
0.7071	Intermediate Similarity	NPC102277
0.7071	Intermediate Similarity	NPC279209
0.7071	Intermediate Similarity	NPC304675
0.7068	Intermediate Similarity	NPC268008
0.7065	Intermediate Similarity	NPC221820
0.7062	Intermediate Similarity	NPC469889
0.7062	Intermediate Similarity	NPC472906
0.7056	Intermediate Similarity	NPC150131
0.7056	Intermediate Similarity	NPC476331
0.7047	Intermediate Similarity	NPC153631
0.7041	Intermediate Similarity	NPC160570
0.7041	Intermediate Similarity	NPC472277
0.7037	Intermediate Similarity	NPC133011
0.7037	Intermediate Similarity	NPC82285
0.7035	Intermediate Similarity	NPC316292
0.7035	Intermediate Similarity	NPC222524
0.703	Intermediate Similarity	NPC135772
0.703	Intermediate Similarity	NPC476273
0.703	Intermediate Similarity	NPC475566
0.702	Intermediate Similarity	NPC288813

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC232533 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	202
0.1-0.2	707
0.2-0.3	1217
0.3-0.4	2374
0.4-0.5	2559
0.5-0.6	1512
0.6-0.7	523
0.7-0.8	26
0.8-0.85	26
0.85-0.9	4
0.9-0.95	6
0.95-1	5

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD2491	Approved
0.9889	High Similarity	NPD3448	Approved
0.9779	High Similarity	NPD2972	Approved
0.9779	High Similarity	NPD3533	Approved
0.967	High Similarity	NPD3057	Approved
0.9365	High Similarity	NPD5676	Approved
0.9194	High Similarity	NPD4482	Phase 3
0.914	High Similarity	NPD4107	Approved
0.904	High Similarity	NPD5619	Clinical (unspecified phase)
0.9031	High Similarity	NPD4111	Phase 1
0.9031	High Similarity	NPD4665	Approved
0.8913	High Similarity	NPD2490	Approved
0.8913	High Similarity	NPD2488	Approved
0.8844	High Similarity	NPD7907	Approved
0.8587	High Similarity	NPD3534	Clinical (unspecified phase)
0.8486	Intermediate Similarity	NPD2971	Approved
0.8486	Intermediate Similarity	NPD2968	Approved
0.8458	Intermediate Similarity	NPD5980	Discovery
0.8402	Intermediate Similarity	NPD2494	Approved
0.8402	Intermediate Similarity	NPD2493	Approved
0.8389	Intermediate Similarity	NPD7048	Phase 3
0.8367	Intermediate Similarity	NPD4040	Phase 1
0.8367	Intermediate Similarity	NPD4582	Approved
0.8367	Intermediate Similarity	NPD4583	Approved
0.8352	Intermediate Similarity	NPD27	Approved
0.8352	Intermediate Similarity	NPD2489	Approved
0.8316	Intermediate Similarity	NPD4004	Approved
0.8316	Intermediate Similarity	NPD4002	Approved
0.8308	Intermediate Similarity	NPD3452	Approved
0.8308	Intermediate Similarity	NPD3450	Approved
0.8197	Intermediate Similarity	NPD2970	Approved
0.8197	Intermediate Similarity	NPD2969	Approved
0.8196	Intermediate Similarity	NPD2973	Approved
0.8196	Intermediate Similarity	NPD2975	Approved
0.8196	Intermediate Similarity	NPD2974	Approved
0.8163	Intermediate Similarity	NPD4580	Approved
0.8043	Intermediate Similarity	NPD3051	Approved
0.8	Intermediate Similarity	NPD7312	Approved
0.8	Intermediate Similarity	NPD7310	Approved
0.8	Intermediate Similarity	NPD7311	Approved
0.8	Intermediate Similarity	NPD7313	Approved
0.7958	Intermediate Similarity	NPD7309	Approved
0.7874	Intermediate Similarity	NPD7047	Phase 3
0.7766	Intermediate Similarity	NPD4481	Phase 3
0.772	Intermediate Similarity	NPD4578	Approved
0.772	Intermediate Similarity	NPD4577	Approved
0.7692	Intermediate Similarity	NPD4663	Approved
0.7653	Intermediate Similarity	NPD6997	Phase 2
0.7563	Intermediate Similarity	NPD7906	Approved
0.7487	Intermediate Similarity	NPD2898	Approved
0.7433	Intermediate Similarity	NPD5616	Clinical (unspecified phase)
0.7282	Intermediate Similarity	NPD7501	Clinical (unspecified phase)
0.726	Intermediate Similarity	NPD7497	Discontinued
0.7222	Intermediate Similarity	NPD4419	Clinical (unspecified phase)
0.7216	Intermediate Similarity	NPD4575	Clinical (unspecified phase)
0.7202	Intermediate Similarity	NPD6071	Discontinued
0.7158	Intermediate Similarity	NPD2563	Approved
0.7158	Intermediate Similarity	NPD2560	Approved
0.7143	Intermediate Similarity	NPD2163	Approved
0.7135	Intermediate Similarity	NPD1754	Clinical (unspecified phase)
0.7107	Intermediate Similarity	NPD3050	Clinical (unspecified phase)
0.7092	Intermediate Similarity	NPD3446	Phase 1
0.7087	Intermediate Similarity	NPD7667	Clinical (unspecified phase)
0.7068	Intermediate Similarity	NPD5977	Approved
0.7068	Intermediate Similarity	NPD5978	Approved
0.7019	Intermediate Similarity	NPD4420	Approved
0.7018	Intermediate Similarity	NPD8404	Phase 2
0.6976	Remote Similarity	NPD5525	Clinical (unspecified phase)
0.6976	Remote Similarity	NPD3808	Clinical (unspecified phase)
0.697	Remote Similarity	NPD7177	Discontinued
0.6968	Remote Similarity	NPD3639	Approved
0.6968	Remote Similarity	NPD3640	Phase 3
0.6968	Remote Similarity	NPD3641	Approved
0.6961	Remote Similarity	NPD6040	Clinical (unspecified phase)
0.6961	Remote Similarity	NPD7291	Discontinued
0.6915	Remote Similarity	NPD7038	Approved
0.6915	Remote Similarity	NPD7039	Approved
0.6912	Remote Similarity	NPD5038	Approved
0.6912	Remote Similarity	NPD5037	Approved
0.6911	Remote Similarity	NPD4772	Phase 2
0.6911	Remote Similarity	NPD4773	Phase 2
0.6911	Remote Similarity	NPD6386	Approved
0.6911	Remote Similarity	NPD6385	Approved
0.6907	Remote Similarity	NPD7833	Phase 2
0.6907	Remote Similarity	NPD7831	Phase 2
0.6907	Remote Similarity	NPD7832	Clinical (unspecified phase)
0.6895	Remote Similarity	NPD824	Approved
0.6887	Remote Similarity	NPD5006	Approved
0.6887	Remote Similarity	NPD5005	Approved
0.6882	Remote Similarity	NPD5241	Discontinued
0.6875	Remote Similarity	NPD7577	Discontinued
0.6863	Remote Similarity	NPD5036	Approved
0.6859	Remote Similarity	NPD1337	Clinical (unspecified phase)
0.6842	Remote Similarity	NPD4361	Phase 2
0.6842	Remote Similarity	NPD4362	Clinical (unspecified phase)
0.6827	Remote Similarity	NPD4466	Phase 1
0.681	Remote Similarity	NPD5564	Approved
0.6806	Remote Similarity	NPD7701	Phase 2
0.6794	Remote Similarity	NPD4360	Phase 2
0.6794	Remote Similarity	NPD4363	Phase 3
0.6784	Remote Similarity	NPD6167	Clinical (unspecified phase)
0.6784	Remote Similarity	NPD6168	Clinical (unspecified phase)
0.6784	Remote Similarity	NPD6166	Phase 2
0.6782	Remote Similarity	NPD3823	Discontinued
0.6769	Remote Similarity	NPD3882	Suspended
0.6766	Remote Similarity	NPD6042	Phase 2
0.6766	Remote Similarity	NPD42	Phase 2
0.6766	Remote Similarity	NPD5844	Phase 1
0.6763	Remote Similarity	NPD6377	Clinical (unspecified phase)
0.6763	Remote Similarity	NPD6836	Approved
0.6751	Remote Similarity	NPD4666	Phase 3
0.6749	Remote Similarity	NPD5031	Approved
0.6749	Remote Similarity	NPD5027	Approved
0.6749	Remote Similarity	NPD5029	Approved
0.6748	Remote Similarity	NPD3863	Clinical (unspecified phase)
0.6739	Remote Similarity	NPD6029	Clinical (unspecified phase)
0.6739	Remote Similarity	NPD6028	Clinical (unspecified phase)
0.6732	Remote Similarity	NPD8053	Approved
0.6732	Remote Similarity	NPD8054	Approved
0.6732	Remote Similarity	NPD7090	Clinical (unspecified phase)
0.673	Remote Similarity	NPD7238	Clinical (unspecified phase)
0.672	Remote Similarity	NPD2420	Approved
0.672	Remote Similarity	NPD2421	Approved
0.6719	Remote Similarity	NPD2651	Approved
0.6719	Remote Similarity	NPD2649	Approved
0.6716	Remote Similarity	NPD5026	Approved
0.6716	Remote Similarity	NPD36	Approved
0.6716	Remote Similarity	NPD5028	Approved
0.6716	Remote Similarity	NPD4955	Approved
0.6716	Remote Similarity	NPD4954	Approved
0.6716	Remote Similarity	NPD5034	Approved
0.6703	Remote Similarity	NPD3140	Approved
0.6703	Remote Similarity	NPD3142	Approved
0.6701	Remote Similarity	NPD5709	Phase 3
0.6701	Remote Similarity	NPD6844	Discontinued
0.6701	Remote Similarity	NPD1934	Approved
0.6699	Remote Similarity	NPD5968	Phase 3
0.6683	Remote Similarity	NPD5312	Approved
0.6683	Remote Similarity	NPD5313	Approved
0.6683	Remote Similarity	NPD5035	Approved
0.6667	Remote Similarity	NPD8434	Phase 2
0.6667	Remote Similarity	NPD5030	Phase 2
0.6667	Remote Similarity	NPD2393	Clinical (unspecified phase)
0.6667	Remote Similarity	NPD7922	Phase 1
0.665	Remote Similarity	NPD4956	Approved
0.6649	Remote Similarity	NPD6873	Phase 2
0.6649	Remote Similarity	NPD7109	Clinical (unspecified phase)
0.6649	Remote Similarity	NPD7110	Phase 1
0.6636	Remote Similarity	NPD7607	Clinical (unspecified phase)
0.6634	Remote Similarity	NPD7893	Clinical (unspecified phase)
0.6634	Remote Similarity	NPD5032	Approved
0.6618	Remote Similarity	NPD8055	Clinical (unspecified phase)
0.6615	Remote Similarity	NPD7427	Discontinued
0.6612	Remote Similarity	NPD3109	Approved
0.6612	Remote Similarity	NPD3110	Approved
0.6602	Remote Similarity	NPD4078	Clinical (unspecified phase)
0.66	Remote Similarity	NPD7315	Approved
0.6599	Remote Similarity	NPD5019	Clinical (unspecified phase)
0.6597	Remote Similarity	NPD4584	Approved
0.6594	Remote Similarity	NPD8469	Approved
0.6589	Remote Similarity	NPD7237	Clinical (unspecified phase)
0.6585	Remote Similarity	NPD5039	Approved
0.6583	Remote Similarity	NPD5494	Approved
0.6582	Remote Similarity	NPD5772	Approved
0.6582	Remote Similarity	NPD5773	Approved
0.6579	Remote Similarity	NPD6666	Approved
0.6579	Remote Similarity	NPD6667	Approved
0.6575	Remote Similarity	NPD4859	Phase 1
0.6569	Remote Similarity	NPD5190	Phase 2
0.6566	Remote Similarity	NPD8005	Clinical (unspecified phase)
0.6562	Remote Similarity	NPD3647	Clinical (unspecified phase)
0.6561	Remote Similarity	NPD4628	Phase 3
0.656	Remote Similarity	NPD8161	Suspended
0.6558	Remote Similarity	NPD6780	Approved
0.6558	Remote Similarity	NPD6777	Approved
0.6558	Remote Similarity	NPD5457	Discontinued
0.6558	Remote Similarity	NPD6778	Approved
0.6558	Remote Similarity	NPD6779	Approved
0.6558	Remote Similarity	NPD6781	Approved
0.6558	Remote Similarity	NPD6782	Approved
0.6558	Remote Similarity	NPD6776	Approved
0.6552	Remote Similarity	NPD3818	Discontinued
0.655	Remote Similarity	NPD8127	Discontinued
0.6546	Remote Similarity	NPD3455	Phase 2
0.6543	Remote Similarity	NPD4664	Clinical (unspecified phase)
0.654	Remote Similarity	NPD7296	Approved
0.6535	Remote Similarity	NPD7278	Phase 2
0.6535	Remote Similarity	NPD7279	Phase 2
0.6533	Remote Similarity	NPD6862	Phase 2
0.6532	Remote Similarity	NPD7827	Phase 1
0.6531	Remote Similarity	NPD7248	Discontinued
0.6524	Remote Similarity	NPD8397	Clinical (unspecified phase)
0.652	Remote Similarity	NPD4603	Phase 2
0.6517	Remote Similarity	NPD5710	Approved
0.6517	Remote Similarity	NPD5711	Approved
0.6515	Remote Similarity	NPD4947	Clinical (unspecified phase)
0.6515	Remote Similarity	NPD4868	Clinical (unspecified phase)
0.6514	Remote Similarity	NPD8320	Phase 1
0.6514	Remote Similarity	NPD8319	Approved
0.6508	Remote Similarity	NPD5177	Phase 3

Structure

CID232533 OpenBabel06191716032D 21 25 0 0 1 0 0 0 0 0999 V2000 -4.0074 -1.5905 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1322 1.6573 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1322 -1.6577 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.4144 2.0717 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.4144 -2.0721 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1322 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.5677 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.8500 0.4140 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1322 0.8284 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1322 -0.8288 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.8500 -0.4144 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -0.6966 1.6573 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6966 -1.6577 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.4144 0.4140 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6966 0.8284 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6966 -0.8288 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.4144 -0.4144 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -3.5677 -0.8288 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0650 2.0970 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0650 -2.0974 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 -0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 18 1 0 0 0 0 2 4 2 0 0 0 0 2 9 1 0 0 0 0 3 5 2 0 0 0 0 3 10 1 0 0 0 0 4 12 1 0 0 0 0 5 13 1 0 0 0 0 6 7 1 0 0 0 0 7 18 1 0 0 0 0 8 9 1 0 0 0 0 9 14 2 0 0 0 0 10 11 1 0 0 0 0 10 17 1 1 0 0 0 11 8 1 6 0 0 0 11 18 1 0 0 0 0 12 15 2 0 0 0 0 12 19 1 0 0 0 0 13 16 1 0 0 0 0 13 20 1 1 0 0 0 14 15 1 0 0 0 0 14 17 1 0 0 0 0 15 21 1 0 0 0 0 16 17 1 1 0 0 0 16 21 1 0 0 0 0 17 6 1 6 0 0 0 M END $$$$

External Identifiers

PubChem CID	5288826
ChEMBL	CHEMBL70
ZINC

Physicochemical Properties

Molecular Weight:	285.14
ALogP:	-0.2545
MLogP:	2.89
XLogP:	0.112
# Rotatable Bonds:	3
Polar Surface Area:	52.93
# H-Bond Aceptor:	4
# H-Bond Donor:	2
# Rings:	5
# Heavy Atoms:	21

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs