CMAUP Plant Collective Molecular Activities

Plant Name: Polygonatum sibiricum

Taxonomic Information:

Plant ID: NPO9935
Plant Latin Name: Polygonatum sibiricum
Taxonomy Genus: Polygonatum
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 261423
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antibacterial; Antifungal; Antirheumatic; Demulcent; Lenitive; Miscellany; Tonic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA12;
Enzyme_unclassified	AKR1B1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP2C9; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.320E-10	1.015E-05	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.571E-10	1.015E-05	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.786E-09	1.297E-05	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.024E-08	5.575E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.782E-08	7.761E-05	AKR1B1, CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.262E-07	3.924E-04	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	2.723E-07	6.588E-04	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.093E-07	6.735E-04	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	1.634E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	1.659E-06	2.779E-03	AKR1B1, CYP19A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.743E-06	9.177E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	1.086E-02	CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	3.081E-04	1.597E-01	CYP19A1, CYP2C19, CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.702E-02	1.000E+00	CYP2C19, CYP2C9, CYP3A4, LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.527E-07	3.971E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.174E-06	2.826E-05	CYP2C9, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.665E-06	3.177E-05	CYP2C9, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.329E-05	2.814E-04	CYP2C9, AKR1B1, CYP2C19, CYP3A4, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.616E-04	1.068E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.289E-04	1.068E-03	CYP3A4, CYP19A1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.876E-04	1.068E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.627E-04	1.179E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.513E-04	2.459E-03	CYP2C9, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.781E-03	1.763E-02	CA12

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases