Plant Name: Bryum rutilans
Taxonomic Information:
Plant ID: NPO8037
Plant Latin Name: Bryum rutilans
Taxonomy Genus: Bryum
Taxonomy Family: Bryaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| TSHR; | |
| PTPN1; PTPN2; ACP1; CDC25B; PTPRF; | |
| PLA2G1B; FAAH; RECQL; TERT; HSD11B1; AKR1B10; POLB; | |
| PPARA; PPARD; PPARG; | |
| RORC; | |
| NR1H4; | |
| TLR2; | |
| ABCB1; | |
| LMNA; FABP3; FABP5; FABP2; FABP4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 5.382E-09 | 1.465E-05 | NR1H4, PPARA, PPARD, PPARG, RORC |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.400E-08 | 2.909E-05 | NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 3.200E-08 | 4.976E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.929E-07 | 2.000E-04 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 4.079E-07 | 3.417E-04 | NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 7.505E-07 | 5.636E-04 | NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.046E-06 | 7.345E-04 | FABP3, PLA2G1B, PPARA, PPARG, TLR2 |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.093E-06 | 1.199E-03 | NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 3.250E-06 | 1.608E-03 | NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 3.805E-06 | 1.801E-03 | FABP3, NR1H4, PPARG, TLR2 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 5.222E-06 | 2.317E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 5.222E-06 | 2.317E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.044E-05 | 3.787E-03 | PTPN1, PTPN2 |
| BP | GO:0065007; biological regulation | GO:0055088; lipid homeostasis | 1.351E-05 | 4.598E-03 | FABP3, FABP4, NR1H4, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.738E-05 | 5.822E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0045834; positive regulation of lipid metabolic process | 2.100E-05 | 6.928E-03 | FABP3, NR1H4, PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0071453; cellular response to oxygen levels | 2.382E-05 | 7.366E-03 | LMNA, PPARD, PPARG, TERT |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 2.605E-05 | 7.366E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 2.605E-05 | 7.366E-03 | PPARG, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 2.605E-05 | 7.366E-03 | PPARA, PPARG |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 2.605E-05 | 7.366E-03 | FABP3, PPARG |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 2.975E-05 | 7.998E-03 | FABP3, LMNA, PPARD, PPARG, PTPN2, TERT, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 3.828E-05 | 9.923E-03 | NR1H4, PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0004726; non-membrane spanning protein tyrosine phosphatase activity | 4.854E-05 | 1.161E-02 | ACP1, PTPN2 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.329E-04 | 3.747E-02 | CDC25B, FABP5, LMNA, NR1H4, POLB, PPARA, PPARD, PPARG, PTPN2, RECQL, RORC, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.657E-12 | 1.913E-10 | FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.189E-04 | 4.281E-03 | PTPN1, ACP1, PTPRF |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 3.737E-04 | 8.968E-03 | PTPN1, PPARA, PTPRF |
| 09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 1.292E-03 | 2.325E-02 | FABP2, PLA2G1B |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 2.397E-03 | 3.452E-02 | FABP4, TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 3.214E-03 | 3.857E-02 | RORC, TLR2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.822E-03 | 3.931E-02 | ABCB1, NR1H4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 1.397E-02 | 1.258E-01 | PTPN1, PTPRF |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 4.579E-02 | 1.832E-01 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 4.080E-02 | 1.832E-01 | AKR1B10 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1; |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | HSD11B1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
