Plant Name: Camellia sinensis
Taxonomic Information:
Plant ID: NPO8258
Plant Latin Name: Camellia sinensis
Taxonomy Genus: Camellia
Taxonomy Family: Theaceae
Plant External Links:
NCBI TaxonomyDB:
4442
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Turkey; Mexico; Indonesia; India; China; Jordan; Sri Lanka; Kenya; Argentina; RussiaTraditional Medicine System:
Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM; HomeopathyMedicinal Functions:
Antidiarrhoeal; Antiemetic; Astringent; Cardiotonic; Diuretic; Stimulant
Geographical Distribution:
Turkey; Mexico; Indonesia; India; Jordan; Kenya; Sri Lanka; China; Argentina; Russia
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HCAR2; | |
| ALPL; TDP1; RECQL; TERT; PGD; POLB; | |
| CDC25B; | |
| BCL2; | |
| MAPK1; | |
| RORC; | |
| NR1H4; | |
| NFKB1; | |
| DNMT1; | |
| ABCB1; | |
| SLCO1B1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Small molecule receptor (family A GPCR) | HCAR2 | Hydroxycarboxylic acid receptor 2 | Q8TDS4 | CHEMBL3785 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 7.665E-07 | 2.504E-03 | ALPL, CYP1A1, CYP1B1, MAPK1, NFKB1, RORC |
| BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 2.748E-06 | 6.650E-03 | BCL2, NR1H4 |
| BP | GO:0009987; cellular process | GO:0033554; cellular response to stress | 5.331E-06 | 8.292E-03 | BCL2, CYP1B1, LMNA, MAPK1, NFKB1, POLB, RECQL, TDP1, TERT |
| BP | GO:0065007; biological regulation | GO:0010817; regulation of hormone levels | 6.586E-06 | 9.561E-03 | CYP1A1, CYP1B1, HCAR2, NFKB1, NR1H4, SLCO1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 6.418E-09 | 8.151E-07 | DNMT1, ABCB1, BCL2, CYP1B1, MAPK1, NFKB1, CDC25B |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 8.216E-06 | 5.217E-04 | LMNA, BCL2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 7.839E-05 | 2.489E-03 | BCL2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.142E-04 | 2.562E-03 | BCL2, MAPK1, NFKB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.988E-05 | 1.688E-03 | SLCO1B1, ABCB1, NR1H4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.211E-04 | 2.562E-03 | BCL2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 1.811E-04 | 2.685E-03 | BCL2, MAPK1, NFKB1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.903E-04 | 2.685E-03 | BCL2, MAPK1, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.903E-04 | 2.685E-03 | BCL2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.389E-04 | 4.304E-03 | BCL2, MAPK1, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 8.360E-04 | 8.167E-03 | HCAR2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 6.048E-04 | 6.908E-03 | BCL2, MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 9.110E-04 | 8.264E-03 | POLB, MAPK1, NFKB1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 6.527E-04 | 6.908E-03 | CYP1A1, CYP1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.706E-03 | 9.360E-03 | MAPK1, NFKB1, CDC25B |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.019E-03 | 8.630E-03 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.323E-03 | 9.360E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 1.765E-03 | 9.360E-03 | POLB, TERT, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 1.563E-03 | 9.360E-03 | BCL2, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.323E-03 | 9.360E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.716E-03 | 9.360E-03 | RORC, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.769E-03 | 9.360E-03 | MAPK1, NFKB1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.369E-03 | 9.360E-03 | CYP1A1, CYP1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 2.101E-03 | 9.453E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 2.159E-03 | 9.453E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.716E-03 | 9.360E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.159E-03 | 9.453E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 2.159E-03 | 9.453E-03 | MAPK1, NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.159E-03 | 9.453E-03 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 2.277E-03 | 9.638E-03 | MAPK1, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; HCAR2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT; BCL2; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | HCAR2; |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; DNMT1; MAPK1; ABCB1; CDC25B; BCL2; |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT; BCL2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; ABCB1; |
| C00-D49: Neoplasms | Soft tissue sarcoma | C00-D49 | DNMT1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | HCAR2; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | DNMT1; |
| I00-I99: Diseases of the circulatory system | Acute ischemic stroke | I61-I63 | HCAR2; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; DNMT1; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | DNMT1; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; ABCB1; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | DNMT1; |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT; |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | HCAR2; |
| C00-D49: Neoplasms | Melanoma | C43 | TERT; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; BCL2; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HCAR2; |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | HCAR2; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | DNMT1; ABCB1; |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
