CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRB3; ADRA2A; ADRA2B; DRD2;
Enzyme_unclassified	TDP1; EIF4A1; APEX1;
Transcription Factor	RELA;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	EIF4A1	Eukaryotic initiation factor 4A-I	P60842	CHEMBL2052028
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRB3	Beta-3 adrenergic receptor	P13945	CHEMBL246
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	1.739E-13	1.262E-09	ADRA2A, ADRA2B, ADRA2C, ADRB3, DRD2
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	3.996E-10	7.250E-07	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	3.996E-10	7.250E-07	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	5.588E-09	6.760E-06	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0045744; negative regulation of G-protein coupled receptor protein signaling pathway	4.457E-07	2.941E-04	ADRA2A, ADRB3, DRD2
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	5.929E-07	3.489E-04	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0043410; positive regulation of MAPK cascade	2.869E-06	1.358E-03	ADRA2A, ADRA2B, ADRA2C, ADRB3, DRD2
BP	Unclassified;	GO:0019229; regulation of vasoconstriction	3.367E-06	1.496E-03	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0030168; platelet activation	2.095E-05	7.601E-03	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	2.533E-12	1.103E-08	ADRA2A, ADRA2B, ADRA2C, ADRB3

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.170E-07	7.959E-06	ADRB3, ADRA2C, DRD2, ADRA2B, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	9.470E-07	3.220E-05	ADRB3, ADRA2C, ADRA2B, ADRA2A
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.613E-04	5.923E-03	DRD2, RELA

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	ADRB3;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	ADRB3;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phaseolus coccineus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities