CMAUP Plant Collective Molecular Activities

Plant Name: Raphanus sativus

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.070E-13	4.658E-10	CA1, CA12, CA2, CA5A, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.685E-08	2.784E-05	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, NR1I2, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.705E-08	5.615E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.093E-06	5.806E-04	NR1I2, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.322E-06	1.053E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.876E-06	1.623E-03	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	6.767E-06	2.585E-03	ALOX15, EGFR, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.471E-06	2.757E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	7.883E-06	2.861E-03	FABP3, FFAR1, PPARG, TLR2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.088E-05	3.687E-03	CA2, CA9, EGFR, HPGD, TSHR
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.422E-05	4.489E-03	ALOX15, CA2, CA9, EGFR, LMNA, MAPT, MIF, PPARD, PPARG, TDP1, TERT
MF	GO:0005488; binding	GO:0043167; ion binding	1.563E-05	4.726E-03	ALOX15, CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9, EGFR, FABP2, FABP3, FABP4, FABP5, FFAR4, HPGD, NR1I2, PPARA, PPARD, PPARG, PTGS1, TERT
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.485E-05	6.850E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	3.313E-05	8.794E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	3.352E-05	8.794E-03	EGFR, FFAR1, MIF, PPARD, TLR2
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	3.724E-05	9.112E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	3.724E-05	9.112E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.724E-05	9.112E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	3.724E-05	9.112E-03	FABP3, PPARG
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.724E-05	9.112E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.050E-19	2.286E-15	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.804E-15	3.053E-11	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	2.997E-19	2.637E-17	CA12; CA1; CA2; CA5A; CA7; CA6; CA9; CA14
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	1.048E-11	4.610E-10	FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	8.841E-05	2.593E-03	FABP4; TSHR; PTGS1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Prostate cancer	C61	TLR2; TERT; EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; TLR2; EGFR
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT; EGFR; EGFR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT; EGFR; EGFR; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1; PPARD; PPARG; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
C00-D49: Neoplasms	Tumors	C00-D48	TERT
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Urethral cancer	NA	EGFR
C00-D49: Neoplasms	Multiple myeloma	C90	TERT
C00-D49: Neoplasms	Melanoma	C43	TLR2; TERT; EGFR
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR
C00-D49: Neoplasms	Breast cancer	C50	CA9; TERT; EGFR; EGFR; EGFR
NA: NA	Rheumatold arthritis	NA	PTGS1
NA: NA	Miosis during ocular surgery	NA	PTGS1
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
C00-D49: Neoplasms	Ovarian cancer	C56	TERT; EGFR; EGFR
C00-D49: Neoplasms	Colon cancer	C50	EGFR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	EGFR; EGFR; PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	MIF; TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	EGFR; EGFR
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; EGFR
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD; NR1I2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2; TERT; EGFR
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD; PPARG
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MIF; PTGS1; FAAH
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; PPARG
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; PPARG; PPARG
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Refractory autoimmune diseases	D84.9, M35.9	MIF
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH
C00-D49: Neoplasms	Liver cancer	C22	TERT
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1; FAAH
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; EGFR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD; MAPT
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1; PPARG
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; TLR2; EGFR
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; EGFR
C00-D49: Neoplasms	Glioma	C71	EGFR; EGFR
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR
C00-D49: Neoplasms	Bladder cancer	C67	EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases