CMAUP Plant Collective Molecular Activities

Plant Name: Raphanus sativus

Taxonomic Information:

Plant ID: NPO7539
Plant Latin Name: Raphanus sativus
Taxonomy Genus: Raphanus
Taxonomy Family: Brassicaceae

Plant External Links:

NCBI TaxonomyDB: 3726
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Israel; Italy; India; Philippines; Indonesia; Lebanon; China; Jordan; Thailand; South Korea

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Anthelmintic; Antibacterial; Antifungal; Antiscorbutic; Antispasmodic; Appetizer; Astringent; Cancer; Carminative; Cholagogue; Digestive; Diuretic; Expectorant; Laxative; Poultice; Stomachic

Geographical Distribution:

Turkey; Israel; Italy; Lebanon; Philippines; Indonesia; India; China; Thailand; Jordan; South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Enzyme_unclassified	TDP1; FAAH; MIF; TERT; HPGD; ALOX15; ALDH1A1;
Protein Kinase	EGFR;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group I	NR1I2;
Oxidoreductase	PTGS1;
Toll-like and Il-1 receptors	TLR2;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	MIF	Macrophage migration inhibitory factor	P14174	CHEMBL2085
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group I	NR1I2	Pregnane X receptor	O75469	CHEMBL3401
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.070E-13	4.658E-10	CA1, CA12, CA2, CA5A, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.685E-08	2.784E-05	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, NR1I2, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.705E-08	5.615E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.093E-06	5.806E-04	NR1I2, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.322E-06	1.053E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.876E-06	1.623E-03	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	6.767E-06	2.585E-03	ALOX15, EGFR, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.471E-06	2.757E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	7.883E-06	2.861E-03	FABP3, FFAR1, PPARG, TLR2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.088E-05	3.687E-03	CA2, CA9, EGFR, HPGD, TSHR
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.422E-05	4.489E-03	ALOX15, CA2, CA9, EGFR, LMNA, MAPT, MIF, PPARD, PPARG, TDP1, TERT
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.485E-05	6.850E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	3.313E-05	8.794E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	3.352E-05	8.794E-03	EGFR, FFAR1, MIF, PPARD, TLR2
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	3.724E-05	9.112E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	3.724E-05	9.112E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.724E-05	9.112E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	3.724E-05	9.112E-03	FABP3, PPARG
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.724E-05	9.112E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.050E-19	2.286E-15	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.804E-15	3.053E-11	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.997E-19	2.637E-17	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.048E-11	4.610E-10	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.841E-05	2.593E-03	FABP4, TSHR, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.149E-03	9.129E-02	ALOX15, PTGS1
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	7.902E-02	2.266E-01	TSHR
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	9.746E-02	2.266E-01	EGFR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	9.887E-02	2.266E-01	EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.045E-01	2.266E-01	EGFR
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.454E-01	2.266E-01	FAAH
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.480E-01	2.266E-01	EGFR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD;
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD;
NA: NA	Dyslipidemia	NA	PPARD;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases