Plant Name: Symphytum tuberosum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.281E-07 | 3.068E-03 | CASP1, CASP7, LCK, XDH |
| MF | GO:0005488; binding | GO:0042610; CD8 receptor binding | 6.433E-07 | 3.068E-03 | FYN, LCK |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.627E-06 | 5.794E-03 | ALDH1A1, ALOX15, CYP2D6, HPGD, HSD17B10, KDM4E, XDH |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 3.865E-06 | 5.794E-03 | CASP1, CASP7, PRKCD |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 7.395E-06 | 7.668E-03 | EGFR, FYN, LCK |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 8.388E-03 | ALOX15, HPGD |
| MF | GO:0003824; catalytic activity | GO:0004715; non-membrane spanning protein tyrosine kinase activity | 9.478E-06 | 8.388E-03 | FYN, LCK, PRKCD |
| BP | GO:0008152; metabolic process | GO:0032270; positive regulation of cellular protein metabolic process | 1.126E-05 | 8.754E-03 | ALOX15, CASP1, CASP7, EGFR, FYN, LCK, PRKCD, XDH |
| MF | GO:0005488; binding | GO:0042608; T cell receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
| MF | GO:0005488; binding | GO:0042609; CD4 receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 8.693E-04 | 2.829E-02 | CASP7; CASP1 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.287E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 1.567E-03 | 2.829E-02 | FYN; EGFR |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 2.357E-03 | 2.829E-02 | PRKCD; EGFR |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.609E-03 | 2.829E-02 | CASP7; CASP1 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 2.782E-03 | 2.829E-02 | PRKCD; EGFR |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 2.893E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 3.007E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.064E-03 | 2.829E-02 | LCK; FYN |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 2.829E-02 | CYP2D6; ALOX15 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 3.924E-03 | 2.829E-02 | THRB; HIF1A |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 4.883E-03 | 3.097E-02 | LCK; FYN |
| hsa04650 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 5.101E-03 | 3.097E-02 | LCK; FYN |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 5.782E-03 | 3.277E-02 | FYN; EGFR |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 7.791E-03 | 4.139E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.994E-03 | 2.829E-02 | XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK |
| I00-I99: Diseases of the circulatory system | Acute myocardial infarction | I21-I22 | PRKCD |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| C00-D49: Neoplasms | Esophageal cancer | C15 | EGFR |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | EGFR |
| C00-D49: Neoplasms | Advanced cancers | C00-C96 | EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; EGFR |
| C00-D49: Neoplasms | Prostate cancer | C61 | EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | EGFR |
| C00-D49: Neoplasms | Colon cancer | C50 | EGFR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | EGFR; EGFR |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | EGFR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | EGFR; EGFR |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| NA: NA | Reperfusion injury and heart attacks | NA | PRKCD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | EGFR |
| C00-D49: Neoplasms | Gastric cancer | C16 | EGFR; EGFR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | EGFR; EGFR |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | EGFR |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| C00-D49: Neoplasms | Melanoma | C43 | EGFR |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| C00-D49: Neoplasms | Locally advanced head and neck cancer | C07-C14, C32, C33 | EGFR |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | EGFR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; EGFR |
| C00-D49: Neoplasms | Malignant tumor | C00-C75, C7A, C7B | EGFR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | EGFR; EGFR |
| C00-D49: Neoplasms | Glioma | C71 | EGFR; EGFR |
| C00-D49: Neoplasms | Inflammatory breast cancer | C50 | EGFR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| C00-D49: Neoplasms | Refractory breast cancer | C50 | EGFR |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | EGFR |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | EGFR; EGFR |
| C00-D49: Neoplasms | Breast cancer | C50 | EGFR; EGFR; EGFR |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Diabetic foot ulcer | L88-L89 | EGFR |
| E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB |
| C00-D49: Neoplasms | Head and neck squamous cell carcinoma | C44 | EGFR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | EGFR; EGFR; EGFR |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; EGFR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Vulnerary | S00-T98 | EGFR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB |