CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; HSD17B10; ALOX15; HPGD; ALDH1A1;
Protein Kinase	FYN; LCK; EGFR; PRKCD;
Nuclear hormone receptor subfamily 1 group A	THRB;
Lysine demethylase	KDM4E;
Cysteine protease	CASP7; CASP1;
Transcription Factor	HIF1A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	5.281E-07	3.068E-03	CASP1, CASP7, LCK, XDH
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.627E-06	5.794E-03	ALDH1A1, ALOX15, CYP2D6, HPGD, HSD17B10, KDM4E, XDH
BP	GO:0009987; cellular process	GO:0097194; execution phase of apoptosis	3.865E-06	5.794E-03	CASP1, CASP7, PRKCD
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	7.395E-06	7.668E-03	EGFR, FYN, LCK
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	9.631E-06	8.388E-03	ALOX15, HPGD
BP	GO:0008152; metabolic process	GO:0032270; positive regulation of cellular protein metabolic process	1.126E-05	8.754E-03	ALOX15, CASP1, CASP7, EGFR, FYN, LCK, PRKCD, XDH
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	2.686E-05	1.315E-02	ALOX15, FYN, LCK
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	6.433E-07	3.068E-03	FYN, LCK
MF	GO:0003824; catalytic activity	GO:0004715; non-membrane spanning protein tyrosine kinase activity	9.478E-06	8.388E-03	FYN, LCK, PRKCD
MF	GO:0005488; binding	GO:0042608; T cell receptor binding	1.348E-05	9.417E-03	FYN, LCK

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.994E-03	2.829E-02	XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.007E-03	2.829E-02	HIF1A, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.567E-03	2.829E-02	FYN, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	2.782E-03	2.829E-02	PRKCD, EGFR
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	3.064E-03	2.829E-02	LCK, FYN
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	2.829E-02	CYP2D6, ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.924E-03	2.829E-02	THRB, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	8.693E-04	2.829E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.287E-03	2.829E-02	HIF1A, EGFR
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.893E-03	2.829E-02	HIF1A, EGFR

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD;
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Symphytum tuberosum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities