CMAUP Plant Collective Molecular Activities

Plant Name: Bryum rutilans

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	5.382E-09	1.465E-05	NR1H4, PPARA, PPARD, PPARG, RORC
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	1.400E-08	2.909E-05	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	3.200E-08	4.976E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.929E-07	2.000E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.079E-07	3.417E-04	NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	7.505E-07	5.636E-04	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.046E-06	7.345E-04	FABP3, PLA2G1B, PPARA, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.093E-06	1.199E-03	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	3.250E-06	1.608E-03	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	3.805E-06	1.801E-03	FABP3, NR1H4, PPARG, TLR2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	5.222E-06	2.317E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	5.222E-06	2.317E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.044E-05	3.787E-03	PTPN1, PTPN2
BP	GO:0065007; biological regulation	GO:0055088; lipid homeostasis	1.351E-05	4.598E-03	FABP3, FABP4, NR1H4, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.738E-05	5.822E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0045834; positive regulation of lipid metabolic process	2.100E-05	6.928E-03	FABP3, NR1H4, PPARA, PPARG
BP	GO:0009987; cellular process	GO:0071453; cellular response to oxygen levels	2.382E-05	7.366E-03	LMNA, PPARD, PPARG, TERT
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.605E-05	7.366E-03	PPARA, PPARG
BP	GO:0009987; cellular process	GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway	2.605E-05	7.366E-03	PPARG, PTPN2
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	2.605E-05	7.366E-03	PPARA, PPARG
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	2.605E-05	7.366E-03	FABP3, PPARG
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	2.975E-05	7.998E-03	FABP3, LMNA, PPARD, PPARG, PTPN2, TERT, TLR2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	3.828E-05	9.923E-03	NR1H4, PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.657E-12	1.913E-10	FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa04520	Adherens junction_Homo sapiens_hsa04520	1.189E-04	4.281E-03	PTPN1; ACP1; PTPRF
hsa04931	Insulin resistance_Homo sapiens_hsa04931	3.737E-04	8.968E-03	PTPN1; PPARA; PTPRF
hsa04975	Fat digestion and absorption_Homo sapiens_hsa04975	1.292E-03	2.325E-02	FABP2; PLA2G1B
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.397E-03	3.452E-02	FABP4; TSHR
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	3.214E-03	3.857E-02	RORC; TLR2
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.822E-03	3.931E-02	ABCB1; NR1H4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1; TLR2
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B; FAAH
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Prostate cancer	C61	TLR2; TERT
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1; PPARD; PPARG; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
C00-D49: Neoplasms	Melanoma	C43	TLR2; TERT
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1; TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	FAAH
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2; TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1; PPARG
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
C00-D49: Neoplasms	Breast cancer	C50	TERT
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Cancer	C00-C96	ABCB1; TLR2; CDC25B
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
C00-D49: Neoplasms	Multiple myeloma	C90	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1; PPARD; PPARD; PPARG
NA: NA	Dyslipidemia	NA	PPARD
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG; PPARG
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
C00-D49: Neoplasms	Liver cancer	C22	TERT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases