Plant Name: Ventilago madraspatana
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.506E-08 | 5.457E-05 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.478E-25 | 9.751E-21 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.748E-06 | 4.604E-03 | CA2, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.257E-20 | 6.813E-16 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.698E-18 | 2.558E-14 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.589E-24 | 1.652E-22 | CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 7.839E-05 | 3.198E-03 | TP53; NFKB1; MTOR |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 9.225E-05 | 3.198E-03 | TP53; NFKB1; MTOR |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.996E-04 | 7.111E-03 | LMNA; TP53; NFKB1 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.323E-03 | 1.871E-02 | NFKB1; MTOR |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.716E-03 | 1.871E-02 | TP53; MTOR |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.419E-04 | 7.111E-03 | CYP1A2; CYP2C19 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.769E-03 | 1.871E-02 | TP53; NFKB1 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.822E-03 | 1.871E-02 | TP53; MTOR |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.931E-03 | 1.871E-02 | CYP1A2; CYP2C19 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 2.159E-03 | 1.871E-02 | TP53; NFKB1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 2.634E-03 | 2.016E-02 | TP53; NFKB1; MTOR |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 3.887E-03 | 2.527E-02 | TP53; NFKB1; MTOR |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.987E-03 | 1.871E-02 | NFKB1; MTOR |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.980E-03 | 2.066E-02 | TP53; NFKB1 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 5.939E-03 | 2.685E-02 | TP53; NFKB1; MTOR |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 4.242E-03 | 2.595E-02 | NFKB1; MTOR |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.714E-03 | 2.016E-02 | CYP1A2; CYP2C19 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 4.737E-03 | 2.595E-02 | NFKB1; MTOR |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 5.527E-03 | 2.685E-02 | TP53; MTOR |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 5.711E-03 | 2.685E-02 | TP53; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 5.711E-03 | 2.685E-02 | TP53; NFKB1 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 8.343E-03 | 3.337E-02 | TP53; NFKB1 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 6.970E-03 | 3.020E-02 | TP53; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 7.276E-03 | 3.027E-02 | TP53; NFKB1 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 9.710E-03 | 3.740E-02 | THPO; MTOR |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 1.142E-02 | 4.243E-02 | SMN2; SMN1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.565E-02 | 4.876E-02 | TP53; MTOR |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.550E-02 | 4.876E-02 | TP53; NFKB1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.507E-02 | 4.876E-02 | NFKB1; TSHR |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.246E-02 | 4.467E-02 | TP53; NFKB1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.594E-02 | 4.876E-02 | TP53; NFKB1 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.312E-02 | 4.549E-02 | TP53; NFKB1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.741E-03 | 2.595E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; MTOR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; TP53; CA9 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| NA: NA | Edema | NA | CA2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; TP53; CA9; CA1; NFKB1 |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; CA9 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR; CA9 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR |
| NA: NA | Coronary artery restenosis | NA | MTOR |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |