CMAUP Plant Collective Molecular Activities

Plant Name: Ventilago madraspatana

Taxonomic Information:

Plant ID: NPO9245
Plant Latin Name: Ventilago madraspatana
Taxonomy Genus: Ventilago
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 345802
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk; Ayurveda; Siddha

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	MTOR;
Lyase	CA2; CA3; CA14; CA7; CA5A; CA6; CA12; CA9; CA1;
Transcription Factor	NFKB1; TP53;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.506E-08	5.457E-05	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.478E-25	9.751E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.748E-06	4.604E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.257E-20	6.813E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.698E-18	2.558E-14	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.372E-05	1.572E-02	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.372E-05	1.572E-02	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	2.884E-05	2.854E-02	CA2, CA9, CYP1A2, MTOR, NFKB1, TSHR
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.015E-05	4.677E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	7.104E-05	4.990E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.589E-24	1.652E-22	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	7.839E-05	3.198E-03	TP53, NFKB1, MTOR
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	9.225E-05	3.198E-03	TP53, NFKB1, MTOR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.996E-04	7.111E-03	LMNA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.323E-03	1.871E-02	NFKB1, MTOR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.716E-03	1.871E-02	TP53, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.419E-04	7.111E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.769E-03	1.871E-02	TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.822E-03	1.871E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.159E-03	1.871E-02	TP53, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases